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Numerical solution of the imprecisely defined inverse heat conduction problem

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Chinese Physics B 2015年第5期24卷 153-162页

作者： smita Tapaswini s.Chakraverty Diptiranjan Behera Department of Mathematics National Institute of Technology Rourkela

This paper investigates the numerical solution of the uncertain inverse heat conduction problem. Uncertainties present in the system parameters are modelled through triangular convex normalized fuzzy sets. In the solution process, double parametric forms of fuzzy numbers are used with the variational iteration method （VIM）. This problem first computes the uncertain temperature distribution in the domain. Next, when the uncertain temperature measurements in the domain are known, the functions describing the uncertain temperature and heat flux on the boundary are reconstructed. Related example problems are solved using the present procedure. We have also compared the present results with those in [Inf. sci. （2008） 178 1917] along with homotopy perturbation method （HPM） and [Int. Commun. Heat Mass Transfer （2012） 39 30] in the special cases to demonstrate the validity and applicability.

关键词： triangular fuzzy number double parametric form of fuzzy numbers uncertain inverse heat con-duction variational iteration method (VIM)

Theoretical study of screening Dependence of Aluminium Doped MgB_2

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Chinese Physics letters 2018年第3期35卷 79-83页

作者： Gargee sharma smita sharma Department of Physics Government Dungar College

The screening dependence of superconducting state parameters （λ, μ＊, Tc, α and NoV） of six alloys of aluminium doped MgB2 systems are studied in the BCs-Eliashberg-MeMillan framework by employing five forms of dielectric screening function, viz. random phase approximation （RPA）, Harrison, Geldart and Vosko （GV）, Hubbard and Overhauser in conjunction with Ashcroft＇s potential. It is observed that electron-phonon coupling strength and Coulomb pseudopotential μ＊ are quite sensitive to the form of dielectric screening, whereas transition temperature Tc, isotope effect exponent α and effective interaction strength NoV show weak dependence on the form of dielectric screening function. It is found that the RPA form of dielectric screening function yields the best results for transition temperature Tc for all alloys of the Mg-Al-B system. The results obtained using GV screening are much higher than the experimental results. This shows that all the four dielectric screenings used here almost describe superconductivity in all the alloys of the Mg-Al-B system, but the GV screening is not suitable for such an alloy system.

关键词： Theoretical study of screening Dependence of Aluminium Doped MgB2 Al

synthesis and Characterization of Bio-based Epoxy Blends from Renewable Resource Based Epoxidized soybean Oil as Reactive Diluent

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Chinese Journal of Polymer science 2015年第1期33卷 137-152页

作者： sushanta K sahoo smita Mohanty sanjay K Nayak Laboratory for Advanced Research in Polymeric Materials (LARPM) Central Institute of Plastics Engineering & Technology (CIPET)B/25 CNI complex Patia Bhubaneswar 751024 Odisha India

A novel bioresin, epoxidized soybean oil was synthesized by in situ method and was characterized employing FTIR and NMR. The bioresin was blended with epoxy（DGEBA） at different ratios as reactive diluents for improved processibility and toughened nature. The composition with 20 wt% bioresin exhibited improved impact strength to the tune of 60% as compared to virgin epoxy. Fracture toughness parameters critical stress intensity factor（KIC） and critical strain energy release rate（GIC） were evaluated using single edge notch bending test and demonstrated superior enhancement in toughness. Dynamic mechanical, thermal, thermo mechanical and fracture morphological analyses have been studied for bio-based epoxy blends. Curing kinetics has been evaluated through DsC analysis to investigate the effect of bioresin on cross-linking reaction of neat epoxy with triethylenetetramine as curing agent.

关键词： Bio-based epoxy soybean oil Fracture toughness Curing kinetics TMA.

Heteromeric and Homomeric Geranyl Diphosphate synthases from Catharanthus roseus and Their Role in Monoterpene Indole Alkaloid Biosynthesis

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Molecular Plant 2013年第5期6卷 1531-1549页

作者： Avanish Rai shachi s. smita Anup Kumar singh Karuna shanker Dinesh A. Nagegowda CsIR-Central Institute of Medicinal and Aromatic Plants Research Centre Bangalore 560065 India CsIR-Central Institute of Medicinal and Aromatic Plants Lucknow 226015 India

Catharanthus roseus is the sole source of two most important monoterpene indole alkaloid （MIA） anti- cancer agents： vinblastine and vincristine. MIAs possess a terpene and an indole moiety derived from terpenoid and shikimate pathways, respectively. Geranyl diphosphate （GPP）, the entry point to the formation of terpene moiety, is a product of the condensation of isopentenyl diphosphate （IPP） and dimethylallyl diphosphate （DMAPP） by GPP synthase （GPPs）. Here, we report three genes encoding proteins with sequence similarity to large subunit （***） and small subunit （***） of heteromeric GPPss, and a homomeric GPPss. *** is a bifunctional enzyme producing both GPP and geranyl geranyl diphosphate （GGPP）, *** is inactive, whereas CrGPPs is a homomeric enzyme forming GPP. Co-expression of both subunits in Escherichia coil resulted in heteromeric enzyme with enhanced activity producing only GPR While *** and CrGPPs showed higher expression in older and younger leaves, respectively, *** showed an increasing trend and decreased gradually. Methyl jasmonate （MelA） treatment of leaves sig- nificantly induced the expression of only ***. GFP localization indicated that *** is plastidial whereas CrGPPs is mitochondrial. Transient overexpression of *** in C. roseus leaves resulted in increased vindoline, immediate monomeric precursor of vinblastine and vincristine. Although C. roseus has both heteromeric and homomeric GPPs enzymes, our results implicate the involvement of only heteromeric GPPs with *** regulating the GPP flux for MIA biosynthesis.

关键词： C. roseus monoterpene indole alkaloids geranyl diphosphate synthase heteromer homomer large subunit small subunit vindoline.

Capuli cherry-mediated green synthesis of silver nanoparticles under white solar and blue leD light

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Particuology 2016年第1期14卷 123-128页

作者： Brajesh Kumar Yolancla Angulo Kumari smita Luis Cumbal Alexis Debut Centro de Nanociencia y Nanotecnologia Universidad de las Fuerzas Armadas-ESPE Av. Gral. Rumifiahui s/n Sangolqui P.O. BOX 171-5-231B Ecuador

In this article, the Capuli （Prunus serotina Ehrh. var. Capuli） cherry extract was used for the synthesis of silver nanoparticles （AgNPs） in the presence of white/visible solar and blue light-emitting diode （leD） light. For the characterization of the extract and the AgNPs, Fourier transform infrared spectroscopy and ultraviolet-visible spectroscopy were employed, along with hydrodynamic particle size analysis, trans- mission electron microscopy and X-ray diffraction. The Ag nanospheres obtained using white light were 40-100 nm in diameter and exhibited an absorption peak at λmax= 445 nm, whereas those obtained using blue leD light were 20-80 nm in diameter with an absorption peak at λmax= 425 nm. Thermal analysis revealed that the content of biomolecules surrounding the AgNPs was about 55-65%, and it was also found that blue leD light AgNPs （56.28%, 0.05 mM） had a higher antioxidant efficacy than the white solar light AgNPs （33.42%, 0.05 mM） against l,l-diphenyl-2-picrylhydrazyl. The results indicate that obtaining AgNPs using a blue leD light may prove to be a simple, cost-effective and easily reproducible method for creating future nanopharmaceuticals.

关键词： silver nanoparticles Capuli leD light Fourier transform infrared spectroscopy Transmission electron microscopy Antioxidant

Effect of Ipomea carnea Jacq. flowers on hematological changes in toluene diisocyanate-induced inflammation in Wistar rats

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Chinese Journal of Natural Medicines 2014年第3期12卷 161-166页

作者： Jain smita Patil U.K. Department of Pharmacognosy VNS Institute of Pharmacy Department of Pharmaceutical sciences Dr. H.S. Gour Central University

AIM： To investigate the active chloroform fraction of the ethanol extract oflpomoea carnea flowers on hematological changes in toluene diisocyanate-induced inflammation in Wistar rats. METHOD： Except for the control group, all of the rats were sensitized with intranasal application of 5 μL of 10% toluene diiso- cyanate （TDI） for 7 days. One week after second sensitization, all of the rats were provoked with 5 ~tL of 5% TDI to induce airway hypersensitivity. After the last challenge, blood and bronchoalvelor lavage （BAL） fluid were collected and subjected to total and differential leucocytes count. Flash chromatography was performed on the most active chloroform fraction to isolate an individual component. REsULTs： Treatment with the ethanolic extract and its chloroform fraction at an oral dose of 200 mg·kg^ -1 showed a significant decrease in circulating neutrophil and eosinophil in blood and BAL as compared with standard dexamethasone （DEXA）. The structure of the compound obtained from chloroform fraction oflpomea carnea was elucidated as stigmast-5, 22-dien-3β-ol on the basis of spectral data analysis. CONCLUsION： The chloroform fraction was found to be more effective to suppress airway hyper reactivity symptoms, and de- creased count of both total and differential inflammatory cells.

关键词： Ipomea carnea Toluene diisocyanate Bronchoalvelor lavage Neutrophils stigmasterol

Isolated gastric Crohn's disease

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World Journal of Clinical Cases 2013年第2期1卷 71-73页

作者： sachin B Ingle Chitra R Hinge sarita Dakhure smita s.bhos.le Department of Pathology and Anaesthesia MIMSR Medical College

Crohn's disease(CD) is a chronic idiopathic inflammatory disease of gastrointestinal tract characterized by segmental and transmural involvement of gastrointestinal tract. Ileocolonic and colonic/anorectal is a most common and account for 40% of cases and involvement of small intestine in about 30%. The stomach is rarely the sole or predominant site of CD. To date there are only a few documented case reports of adults with isolated gastric CD and no reports in the pediatric population. Isolated stomach involvement is very unusual presentation accounting for less than 0.07% of all gastrointestinal CD. The diagnosis is difficult to establish in cases of atypical presentation as in isolated gastroduodenal disease. In the absence of any other source of disease and in the presence of nonspecific upper GI endoscopy and histological findings, serological testing can play a vital role in the diagnosis of atypical CD. Recent stud-ies have suggested that perinuclear anti-neutrophil cytoplasmic antibody and anti-saccharomycescervisia antibody may be used as additional diagnostic tools. The effectiveness of infliximab in isolated gastric CD is limited to only a few case reports of adult patients and the long-term outcome is unknown.

关键词： Gastrointestinal tract Crohn’s disease Perinuclear anti-neutrophil cytoplasmic antibody Anti-saccharomycescervisia antibody

Effect of Phyllanthus *** on burn wound in rats

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Asian Pacific Journal of Tropical Medicine 2010年第2期3卷 105-108页

作者： Tara shanbhag Arul Amuthan smita shenoy sudhakar Department of Pharmacology Kasturba Medical College

Objective:To evaluate the effect of ethanolic extract of Phyllanthus ***(Euphorbiaceae) on experimentally induced burn wound model in rats and to evaluate whether it reverses the wound healing in steroid suppressed ***:Two models including burn wound model and dexamethasone suppressed bum wound model were used in the *** formulations of ethanolic extract of Phyllanthus niruri were prepared in gum acacia at 8%and in ointment base at 10%and were administered orally(400 mg/kg) and externally *** parameters studied were the wound contraction and the period of ***:In bum wound model,oral and topical administration of Phyllanthus niruri did not show any significant effects in wound contraction and period of epithelialisation when compared to *** dexamethasone suppressed burn wound model,wound contraction rate was increased significantly by topical(P strations of Phyllanthus niruri by about 47.57%and 26.16% *** administration has shown significant(P sage *** depressed epithelialisation period was reversed significanUy by topical(P strations of Phyllanthus niruri by about 32.5%and 21.3%***:Both topical and oral administrations of ethanolic extract of Phyllanthus niruri are found to reverse dexamethasone suppressed burn wound healing.

关键词： Phyllanthus niruri Burn wound Dexamethasone suppressed wound healing Wound contraction Epithelialisation period

status of precision medicine approaches to traumatic brain injury

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Neural Regeneration Research 2022年第10期17卷 2166-2171页

作者： sahithi Reddi smita Thakker-Varia Janet Alder Anna O.Giarratana Department of Neuroscience and Cell Biology Rutgers Robert Wood Johnson Medical SchoolPiscatawayNJUSA

Traumatic brain injury(TBI)is a serious condition in which trauma to the head causes damage to the brain,leading to a disruption in brain *** is a significant health issue worldwide,with around 69 million people suffering from TBI each *** following the trauma,damage occurs in the acute phase of injury that leads to the primary outcomes of the *** the hours-to-days that follow,secondary damage can also occur,leading to chronic *** can range in severity from mild to severe,and can be complicated by the fact that some individuals sustain multiple TBIs,a risk factor for worse long-term *** our knowledge about the pathophysiology of TBI has increased in recent years,unfortunately this has not been translated into effective clinical *** *** and Drug Administration has yet to approve any drugs for the treatment of TBI;current clinical treatment guidelines merely offer supportive *** between individuals greatly vary,which makes the treatment for TBI so challenging.A blow of similar force can have only mild,primary outcomes in one individual and yet cause severe,chronic outcomes in *** of the reasons that have been proposed for this differential response to TBI is the underlying genetic differences across the *** to this,many researchers have begun to investigate the possibility of using precision medicine techniques to address TBI *** this review,we will discuss the research detailing the identification of genetic risk factors for worse outcomes after TBI,and the work investigating personalized treatments for these higher-risk *** highlight the need for further research into the identification of higher-risk individuals and the development of personalized therapies for TBI.

关键词： apolipoprotein E biomarkers brain injury brain-derived neurotrophic factor clinical trials personalized treatments precision medicine tau translational research traumatic brain injury