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Efficacy of Gold Nanoparticles against Nephrotoxicity Induced by Schistosoma mansoni Infection in Mice

首届国际手术室护理学术交流暨专题讲座会议

作者： Chan HC Cheng KP Ho CT Lui sm Poon SK Operating Room Department United Christian HospitalHong Kong SAR Operating Room Department United Christian HospitalHong Kong SAR Operating Room Department United Christian HospitalHong Kong SAR Operating Room Department United Christian HospitalHong Kong SAR Operating Room Department United Christian HospitalHong Kong SAR

＜正＞Introduction: Sharp injuries constitute the leading cause of job-related injuries because OR staffs have more chances in handling of surgical blades, suturing needles, injection needles, wires and etc. From the Incident on duty （IOD）’s report, thirty-one cases induced by sharp injuries （n=31） were reported during the 3-year period （2001- 2003）, for an average rate of 0.85 injury per month. Its mean value was 48% (95% CI 35.3% -

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Biomedical and Environmental Sciences 2016年第11期29卷 773-781页

作者： Mohamed A Dkhil Mona F Khalil2 Amira A Bauom Marwa sm Dia Saleh A1-Qura Department of Zoology College of ScienceKing Saud UniversityRiyadh 11451Saudi Arabia Department of Zoology and Entomology Faculty of ScienceHelwan UniversityCairo 11795Egypt Department of Laboratory Sciences College of Science&ArtsA1-RassQassim UniversityAL-Qaseam 51921Saudi Arabia Molecular Drug Evaluation Department National Organization for Drug Control&Research(NODCAR)Giza 12553Egypt

Objective In this study, the ameliorative effects of gold nanoparticles （gold NP） on the renal tissue damage in Schistosoma mansoni （S. mansoni）-infected mice was investigated. Methods High-resolution transmission electron microscopy was used for the characterization of NP. The gold NP at concentrations of 250, 500, and 1000 μg/kg body weight were inoculated into 5. mansoni-infected mice. Results The parasite caused alterations in the histological architecture. Furthermore, it induced a significant reduction in the renal glutathione levels; however, the levels of nitric oxide and malondialdehyde were significantly elevated. The parasite also managed to downregulate KIM-I, NGAL, MCP-1, and TGF-8 mRNA expression in infected animals. Notably, gold NP treatment in mice reduced the extent of histological impairment and renal oxidative damage. Gold NP were able to regulate gene expression impaired by 5. Mansoni infection. Conclusion The curative effect of gold NP against renal toxicity in 5. mansoni-infected mice is associated with their role as free radical scavengers.

关键词： Gold nanoparticles Schistosomiasis Renal damage Gene expression Histopathology Oxidative stress

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Green tea extract as a cryoprotectant additive to preserve the motility and DNA integrity of human spermatozoa

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Asian Journal of Andrology 2021年第2期23卷 150-156页

作者： Odai AM Alqawasmeh Mingpeng Zhao Carol PS Chan Maran BW Leung Ki C Chow Nikunj Agarwal Jennifer sm Mak Chi C Wang Chi P Pang Tin C Li Wai K Chu David YL Chan Assisted Reproductive Technology Unit Department of Obstetrics and GynaecologyFaculty of MedicineThe Chinese University of Hong KongHong KongChina Department of Ophthalmology and Visual Sciences The Chinese University of Hong KongHong KongChina

Cryopreservation impairs sperm quality and functions,including motility and DNA *** additives in sperm freezing media have previously brought improvements in postthawed sperm *** tea extract(GTE)is widely considered as an excellent antioxidant,and its beneficial role has been proven in other human *** study aims to evaluate the GTE as a potential additive in cryopreservation media of human *** part one,the semen of 20 normozoospermic men was used to optimize the concentration of GTE that maintains sperm motility and DNA integrity against oxidative stress,induced by hydrogen peroxide(H_(2)O_(2)).Spermatozoa were treated with GTE at different concentrations before incubation with H_(2)O_(2).In part two,the semen of 45 patients was cryopreserved with or without 1.0 ng ml^(-1)*** 2 weeks,the semen was thawed,and the effect on sperm motility and DNA fragmentation was *** data showed that GTE significantly protected sperm motility and DNA integrity against oxidative stress induced by H_(2)O_(2)when added at a final concentration of 1.0 ng ml^(-1).We found that the addition of 1.0 ng ml^(-1)GTE to cryopreservation media significantly increased sperm motility and DNA integrity(both P<0.05).More interestingly,patients with high sperm DNA damage benefited similarly from the GTE ***,there was no significant change in the reactive oxygen species(ROS)*** conclusion,supplementing sperm freezing media with GTE has a significant protective effect on human sperm motility and DNA integrity,which may be of clinical interest.

关键词： antioxidants cryopreservation additives sperm cryopreservation sperm DNA fragmentation sperm motility

自发性脑出血诊疗指南--美国心脏协会／美国卒中协会的健康职业者指南

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中国脑血管病杂志 2015年第9期12卷 490-504页

作者： Hemphill JC Ⅲ Greenberg sm Anderson CS 文婉玲于瀛黄清海第二军医大学附属长海医院神经外科上海200433

在世界范围内，自发性、非创伤性脑出血（intracranial hemorrhage，ICH）仍然是致死、致残的重要原因。虽然在临床研究及治疗指南的临床证据方面，ICH一直落后于缺血性卒中和动脉瘤性蛛网膜下腔出血，但在过去的10年内有了长足的增长... 详细信息

在世界范围内，自发性、非创伤性脑出血（intracranial hemorrhage，ICH）仍然是致死、致残的重要原因。虽然在临床研究及治疗指南的临床证据方面，ICH一直落后于缺血性卒中和动脉瘤性蛛网膜下腔出血，但在过去的10年内有了长足的增长。基于人群的研究发现，出血量较小的ICH患者几乎均能通过良好的内科治疗而存活［1］，提示良好的内科治疗很可能直接影响ICH患者的残疾率。本指南的目的是，纳入最新临床研究的中期结果，并更新2010年版指南［2］，向临床医师强调，其管理对ICH患者结局有着重要影响，并为临床管理提供相应的循证医学证据。为保证本指南的简洁和实用性，ICH的背景及流行病学均被省略，仅提供参考文献供查阅［1，3-4］。

关键词：自发性脑出血美国心脏协会科学声明指南

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皮肤免疫系统与银屑病

国外医学（皮肤性病学分册） 1994年第5期20卷 295-297页

作者： Breathnach sm 秦思栋

皮肤含有多种免疫细胞,如T淋巴细胞、皮肤郎格罕细胞、真皮树突状细胞及角朊细胞等。其中角朊细胞能产生IL-1、IL-6、IL-7、IL-8、IL-10、α-肿瘤坏死因子、集落刺激因子及生长因子等多种细胞因子。皮肤免疫细胞及其细胞因子以及表皮血... 详细信息

皮肤含有多种免疫细胞,如T淋巴细胞、皮肤郎格罕细胞、真皮树突状细胞及角朊细胞等。其中角朊细胞能产生IL-1、IL-6、IL-7、IL-8、IL-10、α-肿瘤坏死因子、集落刺激因子及生长因子等多种细胞因子。皮肤免疫细胞及其细胞因子以及表皮血管系统的细胞粘附分子,不仅与皮肤的炎症反应有关,而且在银屑病的免疫发病机制中还起着重要的作用。

关键词：银屑病免疫细胞皮肤免疫系统

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Phytopharmacological evaluation of ethanol extract of Sida cordifolia ***

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Asian Pacific Journal of Tropical Biomedicine 2014年第1期4卷 18-24页

作者： Mohammad Abdul Motalib Momin sm Faysal Bellah Sarder Mohammad Raussel Rahman Ahmed Ayedur Rahman Gazi Mohammad Monjur Murshid Sarder Mohammad Saker Billah Talha Bin Emran Department of Pharmacy Jahangirnagar University Department of Clinical Pharmacy and Pharmacology Dhaka University Pharmacy Discipline Life Science SchoolKhulna University Department of Chemistry Gort.M.M.University College Department of Pharmacy BGC Trust University

Objective:To investigate the phytochemical screening(group determination)and selected pharmacological activities(antioxidant,antimicrobial and analgesic activity)of the plant Sida cordifolia Linn(***).Methods:Eighty percent concentrated ethanol extract of the roots was *** identify the chemical constituents of plant extract standard procedures were *** phytochemical screening the crude extract was tested for the presence of different chemical groups like reducing sugar,tannins,saponins,steroids,flavonoids,gums,alkaloids and *** antioxidant property of ethanolic extract of *** was assessed by DPPH free radical scavenging *** activity of the extract was tested using the model of acetic acid induced writhing in *** sodium is used as reference standard drug for the analgesic activity test Antibacterial activity of plant extract was carried out using disc diffusion method with five pathogenic bacteria comparison with kanamycin as a ***:Phytochemical analysis of the ethanolic extract of the roots of *** indicated the presence of reducing sugar,alkaloids,steroids and *** DPPH scavenging assay the IC_(50)value was found to be 50 ug/mL which was not comparable to the standard ascorbic *** crude extract produced 44.3%inhibition of writhing at the dose of 300 mg/kg body weight which is statistically significant(P>0.001).The in vitro antimicrobial activity of the ethanol extract of the roots of *** showed no antimicrobial activity against five types of *** experiment was conducted only with five species of bacteria as test species,which do not at all indicate the total inactivity against ***:The obtained results provide a support for the use of this plant in traditional medicine but further pharmacological studies are required.

关键词： Antioxidant Antimicrobial Analgesic DPPH Phytochemical screening

介绍两种新的游离皮瓣——股内侧皮瓣和股外侧皮瓣

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国外医学.口腔医学分册 1984年第3期 147-149页

作者： Baek sm

随着显微外科的日益发展,大面积游离皮瓣的远处转移已成为整复再造外科的一个重要组成部分。为了寻求一种无肌肉臃肿之弊病,厚薄均匀、并具有良好美容效果、能修复身体各部位缺损的游离皮瓣,作者进行了广泛的解剖学研究。通过对25具尸... 详细信息

随着显微外科的日益发展,大面积游离皮瓣的远处转移已成为整复再造外科的一个重要组成部分。为了寻求一种无肌肉臃肿之弊病,厚薄均匀、并具有良好美容效果、能修复身体各部位缺损的游离皮瓣,作者进行了广泛的解剖学研究。通过对25具尸体50例下肢进行解剖观察及其临床实践,作者在本文介绍了两种新的游离皮瓣,股内侧皮瓣和股外侧皮瓣。

关键词：皮瓣穿动脉短收肌股内侧股骨粗线股外侧血管蒂

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用交叉线细分四边形的土地面积

国外地质与勘测 1990年第4期 56-64页

作者： Easa,sm 程翔

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国家球形环实验的物理设计

国外核聚变 2000年第4期 1-20页

作者： Kaye,sm 尚志

国家球形环实验（ＮＳＴＸ）的任务是通过产生高βｔ等离子体来证明球形环物理原理；此等离子体是非感应维持的，其电流分布是稳态的。ＮＳＴＸ将是第一批运行于高功率（Ｐｉｎ达到１１ＭＷ）以产生高βｔ（２５％－４０％）、低碰撞性... 详细信息

国家球形环实验（ＮＳＴＸ）的任务是通过产生高βｔ等离子体来证明球形环物理原理；此等离子体是非感应维持的，其电流分布是稳态的。ＮＳＴＸ将是第一批运行于高功率（Ｐｉｎ达到１１ＭＷ）以产生高βｔ（２５％－４０％）、低碰撞性、高自举电流份额（≤７０％）放电的超低环径比环（Ｒ／ａ≤１．３）装置之一。将采用射频和中性束加热及电流驱动。ＮＳＴＸ将建造得具有足够的位形灵活性。

关键词：国家球形环实验球形环物理设计