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玻璃体腔注射贝伐单抗治疗PDR黄斑水肿后患者的满意度和视力(英文)

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国际眼科杂志 2009年第9期9卷 1648-1651页

作者： Lala Ceklic slobodanka latinovic Aljoscha S Neubauer Marijana Malesevic 波黑萨拉热窝临床中心眼科塞尔维亚诺维萨德大学眼科诊所德国慕尼黑大学眼科

目的:增生性糖尿病性视网膜病播散性视网膜激光光凝后,用非选择性抗VEGF抑制剂贝伐单抗治疗糖尿病性黄斑水肿,调查患者自我评估的视功能及视力。方法:30例30眼增生性糖尿病性视网膜病伴持续性糖尿病性黄斑水肿连续病例,播散性视网膜激... 详细信息

目的:增生性糖尿病性视网膜病播散性视网膜激光光凝后,用非选择性抗VEGF抑制剂贝伐单抗治疗糖尿病性黄斑水肿,调查患者自我评估的视功能及视力。方法:30例30眼增生性糖尿病性视网膜病伴持续性糖尿病性黄斑水肿连续病例,播散性视网膜激光光凝后,1.25mg贝伐单抗0.05mL (Avastin)单剂量玻璃体腔注射治疗。对照组包括30例30眼增生性糖尿病性视网膜病,只接受播散性视网膜激光光凝。主要的调查结果包括Snellen视力,眼底临床检查和患者自我用0-100分数值范围评价的视觉质量。结果:贝伐单抗组的平均基线视力为0.48±0.58 logMAR,对照组为0.61±0.78 (两组无显著差异)。6mo后,视力没有显著的变化,贝伐单抗组和对照组分别为0.33±0.41和0.52±0.68。临床检查显示黄斑水肿仅有一些改善趋势。患者用直观模拟标度尺主观评价视功能结果显示注射贝伐单抗6mo后由60.2±17.5改善至76.0±15.6 (P<0.001)。对照组自我评估视功能平均值为59.6±19.8,与贝伐单抗组基线值无显著差异,但是低于注射贝伐单抗后分数,差异有高度显著性(P<0.01)。结论:治疗增生性糖尿病性视网膜病的黄斑水肿,贝伐单抗(Avastin)玻璃体腔注射作为播散性激光光凝的辅助治疗较单纯的激光治疗后患者满意度和自我评价的视力显著改善。患者视力在6mo后无明显变化。

关键词：增生性糖尿病性视网膜病视力自我评估贝伐单抗播散性视网膜激光光凝

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复杂性眼外伤治疗(英文)

国际眼科杂志 2011年第5期11卷 767-768页

作者： Lala Ceklic slobodanka latinovic Aljoscha S. Neubauer Djoko Obucina Bobana Petrovic 东萨拉热窝眼科临床中心波黑东萨拉热窝 Ludvig Maximillian大学眼科诊所德国慕尼黑

本文报告开放性眼球损伤1例,鱼钩卡在角膜和虹膜处。由于这种复杂眼外伤可能导致非常危险的并发症,并且严重影响视觉功能。现将处理方法总结如下:首先,取出异物,缝合眼球;其次,抗感染治疗;最后,实施白内障手术以便视力恢复。

关键词：眼外伤前房异物外伤性白内障

头痛和偏头痛的初级护理:大样本人群的会诊、用药和转诊率

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世界核心医学期刊文摘（神经病学分册） 2006年第6期2卷 42-43页

作者： latinovic R. Gulliford M. Ridsdale L. 张慧 King's College London 5 Lambeth Walk London SE11 6SP United Kingdom Dr.

Background/Aims: Headache is the most common new neurological symptom seen by general practitioners and neurologists. This study describes headache consultation, prescription, and referral rates in a large sample of UK general practices. Methods: Analysis of data from patients ≥15 years registered at 253 UK general practices diagnosed with headache/migraine from 1992 to 2000. Rates were age standardised using the European standard population for reference. Results: There were 13.2 million patient years of observation. Headache consultation rates were 6.4/100 patients/year in women and 2.5 in men. They were highest at 15-24 years (15.8/100 in women; 5.8/100 in men), decreasing with age. Antimigraine drugs were prescribed at 36.7%of consultations for women and 26.6%for men. Among refer rals to specialists, 55%were to neurology and 30%to general medicine. The neurology referral rate in patients with headache was 2.1/100, and was higher in men (2.7/100) than women (1.9/100). Conclusions: These results provide precis e age specific and age standardised estimates for headache consulting in general practice, in addition to prescribing and referral to specialist care. Consultat ion rates are highest in young women; hospital referrals peak in middle aged men . Research is needed into reasons for referral, and on better ways of delivering headache services.

关键词：偏头痛转诊率大样本会诊初级护理患者资料男性患者女性患者

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初级护理中心的常见压迫性神经病变发病率

世界核心医学期刊文摘（神经病学分册） 2006年第6期2卷 36-37页

作者： latinovic R. Gulliford M. C. Hughes R. A. C. 陈孝东(译) 不详 Department of Clinical Neuroscience King's College London London SE11UL United Kingdom

Apart from carpal tunnel syndrome, there are no population based studies of the epidemiology of compressive neuropathies. To provide this information, new presentations of compressive neuropathies among patients registered with 253 general practices in the UK General Practice Research Database with 1.83 million patient years at risk in 2000 were analysed. The study revealed that in 2000 the annual age standardised rates per 100 000 of new presentations in primary care were: carpal tunnel syndrome, men 87.8/women 192.8; Morton’s metatarsalgia, men 50.2/women 87.5; ulnar neuropathy, men 25.2/women 18.9; meralgia paraesthetica, men 10.7/women 13.2; and radial neuropathy, men 2.97/women 1.42. New presentations were most frequent at ages 55-64 years except for carpal tunnel syndrome, which was most frequent in women aged 45-54 years, and radial nerve palsy, which was most frequent in men aged 75-84 years. In 2000, operative treatment was undertaken for 31%of new presentations of carpal tunnel syndrome, 3%of Morton’s metatarsalgia, and 30%of ulnar neuropathy.

关键词：压迫性神经病变标准化发病率腕管综合征感觉异常性股痛桡神经麻痹新发病例流行病学调查发病风险医疗研究