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Variational Approach to 2D and 3D Heat Conduction Modeling

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Journal of Applied Mathematics and Physics 2024年第4期12卷 1383-1400页

The paper proposes an approximate solution to the classical (parabolic) multidimensional 2D and 3D heat conduction equation for a 5 × 5 cm aluminium plate and a 5 × 5 × 5 cm aluminum cube. An approximate solution of the generalized (hyperbolic) 2D and 3D equation for the considered plate and cube is also proposed. Approximate solutions were obtained by applying calculus of variations and Euler-Lagrange equations. In order to verify the correctness of the proposed approximate solutions, they were compared with the exact solutions of parabolic and hyperbolic equations. The paper also presents the research on the influence of time parameters τ as well as the relaxation times τ ∗ to the variation of the profile of the temperature field for the considered aluminum plate and cube.

关键词： Classical Equation of Heat Conduction Generalized Equation of Heat Conduction Calculus of Variations Approximate Solution

The effect of reactive plasticizer on viscoelastic and mechanical properties of solid rocket propellants based on different types of HTPB resin

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Defence Technology（防务技术） 2024年第3期33卷 66-77页

作者： Tihomir Kovacevic slavko Mijatov Jelena Grzetic Suzana Cakic Bojana Fidanovski Sasa Brzic Military Technical Institute Ministry of DefenceRatka Resanovica 1BelgradeSerbia Faculty of Technology University of NisBulevar osloboCenja 124LeskovacSerbia

Conventional plasticizers deteriorate mechanical and viscoelastic properties of the propellants due to their migration upon aging and long-term storage,which affects reliability and safety properties during *** address this issue,conventional plasticizer,dioctyl adipate(DOA),is replaced by reactive one,castor oil(CO).In addition,three different types of HTPB were used to obtain propellants with designed viscoelastic and mechanical *** CO increased propellants viscosity,without a significant impact on the propellant processability,regardless to the type of ***,mechanical properties were different depending on the type of resin,which were further analyzed by gel permeation chromatography(GPC).Addition of CO formed a denser polymer network and shifted T_(g) to higher values,compared to the compositions with *** tensile strength of CO-containing propellants was lower at +20℃ and +50℃ compared to the reference compositions,while the strain at maximum load and strain at break were significantly increased with pronounced plastic deformation,especially for samples at -30℃.The inclusion of CO in the propellants composition gives more room for adjusting a wide range of mechanical properties.

关键词： HTPB-based composite propellants Castor oil Reactive plasticizer Gel permeation chromatography Sol-gel analysis Mechanical and viscoelastic properties

Regulation of the mesenchymal stem cell fate by interleukin-17: Implications in osteogenic differentiation

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World Journal of Stem Cells 2021年第11期13卷 1696-1713页

作者： Jelena Krstić slavko Mojsilović Sonja S Mojsilović Juan F Santibanez Gottfried Schatz Research Center Medical University of GrazGraz 8010Austria Group for Hematology and Stem Cells Institute for Medical ResearchNational Institute of Republic of SerbiaUniversity of BelgradeBelgrade 11129Serbia Group for Immunology Institute for Medical ResearchNational Institute of Republic of SerbiaBelgrade 11129Serbia Group for Molecular Oncology Institute for Medical ResearchNational Institute of Republic of SerbiaUniversity of BelgradeBelgrade 11000Serbia Centro Integrativo de Biología y Química Aplicada Universidad Bernardo O’HigginsChile 8370993Chile

Bone regeneration is a tightly regulated process that ensures proper repair and functionality after *** delicate balance between bone formation and resorption is governed by cytokines and signaling molecules released during the inflammatory ***(IL)-17A,produced in the early phase of inflammation,influences the fate of *** to their inherent capacity to differentiate into osteoblasts,mesenchymal stem/stromal cells(MSCs)contribute to bone healing and *** review presents an overview of IL-17A signaling and the leading cellular and molecular mechanisms by which it regulates the osteogenic differentiation of *** main findings demonstrating IL-17A’s influence on osteoblastogenesis are *** this end,divergent information exists about the capacity of IL-17A to regulate MSCs’osteogenic fate,depending on the tissue context and target cell type,along with contradictory findings in the same cell ***,we summarize the data showing both the pro-osteogenic and anti-osteogenic roles of IL-17,which may help in the understanding of IL-17A function in bone repair and regeneration.

关键词： Interleukin-17 Mesenchymal stem cells Osteoblast Bone Osteogenesis Inflammation

Abdominal neurenteric cyst

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World Journal of Gastroenterology 2008年第23期14卷 3759-3762页

作者： Radoje olovi Marjan Micev Miodrag Jovanovi slavko Mati Nikica Grubor Henry Dushan E Atkinson Clinical Center of Serbia Institute for Digestive DiseasesBelgrade 11000Serbia Surgical Directorate Imperial College School of MedicineSt Mary's HospitalPraed StLondon W2 1NYUnited Kingdom

Neurenteric cysts are extremely rare congenital anomalies, often presenting in the first 5 years of life, and are caused by an incomplete separation of the notochord from the foregut during the third week of embryogenesis. They are frequently accompanied with spinal or gastrointestinal abnormalities, but the latter may be absent in adults. Although usually located in the thorax, neurenteric cysts may be found along the entire spine. We present a 24-year-old woman admitted for epigastric pain, nausea, vomiting, low grade fever and leucocytosis. She underwent cystgastrostomy for a Ioculated cyst of the distal pancreas at the age of 4 years, which recurred when she was at the age of 11 years. Ultrasound and computer tomograghy （CT） scan revealed a 16 cmx 15 cm cystic mass in the body and tail of pancreas, with a 6-7 mm thickened wall. Laboratory data and chest X-ray were normal and spinal radiographs did not show any structural abnormalities. The patient underwent a complete cyst excision, and after an uneventful recovery, remained symptom-free without recurrence during the 5-year follow-up. The cyst was found to contain 1200 mL of pale viscous fluid. It was covered by a primitive singlelayered cuboidal epithelium, along with specialized antral glandular parenchyma and hypoplastic primitive gastric mucosa. Focal glandular groups resembling those of the body of the stomach were also seen. In addition, ciliary respiratory epithelium, foci of squamous metaplasia and mucinous glands were present. The wall of the cyst contained a muscular layer, neuroglial tissue with plexogenic nerve fascicles, Paccini corpuscle-like structures, hyperplastic neuroganglionar elements and occasional psammomatous bodies, as well as fibroblast-like areas of surrounding stroma. Cartilagenous tissue was not found in any part of the cyst. Immunohistochemistry confirmed the presence of neurogenic elements marked by S-100, GFAP, NF and NSE. The gastric epithelium showed mostly CK7 and EMA immunoexp

关键词： Neurenteric cyst Congenital Abdomen Pancreas Surgical excision

Polyphenols isolated from Acacia mearnsii bark with anti-inflammatory and carbolytic enzyme inhibitory activities

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Chinese Journal of Natural Medicines 2017年第11期15卷 816-824页

作者： XIONG Jia GRACE Mary H ESPOSITO Debora KOMARNYTSKY slavko WANG Fei LILA Mary Ann Department of Chemical Engineering Jiangsu Key Lab of Biomass-based Green Fuels and Chemicals Nanjing Forestry University Plants for Human Health Institute Department of Food Bioprocessing and Nutrition Sciences North Carolina State UniversityNorth Carolina Research Campus

The present study was designed to characterize the polyphenols isolated from Acacia mearnsii bark crude extract(B) and fractions(B1-B7) obtained by high-speed counter-current chromatography(HSCCC) and evaluate their anti-inflammatory and carbolytic enzymes(α-glucosidase and α-amylase) inhibitory activities. Fractions B4, B5, B6, B7(total phenolics 850.3, 983.0, 843.9, and 572.5 mg·g^(-1)), respectively; proanthocyanidins 75.7, 90.5, 95.0, and 44.8 mg·g^(-1)), respectively) showed significant activities against reactive oxygen species(ROS), nitric oxide(NO) production, and expression of pro-inflammatory genes interleukin-1β(IL-1β) and inducible nitric oxide synthase(iNOS) in a lipopolysaccharide(LPS)-stimulated mouse macrophage cell line RAW 264.7. All the extracts suppressed α-glucosidase and α-amylase activities, two primary enzymes responsible for carbohydrate digestion. A. mearnsii bark samples possessed significantly stronger inhibitory effects against α-glucosidase enzyme(IC_(50) of 0.4-1.4 μg·mL^(-1)) than the pharmaceutical acarbose(IC_(50) 141.8 μg·mL^(-1))). B6 and B7(IC_(50) 17.6 and 11.7 μg·mL^(-1), respectively) exhibited α-amylase inhibitory activity as efficacious as acarbose(IC_(50) 15.4 μg·mL^(-1))). Moreover, B extract, at 25 μg·mL^(-1), significantly decreased the non-mitochondrial oxidative burst that is often associated with inflammatory response in human monocytic macrophages.

关键词： acacia mearnsii Proanthocyanidins Anti-inflammatory α-Amylase α-Glucosidase

Febrile cholestatic disease as an initial presentation of nodular lymphocyte-predominant Hodgkin lymphoma

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World Journal of Gastroenterology 2010年第35期16卷 4491-4493页

作者： Anna Mrzljak slavko Gasparov Ika Kardum-Skelin Vesna Colic-Cvrlje Slobodanka Ostojic Kolonic Slobodanka Ostojic-Kolonic University of ZagrebSchool of Medicine Department of Gastroenterology University Hospital Merkur Department of Pathology and Cytology University Hospital Merkur Laboratory for Cytology and Hematology Department of MedicineUniversity Hospital Merkur Department of Hematology University Hospital Merkur

Febrile cholestatic liver disease is an extremely unusual presentation of Hodgkin lymphoma(HL).The liver biopsy of a 40-year-old man with febrile episodes and cholestatic laboratory pattern disclosed an uncommon subtype of HL,a nodular lymphocyte-predominant HL(NLPHL).Liver involvement in the early stage of the usually indolent NLPHL's clinical course suggests an aggressiveness and unfavorable *** a liver biopsy early in the diagnostic algorithm enables accurate diagnosis and appropriate *** rare,HL should be considered in the differential diagnosis of cholestasis.

关键词： Cholestatic disease Hodgkin lymphoma Nodular lymphocyte-predominant Hodgkin lymphoma

Inflammatory niche:Mesenchymal stromal cell priming by soluble mediators

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World Journal of Stem Cells 2020年第9期12卷 922-937页

作者： Aleksandra Jauković Tamara Kukolj Hristina Obradović Ivana Okić-Đorđević slavko Mojsilović Diana Bugarski Laboratory for Experimental Hematology and Stem Cells Institute for Medical ResearchUniversity of BelgradeBelgrade 11129Serbia

Mesenchymal stromal/stem cells(MSCs)are adult stem cells of stromal origin that possess self-renewal capacity and the ability to differentiate into multiple mesodermal cell *** play a critical role in tissue homeostasis and wound healing,as well as in regulating the inammatory microenvironment through interactions with immune ***,MSCs have garnered great attention as promising candidates for tissue regeneration and cell *** the inflammatory niche plays a key role in triggering the reparative and immunomodulatory functions of MSCs,priming of MSCs with bioactive molecules has been proposed as a way to foster the therapeutic potential of these *** this paper,we review how soluble mediators of the inflammatory niche(cytokines and alarmins)influence the regenerative and immunomodulatory capacity of MSCs,highlighting the major advantages and concerns regarding the therapeutic potential of these inflammatory primed *** data summarized in this review may provide a significant starting point for future research on priming MSCs and establishing standardized methods for the application of preconditioned MSCs in cell therapy.

关键词： Mesenchymal stem cells Pro-inflammatory cytokines Alarmins Priming Boosting the therapeutic potential

Dental mesenchymal stromal/stem cells in different microenvironments— implications in regenerative therapy

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World Journal of Stem Cells 2021年第12期13卷 1863-1880页

作者： Ivana Okić-Đorđević Hristina Obradović Tamara Kukolj Anđelija Petrović slavko Mojsilović Diana Bugarski Aleksandra Jauković Laboratory for Experimental Hematology and Stem Cells Institute for Medical ResearchUniversity of BelgradeBelgrade 11129Serbia

Current research data reveal microenvironment as a significant modifier of physical functions,pathologic changes,as well as the therapeutic effects of stem *** comparing regeneration potential of various stem cell types used for cytotherapy and tissue engineering,mesenchymal stem cells(MSCs)are currently the most attractive cell source for bone and tooth regeneration due to their differentiation and immunomodulatory potential and lack of ethical issues associated with their *** microenvironment of donors and recipients selected in cytotherapy plays a crucial role in regenerative potential of transplanted MSCs,indicating interactions of cells with their microenvironment indispensable in MSC-mediated bone and dental *** a variety of MSC populations have been procured from different parts of the tooth and tooth-supporting tissues,MSCs of dental origin and their achievements in capacity to reconstitute various dental tissues have gained attention of many research groups over the *** review discusses recent advances in comparative analyses of dental MSC regeneration potential with regards to their tissue origin and specific microenvironmental conditions,giving additional insight into the current clinical application of these cells.

关键词： Microenvironment Dental mesenchymal stem cells Modulation of regenerative potential Tissue origin Hypoxia microenvironment Inflammatory microenvironment Clinical application

Perigastric extraskeletal Ewing's sarcoma: A case report

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World Journal of Gastroenterology 2009年第2期15卷 245-247页

作者： Radoje B Colovic Nikica M Grubor Marjan T Micev slavko V Matic Henry Dushan Edward Atkinson Stojan M Latincic Institute for Digestive Diseases Clinical Center of Serbia Koste Todorovica 6 Belgrade 11000 Serbia Imperial College School of Medicine St Mary's Hospital Praed Street London W2 1NY United Kingdom

Ewing's sarcoma (ES) is a neoplasm of undifferentiated small round cells, which occurs in the bones and deep soft tissues of children and adolescents. We present a rare case of a 44-year-old woman with gastric ES presenting with epigastric pain and weight loss. Ultrasound and computed tomography scans indicated a solid/cystic mass in the pancreatic tail. At laparotomy, the tumor was found attached to the posterior surface of the stomach, completely free from the pancreas, with no lymphadenopathy or local metastases. The polynodal, partly pseudocystic, dark-red soft tumor was excised. Histopathology revealed an anaplastic small-round-cell tumor with strong membranous CD99 immunoexpression. Additionally, there was patchy immunostaining for S-100 protein, vimentin, protein gene product (PGP) 9.5 and neuron-specifi c enolase, and weak focal CD117 cytoplasmic immunoreactivity. The patient had no adjuvant chemotherapy; her postoperative recovery was uneventful, and she remains symptom-free, and without any sign of recurrence at 20 mo. To the best of our knowledge, this is only the third ever case of gastric ES.

关键词： Stomach Extraskeletal Ewing's sarcoma