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Healing property of the Piper betel phenol, allylpyrocatechol against indomethacin-induced stomach ulceration and mechanism of action

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World Journal of Gastroenterology 2007年第27期13卷 3705-3713页

作者： S Bhattacharya D Banerjee AK Bauri S Chattopadhyay sk bandyopadhyay Department of Biochemistry Dr. B.C. Roy Post Graduate Institute of Basic Medical Sciences IPGME&R 244B Acharya Jagadish Chandra Bose Road Kolkata-700020 India Bio-Organic Division Bhabha Atomic Research Centre Mumbai-400085 India

AIM：To evaluate the protective activity of allylpyrocatechol （APC）, the major antioxidant constituent of Piper betel, against the indomethacin-induced stomach ulceration in the rat model and correlates with its antioxidative and mucin protecting properties.METHODS： Male Sprague-Dawley rats were divided into five groups. Normal control rats （group Ⅰ ） were given the vehicle oral dose of gum acacia in distilled water （1 mL per rat）; ulcerated control and treated rats （groups Ⅱ-V） were given a single dose of indomethacin （30 mg/kg body wt.）; group Ⅱ rats were sacrificed 4 h after indomethacin administration; groups Ⅲ-Ⅴ rats were given the vehicle （1 mL per rat） or APC （2 mg/kg body wt.） or misoprostol （1.43 μg/kg body wt.） once daily by oral intubation for 7 d starting from 4 h after the indomethacin administration. After 7 d, the stomach tissues were excised for histological examination and biochemical analysis. RESULTS： Treatment with APC （2 mg/kg body wt per day） and misoprostol （1.43 μg/kg body wt per day） for 7 d could effectively heal the stomach ulceration as revealed from the ulcer index and histopathological studies. Compared to the zero day ulcerated group, treatment with APC and misoprostol reduced the ulcer index by 93.4% and 85.4% respectively （P 〈 0.05）. Both APC and misoprostol accelerated ulcer healing observed in natural recovery （P 〈 0.05）, their respective healing capacities not being significantly different. The healing capacities of APC and misoprostol could be attributed to their antioxidant activity as well as the ability to enhance the rnucin content of the gastric tissues. Compared to the ulcerated untreated rats, those treated with APC and rnisoprostol showed near normal MDA levels, while the protein levels were 86% and 78% of the normal value respectively （P 〈 0.05）. Likewise, both APC and rnisoprostol increased the SOD, catalase, and rnucin levels significantly （P 〈 0.05）, the effect of APC being better. CONCLUSION： APC can protect ind

关键词： Allylpyrocatechol Antioxidant Histopathology Indornethacin Mucin Piper betel Stomach ulcer

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Problems and prospects of fish farming in the Chattogram Hill Tracts of Bangladesh:Community-based aquaculture might be a right choice

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Aquaculture and Fisheries 2024年第2期9卷 306-313页

作者： Saifuddin Rana MdNazmul Hasan Abdulla Al Bari Shahida Arfine Shimul skIstiaque Ahmed sk.Ahmad Al Nahid Department of Fisheries Resource Management Faculty of FisheriesChattogram Veterinary and Animal Sciences UniversityKhulshi4225ChattogramBangladesh Department of Oceanography University of ChittagongChittagong4331Bangladesh

The study was carried out in Matiranga Upazila,Bandarban district,which is considered one of Bangladesh’s major hill tract *** study aimed to identify present farming conditions,prospects,and problems and suitable solutions to the problems of fish *** participatory rapid appraisal tools such as focus group discussion,field visits,and farmers’interviews were used to collect relevant fish farming information in the study *** polyculture method was the most practised aquaculture *** the selected farms,eleven fish species were identified as culture *** transportation cost for seeds purchased from remote areas was high(11%of total seed cost).The average transportation-related mortality of fish fry and fingerlings was 7.2%and 2.8%.Feed cost was found as the major cost(58.4%)in *** and revenue for fish production per decimal varied from BDT 311 to 3528 and BDT 23 to *** of vacant lake,youth and women engagement,integrated aquaculture,the desire of people to engage in aquaculture,and available human resources were found as significant *** major problems identified were lack of hatchery,high feed cost,lack of stakeholder linkage,lack of capital for fish farming,and lack of proper knowledge,guidelines,and consultancy for fish culture.A community-based aquaculture model was proposed to overcome the present challenges and problems in the study *** model may help to expand aquaculture and thus improve the livelihood and socio-economic status of the people of the hilly areas of Bangladesh.

关键词： Hilly area Aquaculture model Tribal people Fish farming prospects

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Topological reorganization and functional alteration of distinct genomic components in gallbladder cancer

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Frontiers of Medicine 2024年第1期18卷 109-127页

作者： Guoqiang Li Peng Pu Mengqiao Pan Xiaoling Weng Shimei Qiu Yiming Li sk Jahir Abbas Lu Zou Ke Liu Zheng Wang Ziyu Shao Lin Jiang Wenguang Wu Yun Liu Rong Shao Fatao Liu Yingbin Liu Department of Biliary-Pancreatic Surgery Renji HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghai200127China State Key Laboratory of Oncogenes and Related Genes Shanghai Cancer InstituteShanghai200127China Shanghai Key Laboratory of Biliary Tract Disease Shanghai200082China Department of Health Science and Engineering University of Shanghai for Science and TechnologyShanghai200082China Shanghai Tenth People’s Hospital of Tongji University Shanghai200072China Department of General Surgery Xinhua HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghai200082China Department of Pharmacology Shanghai Jiao Tong University School of MedicineShanghai200025China

Altered three-dimensional architecture of chromatin influences various genomic regulators and subsequent gene expression in human ***,knowledge of the topological rearrangement of genomic hierarchical layers in cancer is largely ***,by taking advantage of in situ Hi-C,RNA-sequencing,and chromatin immunoprecipitation sequencing(ChIP-seq),we investigated structural reorganization and functional changes in chromosomal compartments,topologically associated domains(TADs),and CCCTC binding factor(CTCF)-mediated loops in gallbladder cancer(GBC)tissues and cell *** observed that the chromosomal compartment A/B switch was correlated with CTCF binding levels and gene expression *** inter-TAD interactions with weaker TAD boundaries were identified in cancer cell lines relative to normal ***,the chromatin short loops and cancer unique loops associated with chromatin remodeling and epithelial–mesenchymal transition activation were enriched in cancer compared with their control ***-specific enhancer–promoter loops,which contain multiple transcription factor binding motifs,acted as a central element to regulate aberrant gene *** of individual enhancers in each loop anchor that connects with promoters led to the inhibition of their corresponding gene ***,our data offer the landscape of hierarchical layers of cancer genome and functional alterations that contribute to the development of GBC.

关键词： 3D genome cancer TADs loop gene regulation

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Rethinking neurodegenerative diseases:neurometabolic concept linking lipid oxidation to diseases in the central nervous system

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Neural Regeneration Research 2024年第7期19卷 1437-1445页

作者： Steinunn Sara Helgudóttir Anne skøttrup Mørkholt Jacek Lichota Preben Bruun-Nyzell Mads Christian Andersen Nanna Marie Juhl Kristensen Amanda Krøger Johansen Mikela Reinholdt Zinn Hulda Maria Jensdóttir John Dirk Vestergaard Nieland 2N Pharma ApS NOVI Science ParkAalborgDenmark Molecular Pharmacology Group Department of Health Science and TechnologyAalborg UniversityAalborgDenmark

Currently,there is a lack of effective medicines capable of halting or reve rsing the progression of neurodegenerative disorde rs,including amyotrophic lateral sclerosis,Parkinson s disease,multiple sclerosis,or Alzheimer s *** the unmet medical need,it is necessary to reevaluate the existing para digms of how to to rget these *** considering neurodegenerative diseases from a systemic neurometabolic perspective,it becomes possible to explain the shared pathological *** innovative approach presented in this paper draws upon exte nsive research conducted by the authors and researchers *** this review,we highlight the importance of metabolic mitochondrial dysfunction in the context of neurodegenerative *** provide an overview of the risk factors associated with developing neurodegenerative disorders,including genetic,epigenetic,and environmental fa ***,we examine pathological mechanisms implicated in these diseases such as oxidative stress,accumulation of misfolded proteins,inflammation,demyelination,death of neurons,insulin resistance,dysbiosis,and neurotransmitter ***,we outline a proposal for the restoration of mitochondrial metabolism,a crucial aspect that may hold the key to facilitating curative therapeutic interventions for neurodegenerative disorders in forthcoming advancements.

关键词： brain disease carnitine palmitoyl transferase 1 epigenetics metabolism gut microbiome mitochondrial dysfunction neurodegeneration oxidative stress

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Delineation of groundwater potential zones using remote sensing and Geographic Information Systems(GIS)in Kadaladi region,Southern India

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Journal of Groundwater Science and Engineering 2024年第2期12卷 147-160页

作者： Stephen Pitchaimani V Narayanan MSS Abishek RS Aswin sk Jerin Joe RJ PG and Research Department of Geology V.O.Chidambaram CollegeThoothukudi 628008India Research Scholar Manonmaniam Sundaranar UniversityTirunelveli 627012India

The primary objective of this research is to delineate potential groundwater recharge zones in the Kadaladi taluk of Ramanathapuram,Tamil Nadu,India,using a combination of remote sensing and Geographic Information Systems(GIS)with the Analytical Hierarchical Process(AHP).Various factors such as geology,geomorphology,soil,drainage,density,lineament density,slope,rainfall were analyzed at a specific *** layers were evaluated for quality and relevance using Saaty's scale,and then inte-grated using the weighted linear combination *** weights assigned to each layer and features were standardized using AHP and the Eigen vector technique,resulting in the final groundwater potential zone *** AHP method was used to normalize the scores following the assignment of weights to each criterion or factor based on Saaty's 9-point ***-wise matrix analysis was utilized to calculate the geometric mean and normalized weight for various *** groundwater recharge potential zone map was created by mathematically overlaying the normalized weighted *** layers indicating major elements influencing groundwater occurrence and recharge were derived from satellite images.2 Results indicate that approximately 21.8 km of the total area exhibits high potential for groundwater *** recharge is viable in areas with moderate slopes,particularly in the central and southeastern regions.

关键词： Groundwater Satellite image Remote sensing GIS techniques Analytical Hierarchy Process(AHP)

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Evaluation of Information Technology Implementation for Business Goal Improvement under Process Functionality in Economic Development

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Journal of Data Analysis and Information Processing 2024年第2期12卷 304-317页

作者： sk Ayub Al Wahid Nur Mohammad Rakibul Islam Md. Habibullah Faisal Md. Sohel Rana International American University Los Angeles California USA

Improving organizational performance can be achieved through business process redesign (BPR). When it comes to modern work practices, organizations must often redesign their processes to keep up. This is where enterprise software comes in, offering a common data infrastructure that enables different parts of the organization to access all necessary financial data. The architecture of network accounting business process is divided into three layers. The core layer lies in the enterprise LAN that it can integrate six business processes information into one unity of financial information and non-financial information, including purchasing, inventory, production, sales, finance and customer service, and it can generate flexibly a variety of accounting statements to meet fully the information users’ demands by providing more complete and more valuable related information. The second layer lies in Intranet among enterprises based on the core layer that it can support the link of business processes and the inter-sharing of information among node enterprises of SCM and other external enterprises. The third layer lies in Internet based on the second layer that it can fit society, enterprise and individual together, the specific lays the solid foundation of business collaboration, remote management, online management and centralized management. The operating mechanisms of the network accounting business processes are as follows. When the business event occurs, the probe can get the event information in real-time and the result is stored in the database. Meanwhile, the drive controller can control the business events in real-time by gaining control criteria and standards from database. In case the standard is exceeded, the event is not allowed to occur. Enterprise’ business staff or external personnel can output automatically the required results through report tools if they had the reading authority. Supported the information system and optimizing processes, the managers can

关键词： ISMS OKC EA EAF EAP

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Detection of canine echinococcosis by coproantigen ELISA

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Asian Pacific Journal of Tropical Medicine 2010年第7期3卷 519-522页

作者： De S Pan D Bera AK Sreevatsava V Das sk Das S Rana T bandyopadhyay S Bhattacharya D Indian Veterinary Research Institute Eastern Regional Station37 Belgachia Road.Kolkata-700037India NRC on Yak DirangArunachal PradeshIndia Indian Veterinary Research Institute.Eastern Regional Station.37 Belgachia Road Kolkata-700037India

Objective:To study the canine echinococcosis by coproantigen ELISA ***:During the present investigation experimental infection was established using evaginated worms of Echinococcus granulosus(***).To check cross reactivity two pups were infected with Taenia hydatigena(***).In order to detect the presence of antigen,hyperimmune sera were raised against excretory-secretory products of adult worms *** granulosus. Faecal sample collected either from experimentally infected pups or from other sources were heated at 70℃to detect heat stable soluble ***:Pups harbouring less than 104 worms showed negative *** collected from 14 days onwards from experimentally infected animals harbouring more than 104 worms showed positive *** maximum positive samples were detected in samples collected from in and around slaughter house and the least number of samples were detected positive maintained by dog ***:The affinity purified IgG exhibited promising results for detection of canine echinococcosis by indirect ELISA.

关键词： Echinococcus granulosus Coproantigen ELISA Canine

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Internal States of Temperature Hysteresis in Shape Memory Alloys

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Journal of Materials Science & Technology 1997年第3期13卷 206-210页

作者： Xu, HB Gong, sk Dept. of Materials Science and Engineering Beijing University of Aeronautics and Astronautics Beijing 100083 China

We propose a thermodynamic theory that permits us to connect the size of the temperature hysteresis loop to the interfacial energy between martensite and austenite. The free energy is a function of four variables, viz. deformation of austenite, deformation of martensite, phase fraction and temperature. A diagonal line inside the hysteresis loop in the deformation-temperature diagram is identified as the line of unstable phase equilibrium. Upon reaching this line the phase mixture loses its (meta-)stability, and the transformation from one phase to the other should occur. The theoretical results are supported by experiments on NiTi and CuAlNi specimens.

关键词： Shape memory effect

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Radial basis function‐based exoskeleton robot controller development

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IET Cyber-Systems and Robotics 2022年第3期4卷 228-250页

作者： sk Hasan Department of Mechanical and Manufacturing Engineering Miami UniversityOxfordOhioUSA

The realisation of a model‐based controller for a robot with a higher degree of freedom requires a substantial amount of computational power.A high‐speed CPU is required to maintain a higher sampling *** processors cannot boost the performance or reduce the execution time as the programs are sequentially *** neural network is a great tool to convert a sequentially structured program to an equivalent parallel architecture *** this study,a radial basis function(RBF)neural network is developed for controlling 7 degrees of freedom of the human lower extremity exoskel-eton robot.A realistic friction model is used for modelling joint *** trajectory tracking accuracies have been *** of computational efficiency has been *** stability analysis of the developed controller is *** of variance is used to assess the controller's resilience to parameter *** show the effectiveness of the developed controller,a comparative study was performe between the developed RBF network‐based controller and Sliding Mode Controller,Computed Tor-que Controller,Adaptive controller,Linear Quadratic Regulator and Model Reference Computed Torque Controller.

关键词： exoskeleton robot dynamic modelling lower extremity exoskeleton robot control radial basis function(RBF)controller

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Electrochemical characterization of Ni-Co and Ni-Co-Fe for oxidation of methyl alcohol fuel with high energetic catalytic surface

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燃料化学学报 2014年第1期42卷 87-95页

作者： Subir Paul sk Naimuddin Asmita Ghosh Department of Metallurgical and Material Engineering Jadavpur University

Non Pt based metals and alloys as electrode materials for methyl alcohol fuel cells have been investigated w ith an aim of finding high electrocatalytic surface property for the faster electrode *** w ere fabricated by electrodeposition on pure Al foil,from an electrolyte of Ni,Co,Fe *** optimum condition of electrodeposition w ere found out by a series of experiments,varying the chemistry of the electrolyte,pH valve,temperature,current and cell *** study of the coated Ni-Co or Ni-CoFe alloy on pure Al w as found to exhibit high exchange current density,indicating an improved electro catalytic surface w ith faster charge-discharge reactions at anode and cathode and low *** impedance studies on coated and uncoated surface clearly show ed that the polarization resistance and impedance w ere decreased by Ni-Co or Ni-Co-Fe coating.X-ray diffraction(XRD),energy dispersive X-ray spectroscopy(EDX)and atomic absorption spectroscopy(AAS)studies confirmed the presence of alloying elements and constituents of the *** morphology of the deposits from scanning electron microscope(SEM)images indicated that the electrode surface w as a three dimensional space w hich increased the effective surface area for the electrode reactions to take place.

关键词： electrodeposition Ni-Co alloy electrocatalytic exchange current density impedance X-ray diffraction(XRD) scanning electron microscope(SEM)

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