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miR-204 suppresses porcine reproductive and respiratory syndrome virus(PRRSV)replication via inhibiting LC3B-mediated autophagy

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Virologica Sinica 2023年第5期38卷 690-698页

作者： Yao Yao Sihan Li Yingqi Zhu Yangyang Xu siyuan hao Shuyuan Guo Wen-Hai Feng State Key Laboratory of Animal Biotech Breeding Frontiers Science Center for Molecular Design BreedingMinistry of Agriculture Key Laboratory of Soil Microbiologyand Department of Microbiology and ImmunologyCollege of Biological SciencesChina Agricultural UniversityBeijing100193China

Porcine reproductive and respiratory syndrome(PRRS)caused by PRRS virus(PRRSV)has been regarded as a persistent challenge for the swine farms ***(miRNAs)play key roles in regulating almost every important biological process,including virus-host *** this study,we found that miR-204 was highly expressed in cells that were not permissive to PRRSV infection compared with cells susceptible to PRRSV ***,we demonstrated that overexpression of miR-204 significantly inhibited PRRSV replication in porcine alveolar macrophages(PAMs).Through bioinformatic analysis,we found that there existed a potential binding site of miR-204 on the 30UTR of microtubule associated protein 1 light chain 3B(MAP1LC3B,LC3B),a hallmark of *** experiments including luciferase reporter assay and UV cross-linking and immunoprecipitation(CLIP)assay,we demonstrated that miR-204 directly targeted LC3B,thereby downregulating ***,we investigated the interplay between autophagy and PRRSV replication in PAMs,confirming that PRRSV infection induces autophagy,which in turn facilitates viral ***,we verify that miR-204 suppresses PRRSV replication via inhibiting LC3B-mediated autophagy in *** findings will provide a novel potential approach for us to develop antiviral therapeutic agents and controlling measures for future PRRSV outbreaks.

关键词： Porcine reproductive and respiratory syndrome virus(PRRSV) miR-204 Autophagy LC3B

Absorption-dominant EMI shielding performance of multiple folded Bi_(2)Se_(3)/PVDF nanocomposite films

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Journal of Materiomics 2024年第1期10卷 27-36页

作者： Xinyi Pu Zunpeng Feng siyuan Sun Ke Bi Yanan hao State Key Laboratory of Information Photonics and Optical Communications School of ScienceBeijing University of Posts and TelecommunicationsBeijing100876China Chinese Academy of Engineering Innovation Strategy Beijing100088China

Absorption-dominant electromagnetic interference(EMI)shielding materials are promising in reducing electromagnetic radiation pollution,but their preparation processes are usually difficult and unsuitable for large-scale *** this work,multiple folded Bi_(2)Se_(3)/PVDF nanocomposite films were fabri-cated by using a convenient tape-casting method and multiple folding,which can be easily extended in industrial *** EMI shielding effectiveness(SE)of the composite materials was investigated,which shows typical absorption-dominant behavior and can substantially reduce secondary ***,for the 35%(in volume)Bi_(2)Se_(3)/PVDF nanocomposite film,the SE_(A)of single-layered film with a thickness of 60 mm reaches 20 dB while SE_(R)is lower than 5 *** folding the film into eight layers,the SE_(A)increased to 50 dB while SE_(R)remains below 5 *** method provides an effective way to the fabrication of absorption-dominant electromagnetic absorption(EMA)and EMI shielding material.

关键词： Electromagnetic interference shielding(EMI) Electromagnetic wave absorption Bismuth selenide Composite

Harmonic State Space Based Impedance Modeling and Virtual Impedance Based Stability Enhancement Control for LCC-HVDC Systems

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Journal of Modern Power Systems and Clean Energy 2024年第1期12卷 287-298页

作者： Yifeng Liu Xiaoping Zhou Quan Chen Hanhang Yin Lerong Hong hao Tian Ying Chen siyuan Li the College of Electrical and Information Engineering Hunan UniversityChangsha 410082China the Zhejiang Magtron Intelligent Technology Limited Cooperation Jiaxing 314000China the State Grid Qianjiang Electric Power Company Qianjiang 433100China

Line commutated converter based high-voltage direct-current(LCC-HVDC)transmissions are prone to harmonic oscillation under weak *** modeling is an effective method for assessing interaction ***,this paper proposes an improved calculation method for the DC voltage and AC currents of commutation stations to address the complex linearization of the commutation process and constructs an overall harmonic state-space(HSS)model of an *** on the HSS model,the closed-loop AC impedances on the LCC-HVDC sending and receiving ends are then derived and *** impedance characteristics of the LCC-HVDC are then analyzed to provide a physical explanation for the harmonic oscillation of the *** effects of the grid strength and control parameters on system stability are also *** improve the impedance characteristics and operating stability of the LCC-HVDC system,a virtual impedance based stability enhancement control is proposed,and a parameter design method is considered to ensure satisfactory phase margins at both the sending and receiving ***,simulation results are presented to verify the validity of the impedance model and virtual impedance based stability enhancement control.

关键词： Line commutated converter based high-voltage direct-current(LCC-HVDC)transmission harmonic state space stability analysis harmonic oscillation virtual impedance

Boosting the catalytic performance of Cu-SAPO-34in NO_(x) removal via hydrothermal treatment

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Journal of Environmental Sciences 2024年第1期135卷 640-655页

作者： Xiaoyan Tian Huimin Wang siyuan Xu Lianyun Gao Jinyan Cao Jianjun Chen Qiulin Zhang Ping Ning Jiming hao Faculty of Environmental Science and Engineering Kunming University of Science and TechnologyKunming 650500China National-Regional Engineering Center for Recovery of Waste Gases from Metallurgical and Chemical Industries Kunming University of Science and TechnologyKunming 650500China School of Environment State Key Joint Laboratory of Environment Simulation and Pollution ControlTsinghua UniversityBeijing 100084China

Phosphate ions promoted Cu-SAPO-34(P-Cu-SAPO-34)were prepared using bulk CuO particles as Cu^(2+)precursor by a solid-state ion exchange technique for the selective catalytic reduction of NO_(x) with NH_3(NH_3-SCR).The effects of high temperature(H-T)hydrothermal aging on the NO_(x) removal(de-NO_(x))performance of Cu-SAPO-34 with and without phosphate ions were systematically investigated at atomic *** results displayed that both Cu-SAPO-34 and P-Cu-SAPO-34 presented relatively poor NO_(x) removal activity with a low conversion(<30%)at 250-500℃.However,after H-T hydrothermal treatment(800℃ for 10 hr at 10%H_2O),these two samples showed significantly satisfied NO_(x) elimination performance with a quite high conversion(70%-90%)at 250-500℃.Additionally,phosphate ions decoration can further enhance the catalytic performance of Cu-SAPO-34 after hydrothermal treatment(Cu-SAPO-34H).The textural properties,morphologies,structural feature,acidity,redox characteristic,and surface-active species of the fresh and hydrothermally aged samples were analyzed using various characterization *** systematical characterization results revealed that increases of 28%of the isolated Cu^(2+)active species(Cu^(2+)-2Z,Cu(OH)^(+)-Z)mainly from bulk CuO and 50%of the Bronsted acid sites,the high dispersion of isolated Cu^(2+)active component as well as the Bronsted acid sites were mainly responsible for the accepted catalytic activity of these two hydrothermally aged samples,especially for P-Cu-SAPO-34H.

关键词： NH_(3)-SCR Cu-SAPO-34 Hydrothermal induced Phosphate ions

Sorafenib inhibits ossification of the posterior longitudinal ligament by blocking LOXL2-mediated vascularization

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Bone Research 2024年第2期12卷 372-389页

作者： Longqing Wang Wenhao Jiang siyuan Zhao Dong Xie Qing Chen Qi Zhao hao Wu Jian Luo Lili Yang Spine Center Department of OrthopaedicsShanghai Changzheng HospitalSecond Affiliated Hospital of Naval Medical UniversityShanghai 200003PR China Yangzhi Rehabilitation Hospital(Shanghai Sunshine Rehabilitation Center) Tongji University School of MedicineShanghaiPR China Shanghai Key Laboratory of Regulatory Biology Institute of Biomedical Sciences and School of Life SciencesEast China Normal UniversityShanghaiPR China Department of Orthopaedics No.905 Hospital of PLA NavyShanghaiPR China

Ossification of the Posterior Longitudinal Ligament(OPLL)is a degenerative hyperostosis disease characterized by the transformation of the soft and elastic vertebral ligament into bone,resulting in limited spinal mobility and nerve *** both bulk and single-cell RNA sequencing,we elucidate the molecular characteristics,cellular components,and their evolution during the OPLL process at a single-cell resolution,and validate these findings in clinical *** study also uncovers the capability of ligament stem cells to exhibit endothelial cell-like phenotypes in vitro and in ***,our study identifies LOXL2 as a key regulator in this *** gain-and loss-of-function studies,we elucidate the role of LOXL2 in the endothelial-like differentiation of ligament *** acts via the HIF1A pathway,promoting the secretion of downstream VEGFA and *** function is not related to the enzymatic activity of ***,we identify sorafenib,a broad-spectrum tyrosine kinase inhibitor,as an effective suppressor of LOXL2-mediated vascular *** disrupting the coupling between vascularization and osteogenesis,sorafenib demonstrates significant inhibition of OPLL progression in both BMP-induced and enpp1 deficiency-induced animal models while having no discernible effect on normal bone *** findings underscore the potential of sorafenib as a therapeutic intervention for OPLL.

关键词： LOXL2 ligament finding

Thermal stress simulation analysis of aerospace optical fibers and connectors and related extensions to high-speed railway area

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High-Speed Railway 2024年第2期2卷 122-132页

作者： Feng Zhou siyuan Yu Zeren Gao Jie Kan hao Xu Mengjie Liu The 8th Research Institute of China Electronics Technology Corporation Hefei 230051China Anhui Key Laboratory of Aerospace Optical Fiber Interconnection Technology Hefei 230051China Harbin Institute of Technology Harbin 150001China ANJIANG TEC Wuhu 241000China

Aerospace optical cables and fiber-optic connectors have numerous advantages(e.g.,low loss,wide transmission frequency band,large capacity,light weight,and excellent resistance to electromagnetic interference).They can achieve optical communication interconnections and high-speed bidirectional data transmission between optical terminals and photodetectors in space,ensuring the stability and reliability of data transmission during spacecraft operations in *** have become essential components in high-speed networking and optically interconnected communications for *** stress simulation analysis is important for evaluating the temperature stress concentration phenomenon resulting from temperature fluctuations,temperature gradients,and other factors in aerospace optical cables and connectors under the combined effects of extreme temperatures and vacuum *** this,advanced optical communication technology has been widely used in high-speed railway communication networks to transmit safe,stable and reliable signals,as high-speed railway optical communication in special areas with extreme climates,such as cold and high-temperature regions,requires high-reliability optical cables and ***,based on the finite element method,comprehensive comparisons were made between the thermal distributions of aerospace optical cables and J599III fiber optic connectors under different conditions,providing a theoretical basis for evaluating the performance of aerospace optical cables and connectors in space environments and meanwhile building a technical foundation for potential optical communication applications in the field of high-speed railways.

关键词： Aerospace optical fiber Aerospace optic connector Simulation analysis

结合Beltrami流和递归滤波的高光谱图像分类方法

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农业机械学报 2018年第1期49卷 42-50页

作者：廖建尚王立国郝思媛广东交通职业技术学院计算机工程学院广州510650 哈尔滨工程大学信息与通信工程学院哈尔滨150001 青岛理工大学通信与电子工程学院青岛266520

提出一种结合Beltrami流滤波和域转换递归滤波的高光谱图像分类算法(BFRF-SVM)。分别利用Beltrami流对主成分分析(PCA)降维后的高光谱图像滤波方法和域转换递归滤波方法对全光谱波段进行滤波,两种空间信息进行线性融合后交由支持向量机(... 详细信息

提出一种结合Beltrami流滤波和域转换递归滤波的高光谱图像分类算法(BFRF-SVM)。分别利用Beltrami流对主成分分析(PCA)降维后的高光谱图像滤波方法和域转换递归滤波方法对全光谱波段进行滤波,两种空间信息进行线性融合后交由支持向量机(SVM)完成分类。实验表明,相比使用光谱信息、高光谱降维、空谱结合的SVM分类方法,以及边缘保持滤波和递归滤波以及形态学滤波特征方法,本文提出的BFRF-SVM方法对高光谱图像的分类精度有较大提高,验证了该方法的有效性。

关键词：高光谱图像空间信息分类 Beltrami流域转换递归滤波

A comprehensive review of meal?replacement from dining table to sickbed: beyond biomedical potentials

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Food Science and Human Wellness 2024年

作者： hao Qiang Tianshu Xu Peng Ma siyuan Zhang Guanhua Du Guifen Qiang Tengfei Ji The School of Chemistry， Cardiff University State Key Laboratory of Bioactive Substance and Function of Natural Medicines， Institute of Materia Medica， Chinese Academy of Medical Sciences and Peking Union Medical College and Beijing Key Laboratory of Drug Target and Screening Research State Key Laboratory， Institute of Materia Medica， Chinese Academy of Medical Sciences and Peking Union Medical College

The emergence of meal replacement (MR) originates from physical exercise or fitness as a substitute for one or all meals and later expands to the field of weight loss. Indeed， the main application of current meal replacement is to lose body weight， whether patients with obesity， diabetes， fatty liver， infertile or pregnant women can benefit from weight loss. In addition， MRs still exhibit more biomedical potential in preventing and treating diseases， like anti-diabetes， improving fatty liver and kidney disease， preventing cancer， conceiving and reducing pregnancy complications， and improving life quality. Indeed， there are also disadvantages to meal replacement， including causing adverse effects， although most are acceptable and tolerated. To date， various commercially-developed MRs are walking from dining table to sickbed. Therefore， a scientific understanding of the advantages and disadvantages of meal replacements is crucial for their extensive application beyond biomedical potentials.

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Plant Stem Cell Informatics Database(PSCIdb):A comprehensive computational platform for identifying and analyzing genes related to plant stem cells

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Plant Communications 2024年第5期5卷 100-103页

作者： Xiao Wu Yubo Yuan siyuan Zhou Zewen Wang Hongxiang Li Wanping Wu Zhijie Lei Siyao Liu Kaijie Qi hao Yin Yun Zhou Shaoling Zhang Sanya Institute of Nanjing Agricultural University State Key Laboratory of Crop Genetics&Germplasm Enhancement and UtilizationNanjing Agricultural UniversityNanjing 210095China Department of Botany and Plant Pathology Purdue UniversityWest LafayetteIN 47907USA Purdue Center for Plant Biology Purdue UniversityWest LafayetteIN 47907USA

Dear Editor,Stem cells in the meristems of land plants share conserved functions,remaining undifferentiated while continually dividing and producing daughter cells that eventually differentiate into various new organs(Meyerowitz,1997;Heidstra and Sabatini,2014).Stem cell activity is therefore essential for sustaining plant growth and development,determining yield and biomass production,and dictating the diversity of body formation and plant architecture across species(Meyerowitz,1997;Heidstra and Sabatini,2014;Harrison,2017;Kitagawa and Jackson,2019).

关键词： Informatics eventually dividing