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ARGA-Unet:Advanced U-net segmentation model using residual grouped convolution and attention mechanism for brain tumor MRI image segmentation

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虚拟现实与智能硬件（中英文） 2024年第3期6卷 203-216页

作者： siyi xun Yan ZHANG Sixu DUAN Mingwei WANG Jiangang CHEN Tong TONG Qinquan GAO Chantong LAM Menghan HU Tao TAN Faculty of Applied Sciences Macao Polytechnic UniversityMacao 999078China Jinan Branch of China Telecom Co.Ltd. Jinan 250000China School of Physics and Electronics Shandong Normal UniversityJinan 250000China Department of Dardiovascular Medicine Affiliated Hospital of Hangzhou Normal UniversityHangzhou 310000China Clinical School of Medicine Hangzhou Normal UniversityHangzhou 310000China Hangzhou Institute of Cardiovascular Diseases Hangzhou 310000China Shanghai Key Laboratory of Multidimensional Information Processing Shanghai 200000China School of Communication&Electronic Engineering East China Normal UniversityShanghai 200000China Engineering Research Center of Traditional Chinese Medicine Intelligent Rehabilitation Ministry of EducationShanghai 200000China College of Physics and Information Engineering Fuzhou UniversityFuzhou 350000China

Background Magnetic resonance imaging(MRI)has played an important role in the rapid growth of medical imaging diagnostic technology,especially in the diagnosis and treatment of brain tumors owing to its non invasive characteristics and superior soft tissue ***,brain tumors are characterized by high non uniformity and non-obvious boundaries in MRI images because of their invasive and highly heterogeneous *** addition,the labeling of tumor areas is time-consuming and *** To address these issues,this study uses a residual grouped convolution module,convolutional block attention module,and bilinear interpolation upsampling method to improve the classical segmentation network *** influence of network normalization,loss function,and network depth on segmentation performance is further *** In the experiments,the Dice score of the proposed segmentation model reached 97.581%,which is 12.438%higher than that of traditional U-net,demonstrating the effective segmentation of MRI brain tumor *** In conclusion,we use the improved U-net network to achieve a good segmentation effect of brain tumor MRI images.

关键词： Brain tumor MRI U-net Segmentation Attention mechanism Deep learning

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Taurocholic acid inhibits the response to interferon-αtherapy in patients with HBeAg-positive chronic hepatitis B by impairing CD8^(+)T and NK cell function

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Cellular & Molecular Immunology 2021年第2期18卷 461-471页

作者： Zhen xun Jinpiao Lin Qingqing Yu Can Liu Jinlan Huang Hongyan Shang Jianhui Guo Yuchen Ye Wennan Wu Yongbin Zeng Songhang Wu siyi Xu Tianbin Chen Jing Chen Qishui Ou Department of Laboratory Medicine Gene Diagnosis Research CenterThe First Affiliated HospitalFujian Medical UniversityFuzhouChina Fujian Key Laboratory of Laboratory Medicine The First Affiliated HospitalFujian Medical UniversityFuzhouChina First Clinical College Fujian Medical UniversityFuzhouChina Center of Liver Diseases The First Affiliated HospitalFujian Medical UniversityFuzhouChina

Pegylated interferon-alpha (PegIFNα) therapy has limited effectiveness in hepatitis B e-antigen (HBeAg)-positive chronic hepatitis B (CHB) patients. However, the mechanism underlying this failure is poorly understood. We aimed to investigate the influence of bile acids (BAs), especially taurocholic acid (TCA), on the response to PegIFNα therapy in CHB patients. Here, we used mass spectrometry to determine serum BA profiles in 110 patients with chronic HBV infection and 20 healthy controls (HCs). We found that serum BAs, especially TCA, were significantly elevated in HBeAg-positive CHB patients compared with those in HCs and patients in other phases of chronic HBV infection. Moreover, serum BAs, particularly TCA, inhibited the response to PegIFNα therapy in HBeAg-positive CHB patients. Mechanistically, the expression levels of IFN-γ, TNF-α, granzyme B, and perforin were measured using flow cytometry to assess the effector functions of immune cells in patients with low or high BA levels. We found that BAs reduced the number and proportion and impaired the effector functions of CD3^(+)CD8^(+) T cells and natural killer (NK) cells in HBeAg-positive CHB patients. TCA in particular reduced the frequency and impaired the effector functions of CD3^(+)CD8^(+) T and NK cells in vitro and in vivo and inhibited the immunoregulatory activity of IFN-α in vitro. Thus, our results show that BAs, especially TCA, inhibit the response to PegIFNα therapy by impairing the effector functions of CD3^(+)CD8^(+) T and NK cells in HBeAg-positive CHB patients. Our findings suggest that targeting TCA could be a promising approach for restoring IFN-α responsiveness during CHB treatment.

关键词： Bile acids Pegylated interferon Hepatitis B virus Immune cells Mechanism

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A novel nomogram for prognosis stratification in salvage liver transplantation:a national-wide study with propensity score matching analysis in China

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Hepatobiliary Surgery and Nutrition 2023年第6期12卷 854-867,I0006-I0009页

作者： Kai Wang Fengqiang Gao siyi Dong Jialu Ding Libin Dong Chuxiao Shao Zhoucheng Wang xun Qiu Xuyong Wei Zhengxin Wang Jiayin Yang Qiang Xia Shusen Zheng Xiao Xu Department of Hepatobiliary and Pancreatic Surgery Affiliated Hangzhou First People’s HospitalZhejiang University School of MedicineHangzhouChina Institute of Organ Transplantation Zhejiang UniversityHangzhouChina Key Laboratory of Integrated Oncology and Intelligent Medicine of Zhejiang Province Affiliated Hangzhou First People’s HospitalZhejiang University School of MedicineHangzhouChina NHC Key Laboratory of Combined Multi-organ Transplantation HangzhouChina Zhejiang University School of Medicine HangzhouChina Department of Hepatobiliary and Pancreatic Surgery Affiliated Lishui HospitalZhejiang University School of MedicineLishuiChina National Center for Healthcare Quality Management in Liver Transplant HangzhouChina Graduate School Nanjing University of Chinese MedicineNanjingChina Department of General Surgery Huashan HospitalFudan UniversityShanghaiChina Liver Transplantation Center Department of Liver SurgeryWest China Hospital of Sichuan UniversityChengduChina Department of Liver Surgery Ren Ji HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghaiChina Department of Hepatobiliary and Pancreatic Surgery the First Affiliated HospitalZhejiang University School of MedicineHangzhouChina Department of Hepatobiliary and Pancreatic Surgery Shulan Hospital of HangzhouHangzhouChina

Background:Salvage liver transplantation(SLT)has been reported to be an efficient treatment option for patients with recurrent hepatocellular carcinoma(HCC)after liver resection(LR).However,for recipients who underwent liver transplantation(LT)due to recurrent HCC after LR in China,the selection criteria are not well ***:In this study,data from the China Liver Transplant Registry(CLTR)of 4,244 LT performed from January 2015 to December 2019 were examined,including 3,498 primary liver transplantation(PLT)and 746 SLT *** score matching(PSM)analysis was used to minimize between-group *** overall survival(OS)and disease-free survival(DFS)between PLT and SLT in recipients fulfilling the Milan or Hangzhou criteria were compared based on the multivariate analysis,nomograms were plotted to further classify the SLT group into low-and high-risk ***:In this study,the 1-,3-and 5-year OS and DFS of SLT recipients fulfilling Milan criteria(OS,P=0.01;DFS,P<0.001)or Hangzhou criteria(OS,P=0.03;DFS,P=0.003)were significantly reduced when compared to that of PLT group after PSM *** risk factors,including preoperative transarterial chemoembolization(TACE),alpha fetoprotein(AFP)level,tumor maximum size and tumor total diameter were selected to draw a prognostic *** low-risk SLT recipients(1-year,95.34%;3-year,84.26%;5-year,77.20%)showed a comparable OS with PLT recipients fulfilling Hangzhou criteria (P=0.107). Conclusions: An optimal nomogram model for prognosis stratification and clinical decision guidance of SLT was established. The low-risk SLT recipients based on the nomograms showed comparable survival with those fulfilling Hangzhou criteria in PLT group.

关键词： Salvage liver transplantation(SLT) nomogram primary liver transplantation(PLT) overall survival(OS) disease-free survival(DFS)

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区域国土开发强度与资源环境承载力时空耦合关系研究——以沈阳经济区为例

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中国土地科学 2018年第7期32卷 58-65页

作者：卫思夷居祥荀文会南京农业大学公共管理学院江苏南京210095 沈阳市国土资源发展研究中心辽宁沈阳110004

研究目的:揭示国土开发强度和资源环境承载力互动演化的规律,分析沈阳经济区8个城市国土开发强度与资源环境承载力的耦合协调关系。研究方法:利用耦合协调模型分析评判国土开发强度与资源环境承载力之间协调发展及交互耦合的程度。研究... 详细信息

研究目的:揭示国土开发强度和资源环境承载力互动演化的规律,分析沈阳经济区8个城市国土开发强度与资源环境承载力的耦合协调关系。研究方法:利用耦合协调模型分析评判国土开发强度与资源环境承载力之间协调发展及交互耦合的程度。研究结果:(1)2010年以来沈阳经济区各城市国土开发强度不断增长,资源承载力呈现降低的趋势,但环境承载力和社会经济支撑力呈现增加态势;(2)各市国土开发强度与资源环境承载力之间的耦合协调程度较高,达到良性共振,并且协调度呈总体上升趋势,耦合关系日趋紧密。研究结论:国土开发强度与资源环境承载力之间并不存在必然的对立和制约关系,应因势利导,实现两者之间的协调发展。

关键词：土地利用国土开发强度区域资源环境承载力时空耦合沈阳经济区

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共同内群体认同对医患竞争受害感的影响及其机制

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心理学报 2023年第5期55卷 752-765页

作者：邓洵龙思邑沈依琳赵欢欢贺雯上海师范大学教育学院上海200234 攀枝花学院就业指导中心四川攀枝花617000

本研究基于共同内群体认同模型,以医务人员和患者及家属为研究对象,考察了共同内群体认同对医患竞争受害感的影响及机制。预研究通过问卷调查证明了医患群体间存在竞争受害感;实验1采用共同内群体认同的操作范式,发现共同内群体认同能... 详细信息

本研究基于共同内群体认同模型,以医务人员和患者及家属为研究对象,考察了共同内群体认同对医患竞争受害感的影响及机制。预研究通过问卷调查证明了医患群体间存在竞争受害感;实验1采用共同内群体认同的操作范式,发现共同内群体认同能够有效减少医患双方的竞争受害感;实验2A进一步发现,权力需要在医方和患方共同内群体认同和竞争受害感之间起中介作用,而道德需要的中介作用不显著。实验2B采用更接近社会现实情境的重新范畴化范式,结果显示共同内群体认同的主效应不显著,但与群体身份的交互作用显著,仅医方权力需要的中介路径成立。本研究揭示了共同内群体认同不仅能够直接降低医患双方的竞争受害感,而且可以通过减少权力需要进一步降低竞争受害感,从群际角度为缓和医患之间的紧张关系提供了新的视角。

关键词：医患关系竞争受害感共同内群体认同权力需要道德需要

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理工科院校新文科建设路径研究——以西安石油大学为例

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黑龙江教育（理论与实践） 2023年第5期 48-50页

作者：吴勋任思怡西安石油大学陕西西安710065

新文科建设是当前国家经济文化发展的重大战略部署,也是建设高等教育强国的关键举措。文章通过分析国内典型高校新文科建设的现状,以西安石油大学为例,制定新文科建设举措,即掌握新文科建设基调,明晰新文科建设方向布局,构建具有石油石... 详细信息

新文科建设是当前国家经济文化发展的重大战略部署,也是建设高等教育强国的关键举措。文章通过分析国内典型高校新文科建设的现状,以西安石油大学为例,制定新文科建设举措,即掌握新文科建设基调,明晰新文科建设方向布局,构建具有石油石化特色的文科专业体系;以价值观念的培养为指导,建立新文科课程体系;建设新型智库,把握人文社科类学科特色优势,推动人文社科与自然科学融合,探索理工科院校新文科建设的路径。

关键词：新文科建设文科教育高等教育改革

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不同物料对海滨沙性盐碱地改良效果研究

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土壤 2023年第2期55卷 356-362页

作者：周思怡李晓佳张恂邵天韵隆小华南京农业大学资源与环境科学学院南京210095

本文针对江苏省南通市海滨盐碱地特点,设对照、秸秆、膨化鸡粪、腐熟牛粪、功能有机肥、调理剂I和调理剂II共7个处理,通过原位田间小区试验进行不同改良物料对南通海滨沙性盐碱土壤的改良效果研究。结果表明:改良组的pH基本都显著高于... 详细信息

本文针对江苏省南通市海滨盐碱地特点,设对照、秸秆、膨化鸡粪、腐熟牛粪、功能有机肥、调理剂I和调理剂II共7个处理,通过原位田间小区试验进行不同改良物料对南通海滨沙性盐碱土壤的改良效果研究。结果表明:改良组的pH基本都显著高于对照组;虽各组含盐量结果之间存在一定差异,但改良组两个不同土层(0~10 cm、10~20 cm)的含盐量都分别显著低于对照组,当秸秆、膨化鸡粪、腐熟牛粪、功能有机肥、调理剂I和调理剂II的施入量分别为3.0、1.12、4.5、0.45、0.045和0.060 kg/m2时,0~10 cm深度的土壤中含盐量相较于对照组分别降低91.1%、93.0%、94.3%、88.8%、81.8%、78.5%,而10~20 cm深度土壤中含盐量分别降低75.3%、73.8%、69.3%、79.02%、68.2%、61.5%。研究结果说明施加上述改良物料均对降低土壤含盐量、消减盐碱障碍起到了较为显著的作用,其中在秸秆施入量为3.0 kg/m2时对南通海滨沙性盐碱地改良效果最好。

关键词：盐碱地改良物料土壤改良土壤含盐量 pH

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