检索结果-南通市图书馆

Peroxisome proliferator-activated receptor agonists:A new hope towards the management of alcoholic liver disease

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2024年第35期30卷 3965-3971页

作者： siva Sundara kumar Durairajan Abhay kumar Singh Ashok Iyaswamy Department of Microbiology School of Life SciencesCentral University of Tamil NaduTiruvarur 610005India School of Biomedical Sciences Li Ka Shing Faculty of MedicineUniversity of Hong KongHong Kong 999077China School of Chinese Medicine Hong Kong Baptist UniversityHong Kong 999077China Department of Biochemistry Karpagam Academy of Higher EducationCoimbatore 641021India

In this editorial,we examine a paper by Koizumi et al,on the role of peroxisome proliferator-activated receptor(PPAR)agonists in alcoholic liver disease(ALD).The study determined whether elafibranor protected the intestinal barrier and reduced liver fibrosis in a mouse model of *** study also underlines the role of PPARs in intestinal barrier function and lipid homeostasis,which are both affected by *** therapies are necessary for ALD because it is a critical health issue that affects people *** editorial analyzes the possibility of PPAR agonists as treatments for *** key factors of inflammation and metabolism,PPARs offer multiple methods for managing the complex etiology of *** assess the abilities of PPARα,PPARγ,and PPARβ/δagonists to prevent steatosis,inflammation,and fibrosis due to liver *** research carried out in preclinical and clinical settings has shown that PPAR agonists can reduce the severity of liver *** editorial discusses the data analyzed and the obstacles,advantages,and mechanisms of action of PPAR agonists for *** research is needed to understand the efficacy,safety,and mechanisms of PPAR agonists for treating ALD.

关键词： Alcoholic liver disease Peroxisome proliferator-activated receptors Peroxisome proliferator-activated receptors agonists Liver fibrosis Inflammation Metabolic regulation Hepatoprotection

Role of fecal microbiota transplant in management of hepatic encephalopathy: Current trends and future directions

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Hepatology 2024年第1期16卷 17-32页

作者： Yash R Shah Hassam Ali Angad Tiwari David Guevara-Lazo Natalia Nombera-Aznaran Bhanu siva Mohan Pinnam Manesh kumar Gangwani Harishankar Gopakumar Amir H Sohail SriLakshmiDevi Kanumilli Ernesto Calderon-Martinez Geetha Krishnamoorthy Nimish Thakral Dushyant Singh Dahiya Department of Internal Medicine Trinity Health Oakland/Wayne State UniversityPontiacMI 48341United States Division of Gastroenterology and Hepatology East Carolina University/Brody School of MedicineGreenvilleNC 27858United States Department of Internal Medicine Maharani Laxmi Bai Medical CollegeJhansi 284001India Faculty of Medicine Universidad Peruana Cayetano HerediaLima 15102Peru Department of Internal Medicine John H.Stroger Hospital of Cook CountyChicagoIL 60612United States Department of Internal Medicine The University of ToledoToledoOH 43606United States Department of Gastroenterology and Hepatology University of Illinois College of Medicine at PeoriaPeoriaIL 61605United States Department of Surgery University of New MexicoAlbuquerqueNM 87106United States Department of Internal Medicine GSL Medical CollegeRajamahendravaram 533296India Department of Internal Medicine Universidad Nacional Autonoma de MexicoCiudad De Mexico 04510Mexico Department of Digestive Diseases and Nutrition University of KentuckyLexingtonKY 40536United States Division of Gastroenterology Hepatology&MotilityThe University of Kansas School of MedicineKansas CityKS 66160United States

Fecal microbiota transplantation(FMT)offers a potential treatment avenue for hepatic encephalopathy(HE)by leveraging beneficial bacterial displacement to restore a balanced gut *** prevalence of HE varies with liver disease severity and *** pathogenesis involves ammonia toxicity,gut-brain communication disruption,and *** aims to restore gut microbiota balance,addressing these ***'s efficacy has been explored in various conditions,including *** suggest that FMT can modulate gut microbiota,reduce ammonia levels,and alleviate *** has shown promise in alcohol-associated,hepatitis B and C-associated,and non-alcoholic fatty liver *** include improved liver function,cognitive function,and the slowing of disease ***,larger,controlled studies are needed to validate its effectiveness in these *** have shown cognitive improvements through FMT,with potential benefits in cirrhotic ***,trials have demonstrated reduced serious adverse events and cognitive enhancements in FMT arms compared to the standard of *** evidence is promising,challenges remain:Limited patient numbers,varied dosages,administration routes,and donor *** large-scale,controlled trials are essential to establish standardized guidelines and ensure FMT's clinical applications and *** FMT holds potential for HE management,ongoing research is needed to address these challenges,optimize protocols,and expand its availability as a therapeutic option for diverse hepatic conditions.

关键词： Hepatic encephalopathy Fecal microbiota transplant Cognitive impairment Liver cirrhosis Chronic liver disease

Remimazolam for sedation in gastrointestinal endoscopy:A comprehensive review

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastrointestinal Endoscopy 2024年第7期16卷 385-395页

作者： Dushyant Singh Dahiya Ganesh kumar Syeda Parsa Manesh kumar Gangwani Hassam Ali Amir Humza Sohail Saqr Alsakarneh Umar Hayat Sheza Malik Yash R Shah Bhanu siva Mohan Pinnam Sahib Singh Islam Mohamed Adishwar Rao Saurabh Chandan Mohammad Al-Haddad Division of Gastroenterology Hepatology&MotilityThe University of Kansas School of MedicineKansas CityMO 66160United States Department of Internal Medicine Chandka Medical CollegeSindh 77280Pakistan Department of Gastroenterology and Hepatology University of Arkansas For Medical SciencesLittle RockAR 72205United States Division of Gastroenterology Hepatology and NutritionEast Carolina University/Brody School of MedicineGreenvilleNC 27858United States Department of Surgery University of New Mexico School of MedicineAlbuquerqueNM 87106United States Department of Internal Medicine University of Missouri-Kansas CityKansas CityMO 64108United States Department of Internal Medicine Geisinger Wyoming Valley Medical CenterWilkes BarrePA 18711United States Department of Internal Medicine Rochester General HospitalRochesterNY 14621United States Department of Internal Medicine Trinity Health Oakland/Wayne State UniversityPontiacMI 48341United States Department of Internal Medicine John H.Stroger Hospital of Cook CountyChicagoIL 60612United States Department of Internal Medicine Sinai hospitalBaltimoreMD 21215United States Department of Hepatology University of MissouriColumbiaMO 65211United States Department of Internal Medicine Guthrie Robert Packer HospitalSayrePA 18840United States Division of Gastroenterology and Hepatology Creighton University School of MedicineOmahaNE 68131United States Division of Gastroenterology and Hepatology Indiana University School of MedicineIndianapolisIN 46202United States

Worldwide,a majority of routine endoscopic procedures are performed under some form of sedation to maximize patient ***,benzodiazepines and opioids continue to be widely ***,in recent years,Remimazolam is gaining immense popularity for procedural sedation in gastrointestinal(GI)*** is an ultra-short-acting benzodiazepine sedative which was approved by the Food and Drug Administration in July 2020 for use in procedural *** has shown a favorable pharmacokinetic and pharmacodynamic profile in terms of its non-specific metabolism by tissue esterase,volume of distribution,total body clearance,and negligible drug-drug *** also has satisfactory efficacy and has achieved high rates of successful sedation in GI ***,studies have demonstrated that the efficacy of Remimazolam is non-inferior to Propofol,which is currently a gold standard for procedural sedation in most parts of the ***,the use of Propofol is associated with hemodynamic instability and respiratory *** contrast,Remimazolam has lower incidence of these adverse effects intra-procedurally and hence,may provide a safer alternative to Propofol in procedural *** this comprehensive narrative review,highlight the pharmacologic characteristics,efficacy,and safety of Remimazolam for procedural *** also discuss the potential of Remimazolam as a suitable alternative and how it can shape the future of procedural sedation in gastroenterology.

关键词： Remimazolam Endoscopy Sedation Outcomes Efficacy Safety Pharmacokinetics

Impact of frailty on endoscopic retrograde cholangiopancreatography outcomes in nonagenarians:A United States national experience

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastrointestinal Endoscopy 2024年第3期16卷 148-156页

作者： Sanket Dhirubhai Basida Dushyant Singh Dahiya Muhammad Nadeem Yousaf Brinda Basida Bhanu siva Mohan Pinnam Manesh kumar Gangwani Hassam Ali Sahib Singh Yash R Shah Daksh Ahluwalia Mihir Prakash Shah Saurabh Chandan Neil R Sharma Shyam Thakkar Department of Internal Medicine University of Missouri-ColumbiaColumbiaMO 65212United States Division of Gastroenterology Hepatology&MotilityThe University of Kansas School of MedicineKansas CityKS 66160United States Division of Gastroenterology and Hepatology University of MissouriColumbiaMO 65212United States Department of Rheumatology Medical College of GeorgiaAugusta UniversityNorth AugustaGA 30912United States Department of Internal Medicine John H.Stroger Hospital of Cook CountyChicagoIL 60612United States Department of Internal Medicine The University of ToledoToledoOH 43606United States Division of Gastroenterology and Hepatology East Carolina University/Brody School of MedicineGreenvilleNC 27858United States Department of Internal Medicine Sinai HospitalBaltimoreMD 21215United States Department of Internal Medicine Trinity Health Oakland/Wayne State UniversityPontiacMI 48341United States Division of Gastroenterology and Hepatology Creighton University School of MedicineOmahaNE 68131United States Division of Interventional Oncology&Surgical Endoscopy GI Oncology Tumor Site TeamParkview Cancer InstituteParkview HealthFort WayneIN 46845United States Section of Gastroenterology&Hepatology West Virginia University School of MedicineMorgantownWV 26505United States

BACKGROUND Endoscopic retrograde cholangiopancreatography(ERCP)is an essential therapeutic tool for biliary and pancreatic *** and elderly patients,especially those aged≥90 years are generally considered a higher-risk population for ERCP-related *** To investigate outcomes of ERCP in the Non-agenarian population(≥90 years)concerning *** This is a cohort study using the 2018-2020 National Readmission *** aged≥90 were identified who underwent ERCP,using the international classification of diseases-10 code with clinical *** Hopkins’s adjusted clinical groups frailty indicator was used to classify patients as frail and *** primary outcome was mortality,and the secondary outcomes were morbidity and the 30 d readmission rate related to *** used univariate and multivariate regression models for *** A total of 9448 patients were admitted for any indications of *** and non-frail patients were 3445(36.46%)and 6003(63.53%)*** for ERCP were Choledocholithiasis(74.84%),Biliary pancreatitis(9.19%),Pancreatico-biliary cancer(7.6%),Biliary stricture(4.84%),and Cholangitis(1.51%).Mortality rates were higher in frail group[adjusted odds ratio(aOR)=1.68,P=0.02].The Intra-procedural complications were insigni-ficant between the two groups which included bleeding(aOR=0.72,P=0.67),accidental punctures/lacerations(aOR=0.77,P=0.5),and mechanical ventilation rates(aOR=1.19,P=0.6).Post-ERCP complication rate was similar for bleeding(aOR=0.72,P=0.41)and post-ERCP pancreatitis(aOR=1.4,P=0.44).Frail patients had a longer length of stay(6.7 d vs 5.5 d)and higher mean total charges of hospitalization($78807 vs$71392)compared to controls(P<0.001).The 30 d all-cause readmission rates between frail and non-frail patients were similar(P=0.96).CONCLUSION There was a significantly higher mortality risk and healthcare burden amongst nonagenarian frail patients undergoing ERCP compared

关键词： Endoscopic retrograde cholangiopancreatography Nonagenarians Frailty Mortality Healthcare burden

Improving Performance of a Distributed File System Using a Speculative Semantics-Based Algorithm

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Tsinghua Science and Technology 2015年第6期20卷 583-593页

作者： Talluri Lakshmi siva Rama Krishna Thirumalaisamy Ragunathan Sudheer kumar Battula K L University Andhra PradeshIndia and Research ScholarJawaharlal Nehru Institute of Advanced Studies (JNIAS) ACE Engineering College

File-sharing semantics is used by the file systems for sharing data among concurrent client processes in a consistent manner. Session semantics is a widely used file-sharing semantics in Distributed File Systems(DFSs). The main disadvantage of session semantics is that writes to an open file are visible to the concurrent client processes only during their next session. Recently, "linearizability semantics" was introduced in Blob Seer DFS, in which a Read Client Process(RCP) can read only a previous version of a binary large object(blob), while update operations are carried out on that blob in a concurrent manner. In this paper, we propose a new type of file-sharing semantics, namely "speculative semantics", which permits writes to an open file to be visible to other concurrent processes provided that data consistency is not affected. In addition, we propose a new read algorithm for DFSs based on speculative semantics and a new performance measurement metric called Currency. The experimental results obtained using Blob Seer DFS indicate that the proposed read algorithm performs better than the existing read algorithm of Blob Seer DFS.

关键词： distributed system Hadoop Blobseer concurrency spe

Evaluation of phytochemical and antioxidant activities of the different fractions of Hybanthus enneaspermus (Linn.) ***. (Violaceae).

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Asian Pacific Journal of Tropical Medicine 2011年第5期4卷 391-396页

作者： Dinesh kumar Patel Rajesh kumar Damiki Laloo siva Hemalatha Pharmacognosy Research Laboratory Department of PharmaceuticsInstitute of TechnologyBanaras Hindu UniversityVaranasi-221005.India

Objective:To investigate the naturally occurring antioxidant for the first time from the different solvent fractions of Hybanthus enneaspermus（***） Linn ***（Violaceae）. Methods:Different fractions of *** were tested for total phenolic content,and in vitro antioxidant activity was measured by total antioxidant assay,DPPH assay,reducing power, nitric oxide（NO）,hydrogen peroxide（H2O2） scavenging ***:The ethyl acetate（EA） fraction was found to have high levels of phenolic content[（212.15±0.79） mg GAE/g].The EA fraction exhibited higher total antioxidant capacity,higher percentage of DPPH radical scavenging activity[（127.07±2.29） Fg/mL],nitric oxide[（245.16±1.44）μg/mLJ,hydrogen peroxide[（227.38±7.18）μg/mL],deoxyribose[（270.61±8.72）μg/mL]and higher reducing *** was a significant correlation between total phenolic content and total antioxidant activity（r =0.972）. Conclusions:These results reveal that EA fraction of *** has strong antioxidant potential compared with other *** further study has been extended to the isolation of the possible compound that is responsible for having antioxidant property.

关键词： Hybanthus enneaspermus Antioxidant Total phenolics

Pedalium murex Linn.:An overview of its phytopharmacological aspects

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Asian Pacific Journal of Tropical Medicine 2011年第9期4卷 748-755页

作者： Dinesh kumar Patel Damiki Laloo Rajesh kumar siva Hemalatha Pharmacognosy Research Laboratory Department of PharmaceuticsInstitute of Technology.Banana Hindu University

Pedalium murex Linn(family:Pedaliaceae)(***) commonly known as Large Caltrops and Gokhru(India) is a shrub found in the Southern *** region of India and in some parts of *** parts of the plant are used to treat various ailments like,cough,cold and as an *** is reported traditionally to have an excellent cure in patients with reproductive disorders which are mainly impotency in *** emissions,gonorrhoea as well as leucorrhoea in *** plant has also benifiled in complications like urinary track disorder as well as gastro intestinal tract *** the plant is popular for the presence of a considerable amount of diosgenin and vanillin which are regarded as an important source and useful starting materials for synthesizing steroidal contraceptive drugs and isatin *** phytochemicals reported in the plant includes *** acid,caffeic acid,amino acids(glycine,histidine,tyrosine,threonine,aspartie acid and glutamic acid) and various classes of fatty acids(triacontanoic acid,*** and heptatriacontan-4-one).Pharmacologically,the plant have been investigated for antiulcerogenic. ***,aphrodisiac,antioxidant,antimicrobial and insecticidal *** all these reports it can be concluded that the plant were found to have a better profile with potential natural source for the treatment of various range of either acute or chronic *** overall database of our review article was collected from the scientific sources in regards with all the information ol the research article for *** published so far.

关键词： Pedalium murex Tissue culture Phytochemistry Ulcerogenic Aphrodisiac Nephroprotective Antioxidant Antimicrobial

Purcell's Swimmer Revisited

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

International Journal of Automation and computing 2012年第3期9卷 325-330页

作者： M. siva kumar P. Philominathan Faculty Oman Dental College P.O. Box 835 Postal Code 116 Sultanate of Oman Research and PG Department of Physics AVVM Sri Pushpam College

Purcell’s swimmer was proposed by E. M. Purcell to explain bacterial swimming motions. It has been proved experimentally that a swimmer of this kind is possible under inertial-less and high viscous environment. But we could not investigate all the aspects of this mechanism through experiments due to practical difficulties. The computational fluid dynamics (CFD) provides complementary methods to experimental fluid dynamics. In particular, these methods offer the means of testing theoretical advances for conditions unavailable experimentally. Using such methodology, we have investigated the fluid dynamics of force production associated with the Purcell’s swimmer. By employing dynamic mesh and user-defined functions, we have computed the transient flow around the swimmer for various stroke angles. Our simulations capture the bidirectional swimming property successfully and are in agreement with existing theoretical and experimental results. To our knowledge, this is the first CFD study which shows the fact that swimming direction depends on stroke angle. We also prove that for small flapping frequencies, swimming direction can also be altered by changing frequency-showing breakdown of Stokes law with inertia.

关键词： Very low Reynolds number flow swimming motion of bacteria dynamic mesh Purcell’s swimmer Stokes flow

User Centric Block-Level Attribute Based Encryption in Cloud Using Blockchains

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Computer Systems Science & Engineering 2022年第8期42卷 605-618页

作者： S.Godfrey Winster A.siva kumar R.Ramesh Department of Computer Science and Engineering School of ComputingCollege of Engineering and TechnologySRM Institute of Science and TechnologyChengalpattu603203India Department of Information Technology Sri Sai Ram Engineering CollegeChennai600044India Department of Electronics and Communication Engineering Saveetha Engineering CollegeChennai602105India

Cloud computing is a collection of distributed storage Network which can provide various services and store the data in the efficient *** advantages of cloud computing is its remote access where data can accessed in real time using Remote Method Innovation(RMI).The problem of data security in cloud environment is a major concern since the data can be accessed by any time by any *** to the lack of providing the efficient security the cloud computing they fail to achieve higher performance in providing the efficient *** improve the performance in data security,the block chains are used for securing the data in the cloud ***,the traditional block chain technique are not suitable to provide efficient security to the cloud data stored in the *** this paper,an efficient user centric block level Attribute Based Encryption(UCBL-ABE)scheme is presented to provide the efficient security of cloud data in cloud *** proposed approach performs data transaction by employing the block *** proposed system provides efficient privacy with access control to the user access according to the behavior of cloud user using Data Level Access Trust(DLAT).Based on DLAT,the user access has been restricted in the cloud *** proposed protocol is implemented in real time using Java programming language and uses IBM *** implementation results justifies that the proposed system can able to provide efficient security to the data present in and cloud and also enhances the cloud performance.

关键词： Cloud blockchain data security ABE block-level