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Elucidating the role of gut microbiota dysbiosis in hyperuricemia and gout:Insights and therapeutic strategies

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World Journal of Gastroenterology 2024年第40期30卷 4404-4410页

作者： Abhay kumar Singh siva sundara kumar durairajan Ashok Iyaswamy Leonard L Williams Department of Microbiology School of Life SciencesCentral University of Tamil NaduTiruvarurTN 610005India School of Biomedical Sciences Li Ka Shing Faculty of MedicineThe University of Hong KongHong Kong 999077China School of Chinese Medicine Hong Kong Baptist UniversityHong Kong 999077China Department of Biochemistry Karpagam Academy of Higher EducationCoimbatore 641021India Center for Excellence in Post-Harvest Technologies North Carolina Agricultural and Technical State UniversityGreensboroNC 27411United States

Hyperuricemia(HUA)is a condition associated with a high concentration of uric acid(UA)in the bloodstream and can cause gout and chronic kidney *** gut microbiota of patients with gout and HUA is significantly altered compared to that of healthy *** article focused on the complex interconnection between alterations in the gut microbiota and the development of this *** studies have suggested that changes in the composition,diversity,and activity of microbes play a key role in establishing and progressing HUA and gout ***,we discussed how the gut microbiota contributes to HUA through purine metabolism,UA excretion,and intestinal inflammatory *** examined specific changes in the composition of the gut microbiota associated with gout and HUA,highlighting key bacterial taxa and the metabolic pathways ***,we discussed the effect of conventional gout treatments on the gut microbiota composition,along with emerging therapeutic approaches that target the gut microbiome,such as the use of probiotics and *** also provided insights into a study regarding the gut microbiota as a possible novel therapeutic intervention for gout treatment and dysbiosis-related diagnosis.

关键词： Gut microbiota Dysbiosis Gout Hyperuricemia Inflammation Intestinal barrier Probiotics Prebiotics Fecal microbiota transplantation

Role of Candida species in pathogenesis, immune regulation, and prognostic tools for managing ulcerative colitis and Crohn's disease

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World Journal of Gastroenterology 2024年第48期30卷 5212-5220页

作者： Supriti Patnaik siva sundara kumar durairajan Abhay kumar Singh Senthilkumar Krishnamoorthi Ashok Iyaswamy Shiva Prasad Mandavi Rajesh Jeewon Leonard L Williams Molecular Mycology and Neurodegenerative Disease Research Laboratory Department of MicrobiologyCentral University of Tamil NaduThiruvarur 610005India School of Biomedical Sciences Li Ka Shing Faculty of MedicineThe University of Hong KongPokfulamHong Kong SARChina Mr.&Mrs Ko Chi-Ming Centre for Parkinson’s Disease Research School of Chinese MedicineHong Kong Baptist UniversityHong Kong SARChina Department of Biochemistry Karpagam Academy of Higher EducationCoimbatore 641021India Department of Chemistry Central University of Tamil NaduTiruvarur 610005India Department of Health Sciences Faculty of Medicine and Health SciencesUniversity of MauritiusReduit 80837Mauritius Department of Zoology College of ScienceKing Saud UniversityRiyadh 11451Saudi Arabia Center for Excellence in Post Harvest Technologies North Carolina Agricultural and Technical State UniversityThe North Carolina Research CampusKannapolisNC 28081United States

The gut microbiome plays a key role in the pathogenesis and disease activity of inflammatory bowel disease(IBD).While research has focused on the bacterial microbiome,recent studies have shifted towards host genetics and host-fungal *** mycobiota is a vital component of the gastrointestinal microbial community and plays a significant role in immune *** fungi,Candida species,particularly Candida albicans(***),have been extensively studied due to their dual role as gut commensals and invasive *** findings indicate that various strains of *** exhibit consid-erable differences in virulence factors,impacting IBD's *** fungal dysbiosis and antifungal mucosal immunity may be associated to IBD,especially Crohn's disease(CD).This article discusses intestinal fungal dysbiosis and antifungal immunity in healthy individuals and CD *** discusses factors influencing the mycobiome's role in IBD pathogenesis and highlights significant contributions from the scientific community aimed at enhancing understanding of the mycobiome and encouraging further research and targeted intervention studies on specific fungal *** article also provided insights into a recent study by Wu et al in the World Journal of Gastroenterology regarding the role of the gut microbiota in the pathogenesis of CD.

关键词： Inflammatory bowel disease Ulcerative colitis Crohn's disease Gut mycobiome dysbiosis Candida species Immune regulation Gut inflammation Fecal mycobiota transplantation

Animal models for SARS-CoV-2 and SARS-CoV-1 pathogenesis,transmission and therapeutic evaluation

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World Journal of Virology 2022年第1期11卷 40-56页

作者： Udhaya Bharathy Saravanan Mayurikaa Namachivayam Rajesh Jeewon Jian-Dong Huang siva sundara kumar durairajan Department of Microbiology School of Life SciencesCentral University of Tamil NaduTiruvarur 610005India Department of Health Sciences Faculty of Medicine and Health SciencesUniversity of MauritiusReduit 80837Mauritius CAS Key Laboratory of Quantitative Engineering Biology Shenzhen Institute of Synthetic BiologyShenzhen Institutes of Advanced TechnologyChinese Academy of SciencesShenzhen 518055Guangdong ProvinceChina

There is a critical need to develop animal models to alleviate vaccine and drug development difficulties against zoonotic viral *** coronavirus family,which includes severe acute respiratory syndrome coronavirus 1 and severe acute respiratory syndrome coronavirus 2,crossed the species barrier and infected humans,causing a global outbreak in the 21st *** humans do not have pre-existing immunity against these viral infections and with ethics governing clinical trials,animal models are therefore being used in clinical studies to facilitate drug discovery and testing efficacy of *** ideal animal models should reflect the viral replication,clinical signs,and pathological responses observed in *** animal species should be tested to establish an appropriate animal model to study the disease pathology,transmission and evaluation of novel vaccine and drug candidates to treat coronavirus disease *** this context,the present review summarizes the recent progress in developing animal models for these two pathogenic viruses and highlights the utility of these models in studying SARS-associated coronavirus diseases.

关键词： Animal models SARS-CoV-1 SARS-CoV-2 COVID-19 Mice Hamster Non-human primates Pathogenesis Transmission Therapeutics

Biomechanics of knee joint-- A review

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Frontiers of Mechanical Engineering 2015年第2期10卷 176-186页

作者： Bhaskar kumar MADETI Srinivasa Rao CHALAMALASETTI S. K. sundara siva rao BOLLA PRAGADA Department of Mechanical Engineering Gayatri Vidya Parishad Collegeof Engineering Visakhapatnam 530048 India Department of Mechanical Engineering AU College of EngineeringAndhra University Visakhapatnam 530003 India

The present paper is to know how the work is carried out in the field of biomechanics of knee. Various model formulations are discussed and further classified into mathematical model, two-dimensional model and three-dimensional model. Knee geometry is a crucial part of human body movement, in which how various views of knee is shown in different planes and how the forces act on tibia and femur are studied. It leads to know the forces acting on the knee joint. Experimental studies of knee geometry and forces acting on knee shown by various researchers have been discussed, and comparisons of results are made. In addition, static and dynamic analysis of knee has been also discussed respectively to some extent.

关键词： biomechanics knee geometry ligaments squat femorotibial joint finite element method

A Study on Vibrational Spectra of PH3 and NF3: An Algebraic Approach

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Open Journal of Microphysics 2013年第2期3卷 47-51页

作者： S. R. Karumuri G. Srinivas Vijayasekhar Jaliparthi K. Sunil Babu V. sundara siva kumar A. Hanumaiah Department of Electronics & Instrumentation Engineering Lakireddy Bali Reddy College of Engineering Vijayawada India Department of Physics KL University Guntur India Research Scholar Department of Mathematics Jawaharlal Nehru Technological University Kakinada India Department of Physics Miracle Engineering College Bhogapuram India Department of Electronics & Instrumentation Rajeev Gandhi Memorial Engineering College Nandyal India Department of Physics Lara’s Vignan Institute of Technology and Science Vadlamudi India

With the new theoretical approach i.e. lie algebraic approach, we have calculated the infrared spectra of Phosphine in the range from 3000 cm-1 to 9500 cm-1 and Nitrogen Trifluoride in the range from 900 cm-1 to 4500 cm-1. The model Hamiltonian, so constructed, seems to describe the P-H and N-F stretching modes accurately with only four numbers of parameters.

关键词： Vibrational Spectra Lie Algebraic Model Hamiltonian