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Corydalis Rhizoma as a model for herb-derived trace metabolites exploration:A cross-mapping strategy involving multiple doses and samples

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Journal of Pharmaceutical Analysis 2021年第3期11卷 308-319页

作者： Chanjuan Yu Fengyun Wang Xinyue Liu Jiayan Miao siqi tang Qin Jiang Xudong tang Xiaoyan Gao School of Chinese Materia Medica Beijing University of Chinese MedicineBeijing102488PR China Gastroenterology Department Xiyuan HospitalChina Academy of Chinese Medical SciencesBeijing100091PR China

Deciphering the metabolites of multiple components in herbal medicine has far-reaching significance for revealing pharmacodynamic ***,most chemical components of herbal medicine are secondary metabolites with low content whose in vivo metabolites are close to trace amounts,making it difficult to achieve comprehensive detection and *** this paper,an efficient strategy was proposed:herb-derived metabolites were predicted according to the structural characteristics and metabolic reactions of chemical constituents in Corydalis Rhizoma and chemical structure screening tables for metabolites were *** fragmentation patterns were summarized from representative standards combining with specific cleavage behaviors to deduce structures of *** abundance plays an important role in compound identification,and high ion abundance can improve identification *** types of metabolites in different biological samples were very similar,but their ion abundance might be ***,for trace metabolites in biological samples,we used the following two methods to process:metabolites of high dose herbal extract were analyzed to characterize those of clinical dose herbal extracts in the same biological samples;cross-mapping of different biological samples was applied to identify trace metabolites based on the fact that a metabolite has different ion abundance in different biological *** with not using this strategy,44 more metabolites of clinical dose herbal extract were *** study improved the depth,breadth,and accuracy of current methods for herb-derived metabolites characterization.

关键词： Alkaloid Characteristic fragment Corydalis yanhusuo In vivo metabolism Metabolite

OsNAC120 balances plant growth and drought tolerance by integrating GA and ABA signaling in rice

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Plant Communications 2024年第3期5卷 197-215页

作者： Zizhao Xie Liang Jin Ying Sun Chenghang Zhan siqi tang Tian Qin Nian Liu Junli Huang Key Laboratory of Biorheological Science and Technology of Ministry of Education Bioengineering College of Chongqing UniversityChongqingChina

The crosstalk between gibberellin(GA)and abscisic acid(ABA)signaling is crucial for balancing plant growth and adaption to environmental ***,the molecular mechanism of their mutual antagonism still remains to be fully *** this study,we found that knockout of the rice NAC(NAM,ATAF1/2,CUC2)tran-scription factor gene OsNAC120 inhibits plant growth but enhances drought tolerance,whereas OsNAC120 overexpression produces the opposite *** GA can rescue the semi-dwarf phenotype of osnac120 mutants,and further study showed that OsNAC120 promotes GA biosynthesis by transcriptionally activating the GA biosynthetic genes OsGA20ox1 and *** DELLA protein SLENDER RICE1(SLR1)interacts with OsNAC120 and impedes its transactivation ability,and GA treatment can remove the inhi-bition of transactivation activity caused by *** the other hand,OsNAC120 negatively regulates rice drought tolerance by repressing ABA-induced stomatal *** investigation revealed that OsNAC120 inhibits ABA biosynthesis via transcriptional repression of the ABA biosynthetic genes OsNCED3 and *** OSMOTIC STRESS/ABA-ACTIVATED PROTEIN KINASE 9(OsSAPK9)physically interacts with OsNAC120 and mediates its phosphorylation,which results in OsNAC120 *** treatment ac-celerates OsNAC120 degradation and reduces its transactivation ***,our findings provide evidence that OsNAC120 plays critical roles in balancing GA-mediated growth and ABA-induced drought tolerance in *** research will help us to understand the mechanisms underlying the trade-off between plant growth and stress tolerance and to engineer stress-resistant,high-yielding crops.

关键词： abscisic acid ABA drought stress gibberellin GA OsNAC120 OsSAPK9 rice Oryza sativa L. SLR1

A novel copper metabolism-related signature model for predicting the prognosis,target drugs,and immunotherapy in stomach adenocarcinoma

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Genes & Diseases 2024年第5期11卷 21-24页

作者： Kai Zhuang siqi tang Haixin Feng Jinying Zhang Ying Liu Yong Liu Yongjian Su Jiaqi Yu Zunnan Huang Key Laboratory of Computer-Aided Drug Design of Dongguan City The First Dongguan Affiliated HospitalGuangdong Medical UniversityDongguanGuangdong 523710China Key Laboratory of Big Data Mining and Precision Drug Design of Guangdong Medical University Key Laboratory for Research and Development of Natural Drugs of Guangdong ProvinceSchool of PharmacyGuangdong Medical UniversityDongguanGuangdong 523808China School of Public Health Guangdong Medical UniversityDongguanGuangdong 523808China Marine Biomedical Research Institute of Guangdong Zhanjiang ZhanjiangGuangdong 524203China

Stomach adenocarcinoma(STAD)is one of the most common gastric neoplasms with a high death ***,there is an urgent need to propose an efficient therapy for *** plays key roles in regulating the distribution of immune cells and affecting the tumor immune escape,and may be a novel indicator of immunotherapy in ***,the specific impact of copper metabolism-related genes(CMRGs)on the patient’s prognosis,tumor microenvironment,and immunotherapeutic response remains unelucidated.

关键词： metabolism stomach adenocarcinoma

Genetic and biological properties of H10Nx influenza viruses in China

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Journal of Integrative Agriculture 2024年第11期23卷 3860-3869页

作者： Yina Xu Hailing Li Haoyu Leng Chaofan Su siqi tang Yongtao Wang Shiwei Zhang Yali Feng Yanan Wu Daxin Wang Ying Zhang Key Laboratory of Livestock Infectious Diseases of Ministry of Education/Key Laboratory of Zoonosis of Liaoning Province/Laboratory of Ruminant Infectious Disease Prevention and Control(East)of Ministry of Agriculture and Rural Affairs/Liaoning Panjin Wetland Ecosystem National Observation and Research Station College of Animal Science and Veterinary MedicineShenyang Agricultural UniversityShenyang 110866China

H10 subtype avian influenza viruses(AIV)have been circulating in China for 40 years.H10 AIVs in China have expanded their host range from wild birds to domestic poultry and mammals,even *** of the H10 subtype AIVs reported in China were isolate from the southeast *** isolated an H10N3 AIV,A/Chicken/Liaoning/SY1080/2021(SY1080),from live poultry market(LPM)in Liaoning Province of the Northeast ***1080replicated efficiently in mice lungs and nasal turbinates without prior *** systematically compared SY1080 with other H10 subtype isolates in *** analysis showed that SY1080 and most of the H10strains belonged to the Eurasian lineage.H10 AIVs in China have formed 63 ***1080 as well as the H10N3 strains from human infections belonged to G60 genotype.H10Nx AIV acquired multiple mammalian adaptive and virulence related mutations during circulation and the recent reassortants derived internal genes from chicken H9N2 *** H10Nx subtypes AIVs posed potential threat to public *** results suggested we should strengthen the surveillance and evaluation of H10 subtype strains.

关键词： avian influenza virus H10 subtype adaptation pathogenicity

Identification of the multiple bioactive derivatives and their endogenous molecular targets that may mediate the laxative effect of rhubarb in rats

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Journal of Traditional Chinese Medical Sciences 2020年第2期7卷 210-220页

作者： Lei Xie Ying Wang Gan Luo Wenjuan Zhou Jiayan Miao siqi tang Qin Jiang Yage Guan Xiaoyan Gao School of Chinese Materia Medica Beijing University of Chinese MedicineBeijing102488China

Objective:To determine the mechanism of the laxative effect of rhubarb(Rheum tanguticum *** Balf.)in rats using a combined bioinformatic and in vivo ***:Substances derived from rhubarb that are present in the colorectum were identified using high-performance liquid chromatography,coupled with linear ion-trap quadrupole Orbitrap highresolution mass *** targets with a potential laxative effect were identified from databases and the literature,then used with rhubarb-derived substances in molecular docking *** expression of candidate endogenous target molecules that bound specific components of rhubarb was then measured in constipated rats that had or had not been administered rhubarb by western ***,potentially bioactive compounds were traced back to their prototype ***:We identified 17 anthraquinones and 21 anthrones derived from rhubarb in the colorectum of rats.G-scoring identified three potential mediators of the laxative effect:c-kit,5-hydroxytryptamine receptor 4(5-HT4),and aquaporin-3(AQP3).In addition,10 rhubarb-derived components(aloeemodin,emodin,rhein,chrysophanol,physcion,sennoside A,sennoside C,physcionanthrone,aloeemodinanthrone,and rheinanthrone),which have strong binding affinities for more than one of the three potential targets,were selected as likely active *** extract increased the expression of c-kit and 5-HT4,and reduced the expression of AQP3 in the colon of constipated rats,which might mediate its laxative *** also found that a single prototype component may be metabolized into several active metabolites,and a single active ingredient can also be generated from various prototype ***:The present study demonstrates that various anthraquinones and anthrones present in rhubarb may be metabolized to form bioactive compounds that have additive or synergistic effects to promote defecation via c-kit,5-HT4 and/or AQP3.

关键词： Rhubarb Laxative Anthraquinones Anthrones C-kit Aquaporin-3

不同热解终温和保留时间下污泥生物质炭孔隙结构特征

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北京大学学报（自然科学版） 2017年第5期53卷 890-898页

作者：汤斯奇王经臣 Jaehac Ko 深圳聚硅酸盐复合环保材料工程实验室北京大学深圳研究生院环境与能源学院深圳518055

通过低温(77 K)氮气吸附/脱附等温实验,结合分形维数的概念,分析生活污水污泥在不同热解终温和保留时间下经热解获得的生物质炭孔隙结构变化特征。实验结果表明,随着热解终温的提高,污泥生物质炭BET的比表面积呈先升高后降低的趋势,在60... 详细信息

通过低温(77 K)氮气吸附/脱附等温实验,结合分形维数的概念,分析生活污水污泥在不同热解终温和保留时间下经热解获得的生物质炭孔隙结构变化特征。实验结果表明,随着热解终温的提高,污泥生物质炭BET的比表面积呈先升高后降低的趋势,在600oC时达到最大,为92.3 m^2/g。在低温(不超过500oC)下,污泥生物质炭中的孔以介孔为主,无微孔出现;在高温(超过500oC)下,则以微孔和介孔为主。随热解终温的升高,孔的形状由狭缝型向开放性和平行板式转变,保留时间的延长不改变孔的形状,但改变孔的容积。污泥生物质炭表面分形维数随热解终温升高呈增大趋势;而保留时间的延长,在中高温(600~700oC)下使污泥生物质炭表面分形维数降低,高温(超过700oC)下又使其提高。

关键词：生活污水污泥热解温度保留时间生物质炭孔隙结构

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基于流形学习的网络数据流异常检测

济南大学学报（自然科学版） 2017年第2期31卷 118-128页

作者：唐斯琪潘志松中国人民解放军理工大学指挥信息系统学院江苏南京210007

将非线性流形学习应用于网络数据流的降维过程,基于局部保持投影(LPP)算法基本思想,提出基于类别信息的监督判别LPP(SDLPP)算法;与传统线性降维算法和传统流形学习算法的结果进行对比,以验证算法的准确性与稳定性;建立基于SDLPP算法的... 详细信息

将非线性流形学习应用于网络数据流的降维过程,基于局部保持投影(LPP)算法基本思想,提出基于类别信息的监督判别LPP(SDLPP)算法;与传统线性降维算法和传统流形学习算法的结果进行对比,以验证算法的准确性与稳定性;建立基于SDLPP算法的网络数据流异常检测系统实施模型。结果表明:SDLPP算法通过多目标优化,在保证局部保持投影同时实现类间距离最大与类内距离最小,在挖掘低维特征空间嵌入的同时提高了分类效果;非线性的流形学习算法能有效挖掘高维数据中的低维流形,保证了维数约减过程中的非线性结构;SDLPP算法能够生成显式投影映射,泛化性较好,时间复杂度低,更加适合网络数据流实时监测系统,并可应用于实际的网络数据流入侵检测模型。

关键词：网络数据流异常检测流形学习有监督判别LPP算法

可熔融加工PTFE对FEP在干/湿环境中摩擦磨损性能的影响

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摩擦学学报 2022年第6期42卷 1196-1206页

作者：唐思琪邱孝涛顾爱群余自力四川大学分析测试中心四川成都610064

为建立含氟聚合物的使用性能与干湿工作环境的关系,采用热压成型的方式制备聚四氟乙烯(PTFE)试样,并通过挤出注塑成型方法制得可熔融加工PTFE(M-PTFE)/聚全氟乙丙烯(FEP)共混物.研究PTFE和FEP的相关性能,特别是M-PTFE/FEP共混物的力学... 详细信息

为建立含氟聚合物的使用性能与干湿工作环境的关系,采用热压成型的方式制备聚四氟乙烯(PTFE)试样,并通过挤出注塑成型方法制得可熔融加工PTFE(M-PTFE)/聚全氟乙丙烯(FEP)共混物.研究PTFE和FEP的相关性能,特别是M-PTFE/FEP共混物的力学性能以及在干、湿状态下的摩擦磨损性能.结果表明:在研究的配比范围内,共混材料的拉伸强度随着M-PTFE含量的增加而增大.干摩擦条件下,M-PTFE的质量分数≤20%时,增加MPTFE含量可降低试样的摩擦系数与体积磨损率,但M-PTFE的质量分数达到30%时两个参数均会增大.湿摩擦条件下,试样的摩擦系数和体积磨损率与M-PTFE的添加量之间无规律性,但都低于干摩擦条件的值.对磨面形貌的SEM照片分析表明:在干摩擦条件下,增加M-PTFE添加量会促进转移膜的形成和完善,但湿摩擦会抑制转移膜的形成.

关键词：聚全氟乙丙烯可熔融流动聚四氟乙烯干摩擦湿摩擦摩擦磨损性能

未来气候变化下栎树猝死病菌在中国的适生性分析

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生态学报 2023年第1期43卷 388-397页

作者：汤思琦武扬梁定东郭恺浙江农林大学林业与生物技术学院杭州311300 中华人民共和国杭州海关杭州311300 中华人民共和国宁波海关宁波315000

基于中国国家有害生物检疫信息平台的有关记录和文献以及WoldClim网站,获取栎树猝死病菌的地理分布数据及气候数据,并用SPSS软件和刀切法筛选主导环境变量。利用MaxEnt生态位模型和ArcGIS软件,对栎树猝死病菌现代和未来情景下在我国的... 详细信息

基于中国国家有害生物检疫信息平台的有关记录和文献以及WoldClim网站,获取栎树猝死病菌的地理分布数据及气候数据,并用SPSS软件和刀切法筛选主导环境变量。利用MaxEnt生态位模型和ArcGIS软件,对栎树猝死病菌现代和未来情景下在我国的潜在适生区进行预测,并计算和绘制栎树猝死病菌高风险区质心转移轨迹。通过不同年份和不同气候情况下的受试者工作特征曲线(ROC)的训练集和测试集受试者工作特征曲线下面积(AUC)值均大于0.91,说明MaxEnt模型准确并适用于预测栎树猝死病菌在我国的潜在分布,同时结合其主要寄主植物的地理分布进一步增强预测模型的可信度。预测结果表明,最冷季度降水量、最冷季度平均温度、最干季度平均温度和年均降水量是影响栎树猝死病菌分布的主要环境变量。而2030s(2021—2040年)、2050s(2041—2060年)和2070s(2061—2080年)在3种气候情景下(SSP1-2.6、SSP2-4.5、SSP5-8.5),栎树猝死病菌的潜在适生区相较于现代情景下都有所增加。此外,高风险区面积在3个年代3种情景下的面积增长率均高于45%。高风险区质心变化的预测结果表明,3个年代3种气候情景下高风险区质心移动轨迹均在江西省范围内,且有向北转移的趋势。虽然栎树猝死病菌尚未在我国爆发,但华南、华中、华东和西南的大部分地区为该病菌的中高适生区,因此入侵扩散风险不容小觑。一旦栎树猝死病菌入侵成功,在未来的2030s、2050s和2070s其适生区范围会进一步扩大,从而带来不可逆的生态灾难。因此应当加强相关检疫,防治病木和其他带菌材料传入,从源头上断绝入侵可能。

关键词：栎树猝死病菌适生区最大熵模型 ArcGIS软件

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