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高速公路强制换道持续时间半参数生存分析

浙江大学学报（工学版） 2017年第11期51卷 2215-2221页

作者：吴江玲张生瑞 amit kumar singh 秦思孙振东长安大学公路学院陕西西安710064 Atkins North America Inc.austintxusa78758

为了分析高速公路施工作业区车辆的换道行为,运用生存分析的半参数方法,建立基于风险的车辆强制换道持续时间模型,通过无人机采集包茂高速公路陕西境内某路段施工作业区的交通数据,对道路车辆强制换道持续时间进行估计.结果表明:强制换... 详细信息

为了分析高速公路施工作业区车辆的换道行为,运用生存分析的半参数方法,建立基于风险的车辆强制换道持续时间模型,通过无人机采集包茂高速公路陕西境内某路段施工作业区的交通数据,对道路车辆强制换道持续时间进行估计.结果表明:强制换道持续过程的生存时间大于5s的概率约为80%,大于10s的概率为28%,一半以上处在5～10s之间;当距离小于400m时,换道起点至合流点距离越近,车辆强制换道持续时间越短;当距离大于400m时,车辆换道持续时间开始降低.车辆换道时间持续到t时刻,在至合流点距离50～100m范围内开始换道的车辆,在下一时刻完成换道的可能性最大.

关键词：强制换道换道持续时间施工区生存分析

Impact of nonextensivity on the transport coefficients of strongly interacting QCD matter

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Chinese Physics C 2025年第02期 93-109页

作者： Dhananjay singh Arvind kumar Department of Physics Dr.B R Ambedkar National Institute of Technology Jalandhar

Tsallis nonextensive statistics is applied to study the transport coefficients of strongly interacting matter within the Polyakov chiral SU（3） quark mean field model（PCQMF）.Nonextensivity is introduced within the PCQMF model through a dimensionless parameter q to examine the viscous properties,such as shear viscosity（η）and bulk viscosity（ζb）,and conductive properties,such as electrical conductivity(σel) and thermal conductivity（κ）.Additionally,some key thermodynamic quantities relevant to the transport coefficients,such as the speed of sound(csq2) and specific heat at constant volume(evq),are *** temperature dependence of the transport coefficients is explored through a kinetic theory approach with the relaxation time *** results are compared to those of the extensive case where q approaches *** nonextensive q parameter is found to have a significant effect on all transport *** find that the nonextensive behaviour of the medium enhances specific shear viscosity η/sq,as well as conductive coefficients σel/T and κ/*** contrast,the normalized bulk viscosity ζb/sqis found to decrease as the nonextensivity of the medium *** also studied the transport coefficients for finite values of chemical *** magnitudes of η,σel,and κ increase at lower temperatures,while ζbis found to decrease for systems with non-zero chemical potential.

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Leveraging Artificial Intelligence to Achieve Sustainable Public Healthcare Services in Saudi Arabia: A Systematic Literature Review of Critical Success Factors

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Computer Modeling in Engineering & Sciences 2025年第2期142卷 1289-1349页

作者： Rakesh kumar Ajay singh Ahmed Subahi Ahmed Kassar Mohammed Ismail Humaida Sudhanshu Joshi Manu Sharma Department of Health Management College of Public Health and Health InformaticsUniversity of Ha’ilHa’il81451Saudi Arabia Department of Management&Information Systems College of Business AdministrationUniversity of Ha’ilHa’il81451Saudi Arabia Department of Public Health College of Public Health and Health InformaticsUniversity of Ha’ilHa’il81451Saudi Arabia School of Management Doon UniversityDehradunUttarakhand248001India Department of Management Studies Graphic Era UniversityDehradunUttarakhand248002India

This review aims to analyze the development and impact of Artificial Intelligence(AI)in the context of Saudi Arabia’s public healthcare system to fulfill Vision 2030 *** is extensively devoted to AI technology deployment relevant to disease management,healthcare delivery,epidemiology,and ***,its AI is culturally sensitive and ethically grounded in *** on the PRISMA framework,an SLR evaluated primary academic literature,cases,and practices of Saudi Arabia’s AI implementation in the public healthcare ***,it categorizes prior research based on how AI can work,the issues it poses,and its implications for the Kingdom’s healthcare *** Saudi Arabian context analyses show that AI has increased the discreet prediction of diseases,resource management,and monitoring outbreaks during mass congregations such as ***,the study outlines critical areas for defining the potential for artificial intelligence and areas for enhancing digital development to support global healthcare *** key themes emerging from the review include Saudi Arabia:(i)the effectiveness of AI with human interaction for sustainable health services;(ii)conditions and quality control to enhance the quality of health care services using AI;(iii)environmental factors as influencing factors for public health care;(iv)Artificial Intelligence,and advanced decision-making technology for Middle Eastern health care *** policymakers,healthcare managers,and researchers who will engage with AI innovation,the review proclaims that AI applications should respect the country’s socio-cultural and ethical practices and pave the way for sustainable healthcare *** empirical research is needed on the implementation issues with AI,creating culturally appropriate models of AI,and finding new applications of AI to address the increasing demand for healthcare services in Saudi Arabia.

关键词： Artificial intelligence public health services sustainability healthcare Saudi Arabia PRISMA

Higher abundance of DLD protein in buffalobull spermatozoa causes elevated ROSproduction leading to early sperm capacitationand reduction in fertilizing ability

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Journal of Animal Science and Biotechnology 2025年第1期16卷 107-120页

作者： Seema Karanwal Ankit Pal Fanny Josan Aditya Patel Jatinder singh Chera Sonam Yadav Vikrant Gaur Preeti Verma Shiva Badrhan Vitika Chauhan Mukesh Bhakat Tirtha kumar Datta Rakesh kumar Animal Genomics Laboratory Animal Biotechnology DivisionICAR-National Dairy Research InstituteKarnalHaryanaIndia NBGC Laboratory National Bureau of Animal Genetics ResourcesKarnalHaryanaIndia Artificial Breeding Research Centre LPM DivisionICAR-National Dairy Research InstituteKarnalHaryanaIndia ICAR-Central Institute of Research On Goat MakhdoomMathuraUttar PradeshIndia ICAR-Central Institute for Research On Buffaloes HisarHaryanaIndia

Backgroud Before fertilization,spermatozoa undergo a crucial maturation step called capacitation,which is a unique event regulates the sperm’s ability for successful *** capacitation process takes place as the spermatozoa pass through the female reproductive tract(FRT).Dihydrolipoamide dehydrogenase(DLD)protein is a post-pyruvate metabolic enzyme,exhibiting reactive oxygen species(ROS)production which causes ***,other vital functions of DLD in buffalo spermatozoa are hyperactivation and acrosome *** produces the optimum amount of ROS required to induce capacitation process in *** on physiological or patho-physiological conditions,DLD can either enhance or attenuate the production of reactive oxygen species(ROS).Aim of this study was to investigate whether changes in the production of ROS in sperm cells can impact their ability to fertilize by triggering the capacitation and acrosome *** In this study,abundance of DLD protein was quantified between high(n=5)and low fertile bull(n=5)*** was found that compared to high-fertile(HF)bulls,low-fertile(LF)bulls exhibited significantly(P<0.05)higher DLD ***,we optimised the MICA concentration to inhibit DLD function,spermatozoa were treated with MICA in time(0,1,2,3,4,and 5 h)and concentrations(1,2.5,5,and 10 mmol/L)dependent *** DLD inhibition was found to be at 4 h in 10 mmol/L MICA concentration,which was used for further exper-imentation in HF and *** on DLD inhibition it was seen that LF bull spermatozoa exhibited significantly(P<0.05)higher ROS production and acrosome reaction in comparison to the HF bull *** kinematic parameters of the spermatozoa such as percent total motility,velocity parameters(VCL,VSL,and VAP)and other parameters(BCF,STR,and LIN)were also decreased in MICA treated spermatozoa in comparison to the control(capacitated)*** The present study provides an initial

关键词： Acrosome reaction Capacitation High fertile bull Low fertile bull Protein Reactive oxygen species Spermatozoa

Sodium channel mutation SCN1A T875M,D188V and associated dysfunction with drug resistant epilepsy

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World Journal of Psychiatry 2025年第2期15卷 41-47页

作者： Pradeep kumar Dabla Swapan Gupta Swati singh Aroop Viswas Manisha Yadav Subash Chandra Sonkar Bidhan Chandra Koner Department of Biochemistry Govind Ballabh Pant Institute of Postgraduate Medical Education and ResearchNew Delhi 110002DelhiIndia Department of Neurology Govind Ballabh Pant Institute of Postgraduate Medical Education&ResearchNew Delhi 110002DelhiIndia Department of Biochemistry Govind Ballabh Pant Institute of Postgraduate Medical Education&ResearchNew Delhi 110002DelhiIndia Multi-disciplinary Research Unit Maulana Azad Medical CollegeNew Delhi 110002DelhiIndia Department of Biochemistry Maulana Azad Medical CollegeNew Delhi 110002DelhiIndia

BACKGROUND The NaV1.1 sodium channel alpha subunit,encoded by SCN1A,is crucial for initiating and propagating action potentials in ***1A gene has long been an established target in the etiology and therapy of ***,very few studies have investigated the relevance of genetic variations in epilepsy and anti-epileptic drug *** To investigate associations between polymorphisms,rs121917953 T/A and rs121918623 C/T,and drug resistance in epilepsy patients in the north Indian *** A total of 100 age-and sex-matched epilepsy patients(50 drug responsive and 50 drug resistant subjects)were recruited and SCN1A rs121918623 C/T*and rs121917953 T/A*polymorphisms were analyzed by the allele specific-PCR technique.χ^(2)and Fisher’s exact test were used to estimate differences between the distribution of SCN1A rs121918623 and rs121917953 gene polymorphisms among various *** association between distinct rs121917953 genotypes and drug resistance was analyzed using logistic regression *** For the SCN1A rs121917953 T/A*(D188V)polymorphism,a significantly higher proportion of individuals with AT genotype were observed in the drug-resistant group as compared to the drug-responsive ***,a higher risk association was exhibited by AT genotype for drug resistance with an odds ratio of 3.51 and P value=*** the SCN1A rs121918623 C/T*(T875M)polymorphism,no significant difference in genotype distribution was observed between the drug-resistant and drug-sensitive *** Our findings indicate that the SCN1A polymorphism D188V is associated with a higher risk of drug resistance for the AT variant as compared to the homozygous TT *** research is needed at the functional level and in larger cohorts to determine the potential of these genes as a therapeutic target in epilepsy subjects.

关键词： Epilepsy Single nucleotide polymorphisms Drug-resistant epilepsy SCN1A receptor SCN1A rs121918623 and SCN1A rs121917953 gene polymorphism

Insights into gastrointestinal manifestation of human immunodeficiency virus:A narrative review

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World Journal of Virology 2025年第1期14卷 51-62页

作者： Pratiksha Moliya Anmol singh Navdeep singh Vikash kumar Aalam Sohal Department of Transplant Hepatology University of Nebraska Medical CenterOmahaNE 69198United States Department of Medicine Tristar Centennial Medical CenterNashvilleTN 37203United States Department of Medicine Government Medical CollegeAmritsar 143001PunjabIndia Department of Gastroenterology and Hepatology Creighton University School of MedicinePhoenixAZ 85012United States

Human immunodeficiency virus(HIV)modifies CD4-positive cells,resulting in immunodeficiency and a wide range of gastrointestinal(GI)*** burden of HIV-related GI illnesses has significantly evolved with the widespread use of antiretroviral therapy(ART).While ART has effectively reduced the occurrence of opportunistic infections,it has led to an increase in therapy-related GI *** esophageal conditions in HIV patients include gastroesophageal reflux disease,idiopathic esophageal ulcers,herpes simplex virus,cytomegalovirus(CMV),and candidal ***’s sarcoma,a hallmark of acquired immunodeficiency syndrome,may affect the entire GI *** and peptic ulcer disease are also frequently seen in patients with ***,often linked to both opportunistic infections and ART,requires careful *** diarrhea,often a sign of colitis caused by bacterial infections such as Shigella or Clostridium difficile,is *** bowel lymphoma,although rare,is increasing in *** disorders,including proctitis,fissures,and anal squamous cell carcinoma,are particularly relevant in homosexual men,underlining the importance of timely *** review comprehensively explores the epidemiology,pathogenesis,and treatment considerations for the various GI disorders associated with HIV,highlighting the importance of accurate diagnosis and effective treatment to improve outcomes for HIV-infected patients.

关键词： Human immunodeficiency virus Opportunistic infections Antiretroviral treatment Gastrointestinal

Evaluating the hydrocarbon generation potential of the Paleocene–Eocene carbonaceous rocks in the Barmer and Bikaner-Nagaur Basins, western Rajasthan, India

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China Geology 2025年第1期8卷 77-91页

作者： Alok kumar Khairul Azlan Mustapha Alok K.singh Mohammed Hail Hakimi Ali Y.Kahal Waqas Naseem Hijaz Kamal Hasnan Department of Geology Faculty of ScienceUniversiti MalayaKuala Lumpur 50603Malaysia Department of Geology Institute of ScienceBanaras Hindu UniversityVaranasi 221005India Department of Petroleum Engineering and GeoEngineering Rajiv Gandhi Institute of Petroleum TechnologyJais 229304India Institute of Geology and Petroleum Technologies Kazan Federal UniversityKazan 420008Russia Geology and Geophysics Department King Saud UniversityRiyadh 11451Saudi Arabia Department of Geology University of PoonchRawalakot 12350Pakistan

The Bikaner-Nagaur and Barmer Basins(Rajasthan)are the most important petroliferous sedimentary basins in *** over a decade,the exploration and extraction of hydrocarbons in these ***-Eocene age rocks bear organic-rich sediments in these basins,including lignite and carbonaceous shale *** present research investigates the source rock properties,petroleum potential and thermal maturity of the carbonaceous shale partings from the lignite mines of Gurha(Bikaner-Nagaur Basin)and Kapurdi(Barmer Basin)using petrographical and geochemical *** carbonaceous shales have high organic matter(OM),with considerable total organic carbon(TOC)contents ranging from 13%to 39%.Furthermore,they contain hydrogen-rich kerogen,including types II and II/III,as evidenced by the Rock-Eval and elemental analysis *** existence of these kerogen types indicates the abundance of reactive(vitrinite and liptinite)***,the carbonaceous shales from the Bikaner–Nagaur Basin have oil generation potentials,with a high hydrogen index(up to 516 mg HC/g TOC)and a H/C ratio(up to 1.5)along with a significant presence of oil-prone liptinitic *** from the geochemical and petrological results,the studied shales have low huminite reflectance(0.31%–0.48%),maximum temperature(S_(2) peak;Tmax)between 419℃ and 429℃,and low production index values(PI:0.01–0.03).These results indicate that these carbonaceous shales contain immature OM,and thereby,they cannot yet release commercial amount of *** immaturity level in the studied outcrop section is due to the shallow burial *** proxies further indicate the presence of both oil and gas-prone source rocks.

关键词： Carbonaceous shale Petroliferous Bikaner-Nagaur Basin Barmer Basin High hydrogen index Hydrogen-rich kerogen Western Rajasthan Geochemistry Petrology

Telemedicine and public health–pearls and pitfalls

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World Journal of Methodology 2025年第2期15卷 177-179页

作者： Ranjeet kumar Sinha Sony Sinha Prateek Nishant Arvind kumar Morya Arshi singh Department of Community Medicine Patna Medical CollegePatna 800004BiharIndia Department of Ophthalmology-Vitreo-Retina Neuro-Ophthalmology and OculoplastyAll India Institute of Medical SciencesPatna 801507BiharIndia Department of Ophthalmology ESIC Medical CollegePatna 801103BiharIndia Department of Ophthalmology All India Institute of Medical SciencesHyderabad 508126TelanganaIndia Department of Ophthalmology Guru Nanak Eye CenterNew Delhi 110001India

We hereby comment on the interesting systematic review by Grewal et al where they have provided an overall picture of the current status of available tele-health programs in the United States with emphasis on the Amazon *** analysis is an appreciable effort in discovering the features available and features lacking in these tele-health *** concept of tele-health originated to curtail the need for physical attendance of patients at health clinics,and has been beneficial during the coronavirus disease 2019 *** implore that the pearls and pitfalls of these programs have to be understood by policymakers prior to forming a consensus regarding the availability,accessibility and affordability of these programs as methods of healthcare *** proliferation of tele-health programs in their current form may pose threats to patient and provider safety and medicolegal ***,patients and providers must work together to improve them to meet their expectations and enable them to provide the best care for the ailing public.

关键词： Telemedicine Remote Access Availability Accessibility Affordability Ethics Privacy Medicolegal liability

Current concepts and recent trends in endothelial keratoplasty

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World Journal of Transplantation 2025年第2期15卷 84-105页

作者： Prateek Nishant Bharat Gurnani Prabhakar singh Sony Sinha Kirandeep Kaur Ashish kumar Ranjeet kumar Sinha Department of Ophthalmology-Refractive Surgery Uvea and Neuro-OphthalmologyAkhand Jyoti Eye HospitalMastichakSaran 841219BiharIndia Department of Cataract CorneaExternal DiseasesTraumaOcular SurfaceRefractive Surgery and Contact LensGomabai Netralaya and Research CenterNeemuch 458441Madhya PradeshIndia Department of Ophthalmology-Cornea and Ocular Surface All India Institute of Medical SciencesKalyani 741245West BengalIndia Department of Ophthalmology-Vitreo-Retina Neuro-Ophthalmology and OculoplastyAll India Institute of Medical SciencesPatna 801507BiharIndia Department of Cataracts Pediatric Ophthalmology and StrabismusGomabai Netralaya and Research CenterNeemuch 458441Madhya PradeshIndia Department of Cornea and Refractive Surgery Laxmi NetralayaJamal RoadPatna 800001BiharIndia Department of Community Medicine Patna Medical CollegePatna 800004BiharIndia

Endothelial keratoplasty(EK)is defined as an umbrella term comprising methods for selective surgical replacement of corneal endothelium and adjacent corneal tissue,which retains healthy portions of a patient's cornea while replacing diseased innermost corneal layer(s)with healthy donor tissue,to achieve corneal dehydration and transparency before the onset of irreversible stromal edema and permanent loss of corneal ***,the pathophysiology of corneal decompensation is increasingly being researched *** improvement in pharmacotherapy is progressively leading to reduction in the indications of *** addition,EK techniques have progressed towards using thinner tissue,optimizing visual *** have enabled better donor tissue formulation,usage,and attachment,and surgical modifications have enhanced the tissue utilization in difficult clinical scenarios lowering failure and ***,challenges are encountered in various complex clinical scenarios in-cluding eyes with prior intraocular surgery,complex anterior chamber anatomy,glaucoma,ocular surface disease *** complexities demand tailored surgical strategies,including modifications in graft handling,instru-mentation,and postoperative management to ensure *** to these details and addressing patient-specific factors can help improve outcomes in these difficult *** choice of procedure depends on multiple factors,including the surgeon's experience,patient's ocular anatomy,and the specific clinical *** review article encompasses the recent developments in this field presenting a comprehensive picture of our modern understanding of the indications,contraindications,surgical techniques,clinical situations,community aspects and future directions pertaining to EK.

关键词： Cell-and tissue-based Therapy Corneal transplantation Descemet stripping endothelial keratoplasty Immunosuppression therapy Refractive surgical procedures