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Gut microbiota:a new player in regulating immune-and chemo-therapy efficacy

Cancer Drug Resistance 2020年第3期3卷 356-370页

作者： simone Anfossi George A.Calin Department of Experimental Therapeutics The University of Texas MD Anderson Cancer CenterHoustonTX 77054USA. Center for RNA Interference and Non-coding RNAs The University of Texas MD Anderson Cancer CenterHoustonTX 77054USA.

Development of drug resistance represents the major cause of cancer therapy failure,determines disease progression and results in poor prognosis for cancer *** mechanisms are responsible for drug *** genetic modifications of cancer cells induce the alteration of expression of gene controlling specific pathways that regulate drug resistance:drug transport and metabolism;alteration of drug targets;DNA damage repair;and deregulation of apoptosis,autophagy,and pro-survival *** the other hand,a complex signaling network among the entire cell component characterizes tumor microenvironment and regulates the pathways involved in the development of drug *** microbiota represents a new player in the regulation of a patient’s response to cancer therapies,including chemotherapy and *** particular,commensal bacteria can regulate the efficacy of immune checkpoint inhibitor therapy by modulating the activation of immune responses to *** bacteria can also regulate the efficacy of chemotherapeutic drugs,such as oxaliplatin,gemcitabine,and ***,it has been shown that such bacteria can produce extracellular vesicles(EVs)that can mediate intercellular communication with human host ***,bacterial EVs carry RNA molecules with gene expression regulatory ability that can be delivered to recipient cells of the host and potentially regulate the expression of genes involved in controlling the resistance to cancer *** the other hand,host cells can also deliver human EVs to commensal bacteria and similarly,regulate gene *** intercellular communication between commensal bacteria and host cells may thus represent a novel research area into potential mechanisms regulating the efficacy of cancer therapy.

关键词： Gut microbiota resistance chemotherapy immunotherapy immune checkpoint inhibitor extracellular vesicles miRNAs cell-to-cell communication

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The Dynamic Knowledge Loop:Inter- and Transdisciplinary Cooperation and Adaptation of Climate Change Knowledge

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International Journal of Disaster Risk Science 2014年第1期5卷 21-32页

作者： Maria Hagemeier-Klose simone Annerose Beichler Bart Jan Davidse Sonja Deppisch Research Group‘‘plan B:altic–Climate Change and Spatial Development ’’Department of Urban Planning and Regional DevelopmentHafenCity University Hamburg20457 HamburgGermany

The‘‘dynamic knowledge loop’’explores processes of knowledge generation,knowledge exchange,and social learning in inter-and transdisciplinary cooperation and relates them to adaptive *** capacity building can reduce vulnerabilities and enhance the resilience of urban regions towards the impacts of climate *** use a mix of empirical methods and apply the dynamic knowledge loop as an innovative analytical *** added value of inter-and transdisciplinary cooperation concerning knowledge generation and facilitation of social learning is discussed by applying the dynamic knowledge loop to research about a scenario-planning process and a participatory mapping exercise in the urban region of Rostock,*** results demonstrate that the scenario planning process allowed for a consideration of complex interrelations that have the potential for an integration of different influences,perspectives,and knowledge *** planning facilitated social learning by creating a platform for integration and exchange of different epistemologies and for considering alternative *** participatory mapping exercise demonstrated the scientific value of the integration of local knowledge as *** upon these results,we stress the importance of knowledge generation,knowledge exchange,and social learning to build up adaptive capacity through different forms of cooperation between science and practice.

关键词： Adaptive capacity Climate change Interdisciplinary cooperation Knowledge exchange Social learning Transdisciplinary cooperation

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Advancing prognostic precision in hepatocellular carcinoma:a paradigm shift towards machine learning

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Hepatobiliary Surgery and Nutrition 2023年第5期12卷 810-812页

作者： Flavio Milana simone Famularo Guido Torzilli Department of Biomedical Sciences Humanitas UniversityMilanItaly Division of Hepatobiliary and General Surgery Department of SurgeryIRCCS Humanitas Research HospitalMilanItaly

Introduction Hepatocellular carcinoma(HCC)stands as a significant contributor to cancer-related mortality,ranking as the fifth leading cause of cancer-related death(1).In 80%of cases,HCC arises from an underlying liver disease(2).Despite screening programs for at-risk patients,the prognosis for HCC remains even dismal because of late *** only curative options currently available are liver resection for selected cases,and liver ***,the high rate of recurrence after surgery makes the prognosis *** fact,following curative intent resection,the 5-year recurrence is approximately 60%(3),with 5-year survival after recurrence of 35%(4).

关键词： Hepatocellular carcinoma(HCC) machine learning liver resection early recurrence

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World Journal of Gastroenterology 2023年第14期29卷 2127-2133页

作者： Sujani Yadlapati simone A.Jarrett Daniel Baik Adib Chaaya Department of Gastroenterology Cooper University HospitalCooper Medical School of Rowan UniversityCamdenNJ 08103United States Department of Internal Medicine Einstein Medical CenterSidney Kimmel Medical CollegeThomas Jefferson UniversityPhiladelphiaPA 19140United States

Since its emergence in 2019,it has become apparent that coronavirus 2019(COVID-19)infection can result in multi systemic *** addition to pulmonary symptoms,hepatobiliary involvement has been widely *** of hepatic involvement ranges from minor elevation in liver function tests(LFTs)to significant hepatocellular or cholestatic *** majority of cases,resolution of hepatic injury or improvement in LFTs is noted as patients recover from COVID-19 ***,severe biliary tract injury progressing to liver failure has been reported in patients requiring prolonged intensive care unit stay or mechanical *** to the timing of its presentation,this form of progressive cholestatic injury has been referred to as COVID-19 cholangiopathy or post-COVID-19 cholangiopathy,and can result in devastating consequences for ***-19 cholangiopathy is recognized by dramatic elevation in serum alkaline phosphatase and bilirubin and radiologic evidence of bile duct *** in COVID-19 occurs weeks to months after the initial infection and during the recovery *** findings and pathology often resemble bile duct injury associated with primary or secondary sclerosing *** of COVID-19 cholangiopathy is *** mechanisms have been proposed,including direct cholangiocyte injury,vascular compromise,and cytokine release *** review summarizes existing data on COVID-19 cholangiopathy,including reported cases in the literature,proposed pathophysiology,diagnostic testing,and long-term implications.

关键词： COVID-19 cholangiopathy Post COVID-19 cholangiopathy Cholestatic injury Liver transplant

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Assessment of Cognitive skills via Human-robot Interaction and Cloud Computing

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Journal of Bionic Engineering 2019年第3期16卷 526-539页

作者： Alessandro Di Nuovo simone Varrasi Alexandr Lucas Daniela Conti John McNamara Alessandro Soranzo Sheffield Hallam University Sheffield S1 1WB United Kingdom IBM Hursley Lab Winchester SO21 2JN United Kingdom

Technological advances are increasing the range of applications for artificial intelligence, especially through its embodiment within humanoid robotics platforms. This promotes the development of novel systems for automated screening of neurological conditions to assist the clinical practitioners in the detection of early signs of mild cognitive impairments. This article presents the implementation and the experimental validation of the first robotic system for cognitive assessment, based on one of the most popular platforms for social robotics, Softbank "Pepper", which administers and records a set of multi-modal interactive tasks to engage the user cognitive abilities. The robot intelligence is programmed using the state-of-the-art IBM Watson AI Cloud services, which provide the necessary capabilities for improving the social interaction and scoring the tests. The system has been tested by healthy adults (N= 35) and we found a significant correlation between the automated scoring and one of the most widely used Paper-and-Pencil tests. We conclude that the system can be considered as a screening instrument for cognitive assessment.

关键词： socially assistive robotics brief cognitive testing human-robot interaction neurological screening cloud computing

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In-silico synthesis of lowest-pressure high-T_(c) ternary superhydrides

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npj Computational Materials 2022年第1期8卷 1119-1125页

作者： Roman Lucrezi simone Di Cataldo Wolfgang von der Linden Lilia Boeri Christoph Heil Institute of Theoretical and Computational Physics Graz University of TechnologyNAWI Graz8010GrazAustria Dipartimento di Fisica Sapienza Universitàdi Roma00185RomeItaly Enrico Fermi Research Center Via Panisperna 89 A00184RomeItaly

We report the theoretical prediction of two high-performing hydride superconductors BaSiH_(8)and SrSiH_(8).They are thermodynamically stable above pressures of 130 and 174 GPa,respectively,and metastable below *** anharmonic phonon calculations,we determine the minimum pressures of dynamical stability to be around 3 GPa for BaSiH8 and 27 GPa for SrSiH_(8),and using the fully anisotropic Migdal-Eliashberg theory,we predict Tc’s around 71 and 126 K,*** also introduce a method to estimate the lowest pressure of synthesis,based on the calculation of the enthalpy barriers protecting the BaSiH_(8)Fm3¯m structure from decomposition at various *** kinetic pressure threshold is sensibly higher than the one based on dynamic stability,but gives a much more rigorous limit for synthesizability.

关键词： synthesis stability high

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Benefits of minimally invasive surgery in the treatment of gastric cancer

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World Journal of Gastroenterology 2022年第30期28卷 4227-4230页

作者： simone Sibio Francesca La Rovere Sara Di Carlo Department of Surgery P.Valdoni Unit of Oncologic and Minimally Invasive SurgerySapienza University of RomeUmberto I University HospitalRome 00161Italy Minimally Invasive Surgery Unit Department of SurgeryTor Vergata UniversityRome 00133Italy

We read with great interest the article that retrospectively analyzed 814 patients with primary gastric cancer,who underwent minimally invasive R0 gastrectomy between 2009 and 2014 by grouping them in laparoscopic vs robotic *** results of the study highlighted that age,American Society of Anesthesiologists status,gastrectomy type and pathological T and N status were the main prognostic factors of minimally invasive gastrectomy and showed how the robotic approach may improve long-term outcomes of advanced gastric *** to most of the current literature,robotic surgery is associated with a statistically longer operating time when compared to open and laparoscopic surgery;however,looking at the adequacy of resection,defined by negative surgical margins and number of lymph nodes removed,it seems that robotic surgery gives better results in terms of the 5-year overall survival and recurrencefree *** robotic approach to gastric cancer surgery aims to overcome the difficulties and technical limitations of laparoscopy in major *** threedimensional vision,articulation of the instruments and good ergonomics for the surgeon allow for accurate and precise movements which facilitate the complex steps of surgery such as lymph node dissection,esophagus-jejunal anastomosis packaging and reproducing the technical accuracy of open *** the literature,as well as the analyzed study,offers us countless data regarding the short-term oncological results of robotic surgery in the treatment of gastric cancer,satisfactory data on long-term follow-up are lacking,so future studies are necessary.

关键词： Gastric cancer Robotic gastrectomy Laparoscopy D2 lymphadenectomy Long-term outcomes Morbidity

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3D bioprinting:current status and trends-a guide to the literature and industrial practice

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Bio-Design and Manufacturing 2022年第1期5卷 14-42页

作者： Silvia Santoni simone G.Gugliandolo Mattia Sponchioni Davide Moscatelli Bianca M.Colosimo Department of Mechanical Engineering Politecnico di MilanoVia La Masa120156 MilanItaly Department of Chemistry Materials and Chemical Engineering“Giulio Natta”Politecnico di MilanoPiazza Leonardo da Vinci3220133 MilanItaly

The multidisciplinary research field of bioprinting combines additive manufacturing,biology and material sciences to cre-ate bioconstructs with three-dimensional architectures mimicking natural living *** high interest in the possibility of reproducing biological tissues and organs is further boosted by the ever-increasing need for personalized medicine,thus allowing bioprinting to establish itself in the field of biomedical research,and attracting extensive research efforts from companies,universities,and research institutes *** this context,this paper proposes a scientometric analysis and critical review of the current literature and the industrial landscape of bioprinting to provide a clear overview of its fast-changing and complex *** scientific literature and patenting results for 2000-2020 are reviewed and critically analyzed by retrieving 9314 scientific papers and 309 international patents in order to draw a picture of the scientific and industrial landscape in terms of top research countries,institutions,journals,authors and topics,and identifying the technology hubs *** review paper thus offers a guide to researchers interested in this field or to those who simply want to under-stand the emerging trends in additive manufacturing and 3D bioprinting.

关键词： Additive manufacturing 3D bioprinting Biofabrication Organ-on-a-chip Tissue engineering

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A recursive least squares algorithm with ?1 regularization for sparse representation

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Science China(Information Sciences) 2023年第2期66卷 281-282页

作者： Di LIU simone BALDI Quan LIU Wenwu YU School of Cyber Science and Engineering Southeast University School of Computation Information and Technology Technical University of Munich School of Mathematics Center for Mobile Communication and Security Southeast University School of Artificial Intelligence Southeast University

Sparse representation aims to identify a few basic elements in a signal, so as to use a combination of such elements to reconstruct the original signal. The ?1-norm has been widely applied in sparse representation, either when processing batches of data offline, or online as in adaptive filtering [1–3]. Representative algorithms for online sparse representation include zero-attracting LMS(ZA-LMS) [4],?1-RLS [5], ?1-RRLS [6], zero-attracting RLS(ZA-RLS) [7],

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Viability of thermal imaging in detecting nests of the invasive hornet Vespa velutina

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Insect Science 2021年第1期28卷 271-277页

作者： simone Lioy Ettore Bianchi Alessandro Biglia Mattia Bessone Daniela Laurino Marco Porporato Department of Agriculture Forest and Food SciencesUniversity of TurinGrugliasco(Turin)Italy School of Biological and Environmental Science Liverpool John Moores UniversityLiverpoolUK

Vespa velutina is an invasive hornet species that is colonising Europe,generating considerable impacts on honeybees,beekeeping and *** and early warning strategies for this species are mainly based on monitoring plans and procedures of nest detection and *** tools(harmonic radar,radio-telemetry)have been developed to increase the probabilities of nest detection in new *** hornets are able to regulate nest temperature,thermography may represent an additional technique that may be used,both alone or in support to other *** this study,the viability of thermal imaging in detecting nests of *** was evaluated in controlled *** influence of different environmental and operative variables(time of the day,presence/absence of leaves covering the nest,distance between the nest and the operator)were tested on three nests detected during August 2018 in *** the nests were detectable by thermal imaging,but environmental and operative variables affect their *** temperature difference between the nests and the surrounding reaches its maximum before sunrise and without a tree canopy covering the *** nests were visible in some cases from 30 m,the detectability was higher at shorter distances,even if this variable may also depend on infrared camera *** increase in the environmental temperature also generates a decrease of nest *** some limitations could occur,these results show the applicability of thermography in detecting V velutina nests before the beginning of the reproductive phase,and consequently its potentiality in control strategies.

关键词： alien species Asian yellow-legged hornet monitoring nest detection remote sensing thermography

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