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Delineation of Integrated Anomaly with Generative Adversarial Networks and Deep Neural Networks in the Zhaojikou Pb-Zn Ore District,Southeast China

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Acta Geologica Sinica(English Edition) 2023年第4期97卷 1252-1267页

作者： DUAN Jilin LIU Yanpeng ZHU Lixin MA Shengming GONG Qiuli Alla DOLGOPOLOVA simone a.ludwig School of Earth Sciences East China University of TechnologyNanchang 330013China State Key Laboratory of Nuclear Resources and Environment East China University of TechnologyNanchang 330013China Development Research Centre China Geological SurveyBeijing 100037China Institute of Geophysical and Geochemical Exploration Chinese Academy of Geological SciencesLangfang 065000China Department of Earth Sciences Natural History MuseumLondon SW75BDUnited Kingdom Department of Computer Science North Dakota State UniversityFargo ND 58105USA

Geochemical maps are of great value in mineral *** geochemical anomaly maps provide comprehensive information about mapping assemblages of element concentrations to possible types of mineralization/ore,but vary depending on expert's knowledge and *** paper aims to test the capability of deep neural networks to delineate integrated anomaly based on a case study of the Zhaojikou Pb-Zn deposit,Southeast *** hundred fifty two samples were collected,and each sample consisted of 26 variables covering elemental composition,geological,and tectonic *** first,generative adversarial networks were adopted for data ***,DNN was trained on sets of synthetic and real data to identify an integrated ***,the results of DNN analyses were visualized in probability maps and compared with traditional anomaly maps to check its *** showed that the average accuracy of the validation set was 94.76%.The probability maps showed that newly-identified integrated anomalous areas had a probability of above 75%in the northeast *** also showed that DNN models that used big data not only successfully recognized the anomalous areas identified on traditional geochemical element maps,but also discovered new anomalous areas,not picked up by the elemental anomaly maps previously.

关键词： deep learning deep neural networks generative adversarial networks geochemical map Pb-Zn deposit

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Machine Learning to Detect Alzheimer’s Disease from Circulating Non-coding RNAs

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Genomics, Proteomics & Bioinformatics 2019年第4期17卷 430-440页

作者： Nicole ludwig Tobias Fehlmann Fabian Kern Manfred Gogol Walter Maetzler Stephanie Deutscher simone Gurlit Claudia Schulte Anna-Katharina von Thaler Christian Deuschle Florian Metzger Daniela Berg Ulrike Suenkel Verena Keller Christina Backes Hans-Peter Lenhof Eckart Meese Andreas Keller Department of Human Genetics Saarland University66421 Homburg/SaarGermany Chair for Clinical Bioinformatics Saarland University66123 Saarbru¨ckenGermany Institut fur Gerontologie Universitat Heidelberg69047 HeidelbergGermany Department of Neurology Christian-Albrechts-University of Kiel24118 KielGermany Center for Neurology and Hertie Institute for Clinical Brain Research Department of NeurodegenerationUniversity of Tuebingen72074 TuebingenGermany German Center for Neurodegenerative Diseases(DZNE) 72076 TuebingenGermany Department of Anesthesiology and Intensive Care St.Franziskus Hospital Muenster48145 MuensterGermany Department of Psychiatry and Psychotherapy University Hospital Tuebingen72016 TuebingenGermany Department of Medicine II Saarland University Medical Center66421 Homburg/SaarGermany Center for Bioinformatics Saarland Informatics Campus66123 SaarbruckenGermany

Blood-borne small non-coding(snc RNAs)are among the prominent candidates for blood-based diagnostic ***,high-throughput approaches are applied to discover biomarker *** have to be validated in larger cohorts and evaluated by adequate statistical learning ***,we published high-throughput sequencing based microRNA(miRNA)signatures in Alzheimer’s disease(AD)patients in the United States(US)and ***,we determined abundance levels of 21 known circulating miRNAs in 465 individuals encompassing AD patients and controls by *** computed models to assess the relation between miRNA expression and phenotypes,gender,age,or disease severity(Mini-Mental State Examination;MMSE).Of the 21 miRNAs,expression levels of 20 miRNAs were consistently de-regulated in the US and German cohorts.18 miRNAs were significantly correlated with neurodegeneration(Benjamini-Hochberg adjusted P<0.05)with highest significance for miR-532-5 p(BenjaminiHochberg adjusted P=4.8×10^-30).Machine learning models reached an area under the curve(AUC)value of 87.6%in differentiating AD patients from ***,ten miRNAs were significantly correlated with MMSE,in particular miR-26a/26b-5p(adjusted P=0.0002).Interestingly,the miRNAs with lower abundance in AD were enriched in monocytes and T-helper cells,while those up-regulated in AD were enriched in serum,exosomes,cytotoxic t-cells,and *** study represents the next important step in translational research for a miRNA-based AD test.

关键词： miRNAs Neurodegeneration Alzheimer’s disease Biomarker Non-coding RNAs Gene regulation

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Salt Stress Triggers Phosphorylation of the Arabidopsis Vacuolar K＋ Channel TPK1 by Calcium-Dependent Protein Kinases （CDPKs）

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Molecular Plant 2013年第4期6卷 1274-1289页

作者： Andreas Latz Norbert Mehlmer simone Zapf Thomas D. Mueller Bernhard Wurzinger Barbara Pfister Edina Csaszar Rainer Hedrich Markus Teige Dirk Becker Department of Molecular Plant Physiology and Biophysics Julius-von-Sachs-lnstitute University of Wurzburg Julius-von-Sachs-Platz 2 D-97082 Wurzburg Germany Department of Biochemistry and Cell Biology Max F. Perutz Laboratories University of Vienna Dr. Bohrgasse 9 A-1030 Vienna Austria Present address: Department of Biology I Botany Munich Center for Integrated Protein Science CiPSM Ludwig-Maximilians-Universitat Munchen D-82152 Planegg-Martinsried Germany College of Science King Saud University Riyadh 11451 Saudi Arabia

14-3-3 proteins play an important role in the regulation of many cellular processes. The Arabidopsis vacuolar two-pore K＋ channel 1 （TPK1） interacts with the 14-3-3 protein GRF6 （GF14-λ）. Upon phosphorylation of the putative binding motif in the N-terminus of TPK1, GRF6 binds to TPK1 and activates the potassium channel. In order to gain a deeper understanding of this 14-3-3-mediated signal transduction, we set out to identify the respective kinases, which regulate the phosphorylation status of the 14-3-3 binding motif in TPK1. Here, we report that the calcium-dependent protein kinases （CDPKs） can phosphorylate and thereby activate the 14-3-3 binding motif in TPK1. Focusing on the stress-activated kinase CPK3, we visualized direct and specific interaction of TPK1 with the kinase at the tonoplast in vivo. In line with its proposed role in K＋ homeostasis, TPK1 phosphorylation was found to be induced by salt stress in planta, and both cpk3 and tpkl mutants displayed salt-sensitive phenotypes. Molecular modeling of the TPK1-CPK3 interaction domain provided mechanistic insights into TPK1 stress-regulated phosphorylation responses and pinpointed two arginine residues in the N-terminal 14-3-3 binding motif in TPK1 critical for kinase interaction. Taken together, our studies provide evidence for an essential role of the vacuolar potassium channel TPK1 in salt-stress adaptation as a target of calcium-regulated stress signaling pathways involving Ca2＋, Ca2＋-dependent kinases, and 14-3-3 proteins.

关键词： potassium channel vacuole calcium calcium-dependent kinase 14-3-3 protein salt stress.

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Arterial thrombosis in the context of HCV-associated vascular disease can be prevented by protein C

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Cellular & Molecular Immunology 2017年第12期14卷 986-996页

作者： Philipp Blüm Joachim Pircher Monika Merkle Thomas Czermak Andrea Ribeiro Hanna Mannell Florian Krötz Alexander Hennrich Michael Spannagl simone Köppel Erik Gaitzsch Markus Wörnle Medizinische Klinik und Poliklinik IV InnenstadtKlinikum der Universität München80336 MünchenGermany Walter Brendel Centre of Experimental Medicine and Munich Heart Alliance Ludwig Maximilians University München80336 MünchenGermany Medizinische Klinik und Poliklinik I Klinikum der Universität München80336 MünchenGermany Abteilung für Transfusionsmedizin Zelltherapeutika und HämostaseologieKlinikum der Universität München80336 MünchenGermany

Hepatitis C virus(HCV)infection is a major problem *** is not limited to liver disease but is frequently complicated by immune-mediated extrahepatic manifestations such as glomerulonephritis or vasculitis.A fatal complication of HCV-associated vascular disease is ***:polyribocytidylic acid(poly(I:C)),a synthetic analog of viral RNA,induces a Toll-like receptor 3(TLR3)-dependent arteriolar thrombosis without significant thrombus formation in venules in *** procoagulant effects are caused by increased endothelial synthesis of tissue factor and PAI-1 without platelet *** addition to human umbilical endothelial cells(HUVEC),human mesangial cells(HMC)produce procoagulatory factors,cytokines and adhesion molecules after stimulation with poly(I:C)or HCV-containing cryoprecipitates from a patient with a HCV infection as *** protein C(APC)is able to prevent the induction of procoagulatory factors in HUVEC and HMC in vitro and blocks the effects of poly(I:C)and HCV-RNA on the expression of cytokines and adhesion molecules in HMC but not in *** vivo,protein C inhibits poly(I:C)-induced arteriolar ***,endothelial cells are de facto able to actively participate in immune-mediated vascular thrombosis caused by viral ***,we provide evidence for the ability of protein C to inhibit TLR3-mediated arteriolar thrombosis caused by HCV infection.

关键词： hepatitis C thrombosis toll-like receptor 3

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Overview of clinical forensic services in various countries of the European Union

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Forensic Sciences Research 2020年第1期5卷 74-84页

作者： Sophie Kerbacher Michael Pfeifer Reingard Riener-Hofer Andrea Berzlanovich Maeve Eogan Anita Gali(c)Mihic Gregor Haring Petr Hejna Johannes Höller Sorin Hostiuc Michael Klintschar Peter Kovác Astrid Krauskopf simone Leski Michal Malacka Thorsten Schwark Hanna Sprenger Andrea Verzeletti Duarte Nuno Vieira Sylvia Wolf Kathrin Yen ludwig Boltzmann Institute for Clinical Forensic Imaging Ludwig Boltzmann GesellschaftGrazAustria Center of Forensic Medicine Medical University of ViennaViennaAustria Department of Obstetricsand Gynaecology Rotunda HospitalDublinIreland Institute of Forensic Medicine and Criminalistics School of MedicineUniversity of ZagrebZagrebCroatia Department for Forensic Medicine and Deontology University of LjubljanaLjubljanaSlovenia Department of Forensic Medicine Charles University and University HospitalHradec KraloveCzech Republic Department of Legal Medicine National Institute of Legal MedicineBucharestRomania Department for Legal Medicine Hannover Medical SchoolHannoverGermany Forensic.sk Institút Forenznych Medicínskych ExpertízBratislavaSlovakia Institute of Forensic and Traffic Medicine University of HeidelbergHeidelbergGermany Faculty of Law Palacky University OlomoucOlomoucCzech Republic Department of Forensic Medicine Laboratoire National de SantéDudelangeLuxembourg Department of Medical and Surgical Specialties Radiological Sciences and Public HealthUniversity of BresciaBresciaItaly Department of Forensic Medicine Ethics and Medical LawFaculty of MedicineUniversity of CoimbraCoimbraPortugal

Examination of a person who has been a victim of a physical or sexual assault may be very important for upcoming legal *** the context of a clinical forensic examination,physical findings are recorded and biological trace material is gathered and ***,all forensic findings are documented in a detailed report combined with photographic docu-mentation,which employs a forensic scale to depict the size of the ***,the integrity of such forensic findings depends particularly on two ***,the examination needs to be conducted professionally to ensure that the findings are properly admissible as court ***,the examination should take place as soon as possible because the opportunity to successfully secure biological samples declines rapidly with *** to low-threshold clinical forensic examinations is not evenly provided in all member states of the European Union(EU);in some states,they are not available at *** part of the JUST_(e)U!(Juridical standards for clinical forensic examinations of victims of violence in Europe)pro-ject,the ludwig Boltzmann Institute for Clinical Forensic Imaging in Graz,Austria created(in cooperation with its international partner consortium)a questionnaire:the purpose was to collect information about support for victims of physical and/or sexual assault in obtaining a low-threshold clinical forensic examination in various countries of the *** paper pro-vides a summary of the responses and an overview of the current situation concerning pro-vided clinical forensic services.

关键词： Forensic sciences clinical forensic services violence JUST_(e)U! Directive 2012/29/EU victim examination

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