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Coronary Angiography: Indications, Results and Cost-Effectiveness in the Diagnosis of Stable Angina Pectoris in Two Hospitals in Senegal

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World Journal of Cardiovascular Diseases 2021年第8期11卷 347-356页

作者： Paul Coffi Hessou Joseph Salvador Mingou Maboury Diao Fatou Aw Leye Mouhamadou Bamba Ndiaye simon.antoine sarr Malick Bodian Papa Guirane Ndiaye Bouna Diack Alasane Mbaye Aliou Alassane Ngaïde Laboratory of Physiology and Functional Physiological Explorations Dakar Senegal Faculty of Medicine Pharmacy and Odontology Cheick Anta Diop University Dakar Senegal Department of Cardiology University Hospital Center Aristide le Dantec Dakar Senegal Department of Cardiology Idrissa Pouye General Hospital Dakar Senegal

Background: The current gold standard for the diagnosis of stable coronary artery disease (CAD) is invasive coronary angiography. But a large proportion of patients undergoing coronary angiography don’t have obstructive coronary artery disease. Objective: The aim of the present study was to evaluate the diagnostic performance of invasive coronary angiography for patients without known coronary artery disease presenting with stable chest pain syndrome at two hospitals structures in Senegal. Method: We conducted a prospective, descriptive, and analytical study from March 1, 2019, to December 31, 2020 in the Cardiology Departments of General Hospital Idrissa Pouye (HOGIP) and Aristide Le Dantec Hospital (HALD). During the study period a cohort of patients referred to angiography coronary for diagnostic CAD because of suspected stable angina were enrolled. Demographic characteristics, risk factors, symptoms, and noninvasive test results were correlated with the presence of obstructive coronary artery disease. Results: A total of 143 patients were included in our study with a median age of 60.91 ± 10.58 years;men were 96 (67.13%) and women 47 (32.87%). The prevalence of hypertension was 60.84%;diabetes was 34.27%;dyslipidemia was 32.17% and sedentary was 26.57% in our study population. Typical and atypical angina symptoms were present in 37.76% (n = 54) and 49.65% (n = 71) respectively, while 10.49% had dyspnea. Coronary angiography revealed 59 (41.26%) patients with no CAD as well as 27 (18.88%) with one-vessel;28 (19.58%) with two-vessel, and 29 (20.28%) with three-vessel disease. Independent predictive factors for stable angina with the presence of obstructive lesion were: patient age (OR,

关键词： Stable Angina Invasive Angiography Diagnostic Efficacy Senegal

Prevalence and Study of the Clonality of Extended-Spectrum Beta-Lactamase-Producing Klebsiella pneumoniae Strains in Neonatology at the University Hospitals of Abidjan by the Pulsed Field Gel Electrophoresis and the Quantitative Antibiogram

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Advances in Microbiology 2024年第9期14卷 416-429页

作者： Valérie M’Bengue Gbonon Sidjè Arlette Afran Stanislas Assohoun Egomli Djeda Franck Arnaud Gnahoré Aboubakar Sylla N’Golo David Coulibaly Nathalie Guessennd Assanvo simon-Pierre N’Guetta Mireille Dosso Antibiotics Natural Substances and Anti-Infectious Resistance Surveillance Unit Pasteur Institute of Cte dIvoire Abidjan Cte dIvoire Molecular Genetics Platform Pasteur Institute of Cte dIvoire Abidjan Cte dIvoire Genetics and Species Improvement Laboratory Flix Houphout Boigny University Abidjan Cte dIvoire Mechanics and Computer Sciences Laboratory Flix Houphout Boigny University Abidjan Cte dIvoire Biology and Health Laboratory Flix Houphout Boigny University Abidjan Cte dIvoire Molecular Biology Platform Pasteur Institute of Cte dIvoire Abidjan Cte dIvoire

Background: ESBL-producing strains of Klebsiella pneumoniae, one of the main causes of nosocomial and hospital-acquired infections, are commonly associated with therapeutic impasses. Surveillance of these multidrug-resistant pathogens is a crucial tool for controlling and preventing infections. This surveillance involves the use of appropriate molecular and phenotypic typing techniques. The choice of techniques is based on criteria such as discriminatory power, intra- and inter-laboratory reproducibility, epidemiological concordance, ease of use and cost. The aim of our study was to identify clusters of Extended-Spectrum Beta-Lactamase-producing Klebsiella pneumoniae (ESBL-K. pneumoniae) strains circulating in neonatology using quantitative antibiogram (QA) and Pulsed Field Gel Electrophoresis (PFGE). Materials and Methods: This cross-sectional study included 55 K. pneumoniae strains isolated from a total of 513 samples. These various samples are taken from newborns, healthcare personnel, and the environment. K. pneumoniae identification followed standard bacteriological procedures and was confirmed using the Vitek® 2 (bioMérieux). The detection of the ESBL phenotype was performed using the synergy test. QA and PFGE were used to identify clonal relationships between the various strains isolated. Concordance between these two methods was assessed by calculating Cohen’s KAPPA coefficient and Simpson’s diversity index. Results: Among the 55 K. pneumoniae strains included in this study, 58.2% (32/55) were found to be Extended-Spectrum Beta-Lactamase (ESBL) producers. Most of these strains were isolated from neonatal samples (blood samples and rectal swabs). The quantitative antibiogram method applied to 28 out of the 32 ESBL-producing strains revealed that the isolates were grouped into 5 clusters. Pulsed Field Gel Electrophoresis performed on a total of 16 ESBL-producing strains showed the existence of four profiles. A perfect concordance was observed between the two m

关键词： Resistance-Clone-Klebsiella pneumoniae-Pulsed Field Gel Electrophoresis-Quantitative Antibiogram

Arsenobetaine and thio-arsenic species in marine macroalgae and herbivorous animals: Accumulated through trophic transfer or produced in situ?

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Journal of Environmental Sciences 2016年第11期28卷 131-139页

作者： simon Foster William Maher Ecochemistry Laboratory Institute for Applied Ecology University of Canberra

Arsenobetaine（AB） and thio-arsenoribosides were measured in common macroalgae species（8 phaeophyta, 4 rhodophyta and 2 chlorphyta）, along the Australian south east coast line. As well, arsenic species profiles were measured for two common marine herbivores, the sea urchin Centrostephanus rodgersii and the fish Odax cyanomelas that graze on these macroalgae to understand if trophic transfer of these species would account for their presence in marine herbivores. AB was found in seven of the fourteen macroalgae species investigated but does not contributed significantly to any of the macroalgae arsenic content（0.01-1.2 μg/g）. AB was found in only two of the brown macroalgae and all the red and green macroalgae（with the exception of Corallina officinalis）. Thio-arsenic species were found sporadically, but not in high concentrations in any of the macroalgae *** present in macroalgae is likely to be associated with epiphytic organisms while thio-arsenoribosides are likely to be produced by decaying parts of damaged macroalgae.A laboratory feeding experiment in which the herbivorous gastropod, Austrocochlea constricta, was fed macroalgae containing thio-arsenoribosides for a 24 hr period every three days showed that these are readily accumulated over a short period. Thio-arsenoribosides in herbivores are therefore probably obtained through trophic transfer. Some AB is also obtained through trophic transfer; however, the presence of trimethylated arsonioribosides,a hypothesized precursor of AB formation in herbivores, suggests that some AB is produced within herbivores from the transformation of arsenoribosides accumulated from their diet.

关键词： Arsenobetaine Arsenic Metabolism Thio-arsenosugars Macroalgae Gastropods

Holomorphic Factorization of Superstring Scattering Amplitudes

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Communications in Theoretical Physics 2011年第1期55卷 1-5页

作者： simon Davis Research Foundation of Southern Califoria

The holomorphic factorization of the superstring partition function is verified at arbitrary genus. The evaluation of scattering amplitudes and the implications of genus-dependent estimates on the string coupling are ... 详细信息

关键词： holomorphic factorization Ramond measure supermoduli space coordinate

Univalent Functions and Diff(S^1)/S^1

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Acta Mathematica Sinica,English Series 2012年第6期28卷 1233-1236页

作者： simon DAVIS Research Foundation of Southern California

The relation between Diff（S^1）/S^1 and the space of univalent analytic functions on the disk is elucidated and shown to provide upper bounds for the volumes of exhaustive approximations to an analytic submanifold of an infinite-dimensional space. The maximum magnitudes of the coefficients in the series expansions of univalent superanalytic functions on the superdisk are inferred.

关键词： Univalent diffeomorphism group superanalytic functions

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57万亿电动车市场引爆

商业周刊（中文版） 2024年第1期 42-47页

作者： Malcolm Scott Amy Stillman Zoltan simon Patpicha Tanakasempipat Paul Burkhardt Jacob Lorinc 许诺(译) 不详

长达一个世纪的内燃机汽车时代在迈向电动车时代,这一历史性转变正在世界经济的某些令人意想不到的角落制造引爆点。而且现在才刚刚开始。在自然资源丰富的加拿大“火环地带”,由于对环境退化的担忧,电动汽车生产所需矿物的开采许可审... 详细信息

长达一个世纪的内燃机汽车时代在迈向电动车时代,这一历史性转变正在世界经济的某些令人意想不到的角落制造引爆点。而且现在才刚刚开始。在自然资源丰富的加拿大“火环地带”,由于对环境退化的担忧,电动汽车生产所需矿物的开采许可审批速度放缓,不同的环保目标之间在发生冲突。

关键词：内燃机汽车环境退化电动汽车自然资源历史性转变引爆点电动车加拿大

Quasi-morphisms via Local Action Data and Quasi-isometries

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Algebra Colloquium 2016年第1期23卷 111-116页

作者： Gabi Ben-simon Department of Mathematics ORT Braude College P.O. Box 78 Karmiel 2161002 Israel

In this work we first present a principle which says that quasi-morphisms can be obtained via local data of group action on certain appropriate spaces. In a rough manner the principle says that instead of starting with a given group and trying to build or study its space of quasi-morphisms, we should start with a space with a certain structure, in such a way that groups acting on this space and respecting this structure will automatically carry quasi-morphisms, where these are supposed to be better understood. This principle plays an important role in the second result of this paper, which is a universal embedding of the projective space of the linear space of quasi-morphisms of any given countable group, into the space of quasi-isometries of a certain universal metric space.

关键词： quasi-rnorphisms discrete groups quasi-isometries

Practical Approaches to Risk Assessment

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Biomedical and Environmental Sciences 2001年第1期14卷 14-20页

作者： simon BROOKE-TAYLOR AustraliaNewZealandFoodAuthority

he importance of using risk assessment in developing food regulations is growing with the globalization of our food supply. The World Trade Organization has entrenched the principles of science based risk assessment in the Agreement on Sanitary and Phytosanitary Measures. The relevant international organization for food standards, the Codex Alimentarius Commission, recognises risk analysis, and its component parts risk assessment, risk management and risk communication, as the basis for scientific decision making. Risk assessment comprises two activities: hazard evaluation; and exposure estimation. A hazard may be chemical, microbiological or nutritional in origin. The practical application of risk assessment in Australia is illustrated in this presentation by four examples involving: (1) food additives, (2) microbiological safety of imported raw milk cheeses, (3) genetically modified foods and (4) imported food inspection.

关键词： risk assessment World Trade Organization practical application risk communication food inspection risk analysis principles of food supply raw milk

Identifying high-risk over-entitlement in access control policies using fuzzy logic

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Cybersecurity 2022年第2期5卷 75-91页

作者： simon Parkinson Saad Khana Department of Computer Science University of HuddersfieldHuddersfieldHD13DHUK

Analysing access control policies is an essential process for ensuring over-prescribed permissions are identified and removed. This is a time-consuming and knowledge-intensive process, largely because there is a wealth of policy information that needs to be manually examined. Furthermore, there is no standard definition of what constitutes an over-entitled permission within an organisation’s access control policy, making it not possible to develop automated rule-based approaches. It is often the case that over-entitled permissions are subjective to an organisation’s role-based structure, where access is be divided and managed based on different employee needs. In this context, an irregular permission could be one where an employee has frequently changed roles, thus accumulating a wide-ranging set of permissions. There is no one size fits all approach to identifying permissions where an employee is receiving more permission than is necessary, and it is necessary to examine them in the context of the organisation to establish their individual risk. Risk is not a binary measure and, in this work, an approach is built using Fuzzy Logic to determine an overall risk rating, which can then be used to make a more informed decision as to whether a user is over-entitled and presenting risk to the organisation. This requires the exploratory use of establishing resource sensitivity and user trust as measures to determine a risk rating. The paper presents a generic solution, which has been implemented to perform experimental analysis on Microsoft’s New Technology File System to show how this works in practice. A simulation using expert knowledge for comparison is then performed to demonstrate how effective it is at helping the user identify potential irregular permissions.

关键词： Fuzzy control Fuzzy systems Security Access control policies Security analysis Risk Fuzzy logic Risk-adaptive access control