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Hyperoncotic human albumin solutions for intravenous fluid therapy: Effectiveness of pathogen safety and purification methods, and clinical safety

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Biosafety and Health 2023年第1期5卷 21-29页

作者： Toby simon Philipp Schumann Michael Bieri Kathrin Schirner Eleonora Widmer CSL Plasma 900 Broken Sound ParkwaySuite 400Boca RatonFL 33487the United States CSL Behring AG Wankdorfstrasse 10CH-3014 BernSwitzerland CSL Behring Innovation GmbH Emil-von-Behring-Str.7635041 MarburgGermany

Albumin solutions derived from human plasma have demonstrated clinical benefits as intravenous fluid therapy in clinical settings such as liver disease,sepsis,intensive care,and *** all plasma-derived medicinal products,there is a potential risk from pathogens,including relevant blood-borne viruses,emerging viruses,and prion *** minimize the risk of transmissible infections,the production of human albumin solutions includes rigorous donor selection and plasma testing,and effective pathogen removal and inactivation methods such as fractionation and *** with international pharmacopeial standards for purity and prekallikrein activator and aluminum content is crucial,as is post-marketing pharmacovigilance for the continuous monitoring of adverse *** review focuses on the effectiveness of manufacturing methods in the production of plasma-derived albumin,to ensure the safety of hyperoncotic solutions for volume *** evaluated evidence identified through online database(PubMed)searches and from unpublished sources,on the manufacturing and pathogen safety of plasma-derived albumin *** results confirmed the already established and evolving pathogen reduction capacity of the reviewed manufacturing ***-to-date post-marketing pharmacovigilance data and log 10 reduction factors for known and emerging pathogens during albumin production are *** the goal of ever-increasing clinical safety,potential areas of improvement,such as compliance rates for the completion of donor health questionnaires,are also *** together,the current manufacturing and pathogen reduction steps result in albumin products of greater purity than previous-generation products,with a high margin of pathogen safety against known and emerging pathogens,such as severe acute respiratory syndrome coronavirus 2(SARS-CoV-2).

关键词： Hyperoncotic albumin Human albumin solutions Viral reduction Pathogen safety Pasteurization Plasma-derived medicinal product

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Image-Based Methods for Interaction with Head-Worn Worker-Assistance Systems

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Journal of Intelligent Learning Systems and Applications 2014年第3期6卷 141-152页

作者： Frerk Saxen Omer Rashid Ayoub Al-Hamadi simon Adler Alexa Kernchen Rüdiger Mecke Fraunhofer Institute for Factory Operation and Automation (IFF) Magdeburg Germany Institute for Information Technology and Communications Otto-von-Guericke-University Magdeburg Germany

In this paper, a mobile assistance-system is described which supports users in performing manual working tasks in the context of assembling complex products. The assistance system contains a head-worn display for the visualization of information relevant for the workflow as well as a video camera to acquire the scene. This paper is focused on the interaction of the user with this system and describes work in progress and initial results from an industrial application scenario. We present image-based methods for robust recognition of static and dynamic hand gestures in realtime. These methods are used for an intuitive interaction with the assistance-system. The segmentation of the hand based on color information builds the basis of feature extraction for static and dynamic gestures. For the static gestures, the activation of particular sensitive regions in the camera image by the user’s hand is used for interaction. An HMM classifier is used to extract dynamic gestures depending on motion parameters determined based on the optical flow in the camera image.

关键词： Head Mounted Display Gesture Recognition Mobile Assistance System

Regeneration of Nothofagus dombeyi(Mirb.)?*** little to moderately disturbed southern beech forests in the Andes of Patagonia(Argentina)

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Forest Ecosystems 2023年第4期10卷 472-482页

作者： Stefan Zerbe Stefanie T.Storz Georg Leitinger Natalia Zoe Joelson José Bava Steffi Heinrichs Christoph Leuschner Gabriel Loguercio Alois simon María F.Urretavizcaya Helge Walentowski Faculty of Agricultural Environmental and Food SciencesFree University of Bozen-Bolzano Department of Ecology University of Innsbruck Faculty of Resource Management HAWK University of Applied Sciences and Arts Department of Plant Ecology and Ecosystem Research Albrecht-von-Haller-Institute for Plant SciencesUniversity of G?ttingen Centro de Investigación y Extensión Forestal Andino Patagónico(CIEFAP) Department of Forest Planning Tyrol Forest Administration Office of the Tyrolean Government

Natural forests and stands subj ected to little to moderate human impact are continuously declining worldwide and with these,their biodiversity and ecosystem *** Nothofagus forests in the south of the South American continent are in a pristine state or only moderately impacted by *** grazing by livestock,in the past and still today often practiced in a non-sustainable way is,however,increasingly under discussion to meet current environmental and socio-economic ***,we investigate the regeneration of Nothofagus dombeyi,a keystone species of the Patagonian Andes,in secondary forests in Argentinian northern Patagonia,particularly addressing the role of disturbance through grazing by livestock at various *** test the hypothesis that the regeneration of this tree species is favored by grazing impact and,thus,disturbance of the herb layer and soil *** support of our hypothesis,Nothofagus dombeyi regeneration was significantly higher in terms of individuals and height classes in moderately grazed *** analysis shows significant positive effects of moderate grazing pressure,herb layer cover,and the occurrence of bare soil on the regeneration of Nothofagus *** results show that an integration of livestock grazing and forest regeneration is possible and that agroforestry systems can be an adequate management option for stakeholders in the region.A grazing management can also be part of a forest fire prevention ***,the regeneration success and grazing pressure should be continuously monitored.

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Dev Cell:科学家阐明人类胚胎原生殖细胞发育的分子机制

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现代生物医学进展 2016年第35期16卷 I0002-I0002页

作者： Ferdinand von Meyenn Rebecca V. Berrens simon Andrews Fátima Santos Amanda J. Collier Felix Krueger Rodrigo Osorno Wendy Dean Peter J. Rugg-Gunn Wolf Reik Wellcome Trust Sanger Institute Hinxton CB10 1SA UK

近日,刊登于国际杂志Developmental Cell上的一项研究报道中，来自巴布拉汉研究所（Babraham Insdtute）的研究人员通过研究调查了原生殖细胞发育的早期阶段，同时他们在实验室开发了一种产生类似细胞的策略，这种酷似人类原始生殖细胞... 详细信息

近日,刊登于国际杂志Developmental Cell上的一项研究报道中，来自巴布拉汉研究所（Babraham Insdtute）的研究人员通过研究调查了原生殖细胞发育的早期阶段，同时他们在实验室开发了一种产生类似细胞的策略，这种酷似人类原始生殖细胞的产生对于未来生殖领域的研究，以及分析人类潜在的继代基因调控的遗传机制非常重要。

关键词：生殖细胞发育人类胚胎 Cell 分子机制科学家原始生殖细胞早期阶段研究人员

Multi-positional image-based vibration measurement by holographic image replication

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Light(Advanced Manufacturing) 2021年第4期2卷 80-88页

作者： simon Hartlieb Michael Ringkowski Tobias Haist Oliver Sawodny Wolfgang Osten Institute for Applied Optics University of StuttgartPfaffenwaldring 9Stuttgart 70569Germany Institute for System Dynamics University of StuttgartWaldburgstra?e 17/19Stuttgart 70563Germany

In this study we present a novel and flexibly applicable method to measure absolute and relative vibrations accurately in a field of 148 mm×110 mm at multiple positions *** method is based on imaging in combination with holographic image replication of single light sources onto an image sensor,and requires no calibration for small *** experimentally show that oscillation amplitudes of 100 nm and oscillation frequencies up to 1000 Hz can be detected clearly using standard image *** presented experiments include oscillations of variable amplitude and a chirp signal generated with an inertial *** experiments were verified using state-of-the-art *** contrast to conventional vibration measurement approaches,the proposed method offers the possibility of measuring relative movements between several light sources *** show that classical band-pass filtering can be omitted,and the relative oscillations between several object points can be monitored.

关键词： holographic oscillation absolute

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食管肿瘤X线诊断的现状

放射学实践 1992年第3期7卷 93-95页

作者： Max Georgi Hans-Peter Busch Rainer simon Andre Sommer Eduard Wetzel 王天才 Institut fur Klinische Radiologie des Klinikums Mannheim Th.-Katzer-Ufer6800 MannheimFRG.Prof 同济医科大学附属同济医院

传统X线检查方法能及时、无痛苦地诊断吞咽困难。X线诊断应在内窥镜检查前进行,因其病理结果对内窥镜的施行具有参考意义。低张双对比造影是一种重要的补充,而CT和磁共振对于术前肿瘤分期有重要意义。

关键词：食管肿瘤 X线诊断

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Introducing the Open Energy Ontology: Enhancing data interpretation and interfacing in energy systems analysis

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能源与人工智能(英文) 2021年第3期5卷 53-66页

作者： Meisam Booshehri Lukas Emele simon Flügel Hannah Förster Johannes Frey Ulrich Frey Martin Glauer Janna Hastings Christian Hofmann Carsten Hoyer-Klick Ludwig Hülk Anna Kleinau Kevin Knosala Leander Kotzur Patrick Kuckertz Till Mossakowski Christoph Muschner Fabian Neuhaus Michaja Pehl Martin Robinius Vera Sehn Mirjam Stappel Institute for Applied Ecology BerlinGermany Institute for Applied Informatics(InfAI)/Leipzig University Germany Department of Energy Systems Analysis Institute of Networked Energy SystemsGerman Aerospace Center(DLR)StuttgartGermany Faculty of Computer Science Otto-von-Guericke-Universität MagdeburgGermany Reiner Lemoine Institut BerlinGermany Institute of Techno-economic Systems Analysis(IEK-3) Forschungszentrum JülichJülichGermany Institute of Energy Economics and Rational Energy Use University of StuttgartGermany Potsdam Institute for Climate Impact Research PotsdamGermany Fraunhofer Institute for Energy Economics and Energy System Technology KasselGermany

Heterogeneous data,different definitions and incompatible models are a huge problem in many domains,with no exception for the field of energy systems ***,it is hard to re-use results,compare model results or couple models at *** provide a precisely defined vocabulary to build a common and shared conceptu-alisation of the energy ***,we present the Open Energy Ontology(OEO)developed for the domain of energy systems *** the OEO provides several benefits for the ***,it enables consistent annotation of large amounts of data from various research *** example is the Open Energy Platform(OEP).Adding such annotations makes data semantically searchable,exchangeable,re-usable and ***,computational model coupling becomes much *** advantages of using an ontology such as the OEO are demonstrated with three use cases:data representation,data annotation and interface *** also describe how the ontology can be used for linked open data(LOD).

关键词： Collaborative ontology development Linked open data Metadata annotation Energy systems analysis

Tumor microenvironment-dependent epigenetic imprinting in the vasculature predicts colon cancer outcome

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Cancer Communications 2023年第11期43卷 1280-1285页

作者： Elisabeth Naschberger Maximilian Fuchs Nicholas Dickel Meik Kunz Bernt Popp Charles Gwellem Anchang Richard Demmler Yanmin Lyu Steffen Uebe Arif Bülent Ekici Carol Immanuel Geppert Arndt Hartmann Christian Flierl Katja Petter Tobias Gass simon Völkl Michael Scharl Andreas Ramming Claudia Günther Susanne Merkel Vera simone Schellerer Michael Stürzl Division of Molecular and Experimental Surgery Translational Research CenterUniversitätsklinikum ErlangenFriedrich-Alexander-Universität Erlangen-Nürnberg (FAU)ErlangenBavariaGermany Comprehensive Cancer Center Erlangen-EMN (CCC ER-EMN) ErlangenBavariaGermany Chair of Medical Informatics Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU)ErlangenBavariaGermany Fraunhofer Institute of Toxicology and Experimental Medicine Lower saxonyHannoverGermany Institute of Human Genetics Universitätsklinikum ErlangenFriedrich-Alexander-Universität Erlangen-Nürnberg (FAU)ErlangenBavariaGermany Department of Medicine 3 Universitätsklinikum ErlangenFriedrich-Alexander-Universität Erlangen-Nürnberg (FAU)ErlangenBavariaGermany Institute of Pathology Universitätsklinikum ErlangenFriedrich-Alexander-Universität Erlangen-Nürnberg (FAU)ErlangenBavariaGermany Department of Internal Medicine 5 – Hematology and Oncology Universitätsklinikum ErlangenFriedrich-Alexander-Universität Erlangen-Nürnberg (FAU)ErlangenBavariaGermany Department of Gastroenterology and Hepatology University Hospital ZurichUniversity of ZurichCanton ZurichZurichSwitzerland Department of Medicine 1 Universitätsklinikum ErlangenFriedrich-Alexander-Universität Erlangen-Nürnberg (FAU)ErlangenBavariaGermany Department of Surgery Universitätsklinikum ErlangenFriedrich-Alexander-Universität Erlangen-Nürnberg (FAU)ErlangenBavariaGermany

Dear Editor,Tumor microenvironment(TME)-dependent stromal cell plasticity governs tumor development and therapy *** endothelial cells(TECs)are a major cellular component in this context[1].In colorectal carcinoma(CRC),the stromal cell-dependent impact of the TME is illustrated by an improved survival depending on an interferon(IFN)-γ-dominated Th1-like TME associated with high T-cell density[2]and suppressed angiogenesis[3,4].Cellular transcriptional memory is reported in cell lines after repeated exposure to IFN-γin vitro[5],suggesting that a Th1-like TME may also exert stable imprinting effects in ***,we investigated whether TME-dependent transcriptional imprinting in TECs from CRC patients can be exploited to retrieve clinically relevant signatures predicting outcomes.

关键词： imprinting colon interferon

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嗜酸细胞增多综合征引发的结节性类天疱疮?

世界核心医学期刊文摘（皮肤病学分册） 2006年第8期2卷 29-29页

作者： von Felbert V. simon D. Braathen L. Hunziker T. 潘敏 Klinik und Poliklinik für Dermatologie Universittsklinikum der RWTH Pauwelsstr. 30 52074 Aachen Germany Dr.

Pemphigoid nodularis (PN) is a rare clinical variant of pemphigoid characterized by prurigo-like skin lesions and antibodies against BP180 and BP230 characteristic for bullous pemphigoid. Interestingly, most PN patients never develop blisters. This condition is often resistant to treatment. We describe a female patient who was initially diagnosed with hypereosinophilic dermatitis. Later on, in the presence of eosinophilic infiltrations in the gastrointestinal tract, obstructive ventilation disorder, pericardial and pleural effusions, the diagnosis of idiopathic hypereosinophilic syndrome was made. During the following 3 years she developed recalcitrant PN.

关键词：嗜酸细胞增多综合征结节性类天疱疮大疱性类天疱疮嗜酸粒细胞增多性嗜酸性粒细胞浸润气道阻塞性疾病女性患者 BP230 临床变异胸腔积液

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