检索结果-南通市图书馆

Machine perfusion of the liver: Which is the best technique to mitigate ischaemia-reperfusion injury?

World Journal of Transplantation 2019年第1期9卷 14-20页

作者： Yuri L Boteon simon c afford Liver Unit Queen Elizabeth HospitalUniversity Hospitals Birmingham NHS Foundation Trust centre for Liver and Gastrointestinal Research Institute of Immunology and ImmunotherapyCollege of Medical and Dental SciencesUniversity of Birmingham National Institute for Health Research (NIHR) Birmingham Biomedical Research centre University of Birmingham and University Hospitals Birmingham NHS Foundation Trust

Longstanding research describes the mechanisms whereby the restoration of blood flow and reoxygenation(reperfusion) aggravates the ischaemic injury caused by a period of anoxia to a donor liver. This phenomenon, called ischaemia-reperfusion injury(IRI), leads to parenchymal cell death,microcirculatory failure, and inflammatory immune response. clinically, IRI is the main factor responsible for the occurrence of posttransplant graft dysfunction and ischaemic-type biliary lesions. While extended criteria donor livers are more vulnerable to IRI, their utilisation is required to address the shortfall in donor organs. Thus, the mitigation of IRI should drive the setting of a new benchmark for marginal organ preservation. Herein, strategies incorporating different modalities of machine perfusion of the liver to alleviate IRI are discussed in conjunction with advantages and disadvantages of individual *** leading to reperfusion of the liver during machine perfusion(in situ normothermic regional perfusion and ex situ normothermic machine perfusion)may mitigate IRI by shortening the ischaemic period of the organs. This benefit potentially escalates from the minimum level, obtained following just partial alleviation of the ischaemic period, to the maximum level, which can be potentially achieved with ischaemia-free organ transplantation. Techniques that do not lead to reperfusion of the liver during machine perfusion(hypothermic,subnormothermic, and controlled-oxygenated rewarming) optimise mitochondrial oxidative function and replenish cellular energy stores, thereby lowering reactive oxygen species production as well as the activation ofdownstream inflammatory pathways during reperfusion. Further mechanistic insights into IRI may guide the development of donor-specific protocols of machine perfusion on the basis of the limitations of individual categories of extended criteria donor organs.

关键词： Machine perfusion of the liver Ischaemia-reperfusion injury Liver transplantation Organ preservation Organ reconditioning

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Mechanisms of autophagy activation in endothelial cell and their targeting during normothermic machine liver perfusion

引用

World Journal of Gastroenterology 2017年第48期23卷 8443-8451页

作者： Yuri L Boteon Richard Laing Hynek Mergental Gary M Reynolds Darius F Mirza simon c afford Ricky H Bhogal The Liver Unit University Hospitals of BirminghamMindelsohn Way The centre for Liver Research Institute for Biomedical ResearchUniversity of Birmingham

Ischaemia-reperfusion injury(IRI) is the leading cause of injury seen in the liver following transplantation. IRI also causes injury following liver surgery and haemodynamic shock. The first cells within the liver to be injured by IRI are the liver sinusoidal endothelial cells(LSEc). Recent evidence suggests that LSEc coordinate and regulates the livers response to a variety of injuries. It is becoming increasingly apparent that the cyto-protective cellular process of autophagy is a key regulator of IRI. In particular LSEc autophagy may be an essential gatekeeper to the development of IRI. The recent availability of liver perfusion devices has allowed for the therapeutic targeting of autophagy to reduce IRI. In particular normothermic machine liver perfusion(NMP-L) allow the delivery of pharmacological agents to donor livers whilst maintaining physiological temperature and hepatic flow rates. In this review we summarise the current understanding of endothelial autophagy and how this may be manipulated during NMP-L to reduce liver IRI.

关键词： Autophagy Liver transplant Ischaemiareperfusion injury Normothermic machine liver perfusion

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Impact of machine perfusion of the liver on post-transplant biliary complications: A systematic review

引用

World Journal of Transplantation 2018年第6期8卷 220-231页

作者： Yuri L Boteon Amanda PcS Boteon Joseph Attard Lorraine Wallace Ricky H Bhogal simon c afford Liver Unit Queen Elizabeth Hospital University Hospitals Birmingham NHS Foundation Trust centre for Liver and Gastrointestinal Research Institute of Immunology and Immunotherapy College of Medical and Dental Sciences University of Birmingham National Institute for Health Research (NIHR) Birmingham Biomedical Research centre University of Birmingham and University Hospitals Birmingham NHS Foundation Trust

AIM To review the clinical impact of machine perfusion(MP) of the liver on biliary complications post-transplantation, particularly ischaemic-type biliary lesions(ITBL). METHODS This systematic review was performed in accordance with the Preferred Reporting Systematic Reviews and MetaAnalysis(PRISMA) protocol. The following databases were searched: PubMed, MEDLINE and Scopus. The keyword "liver transplantation" was used in combination with the free term "machine perfusion". clinical studies reporting results of transplantation of donor human livers following ex situ or in situ MP were analysed. Details relating to donor characteristics, recipients, technique of MP performed and post-operative biliary complications(ITBL, bile leak and anastomotic strictures) were critically *** Fifteen articles were considered to fit the criteria for this review. Ex situ normothermic MP was used in 6 studies, ex situ hypothermic MP in 5 studies and the other 4 studies investigated in situ normothermic regional perfusion(NRP) and controlled oxygenated rewarming. MP techniques which have per se the potential to alleviate ischaemia-reperfusion injury: Such as hypothermic MP and NRP, have also reported lower rates of ITBL. Other biliary complications, such as biliary leak and anastomotic biliary strictures, are reported with similar incidences with all MP techniques. There is currently less clinical evidence available to support normothermic MP as a mitigator of biliary complications following liver transplantation. On the other hand, restoration of organ to full metabolism during normothermic MP allows assessment of hepatobiliary function before transplantation, although universally accepted criteria have yet to be *** MP of the liver has the potential to have a positive impact on post-transplant biliary complications, specifically ITBL, and expand extended criteria donor livers utilisation.

关键词： Liver transplantation Ex situ machine perfusion of the liver Donation after circulatory death Non-anastomotic intra-hepatic stricture Ischemic-type biliary lesions Extended criteria donors

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Data-driven diagnosis of high temperature PEM fuel cells based on the electrochemical impedance spectroscopy: Robustness improvement and evaluation

引用

Journal of Energy chemistry 2024年第9期96卷 544-558页

作者： Dan Yu Xingjun Li Samuel simon Araya simon Lennart Sahlin Vincenzo Liso Department of Energy Aalborg UniversityAalborg 9220Denmark Walker Department of Mechanical Engineering The University of Texas at AustinAustinTX 78712USA Materials Research and Technology Development Luxembourg Institute of Science and Technology(LIST)4422 BelvauxLuxembourg

Utilizing machine learning techniques for data-driven diagnosis of high temperature PEM fuel cells is beneficial and meaningful to the system durability. Nevertheless, ensuring the robustness of diagnosis remains a critical and challenging task in real application. To enhance the robustness of diagnosis and achieve a more thorough evaluation of diagnostic performance, a robust diagnostic procedure based on electrochemical impedance spectroscopy (EIS) and a new method for evaluation of the diagnosis robustness was proposed and investigated in this work. To improve the diagnosis robustness: (1) the degradation mechanism of different faults in the high temperature PEM fuel cell was first analyzed via the distribution of relaxation time of EIS to determine the equivalent circuit model (EcM) with better interpretability, simplicity and accuracy;(2) the feature extraction was implemented on the identified parameters of the EcM and extra attention was paid to distinguishing between the long-term normal degradation and other faults;(3) a Siamese Network was adopted to get features with higher robustness in a new embedding. The diagnosis was conducted using 6 classic classification algorithms—support vector machine (SVM), K-nearest neighbor (KNN), logistic regression (LR), decision tree (DT), random forest (RF), and Naive Bayes employing a dataset comprising a total of 1935 collected EIS. To evaluate the robustness of trained models: (1) different levels of errors were added to the features for performance evaluation;(2) a robustness coefficient (Roubust_c) was defined for a quantified and explicit evaluation of the diagnosis robustness. The diagnostic models employing the proposed feature extraction method can not only achieve the higher performance of around 100% but also higher robustness for diagnosis models. Despite the initial performance being similar, the KNN demonstrated a superior robustness after feature selection and re-embedding by triplet-loss method, which sug

关键词： PEM fuel cell Data-driven diagnosis Robustness improvement and evaluation Electrochemical impedance spectroscopy

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Experimental and Numerical Analysis of a PcM-Integrated Roof for Higher Thermal Performance of Buildings

引用

Journal of Thermal Science 2024年第2期33卷 522-536页

作者： simon François RUIZ-VALERO Letzai GIRARD Aymeric GALLEGUILLOS Hector centro de Desarrollo Urbano Sustentable(cEDEUS) Pontificia Universidad Católica de Chile7500000SantiagoChile Facultad de ciencias e Ingeniería Pontificia Universidad Católica Madre y Maestra(PUCMM)10103Santo DomingoDominican Republic LMGc IMT Mines AlesUniv MontpellierCNRS30100AlèsFrance Facultad de Ingeniería y ciencias Universidad Adolfo Ibañez2520000Viña del MarChile centro de Desarrollo Energético Antofagasta(cDEA) Universidad de Antofagasta1240000AntofagastaChile

Phase change materials(PcMs) designate materials able to store latent *** change state from solid to liquid over a defined temperature *** process is reversible and can be used for thermo-technical *** present paper aims to study the thermal performance of an inorganic eutectic PcM integrated into the rooftop slab of a test room and analyze its potential for building thermal *** experiment is conducted in two test rooms in Antofagasta(chile) during summer,fall,and *** PcM is integrated into the rooftop of the first test room,while the roof panel of the second room is a sealed air *** work introduces a numerical model,which is built using the finite difference method and used to simulate the rooms' thermal *** thermal simulations of the PcM room are performed for other chilean locations to evaluate and compare the capability of the PcM panel to store latent heat thermal energy in different *** show that the indoor temperature of the PcM room in Antofagasta varies only 21.1℃±10.6℃,while the one of the air-panel room varies 28.3℃±18.5℃.Under the experiment's conditions,the PcM room's indoor temperature observes smoother diurnal fluctuations,with lower maximum and higher minimum indoor temperatures than that of the air-panel *** simulations in other cities show that the PcM panel has a better thermal performance during winter,as it helps to maintain or increase the room temperature by some degrees to reach comfort *** demonstrates that the implementation of such PcM in the building envelope can effectively reduce space heating and cooling needs,and improve indoor thermal comfort in different climates of chile.

关键词： phase change material thermal energy storage building space heating and cooling energy efficiency designbuilder

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Exploring a New Lifetime Distribution for Modelling the Waiting Time of Bank customers

引用

Journal of Applied Mathematics and Physics 2024年第1期12卷 194-209页

作者： simon A. Ogumeyo Jacob c. Ehiwario Festus c. Opone Department of Mathematics Delta State University of Science and Technology Ozoro Nigeria Department of Statistics University of Delta Agbor Nigeria Department of Statistics Delta State University of Science and Technology Ozoro Nigeria

The fitting of lifetime distribution in real-life data has been studied in various fields of research. With the theory of evolution still applicable, more complex data from real-world scenarios will continue to emerge. Despite this, many researchers have made commendable efforts to develop new lifetime distributions that can fit this complex data. In this paper, we utilized the KM-transformation technique to increase the flexibility of the power Lindley distribution, resulting in the Kavya-Manoharan Power Lindley (KMPL) distribution. We study the mathematical treatments of the KMPL distribution in detail and adapt the widely used method of maximum likelihood to estimate the unknown parameters of the KMPL distribution. We carry out a Monte carlo simulation study to investigate the performance of the Maximum Likelihood Estimates (MLEs) of the parameters of the KMPL distribution. To demonstrate the effectiveness of the KMPL distribution for data fitting, we use a real dataset comprising the waiting time of 100 bank customers. We compare the KMPL distribution with other models that are extensions of the power Lindley distribution. Based on some statistical model selection criteria, the summary results of the analysis were in favor of the KMPL distribution. We further investigate the density fit and probability-probability (p-p) plots to validate the superiority of the KMPL distribution over the competing distributions for fitting the waiting time dataset.

关键词： KM-Transformation Power Lindley Distribution Data Fitting Moments Quantiles

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Predictors of survival in autoimmune liver disease overlap syndromes

引用

World Journal of Hepatology 2024年第9期16卷 1269-1277页

作者： Dujinthan Jayabalan Yi Huang Luis calzadilla-Bertot Malik Janjua Bastiaan de Boer John Joseph Wendy cheng simon Hazeldine Briohny W Smith Gerry c MacQuillan Michael c Wallace George Garas Leon A Adams Gary P Jeffrey Medical School University of Western AustraliaNed-lands 6009Western AustraliaAustralia Department of Hepatology Sir Charles Gairdner HospitalNedlands 6009Western AustraliaAustralia Department of Anatomical Pathology PathWest Laboratory MedicineNedlands 6009Western AustraliaAustralia Department of Gastroenterology and Hepatology Royal Perth HospitalPerth 6000Western AustraliaAustralia Department of Gastroenterology and Hepatology Fiona Stanley HospitalMurdoch 6150Western AustraliaAustralia Medical School University of Western AustraliaNedl-ands 6009Western AustraliaAustralia

BAcKGROUND Survival in patients with autoimmune liver disease overlap syndromes(AILDOS)compared to those with single autoimmune liver disease is *** To investigate the survival of patients with AILDOS and assess the accuracy of non-invasive serum models for predicting liver-related *** Patients with AILDOS were defined as either autoimmune hepatitis and primary biliary cholangitis overlap(AIH-PBc)or autoimmune hepatitis and primary sclerosing cholangitis overlap(AIH-PSc)and were identified from three tertiary centres for this cohort ***-related death or transplantation(liver-related mortality)was determined using a population-based data linkage *** scores for liver-related death were compared for accuracy[including liver outcome score(LOS),Hepascore,Mayo Score,model for end-stage liver disease(MELD)score and MELD incorporated with serum sodium(MELD-Na)score].RESULTS Twenty-two AILDOS patients were followed for a median of 3.1 years(range,0.35-7.7).Fourteen were female,the median age was 46.7 years(range,17.8 to 82.1)and median Hepascore was 1(range,0.07-1).At five years post enrolment,57%of patients remained free from liver-related mortality(74%AIH-PBc,27%AIH-PSc).There was no significant difference in survival between AIH-PBc and *** was a significant predictor of liver-related mortality(Pc(n=14)but not AIH-PSc(n=8).A LOS cut-point of 6 discriminated liver-related mortality in AIH-PBc patients(P=0.012,log-rank test,100%sensitivity,77.8%specificity)(Harrell's c-statistic 0.867).The MELD score,MELD-Na score and Mayo Score were not predictive of liver-related mortality in any *** Survival in the rare,AILDOS is *** current study supports the LOS as a predictor of liver-related mortality in AIH-PBc *** trials investigating predictors of survival in AILDOS are required.

关键词： Autoimmune liver disease overlap syndromes Liver outcome score Liver-related death Hepascore Autoimmune hepatitis Primary biliary cholangitis Primary sclerosing cholangitis

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Rekindling *** cooperation

引用

Beijing Review 2024年第38期67卷 22-23页

作者： Denis simon The Institute for china-America Studies in Washington D.C

chinese President Xi Jinping's recent reply to a letter from Lamont Repollet,/President of Kean University in New Jersey,the U.S.,could not have occurred at a more opportune *** against the backdrop of the 50,000-student initiative announced by President Xi during a visit to the United States in November 2023,the letter emphasized the importance of educational exchanges in building positive bilateral relations,and called on universities in both countries to strengthen cooperation in pursuing ***.

关键词： U.S. letter universities

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Evaluation of ruminal methane and ammonia formation and microbiota composition as affected by supplements based on mixtures of tannins and essential oils using Rusitec

引用

Journal of Animal Science and Biotechnology 2024年第4期15卷 1607-1622页

作者： Giulia Foggi Melissa Terranova Matteo Daghio Sergej L.Amelchanka Giuseppe conte simon Ineichen Monica Agnolucci carlo Viti Alberto Mantino Arianna Buccioni Michael Kreuzer Marcello Mele Department of Agriculture Food and Environment(DAFE)University of Pisa56124 PisaItaly AgroVet‑Strickhof ETH ZurichLindauSwitzerland Department of Agriculture FoodEnvironment and ForestryUniversity of FlorenceFlorence 50144Italy centro Di Ricerche Agro‑Ambientali“E.Avanzi” University of PisaPisa 56122Italy School of Agricultural Forest and Food Sciences HAFLBern University of Applied SciencesZollikofenSwitzerland Institute of Agricultural Sciences ETH ZurichLindauSwitzerland

Background Dietary supplements based on tannin extracts or essential oil compounds(EOc)have been repeatedly reported as a promising feeding strategy to reduce the environmental impact of ruminant husbandry.A previous batch culture screening of various supplements identified selected mixtures with an enhanced potential to mitigate ruminal methane and ammonia *** these,Q-2(named after quebracho extract and EOc blend 2,composed of carvacrol,thymol,and eugenol)and c-10(chestnut extract and EOc blend 10,consisting of oregano and thyme essential oils and limonene)have been investigated in detail in the present study with the semi-continuous rumen simulation technique(Rusitec)in three independent *** this purpose,Q-2 and c-10,dosed according to the previous study,were compared with a non-supplemented diet(negative control,Nc)and with one supplemented with the commercial EOc-based Agolin^(R) Ruminant(positive control,Pc).Results From d 5 to 10 of fermentation incubation liquid was collected and analysed for pH,ammonia,protozoa count,and gas *** residues were collected for the determination of ruminal *** d 10,samples of incubation liquid were also characterised for bacterial,archaeal and fungal communities by high-throughput sequencing of 16S rRNA and 26S ribosomal large subunit gene *** of the duration of the fermentation period,Q-2 and c-10 were similarly efficient as Pc in mitigating either ammonia(-37%by Q-2,-34%by Pc)or methane formation(-12%by c-10,-12%by Pc).The Pc was also responsible for lower feed degradability and bacterial and fungal richness,whereas Q-2 and c-10 effects,particularly on microbiome diversities,were limited compared to *** All additives showed the potential to mitigate methane or ammonia formation,or both,in vitro over a period of 10 ***,several differences occurred between Pc and Q-2/c-10,indicating different mechanisms of *** pronounced defaunation caused by Pc a

关键词： Additive Bacteria continuous culture Degradability Fermentation Fungi Greenhouse gas In vitro Microbiome Rumen

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

A system-on-chip microwave photonic processor solves dynamic RF interference in real time with picosecond latency

引用

Light(Science & Applications) 2024年第1期13卷 91-102页

作者： Weipeng Zhang Joshua c.Lederman Thomas Ferreira de Lima Jiawei Zhang simon Bilodeau Leila Hudson Alexander Tait Bhavin J.Shastri Paul R.Prucnal Department of Electrical and computer Engineering Princeton UniversityPrinceton08544NJUSA NEc Laboratories America Princeton08540NJUSA Department of Electrical and computer Engineering Queen’s UniversityKingstonK7L 3N6OntarioCanada Department of Physics Engineering Physics and AstronomyQueen’s UniversityKingstonK7L 3N6OntarioCanada

Radio-frequency interference is a growing concern as wireless technology advances,with potentially life-threatening consequences like interference between radar altimeters and 5 G cellular *** transceivers mix signals with varying ratios over time,posing challenges for conventional digital signal processing(DSP)due to its high *** challenges will worsen as future wireless technologies adopt higher carrier frequencies and data ***,conventional DSPs,already on the brink of their clock frequency limit,are expected to offer only marginal speed *** paper introduces a photonic processor to address dynamic interference through blind source separation(BSS).Our system-on-chip processor employs a fully integrated photonic signal pathway in the analogue domain,enabling rapid demixing of received mixtures and recovering the signal-of-interest in under 15 *** reduction in latency surpasses electronic counterparts by more than three orders of *** complement the photonic processor,electronic peripherals based on field-programmable gate array(FPGA)assess the effectiveness of demixing and continuously update demixing weights at a rate of up to 305 *** compact setup features precise dithering weight control,impedance-controlled circuit board and optical fibre packaging,suitable for handheld and mobile *** experimentally demonstrate the processor’s ability to suppress transmission errors and maintain signal-to-noise ratios in two scenarios,radar altimeters and mobile *** work pioneers the real-time adaptability of integrated silicon photonics,enabling online learning and weight adjustments,and showcasing practical operational applications for photonic processing.

关键词： processor mixing dynamic

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：