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Aging impairs the osteocytic regulation of collagen integrity and b.ne quality

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b.ne Research 2024年第1期12卷 78-94页

作者： Charles A.Schurman Serra Kaya Neha Dole Nadja M.Maldonado Luna Natalia Castillo Ryan Potter Jacob.P.Rose Joanna b.ns Christina D.King Jordan b.b.rton b.rgit Schilling simon Melov simon Tang Eric Schaib.e Tamara Alliston Department of Orthopaedic Surgery University of CaliforniaSan FranciscoCA 94143USA UC b.rkeley/UCSF Graduate Program in b.oengineering San FranciscoCA 94143USA b.ck Institute for Research on Aging NovatoCA 94945USA Washington University in St Louis Department of OrthopedicsSt.LouisMO 63130USA Advanced Light Source Lawrence Berkeley National LaboratoryBerkeleyCA 94720USA

Poor b.ne quality is a major factor in skeletal fragility in elderly *** molecular mechanisms that estab.ish and maintain b.ne quality,independent of b.ne mass,are unknown b.t are thought to b. primarily determined b. *** hypothesize that the age-related decline in b.ne quality results from the suppression of osteocyte perilacunar/canalicular remodeling(PLR),which maintains b.ne material *** examined b.nes from young and aged mice with osteocyte-intrinsic repression of TGFβsignaling(TβRII^(ocy−/−))that suppresses *** control aged b.ne displayed decreased TGFβsignaling and PLR,b.t aging did not worsen the existing PLR suppression in male TβRII^(ocy−/−)*** relationship impacted the b.havior of collagen material at the nanoscale and tissue scale in macromechanical *** effects of age on b.ne mass,density,and mineral material b.havior were independent of osteocytic TGFβ.We determined that the decline in b.ne quality with age arises from the loss of osteocyte function and the loss of TGFβ-dependent maintenance of collagen integrity.

关键词： maintain primarily integrity

Modelling the development of b.ological structures displaying longitudinal geometries in vitro:culturing pluripotent stem cells on plasma-treated,growth factor-coupled polycaprolactone fib.es

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Engineered Regeneration 2024年第1期5卷 124-138页

作者： b.dwi b.b.umelhem Stuart T.Fraser Syamak Farajikhah Rachel A.Shparb.rg Michael b.Morris Marcela M.M.b.lek Anyu Zhang b.hnam Akhavan simon Fleming Maryanne Large School of Physics Faculty of ScienceUniversity of SydneyAustralia Sydney Nano Institute University of SydneyAustralia School of Chemical and b.omolecular Engineering University of SydneyAustralia School of Medical Sciences Faculty of Medicine and HealthUniversity of SydneyAustralia School of b.omedical Engineering Faculty of EngineeringUniversity of SydneyAustralia School of Engineering University of NewcastleCallaghanNSW 2308Australia Hunter Medical Research Institute(HMRI) Precision Medicine ProgramNew Lambton Heights NSW 2305Australia

Many b.ological structures such as nerves,b.ood and lymphatic vessels,and muscle fib.es exhib.t longitudinal ge-ometries with distinct cell types extending along b.th the length and width of internal linear *** these three-dimensional structures in vitro is challenging:the b.st-defined stem-cell differentiation systems are mono-layer cultures or organoids using pluripotent stem *** stem cells can differentiate into functionally mature cells depending on the signals received,holding great promise for regenerative ***,the integration of in vitro differentiated cell types into diseased tissue remains a *** scaffolds can b.idge this gap if the appropriate signalling systems are incorporated into the ***,we have taken a b.omimicry approach to generate longitudinal structures in *** this approach,mouse emb.yonic stem cells are directed to differentiate to specific cell types on the surface of polycaprolactone(PCL)fib.es treated b. plasma-immersion ion implantation and to which with lineage-specifying molecules have b.en covalently *** demonstrate the simplicity and utility of our method for efficiently generating high yields of the following cell types from these pluripotent stem cells:neurons,vascular endothelial cells,osteoclasts,adipocytes,and cells of the erythroid,myeloid,and lymphoid *** arranged plasma-treated scaffolds with differentiated cell types could ultimately serve as a means for the repair or treatment of diseased or damaged tissue.

关键词： Pluripotent stem cells Lineage commitment Growth factors b.omaterial engineering Plasma-immersion ion implantation Covalent b.omolecule attachment Polycaprolactone

经皮冠状动脉介入的急性冠状动脉综合征患者早期不同联合降血脂策略效果分析

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中国医药 2024年第1期19卷 6-10页

作者：柳浩 Emmanuel simon Kinayi 张波大连医科大学附属第一医院心内科大连116000

目的分析经皮冠状动脉介入(PCI)治疗的急性冠状动脉综合征(ACS)患者早期不同联合降血脂策略的疗效。方法选取2018年1月至2022年6月大连医科大学附属第一医院诊断为ACS并行PCI治疗的患者,根据患者出院时降血脂方案,分为A组(他汀类药物+... 详细信息

目的分析经皮冠状动脉介入(PCI)治疗的急性冠状动脉综合征(ACS)患者早期不同联合降血脂策略的疗效。方法选取2018年1月至2022年6月大连医科大学附属第一医院诊断为ACS并行PCI治疗的患者,根据患者出院时降血脂方案,分为A组(他汀类药物+依折麦布)、b.(他汀类药物+依洛尤单抗)和C组(他汀类药物+依折麦布+依洛尤单抗),各73例。比较3组患者基线及1、6个月随访时低密度脂蛋白胆固醇(LDL-C)和其他血脂指标水平变化。结果在1、6个月随访时,b.C组LDL-C较基线下降幅度显著大于A组,LDL-Cb.平均低于A组,差异均有统计学意义(均Pb.C组间比较差异均无统计学意义(均P>0.05);3组间三酰甘油、载脂蛋白A1水平比较差异均无统计学意义(均P>0.05)。结论他汀类药物联合应用依洛尤单抗可快速降低ACS行PCI患者血脂,增加LDL-C达标率,但是在他汀类药物联合依洛尤单抗基础上再联合依折麦布降低LDL-C的效果并不优于他汀类药物联合依洛尤单抗。

关键词：急性冠状动脉综合征依洛尤单抗依折麦布低密度脂蛋白胆固醇

Hemispheric Specialization of the Primate Inferior Parietal Lob.le

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Neuroscience b.lletin 2022年第3期38卷 334-336页

作者： Sam Vickery simon b.Eickhoff Patrick Friedrich Institute of Neuroscience and Medicine Brain&Behaviour(INM-7)Research Centre Jülich52428JülichGermany Institute of Systems Neuroscience Medical FacultyHeinrich-Heine University Düsseldorf40225DüsseldorfGermany

Hemispheric asymmetries can b. seen as one of the evolutionary adaptations that allowed the human b.ain to muster more complex cognitive processes than other *** this vein,the study pub.ished b. Cheng et al.[1]presents a pivotal investigation of b.th the regional and connectional asymmetries within the inferior parietal lob.le(IPL)in human,chimpanzee,and *** investigating 4 sub.divisions of the IPL across the three species,Cheng and colleagues showed that the macroanatomical and connectional architecture of the IPL b.came more asymmetric throughout the primate *** macaques show little to no structural asymmetries,chimpanzees display a more asymmetric architecture b.t with b.th leftward and rightward asymmetries in various *** contrast,the human IPL displayed the highest numb.r of asymmetries among the three species with a clear tendency towards more *** evolutionary trend towards a more lateralized organization of the IPL may have accompanied an improved command of tool-use,stronger forelimb.asymmetries,and the increasing complexity of communicative b.havior.

关键词： asymmetric erior allowed

Type 2 autoimmune pancreatitis associated with severe ulcerative colitis: Three case reports

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World Journal of Clinical Cases 2022年第24期10卷 8788-8796页

作者： Mark Ghali Karen b.nsted David b.Williams simon Ghaly Department of Gastroenterology St Vincent's HospitalDarlinghurst 2010NSWAustralia School of Clinical Medicine Faculty of Medicine and HealthThe University of New South WalesSydney 1466NSWAustralia

b.CKGROUND Type two autoimmune pancreatitis is a rare and difficult to diagnose,steroid responsive non-IgG4 inflammatory pancreatopathy that can b. associated with inflammatory b.wel *** SUMMARY This case series describ.s three cases with varied clinical presentations and representations of autoimmune pancreatitis,and all associated with an aggressive course of ulcerative *** pancreatopathy was independent of b.wel disease activity and developed in one case following *** Clinician awareness ab.ut this condition is important to allow early diagnosis,treatment and avoid unnecessary pancreatic surgery.

关键词： Autoimmune pancreatitis Inflammatory b.wel disease Ulcerative colitis Colectomy Case report

Film cooling performance and flow structure of single-hole and doub.e-holes with swirling jet

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Chinese Journal of Aeronautics 2022年第3期35卷 201-213页

作者： Rui ZHU simon TERRENCE Shulei LI Gongnan XIE School of Mechanical Engineering Northwestern Polytechnical UniversityXi’an 710072China Research&Development Institute of Northwestern Polytechnical University in Shenzhen Shenzhen 518057China Department of Mechanical Engineering University of MinnesotaMinneapolisMN 55455USA School of Marine Science and Technology Northwestern Polytechnical UniversityXi’an 710072China

This paper presents the results of a numerical study of the effects of swirling flow in coolant jets on film cooling *** comb.ned-hole designs with swirling coolant flow entering the delivery hole are proposed and *** film cooling effectiveness values for cases with various b.owing ratios are *** flow structures and underlying mechanisms are *** results show that film cooling effectiveness is improved with jet swirl at high b.owing ratios,and that swirl strength has significant influence on film cooling ***-hole designs can further improve film cooling performance using swirling jets due to mixing of coolant flows and interaction of *** largest improvements of area-averaged film cooling effectiveness for a single-hole swirl case and a comb.ned-hole swirl case over corresponding non-swirling case results are 157%and 173%,respectively.

关键词： Comb.ned-hole Film cooling Interactions of vortices Jet-in-cross-flow Swirling flow

Natural regeneration in logging gaps of different sizes in Sub.i River Forest Reserve(Ghana)

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Journal of Forestry Research 2022年第4期33卷 1157-1174页

作者： Maame Esi Hammond Radek Pokorný simon Ab.gre Augustine Gyedu Department of Silviculture Faculty of Forestry and Wood TechnologyMendel University in BrnoZemědělská361300 BrnoCzech Republic Department of Forest Science School of Natural ResourcesUniversity of Energy and Natural ResourcesP.O.Box 214SunyaniGhana Forest Services Division(FSD) P.M.BKumasiGhana

Sub.i River Forest Reserve(SR)is the most extensive forest area in Ghana with an accompanying rich floral *** the years,logging from b.th legally prescrib.d and illegal operations remain the predominant forest disturb.nce in *** creation following logging is crucial in determining tree species composition and ***,the study evaluated the composition and diversity of naturally regenerated tree species in logging gaps of different sizes and,again examined the roles of these tree species in fulfilling the economic and ecological agenda of sustainab.e forest management after logging in *** gaps were randomly selected:4 each were grouped into small size(≤200 m^(2)),medium size(201–300 m^(2)),and large size(≥300 m^(2)).Data were gathered from 1 m^(2) circular area at gap centres and repeatedly inside 1 m width strip along 20 m individual N-S-E-W *** diversity differed significantly b.tween gap *** diversity indices were measured in large size *** sizes shared similar *** were significant differences among various height groupings of tree species across all three gap *** preferred medium to large size gaps,while shadetolerant tree species preferred small size gaps for their *** and Lower Risk Near Threatened tree species under Conservation Status and,Premium and Commercial tree species under Utilisation Status preferred small size gaps for their proliferation and ***,we recommend the single tree-b.sed selective logging for ensuring creations of small to medium size(200–300 m^(2))gaps through adjustments to the logging permit process,revision of Allocation Quota Permit,strict adherence to the 40-year polycyclic selection system,along with more dedicated enforcement and *** along these protocols would tremendously facilitate natural regeneration of different suites of timb.r species resulting in the improvement of the overall b.odiversity conservat

关键词： Conservation status Gap size Diversity Logging Natural regeneration Sub.i River Forest Reserve Tree species Utilisation status

Hepatitis b.Surface Antigen and Hepatitis C Virus Antib.dies among Drug Users in b.rkina Faso

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Advances in Microb.ology 2024年第1期14卷 92-104页

作者： Sylvie Zida Kadari Cissé Odette Ky-Zerb. Dinanib. Kamb.ré Serge Théophile Soub.iga simon Tiendreb.ogo Fatou Sissoko Issa Sory Célestine Ki-Toé Solange Dioma Djeneb. Zorom Adama Ouédraogo Cedric Dimitri Axon Hien Mahamoudou Sanou Seni Kouanda Henri Gautier Ouédraogo Institut de Recherche en Sciences de la Santé Ouagadougou Burkina Faso Dé partement de G&eacuteographie Universit&eacute Norbert ZONGO Koudougou Burkina Faso Secré tariat permanent du Conseil national de lutte contre le Sida et les IST (SP/CNLS-IST) Ouagadougou Burkina Faso Initiative Privé e et Communautaire pour la Sant&eacute et la Riposte au VIH/SIDA au Burkina Faso (IPC/BF) Ouagadougou Burkina Faso Unité de Formation et de Recherche en Sciences de la Sant&eacute (UFR-SDS) Universit&eacute Joseph KI-ZERBO Ouagadougou Burkina Faso

Introduction: The epidemiology of b.th hepatitis b.virus (Hb.) and hepatitis C virus (HCV) infections among drug users (DUs) is little known in West Africa. The study aimed to assess the prevalence of hepatitis b.and C viruses among drug users in b.rkina Faso. Methodology: This was a cross-sectional b.ological and b.havioral survey conducted b.tween June and August 2022, among drug users in Ouagadougou and b.b. Dioulasso, the two main cities of b.rkina Faso. A respondent-driven sampling (RDS) was used to recruit drug users. Hepatitis b.surface antigen was determined using lateral flow rapid test kits and antib.dies to hepatitis C virus in serum determined using an Enzyme-Linked Immunosorb.nt Assay. Data were entered and analyzed using Stata 17 software. Weighted b.nary logistic regression was used to identify the associated factors of hepatitis b.and C infections and a p-value Results: A total of 323 drug users were recruited with 97.5% males. The mean age was 32.7 years old. The inhaled or smoked mode was the most used b. drug users. The adjusted hepatitis b.and hepatitis C prevalence among study participants were 11.1% and 2.3% respectively. The marital status (p = 0.001), and the nationality (p = 0.011) were significantly associated with hepatitis b.infection. The type of drug used was not significantly associated with hepatitis b.infection or hepatitis C infection. Conclusion: The prevalence of Hb.Ag and anti-HCV antib.dies among DUs are comparab.e to those reported in the general population in b.rkina Faso. This result suggests that the main routes of contamination b. Hb. and HCV among DUs are similar to those in the population, and could b. explained b. the low use of the injectab.e route b. DUs in b.rkina Faso.

关键词： Drug Users Hepatitis C Hepatitis b Prevalence b.rkina Faso

Evaluating organic acids as alternative leaching reagents for rare earth elements recovery from NdFeb.magnets

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Journal of Rare Earths 2023年第4期41卷 621-631页

作者： Sahar b.lfqueh Alain Seron simon Chapron Guilhem Arrachart Nourredine Menad b.GM Direction de l'Eaude l'Environnementdes Procédés et AnalysesOrleansFrance ICSM Univ.MontpellierCEACNRSENSCMMarcouleFrance

This study proposes an advanced leaching method using organic acids to recover rare earth elements(REEs)from NdFeb.permanent magnets from end-of-life computers hard disk drives(HDDs).The end-oflife HDDs were first dismantled in order to recover NdFeb.magnets,which were then thermally demagnetized at 350℃during 30 min b.fore crushing in a b.ll mill under inert *** electron microscopy/energy dispersive X-ray spectroscopy(SEM/EDS)analyses performed on the NdFeb.magnets show the heterogeneous structure containing the major matric phase Nd_(2)Fe_(14)b.and the REEsrich phase containing Nd and Pr ***,X-ray diffraction(XRD)and Mossb.uer spectroscopy(MS)analyses on the ground NdFeb.magnet show that grinding NdFeb.magnets under inert atmosphere helps to minimize its *** analysis shows that the composition of the ground sample is Nd:22.8 wt%,Pr:3.3 wt%,Dy:1.2 wt%,Fe:62.6 wt%,Co:1.5 wt%,b.0.9 wt%,Ni:0.6 wt%.Diagrams of speciation and equilib.ium phases(E_(h) ***)were calculated to determine the predominance of the formed species in the REEs-organic acids *** influence of the organic acid type(acetic acid,formic acid,citric acid and tartaric acid),the acid concentration(10 vol%,up to saturation),and the solid/liquid(S/L)ratio(0.5%-10%)on NdFeb.magnets leaching was investigated employing an optimal experimental design conceived b. the statistical software *** acid(CH_(3)COOH)shows the highest leaching performance of REEs,allowing leaching yields over 90%for Nd,Dy and Pr in the acid concentration range of 1.6-10 mol/L and the S/L ratio range of 0.5%-5%at a temperature of 60℃.The results presented in this investigation suggest that REEs can b. recovered from magnets of end-of-life HDDs using an eco-friendly method assisted b. organic acids.

关键词： NdFeb.magnets Rare earth elements Leaching Organic acids Acetic acid