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Serum Levels of Prostate Specific Antigen Parameters among Male Patients with Lepromatous Leprosy in Edo State, Nigeria

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Health 2021年第9期13卷 920-933页

作者： Babatunde Ishola Gabriel Adejumo David Osebhor Uchechukwu Dimkpa Usman Itakure Abdulkadir Oladimeji Nasiru Abdulrahman uzor simon Kelechi Ncheta Nkwazema Noreen Ebelechukwu Agbapuonwu Grace Umahi-Ottah Medical Laboratory Science Department University of Benin Benin City Nigeria Physiology Department Nnewi Campus Nnamdi Azikiwe University Awka Nigeria Department of Medical Laboratory Science College of Health Sciences and Technology Markafi Kaduna State Nigeria Department of Medical Laboratory Science College of Health Technology Offa Kwara State Department of Applied Science Faculty of Health and Applied Sciences University of West of England Bristol UK Medical Laboratory Science Department National Ear Care Centre Kaduna Kaduna State Nigeria Department of Nursing Nnamdi Azikwe University Akwa Nigeria Department of Physiology Ebonyi State University Abakaliki Nigeria

Aim: This study is aimed at determining the total PSA (tPSA), free PSA (fPSA) concentrations and free to total PSA ratio (f/tPSA) and their utility in prostate cancer (PCa) risk stratification among male lepromatous leprosy patients in Edo state, Nigeria. Methods: Forty participants and thirty controls participated in this study. A structured questionnaire was administered to each participant to elicit details such as their personal data, age, sex, residence, medications, alcohol consumption, smoking habit, length of time of diagnosis, sexual activities, as well as the history of any other underlying diseases. Blood samples were collected from the participants. Total and free PSA concentrations in the samples were measured using ELISA method. Results: Significantly (p = 0.042) higher serum fPSA among the leprosy patients (0.22 ± 0.12 ng/ml) compared with the healthy controls (0.17 ± 0.09 ng/ml). There were no significant (p = 0.055) difference in the mean tPSA between the leprosy patients (2.69 ± 2.25 ng/ml) compared with the control (1.95 ± 0.69 ng/ml). Similarly, no significant (p = 0.548) difference was observed in PSA ratio between the control (0.08 ± 0.04) and the leprosy patients (0.09 ± 0.03). Conclusion: Our study indicated no significant differences in tPSA and f/tPSA between the leprosy patients and their healthy control. Elevated tPSA as well as f/tPSA levels that fell within the high risk zones of PCa were more prevalent among patients aged ≥ 70 years, not married, who rarely had sexual intercourse and those with longer disease duration.

关键词： Serum Prostate Cancer Total PSA Free PSA Male Leprosy

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Serum Levels of Reproductive Hormones and Their Relationship with Age in Men with Benign Prostatic Hyperplasia in Benin City, Edo State

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Health 2020年第9期12卷 1121-1131页

作者： Babatunde Ishola Gabriel Adejumo Omolei Lilian Williams Efosa Bolaji Odigie Ifeoma Gloria Unachukwu Oladimeji Nasiru Abdulrahman Uchechukwu Dimkpa simon uzor Oyarazi Margaret Adebowale Ojo Moses Oke Department of Medical Laboratory Science University of Benin Benin City Nigeria Department of Medical Laboratory Science College of Health Technology Offa Nigeria Department of Human Physiology Nnamdi Azikwe University Nnewi Campus Nnewi Nigeria Department of Applied Science Faculty of Health and Applied Sciences University of West of England Bristol UK Department of Virology/Immunology Federal School of Medical Laboratory Science Jos Nigeria Department of Medical Laboratory Science College of Health Technology Akure Nigeria

Background: Benign Prostatic Hyperplasia (BPH) is a common condition which occurs as men get older. Aim: We aimed at investigating the reproductive hormone profile of men with BPH and the relationship of these hormones with age. Methods: Twenty-nine men of age > 40 years were screened for prostate symptoms. The prostate examination included digital rectal examination and measurement of serum prostate-specific antigen levels. Demographic and clinical characteristics of subjects were obtained using a structured questionnaire. The serum levels of Testosterone (Te), Luteinizing hormone (LH), Follicle stimulating hormone (FSH) and Prolactin (PRL) were measured using ELISA method. Results: Our study indicated that age and levels of prostate specific antigen (PSA), LH and FSH were significantly (p Conclusion: This study suggests that the rise in serum levels of the hypothalamic-pituitary-testicular axis hormones in BPH patients as demonstrated by the present findings may be age-related since testicular dysfunction in aging men is associated with the decrease in androgen production which may stimulate an increased production of gonadotropins by negative feedback.

关键词： Hormones Age Men Prostate Hyperplasia

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Assessment of Risks of Cardiovascular Diseases among Leprosy Patients Settlement at Ossiomo-Ogan Rehabilitation Center, Edo State, Nigeria

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Health 2021年第12期13卷 1475-1487页

作者： Grace Umahi-Ottah Babatunde Ishola Gabriel Adejumo Laurel Imose Oyakhilome Uchechukwu Dimkpa simon uzor Oladimeji Nasiru Abdulrahman Noreen Ebelechukwu Agbapuonwu Onochie Anslem Ajugwo Musiliu Adewale Oyenike Department of Physiology Ebonyi State University Abakaliki Nigeria Department of Medical Laboratory Science University of Benin Benin City Nigeria Department of Physiology Nnewi Campus Nnamdi Azikiwe University Awka Nigeria Department of Applied Science Faculty of Health and Applied Sciences University of West of England Bristol UK Department of Medical Laboratory Science College of Health Technology Offa Kwara State Nigeria Department of Nursing Nnamdi Azikwe University Akwa Nigeria Department of Medical Laboratory Science Madonna University Elele Rivers State Nigeria Department of Medical Laboratory Science College of Health Sciences Ladoke Akintola University of Technology Ogbomoso Oyo State Nigeria

Background/Aim: Quality of life is reduced in people living with leprosy as a result of its impact on human activities. Lipid profile means pattern of lipids in the blood, which is routinely done to assess cardiovascular risk. The aim of this study is to assess the risk of cardiovascular diseases among the leprosy patients settlement at Ossiomo-Ogan, Edo state. Method: Blood samples were collected from a total number of one hundred and eight (108) (57 leprosy patients and 51 controls) subjects. The lipid profiles of the participants were determined using standard methods. Results: Significantly (p Conclusion: In this study, lipid profile levels of leprosy patients significantly increased despite moderate level of BMI. This study also showed significant positive correlation between the anthrogenic index of plasma and all the lipid profile. Many of the leprosy patients are not conscious of their diet which was tilted towards heavy carbohydrate and fatty meals. None of the participants is at high risk of cardiovascular diseases but the risk may increase with further elevation of the lipid profiles. Efforts should be made by all stakeholders to improve on the awareness of leprosy disease and encourage the sufferers to live decent lives.

关键词： Leprosy Cholesterol Triglycerides HDL LDL Edo State

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Reproductive Hormone Profiles and Their Relationships with Sexual Function in Patients with Prostate Cancer after Rapid Prostatectomy in Benin City

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Advances in Sexual Medicine 2020年第4期10卷 119-130页

作者： Babatunde Ishola Gabriel Adejumo Omolei Lilian Williams Efosa Bolaji Odigie Ifeoma Gloria Unachukwu Oladimeji Nasiru Abdulrahman Uchechukwu Dimkpa simon uzor Oyarazi Margaret Adebowale Ojo Moses Oke Department of Medical Laboratory Science University of Benin Benin Nigeria Department of Medical Laboratory Science College of Health Technology Ilorin Nigeria Department of Human Physiology Nnamdi Azikwe University Nnewi Campus Awka Nigeria Department of Applied Science Faculty of Health and Applied Sciences University of West of England Bristol UK Department of Virology/Immunology Federal School of Medical Laboratory Science Jos Nigeria Department of Medical Laboratory Science College of Health Technology Akure Nigeria

There are limited studies examining the relationship between serum reproductive hormone levels and sexual functions among prostate cancer (PCa) patients after rapid prostatectomy (RP). Aim: The present study aimed at evaluating the correlation between post-operative serum levels of some male reproductive hormones of PCa patients and their sexual functions in the months following RP. A total of 20 male patients with clinically localized PCa who had undergone RP within the last 12 months prior to commencement of the study, were invited to participate. The postoperative serum levels of their luteinizing hormone (LH), follicle stimulating hormone (FSH) and total testosterone (Te) were measured. They also completed a structured health and lifestyle questionnaire to obtain information on their demographic characteristics and detailed medical history. Our data indicated normal mean levels of post-operative Te (4.34 ± 4.38 ng/ml) in the patients following RP, while the mean levels of FSH (39.24 ± 34.12 miu/ml) and LH (21.67 ± 25.73 miu/ml) were on the increase and far above normal ranges for healthy men. Data indicated a significant positive correlation between Te and frequency of sexual intercourse (r = 508;p < 0.05), libido (r = 0.429;p <

关键词： Reproductive Hormone Sexual Function Prostate Cancer Rapid Prostatectomy

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The Effects of Cigarette Smoking on Serum Carboxyhemoglobin and Calcium Levels in Apparently Healthy Male Smokers in Benin City, Nigeria

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Journal of Biomedical Science and Engineering 2022年第1期15卷 26-35页

作者： Grace Umahi-Ottah Babatunde Ishola Gabriel Adejumo Elvis Osamede Godwins Uchechukwu Dimkpa simon uzor Usman Itakure Abdulkadir Oladimeji Nasiru Abdulrahman Noreen Ebelechukwu Agbapuonwu Onochie Anslem Ajugwo Musiliu Adewale Oyenike Department of Physiology Ebonyi State University Abakaliki Nigeria Department of Medical Laboratory Science University of Benin Benin City Nigeria Department of Physiology Nnewi Campus Nnamdi Azikiwe University Awka Nigeria Department of Applied Science Faculty of Health and Applied Sciences University of West of England Bristol UK Department of Medical Laboratory Science College of Health Sciences and Technology Markafi Nigeria Department of Medical Laboratory Science College of Health Technology Offa Nigeria Department of Nursing Nnamdi Azikwe University Akwa Nigeria Department of Medical Laboratory Science Madonna University Elele Nigeria Department of Medical Laboratory Science College of Health Sciences Ladoke Akintola University of Technology Ogbomoso Nigeria

The aim of this study is to determine the effects of cigarette smoking on carboxylhaemoglobin (COHb) and calcium levels in apparently healthy male cigarette smokers in Benin City, Nigeria. Thirty active cigarette smokers and thirty healthy, non-smokers within the same age range participated in this study. Serum COHb level was estimated using ELISA reagent from Calbiotech, USA, while calcium concentration was estimated spectrophotometrically with commercially purchased kit from Randox, UK. Results showed higher concentration of COHb but lower concentration of calcium level among the cigarette smokers when compared with the non-smokers. There were no statistically significant differences observed in COHb levels between smokers with regard to smoking duration (<5 yrs vs. ≥5 yrs;p = 0.893) and number of sticks of cigarette per day (<5 sticks/day vs. ≥5 sticks/day;p = 0.256). In contrast, significantly higher mean COHb level was found in subjects who smoked “always” compared with those who smoked “occasionally” (p = 0.04) and those who smoked “rarely” (p = 0.006). On the other hand, the smokers’ serum calcium level was not affected by smoking duration, frequency and number of sticks consumed. In conclusion, the present study confirms that cigarette smoking contributes to abnormally high COHb levels, which is associated with adverse health consequences from carbon-monoxide poisoning in the body. In addition, cigarette smoking may interfere with the mechanisms responsible for the absorption of calcium in the gastro-intestinal tract, thus leading to poor absorption as well as low levels of calcium in the body.

关键词： Carboxyhaemoglobin Calcium Smokers Nonsmokers Benin City

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The effect of age, gender, level of adiposity and diabetes duration on glycated hemoglobin reduction after anti-diabetic therapy in type-2 diabetic patients

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Journal of Diabetes Mellitus 2012年第2期2卷 245-250页

作者： Chinwe O. Ewenighi Uchechukwu Dimkpa Babatunde I. Adejumo Joel C. Onyeanusi Isaac N. Nnatuanya uzor simon Linus U. M. Onoh Uchechukwu Ezeugwu Department of Chemical Pathology/Toxicology Faculty of Medical Lab Sciences Elele Campus Madonna University Okija Nigeria Department of Community Medicine Enugu State University of Science and Technology Enugu Nigeria Department of Physiotherapy University of Nigeria Teaching Hospital Enugu Nigeria Medical Laboratory Science Department Ebonyi State University Abakaliki Nigeria Medical Laboratory Science Department University of Benin Benin City Nigeria Physiology Department Nnewi Campus Nnamdi Azikiwe University Enugu Nigeria

Background: It is established that glycemic control measures involving diet and oral medication reduce glycated hemoglobin concentration (HbA1c) in type-2 diabetic patients. Aim: We aimed to determine whether HbA1c reduction after diabetic treatment is affected by age, gender, level of adiposity and diabetes duration in type-2 diabetic patients. Methods: One hundred and four type-2 diabetic patients participated in a 20-week diabetic control therapy involving oral medication (metformin) and lifestyle intervention (diet). We compared the HbA1c reduction after treatment between the elderly and non-elderly;males and females;overweight/obese and non-overweight/obese;and long-standing and newly diagnosed patients. Results: After the treatment, participants had mean HbA1c reduction of 1.1 ± 1.31% and weight loss of 2.46 ± 1.79 kg. Forty-six (44.2%) of the patients had acceptable HbA1c level of p p p < 0.001), respectively. HbA1c reduction did not indicate significant sex differences. Conclusion: The present findings suggest that treatment criteria for type-2 diabetes should account for the age, level of adiposity and diabetes duration of the patient in order to make optimal therapeutic decisions for the treatment of diabetes mellitus in adults.

关键词： Glycated Hemoglobin Age Gender Adiposity Metformin Diet

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Data-driven diagnosis of high temperature PEM fuel cells based on the electrochemical impedance spectroscopy: Robustness improvement and evaluation

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Journal of Energy Chemistry 2024年第9期96卷 544-558页

作者： Dan Yu Xingjun Li Samuel simon Araya simon Lennart Sahlin Vincenzo Liso Department of Energy Aalborg UniversityAalborg 9220Denmark Walker Department of Mechanical Engineering The University of Texas at AustinAustinTX 78712USA Materials Research and Technology Development Luxembourg Institute of Science and Technology(LIST)4422 BelvauxLuxembourg

Utilizing machine learning techniques for data-driven diagnosis of high temperature PEM fuel cells is beneficial and meaningful to the system durability. Nevertheless, ensuring the robustness of diagnosis remains a critical and challenging task in real application. To enhance the robustness of diagnosis and achieve a more thorough evaluation of diagnostic performance, a robust diagnostic procedure based on electrochemical impedance spectroscopy (EIS) and a new method for evaluation of the diagnosis robustness was proposed and investigated in this work. To improve the diagnosis robustness: (1) the degradation mechanism of different faults in the high temperature PEM fuel cell was first analyzed via the distribution of relaxation time of EIS to determine the equivalent circuit model (ECM) with better interpretability, simplicity and accuracy;(2) the feature extraction was implemented on the identified parameters of the ECM and extra attention was paid to distinguishing between the long-term normal degradation and other faults;(3) a Siamese Network was adopted to get features with higher robustness in a new embedding. The diagnosis was conducted using 6 classic classification algorithms—support vector machine (SVM), K-nearest neighbor (KNN), logistic regression (LR), decision tree (DT), random forest (RF), and Naive Bayes employing a dataset comprising a total of 1935 collected EIS. To evaluate the robustness of trained models: (1) different levels of errors were added to the features for performance evaluation;(2) a robustness coefficient (Roubust_C) was defined for a quantified and explicit evaluation of the diagnosis robustness. The diagnostic models employing the proposed feature extraction method can not only achieve the higher performance of around 100% but also higher robustness for diagnosis models. Despite the initial performance being similar, the KNN demonstrated a superior robustness after feature selection and re-embedding by triplet-loss method, which sug

关键词： PEM fuel cell Data-driven diagnosis Robustness improvement and evaluation Electrochemical impedance spectroscopy

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In situ characterization of particle formation in spray flame synthesis using wide-angle light scattering

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Particuology 2024年第3期86卷 304-312页

作者： simon Aβmann Franz J.T.Huber Stefan Will Lehrstuhl für Technische Thermodynamik(LTT) Friedrich-Alexander-Universitat Erlangen-Nürnberg(FAU)Erlangen91058Germany Erlangen Graduate Schoolin Advanced Optical Technologies(SAOT) Friedrich-Alexander-Universitat Erlangen-Nurnberg(FAU)Erlangen91052Germany Competence Unit Engineering of Advanced Materials(EAM) Friedrich-Alexander-Universitat Erlangen-Nürnberg(FAU)Erlangen91052Germany

Wide-angle light scattering(WALS)was used for in situ measurements of droplet and nanoparticle size distributions during the synthesis of titania and iron oxide particles from liquid precursor solutions in the standardized SpraySyn burner for spray flame *** was synthesized from titanium tetraisopropoxide(TTIP)and iron oxide from iron(II)nitrate nonahydrate(INN)using ethanol(EtOH)as *** images were taken at heights up to 120 mm above the burner surface and classified into droplet and particle *** size distributions were derived from a sequential analysis of scattering data containing the oscillating Mie pattern,the lognormal size distribution parameters for spherical and fractal particle fractions from a multivariate approach on averaged particle scattering *** results show that the precursor addition leads to altered evaporation behavior and even droplet disruption probably induced by puffing or micro-explosions compared to pure *** the case of TTIP(a hygroscopic alkoxide),the synthesis of a large fraction of spheres was observed,while the nitrate INN leads to the formation of mostly fractal aggregates.

关键词： Spray flame synthesis Metal oxide particles Elastic light scattering Droplet size distribution Nanoparticle morphology Particle size distribution

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Towards Domain-agnostic Depth Completion

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Machine Intelligence Research 2024年第4期21卷 652-669页

作者： Guangkai Xu Wei Yin Jianming Zhang Oliver Wang simon Niklaus simon Chen Jia-Wang Bian Zhejiang University Hangzhou 310058China DaJiang Technology Shenzhen 518057China Adobe Research California 95110USA University of Oxford Oxford OX12JDUK

Existing depth completion methods are often targeted at a specific sparse depth type and generalize poorly across task *** present a method to complete sparse/semi-dense,noisy,and potentially low-resolution depth maps obtained by various range sensors,including those in modern mobile phones,or by multi-view reconstruction *** method leverages a data-driven prior in the form of a single image depth prediction network trained on large-scale datasets,the output of which is used as an input to our *** propose an effective training scheme where we simulate various sparsity patterns in typical task *** addition,we design two new benchmarks to evaluate the generalizability and robustness of depth completion *** simple method shows superior cross-domain generalization ability against state-of-the-art depth completion methods,introducing a practical solution to highqualitydepthcapture onamobile device.

关键词： Monocular depth estimation depth completion zero-shot generalization scene reconstruction neural network.

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Experimental and Numerical Analysis of a PCM-Integrated Roof for Higher Thermal Performance of Buildings

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Journal of Thermal Science 2024年第2期33卷 522-536页

作者： simon François RUIZ-VALERO Letzai GIRARD Aymeric GALLEGUILLOS Hector Centro de Desarrollo Urbano Sustentable(CEDEUS) Pontificia Universidad Católica de Chile7500000SantiagoChile Facultad de Ciencias e Ingeniería Pontificia Universidad Católica Madre y Maestra(PUCMM)10103Santo DomingoDominican Republic LMGC IMT Mines AlesUniv MontpellierCNRS30100AlèsFrance Facultad de Ingeniería y Ciencias Universidad Adolfo Ibañez2520000Viña del MarChile Centro de Desarrollo Energético Antofagasta(CDEA) Universidad de Antofagasta1240000AntofagastaChile

Phase change materials(PCMs) designate materials able to store latent *** change state from solid to liquid over a defined temperature *** process is reversible and can be used for thermo-technical *** present paper aims to study the thermal performance of an inorganic eutectic PCM integrated into the rooftop slab of a test room and analyze its potential for building thermal *** experiment is conducted in two test rooms in Antofagasta(Chile) during summer,fall,and *** PCM is integrated into the rooftop of the first test room,while the roof panel of the second room is a sealed air *** work introduces a numerical model,which is built using the finite difference method and used to simulate the rooms' thermal *** thermal simulations of the PCM room are performed for other Chilean locations to evaluate and compare the capability of the PCM panel to store latent heat thermal energy in different *** show that the indoor temperature of the PCM room in Antofagasta varies only 21.1℃±10.6℃,while the one of the air-panel room varies 28.3℃±18.5℃.Under the experiment's conditions,the PCM room's indoor temperature observes smoother diurnal fluctuations,with lower maximum and higher minimum indoor temperatures than that of the air-panel *** simulations in other cities show that the PCM panel has a better thermal performance during winter,as it helps to maintain or increase the room temperature by some degrees to reach comfort *** demonstrates that the implementation of such PCM in the building envelope can effectively reduce space heating and cooling needs,and improve indoor thermal comfort in different climates of Chile.

关键词： phase change material thermal energy storage building space heating and cooling energy efficiency designbuilder

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