检索结果-南通市图书馆

Use of testicular sperm in couples with SCSA-defined high sperm DNA fragmentation and failed intracytoplasmic sperm injection using ejaculated sperm

引用

Asian Journal of Andrology 2020年第4期22卷 348-353页

作者： Mohannad Alharbi Fadl Hamouche simon phillips Jacques Isaac Kadoch Armand Zini Division of Urology Department of SurgeryMcGill UniversityMontreal H4A3J1Canada Department of Urology College of MedicineQassim UniversityQassim 1162Saudi Arabia OVO Fertility Clinic Montreal H4P2S4Canada Department of Obstetrics and Gynecology University of MontrealMontreal H3C3J7Canada

Sperm DNA fragmentation(SDF)has been linked with male infertility,and previous studies suggest that SDF can have negative influence on pregnancy outcomes with assisted *** performed a retrospective review of consecutive couples with a high SDF level that had intracytoplasmic sperm injection(ICSI)using testicular sperm(T-ICSI).We compared the T-ICSI outcomes to that of two control groups:87 couples with failed first ICSI cycle and who had a second ICSI cycle using ejaculated sperm(Ej-ICSI),and 48 consecutive couples with high sperm chromatin structure assay(SCSA)-defined SDF(>15%)that underwent an ICSI cycle using ejaculated sperm after one or more failed ICSI cycles(Ej-ICSI-high SDF).The mean number of oocytes that were retrieved and the total number of embryos were not different among the three *** mean number of transferred embryos in the T-ICSI group was higher than the Ej-ICSI group but not significantly different than the Ej-ICSI-high SDF group(1.4,1.2,and 1.3,respectively,P0.05).No significant difference was found in live birth rate when comparing T-ICSI to Ej-ICSI and Ej-ICSI-high SDF *** results suggest that pregnancy outcomes and live birth rates with T-ICSI are not significantly superior to Ej-ICSI in patients with an elevated SCSA-defined sperm DNA fragmentation and prior ICSI failure(s).

关键词： intracytoplasmic sperm injection male infertility sperm chromatin structure assay sperm DNA fragmentation sperm retrieval testicular sperm

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Selective reduction of a triplet heterotopic cervical pregnancy after embryo transfer

引用

Case Reports in Clinical Medicine 2013年第9期2卷 568-572页

作者： Delphine Delrieu Roland Antaki simon phillips Isaac-Jacques Kadoch OVO Clinic Montreal Canada OVO Clinic Montreal Canada 2University of Montreal Department of Obstetrics and Gynaecology Saint-Luc Hospital (CHUM) Montreal Canada OVO Clinic Montreal Canada University of Montreal Department of Obstetrics and Gynaecology Saint-Luc Hospital (CHUM) Montreal Canada

Cervical pregnancy is rare and heterotopic cervical pregnancy is more uncommon ever. Assisted Reproduction Technology enhances these pregnancies. The diagnosis and the treatment which are in emergency can be sometimes difficult. This article is a case report of a triplet heterotopic cervical pregnancy after embryo transfer, and a scientist review of the literature found in MEDLINE. To date, in the English literature, we found only 7 cases report of triplet heterotopic cervical pregnancies.

关键词： Heterotopic Pregnancy Cervical Pregnancy Ectopic Pregnancy IVF Embryo Transfer Assisted Reproduction Technology

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Fertility Preservation in Premature Ovarian Insufficiency (POI) Secondary to FSH Receptor Gene (FSHR) Mutation: Is There a New Hope?

引用

Case Reports in Clinical Medicine 2017年第10期6卷 274-280页

作者： Pierre-Antoine Pradervand Roland Antaki simon phillips C. Sylvestre Zaki El Haffaf Ariane Godbout Isaac Jacques Kadoch Pierre Lehmann OVO Fertility OVO Clinic Montreal Canada Assisted Procreation Clinic Centre Hospitalier de l’Université de Montréal (CHUM) Montreal Canada Division of Reproductive Endocrinology and Infertility Centre Hospitalier Universitaire (CHU) Ste-Justine Montreal Canada Department of Obstetrics and Gynecology H&ocircpital Sacré Coeur de Montréal Montreal Canada

A 19 years old patient with primary amenorrhea was referred to our center. Based on discrepancy between high follicle stimulating hormone (FSH) level and normal ovarian reserve parameters, follicle stimulating hormone receptor (FSHR) mutation was screened. The patient was homozygous in exon 6 of the FSHR gene for the new variant c.479T > C and predicted to result in an aminoacid substitution ***160Thr. One year later, her anti-müllerian hormone (AMH) level inexplicably decreased. Oocyte vitrification was thus offered for fertility preservation. After 17 days of recombinant follicle stimulating hormone (recFSH) (900 IU daily), no follicular growth was seen and estradiol levels remained low. In vitro maturation (IVM) was then suggested. Ten oocytes were successfully vitrified.

关键词： FSH Receptor Mutation Fertility Preservation in Vitro Maturation AMH Primary Ovarian Insufficiency

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Nature:研究首次证实帕金森病部分上是一种自身免疫疾病

引用

现代生物医学进展 2017年第27期17卷 I0002-I0002页

作者： David Sulzer, Francesca Garretti, Ellen Kanter, Julian Agin-Liebes, Elizabeth phillips, simon Mallal David Sulzer, Roy N. Alcalay, Lucien Cote, Christopher Liong, Elizabeth phillips, simon Mallal David Sulzer Curtis McMurtrey, William H. Hildebrand Xiaobo Mao, Valina L. Dawson, Ted M. Dawson Xiaobo Mao, Valina L. Dawson, Ted M. Dawson Valina L. Dawson Valina L. Dawson, Ted M. Dawson Ted M. Dawson Carla Oseroff, John Pham, John Sidney, Myles B. Dillon, Chelsea Carpenter, Daniela Weiskopf, Bjoern Peters, April Frazier, Cecilia S. Lindestam Arlehamn, Alessandro Sette Elizabeth phillips, simon Mallal Departments of Psychiatry Columbia University Division of Molcular Therapeutics New York State Psychiatric Institute New York New York 10032 USA Department of Neurology Columbia University New York New York 10032 USA Department of Pharmacology Columbia University New York New York 10032 USA Department of Microbiology and Immunology University of Oklahoma Oklahoma City Oklahoma 73104 USA Neuroregeneration and Stem Cell Program Institute for Cell Engineering and the Department of Neurology Johns Hopkins University School of Medicine Baltimore Maryland 21205 USA Adrienne Helis Malvin Medical Research Foundation New Orleans Louisiana 70130-2685 USA Department of Physiology Johns Hopkins University School of Medicine Baltimore Maryland 21205 USA Solomon H. Snyder Department of Neuroscience Johns Hopkins University School of Medicine Baltimore Maryland 21205 USA Department of Pharmacology & Molecular Sciences Johns Hopkins University School of Medicine Baltimore Maryland 21205 USA Division of Vaccine Discovery La Jolla Institute for Allergy and Immunology La Jolla California 92037 USA Institute for Immunology and Infectious Diseases Murdoch University Perth Western Australia 6150 Australia Vanderbilt University School of Medicine Nashville Tennessee 37235 USA

帕金森病是一种神经退行性疾病。这种疾病的一种关键特征是受损的a-突触核蛋白（alpha-synuclein）在帕金森病患者体内的一种被称作多巴胺能神经元的脑细胞中堆积。在一项新的研究中，来自美国哥伦比亚大学医学中心和拉荷亚过敏症与免... 详细信息

帕金森病是一种神经退行性疾病。这种疾病的一种关键特征是受损的a-突触核蛋白（alpha-synuclein）在帕金森病患者体内的一种被称作多巴胺能神经元的脑细胞中堆积。在一项新的研究中，来自美国哥伦比亚大学医学中心和拉荷亚过敏症与免疫学研究所等研究机构的研究人员发现首个直接的证据证实自身免疫反应在帕金森病中发挥着作用。

关键词：自身免疫疾病帕金森病神经退行性疾病多巴胺能神经元哥伦比亚大学免疫反应研究人员研究机构

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：