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釉基质蛋白衍生物(EMD)对不同钛表面人脐静脉内皮细胞成血管行为的影响

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釉基质蛋白衍生物(EMD)对不同钛表面人脐静脉内皮细胞成血管行为...

Reactivation of the Archean lower crust:Implications for zircon geochronology,elemental and Sr-Nd-Hf isotopic geochemistry of late Mesozoic granitoids from northwestern Jiaodong Terrane,the North China Craton

中华口腔医学会第三次全国口腔药学学术会议

作者：施斌 Oleh Andrukhov simon Berner Andreas Schedle Xiaohui Rausch-fan 福建医科大学附属第一医院口腔颌面外科 Department of Periodontology Bernhard Gottlieb University Clinic of DentistryMedical University of ViennaAustria Central Research Unit Bernhard Gottlieb University Clinic of DentistryMedical University of ViennaAustria

目的釉基质蛋白衍生物(Enamel matrix derivative,EMD)具有促进牙周组织再生及创口愈合的潜能,本研究的目的为评价EMD对生长在不同钛表面的内皮细胞成血管行为的影响。方法人脐静脉内皮细胞(Humanumbilical vein endothelial cells,HUV... 详细信息

目的釉基质蛋白衍生物(Enamel matrix derivative,EMD)具有促进牙周组织再生及创口愈合的潜能,本研究的目的为评价EMD对生长在不同钛表面的内皮细胞成血管行为的影响。方法人脐静脉内皮细胞(Humanumbilical vein endothelial cells,HUVEC)培养于不同表面上:预处理光滑钛表面(Pretreated smooth surface,PT)、酸蚀钛表面(Acid-etched surface,A)、大颗粒喷砂及酸蚀钛表面(Coarse-gritblasted and acid-etched surface,SLA)及组织培养板表面(Tissue culture plastic surface,TCPS)。24小时后实验组培养液更换为含50μg/ml EMD的培养液。对照组则使用不含EMD的培养液培养。再培养24小时后,使用细胞计数法计算内皮细胞数,使用MTT法评价内皮细胞活力。实时定量PCR检测内皮细胞表面成血管相关基因vWF,ICAM-1,EPCR,E-Selectin及Ang-2的表达水平。结果 EMD抑制生长于不同钛表面内皮细胞的细胞数量及细胞活性。但EMD促进了粗糙SLA表面内皮细胞vWF,ICAM-1及EPCR的基因表达水平。而且EMD的促内皮细胞成血管相关基因表达作用与钛表面粗度成正相关。结论EMD有可能通过诱导内皮细胞的成血管作用来促进种植术后种植体周围的组织再生和创口愈合。

关键词：釉基质蛋白衍生物血管生成内皮细胞牙种植体钛表面。

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Reactivation of the Archean lower crust:Implications for zir...

A Th2 phenotype of regulatory T cells that supports tissue protection

中国科学院地质与地球物理研究所2012年度（第12届）学术年会

作者： Kui-Feng Yang Hong-Rui fan M.Santosh fang-fang Hu simon A.Wilde Ting-Guang Lan Li-Na Lu Yong-Sheng Liu Key Laboratory of Mineral Resources Institute of Geology and GeophysicsChinese Academy of Sciences Division of Interdisciplinary Science Faculty of ScienceKochi UniversityKochi 780-8520Japan Geoscience Frontiers China University of Geosciences State Key Laboratory of Geological Processes and Mineral Resources China University of Geosciences

The late Mesozoic granitoids widely distributed in the nortliwestern Jiaodong Terrane are important markers of cratonic destruction and lithospheric thinning of the eastern North China Craton(NCC).Here we investigate the Late Jurassic Linglong and Luanjiahe granites and report zircon U-Pb emplacement ages of 157- 159 *** rocks also contain abundant late Archean,Paleoproterozoic,Neoproterozoic,early Paleozoic and Triassic inherited zircons,suggesting the involvement of continental crustal materials from both the NCC and Yangtze Craton in magma *** rocks investigated in this study show high NaO + KO and low MgO and are peraluminous,with enrichment in LREEs and LILEs(Rb,Ba,U,and Sr) and depletion in HFSEs(Nb,Ta,P,and Ti).They also display lowε(t) values and high Sr/Y ratios,comparable to adakitic rocks,suggesting that the Linglong and Luanjiahe granitoids formed under relatively high pressure conditions and were likely derived from the partial melting of the thickened lower crust of the *** Guojialing granodiorites were emplaced in the early Cretaceous(129 Ma),and also contain abundant late Archean and Paleoproterozoic inherited *** rocks possess high CaO,TFeO and MgO,and are metalumrnous,with enrichment in LREEs and LILEs and depletion in *** are also characterized by high Sr/Y ratios,and have higherε(t) andε(t) values than the Late Jurassic granitoids,suggesting the involvement of mantle components in the magmatic *** correlate the magma tectonics with the processes accompanying the subduction of the Pacific Plate beneath the NCC and the associated asthenospheric upwelling.

关键词： Geochemistry Zircon geochronology Late Mesozoic granitoids Northwestern Jiaodong Terrane North China Craton

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A Th2 phenotype of regulatory T cells that supports tissue p...

Multimorbidity patterns and association with mortality in 0.5 million Chinese adults

第十二届全国免疫学学术大会

作者： Liu Quan Lott Jeremy Zhao Yifei Li Huihua Mathews Lisa Zhu Qiang Delvin Jason Watkins simon Greg Delgoffe fan Ming-Hui Billiar Timothy Turnquist Heth University of Pittsburgh School of Medicine The 2nd Affiliated Hospital of Harbin Medical University Tsinghua University School of Medicine

Background:The capacities of CD4 Foxp3 regulatory T cells(T) in modulating organismal metabolism and maintaining tissue homeostasis have been recently *** of these T cells express ST2,receptor for the alarmin interleukin-33(IL-33).However,the immunobiological profile of ST2T cells is yet to be fully *** we report a Th2 phenotype of these cells that supports tissue ***:Cells were analyzed by flow *** extracellular flux analysis was performed on FACS-sorted T ***-13 in cell culture and whole lung lysates were tested by cytometric bead ***-sorted T cells were adoptively transfer into Rag2gamma(c) ***-sorted common lymphoid progenitors(CLP) were transplanted into irradiated Rag2gamma(c) *** damage was induced by bleomycin intratracheal ***:We found ST2CLP gave rise to both ST2 or ST2T *** adoptively transferring mouse ST2 or ST2Tcells,we demonstrated that mouse T cells dynamically gained and lost ST2 *** those from peripheral and lymphoid tissues were highly comparable in their expression of functional molecules,ST2 T cells were unique relative to their ST2counterparts in terms of metabolism and ***2 but not ST2" mouse T cells exhibited aerobic glycolysis and secreted IL-13 in response to TCR ***-33 also promoted human T proliferation and IL-13 *** mouse lung damage,IL-13 in I133 lungs was enormously lower than that in WT ***,I133 and I11 r11 mice were more susceptible to lung damage-associated lethality comparing with WT mice,which could be rescued by exogenous recombinant IL-33 or IL-13 in the presence of T cells,suggesting a critical tissue protection role of IL-33-ST2 ***:Taken together,our findings demonstrate a Th2 phenotype of ST2 T cells that is crucial to tissue protection and suggest potential therapeutic strategy for acute lung injury.

关键词： Treg IL-33 ST2 IL-13 tissue protection

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Chinese Medical Journal 2022年第6期135卷 648-657页

作者： Junning fan Zhijia Sun Canqing Yu Yu Guo Pei Pei Ling Yang Yiping Chen Huaidong Du Dianjianyi Sun Yuanjie Pang Jun Zhang simon Gilbert Daniel Avery Junshi Chen Zhengming Chen Jun Lyu Liming Li On Behalf of the China Kadoorie Biobank Collaborative Group Department of Epidemiology and Biostatistics School of Public HealthPeking UniversityBeijing 100191China Peking University Center for Public Health and Epidemic Preparedness and Response Peking UniversityBeijing 100191China National Clinical Research Center of Cardiovascular Diseases National Center for Cardiovascular DiseasesFuwai HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100037China China Kadoorie Biobank National Coordination Centre Chinese Academy of Medical SciencesBeijing 100730China Nuffield Department of Population Health Medical Research Council Population Health Research UnitUniversity of OxfordOxford OX37LFUnited Kingdom Nuffield Department of Population Health University of OxfordClinical Trial Service Unit and Epidemiological Studies Unit(CTSU)Oxford OX37LFUnited Kingdom Suzhou Center for Disease Control and Prevention SuzhouJiangsu 215004China China National Center for Food Safety Risk Assessment Beijing 100022China Key Laboratory of Molecular Cardiovascular Sciences Peking UniversityMinistry of EducationBeijing 100191China 不详

Background:Few studies have assessed the relationship between multimorbidity patterns and mortality risk in the Chinese *** aimed to identify multimorbidity patterns and examined the associations of multimorbidity patterns and the number of chronic diseases with the risk of mortality among Chinese middle-aged and older ***:We used data from the China Kadoorie Biobank and included 512,723 participants aged 30 to 79 *** was defined as the presence of two or more of the 15 chronic diseases collected by self-report or physical examination at *** patterns were identified using hierarchical cluster *** regression was used to estimate the associations of multimorbidity patterns and the number of chronic diseases with all-cause and cause-specific ***:Overall,15.8%of participants had *** prevalence of multimorbidity increased with age and was higher in urban than rural *** multimorbidity patterns were identified,including cardiometabolic multimorbidity(diabetes,coronary heart disease,stroke,and hypertension),respiratory multimorbidity(tuberculosis,asthma,and chronic obstructive pulmonary disease),gastrointestinal and hepatorenal multimorbidity(gallstone disease,chronic kidney disease,cirrhosis,peptic ulcer,and cancer),and mental and arthritis multimorbidity(neurasthenia,psychiatric disorder,and rheumatoid arthritis).During a median of 10.8 years of follow-up,49,371 deaths *** with participants without multimorbidity,cardiometabolic multimorbidity(hazard ratios[HR]=2.20,95%confidence intervals[CI]:2.14-2.26)and respiratory multimorbidity(HR=2.13,95%CI:1.97-2.31)demonstrated relatively higher risks of mortality,followed by gastrointestinal and hepatorenal multimorbidity(HR=1.33,95%CI:1.22-1.46).The mortality risk increased by 36%(HR=1.36,95%CI:1.35-1.37)with every additional ***:Cardiometabolic multimorbidity and respiratory multimorbidity

关键词： Multimorbidity Pattern Mortality Chinese

基于PageRank算法与引文分析的奖项影响力评价研究——以经济管理学领域国际学术奖项为例

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情报杂志 2018年第6期37卷 113-118页

作者：姜帆上海交通大学高等教育研究院上海200240

[目的/意义]国际学术奖项作为一种学术认可机制在现代学术社会中扮演着不可替代的评价职能,同时也是推动学术体制不断发展的重要力量。以经济管理学领域国际学术奖项为例,基于共同获奖人数据和引文数据考察各国际学术奖项的影响力大小。... 详细信息

[目的/意义]国际学术奖项作为一种学术认可机制在现代学术社会中扮演着不可替代的评价职能,同时也是推动学术体制不断发展的重要力量。以经济管理学领域国际学术奖项为例,基于共同获奖人数据和引文数据考察各国际学术奖项的影响力大小。[方法/过程]通过调查问卷及履历分析建立了经济管理学领域的44项国际学术奖项清单,运用Gephi软件绘制赋权奖项图谱并采用PageRank算法与引文分析方法考察各奖项的中心性影响力与文献影响力。[结果/结论]研究发现诺贝尔经济学奖的PageRank值最高,其次为约翰·贝茨·克拉克奖章和约翰·冯·诺依曼奖等;在引文表现方面,德意志银行金融经济学奖最高,其次为全球经济奖——经济学类和司马贺奖等。最终结果表明,诺贝尔经济学奖的综合影响力最高,其次为约翰·贝茨·克拉克奖章和全球经济奖——经济学类等。

关键词：国际学术奖项科研评价 PageRank算法引文分析

Retrohepatic vena cava deroofing in living donor liver transplantation for caudate hepatocellular carcinoma

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Hepatobiliary & Pancreatic Diseases International 2013年第5期12卷 552-555页

作者： See Ching Chan William W Sharr Tan To Cheung Albert CY Chan simon HY Tsang Kenneth SH Chok Kin Chung Leung Chung Mau Lo Department of Surgery The University of Hong Kong State Key Laboratory for Liver Research The University of Hong Kong Department of Pathology The University of Hong Kong

The removal of tumor together with the native liver in living donor liver transplantation for hepatocellular carcinoma is challenged by a very close resection margin if the tumor abuts the inferior vena *** is in contrast to typical deceased donor liver transplantation where the entire retrohepatic inferior vena cava is included in total *** we report a case of deroofing the retrohepatic vena cava in living donor liver transplantation for caudate hepatocellular *** order to ensure clear resection margins,the anterior portion of the inferior vena cava was *** right liver graft was inset into a Dacron vascular graft on the back table and the composite graft was then implanted to the recipient inferior vena *** this technique,we observed the no-touch technique in tumor removal,hence minimizing the chance of positive resection margin as well as the chance of shedding of tumor cells during manipulation in operation.

关键词： hepatocellular carcinoma liver transplantation

Distinct functions of polycomb group proteins in regulating Ci transcription in developing Drosophila

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Journal of Molecular Cell Biology 2018年第5期10卷 475-478页

作者： Xiangdong Lv Hao Chen Shuo Zhang Zhao Zhang Chenyu Pan Yuanxin Xia Jialin fan Wenqing Wu Yi Lu Lei Zhang Hailong Wu Yun Zhao State Key Laboratory of Cell Biology CASCenter for Excellence in Molecular Cell Science Innovation Center for Cell Signaling Network Shanghai Institute of Biochemistry and Cell Biology Chinese Academy of Sciences University of Chinese Academy of Sciences. Shanghai 200031. China School of Life Science and Technology Shanghai Tech University Shanghai 201210China

Dear Editor, The highly conserved polycomb group （PcG） proteins were initially identified in Drosophila to maintain repression state of the transcription of homeotic genes, which is critical for animal development control （Sawarkar and Paro, 2010）. Polycomb repressive complexes 1 （PRC1） and 2 （PRC2） are two important multi-protein complexes of PcG proteins regulating target gene expression. In Drosophila, PRC2 is composed of Enhancer of zeste （E（z））, Suppressor of zeste 12 （5u（z）I2）, Extra sex combs （esc）, and Chromatin assembly factor 1 subunit （Cafl）. E（z） is the catalytic subunit for H3K27me2/3, while both Su（z）l_2 and Esc are required for the proper catalytic activity in vivo （Helin and Morey, 2010）. PRC1 contains a core of four proteins： Polycomb （Pc）, Polyhomeotic （Ph）, Sex combs extra （Sce）, and Posterior sex combs （Psc）. Through its chromodomain, Pc can specifically recognize H3K27me3, and recruit other components to selected chromatin sites （Beisel and Paro, 2011）, although H3K27me3-independent recruitment of PRC1 has also been reported. PRC1 can repress its targets by either catalyzing H2A mono-ubiquitination （Wang et al., 2004） or inducing local chromatin condensation （Eskeland et al., 2010）.

关键词：开发控制蛋白质果蝇调整 Ci 组织催化活动 PRC1

维普期刊数据库评论

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幽默与笑话

今日中学生 2004年第Z3期 53-54页

作者： simon

Kidspeak 儿童语言Our four-year-old son speaks English and French,and hehas picked up some Guangdongese since living in Hong *** day Iwas getting ready to take him to a rugby *** mother,not being arugby fan,planned a q... 详细信息

关键词：笑话民间文学

Tumor shrinkage by cyclopamine tartrate through inhibiting hedgehog signaling

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Chinese Journal of Cancer 2011年第7期30卷 472-481页

作者： Qipeng fan Dongsheng Gu Miao He Hailan Liu Tao Sheng Guorui Xie Ching-xin Li Xiaoli Zhang Brandon Wainwright Arash Garrossian Massoud Garrossian Dale Gardner Jingwu Xie Wells Center for Pediatric Research Department of Pediatrics and The Simon Cancer Center Indiana University Indianapolis IN 46202 USA Key Laboratory for Oral Biomedical Engineering of Ministry of Education School and Hospital of Stomatology Wuhan University Wuhan Hubei 430079 P. R. China Department of Dermatology Xijing Hospital Xi'an Shaanxi 710032 P.R. China Institute for Molecular Bioscience The University of Queensland Brisbane QLD 4072 Australia Logan Natural Products Inc. Dallas TX 75025 USA United States Department of Agriculture Agriculture Research Services Poisonous Plant Research Laboratory Logan UT 84341 USA.

The link of hedgehog (Hh) signaling activation to human cancer and synthesis of a variety of Hh signaling inhibitors raise great expectation that inhibiting Hh signaling may be effective in human cancer treatment. Cyclopamine (Cyc), an alkaloid from the Veratrum plant, is a specific natural product inhibitor of the Hh pathway that acts by targeting smoothened (SMO) protein. However, its poor solubility, acid sensitivity, and weak potency relative to other Hh antagonists prevent the clinical development of Cyc as a therapeutic agent. Here, we report properties of cyclopamine tartrate salt (CycT) and its activities in Hh signaling-mediated cancer in vitro and in vivo. Unlike Cyc, CycT is water soluble (5-10 mg/mL). The median lethal dose (LD50) of CycT was 62.5 mg/kg body weight compared to 43.5 mg/kg for Cyc, and the plasma half-life (T1/2) of CycT was not significantly different from that of Cyc. We showed that CycT had a higher inhibitory activity for Hh signaling-dependent motor neuron differentiation than did Cyc (IC50 = 50 nmol/L for CycT vs. 300 nmol/L for Cyc). We also tested the antitumor effectiveness of these Hh inhibitors using two mouse models of basal cell carcinomas (K14cre:Ptch1neo/neo and K14cre:SmoM2YFP). After topical application of CycT or Cyc daily for 21 days, we found that all CycT-treated mice had tumor shrinkage and decreased expression of Hh target genes. Taken together, we found that CycT is an effective inhibitor of Hh signaling-mediated carcinogenesis.

关键词： Hedgehog 酒石酸盐抗肿瘤信号癌症治疗小鼠模型半数致死量运动神经元