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Inactivation of Mitochondrial Complex Ⅰ Induces the Expression of a Twin Cysteine Protein that Targets and Affects Cytosolic, Chloroplastidic and Mitochondrial Function

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Molecular Plant 2016年第5期9卷 696-710页

作者： Yan Wang Wenhui Lyu Oliver Berkowitz Jordan d. Radomiljac simon R. Law Monika W. Murcha Chris Carrie Pedro F. Teixeira Beata Kmiec Owen duncan Olivier Van Aken Reena Narsai Elzbieta Glaser Shaobai Huang Ute Roessner A. Harvey Millar James Whelan department of Animal Plant and Soil Science Australian Research Council Centre of Excellence in Plant Energy Biology School of Life Science La Trobe University Bundoora VIC 3086 Australia Ume(a)Plant Science Centre(UPSC) Faculty of Science and Technology Ume(a)University Ume(a) Sweden Australian Research Council Centre of Excellence in Plant Energy Biology University of Western Australia 35 Stirling Highway Crawley WA 6009 Australia department of Biology I Botany Ludwig-Maximilians-Universitat Munchen Groβhaderner Strasse 2-4 82152 Planegg-Martinsried Germany department of Biochemistry and Biophysics Stockholm University Atrhenius Laboratories for Natural Sciences 10691 Stockholm Sweden School of BioSciences The University of Melbourne Melbourne VIC 3010 Australia

At12Cys-1 （At5g64400） and At12Cys-2 （At5g09570） are two closely related isogenes that encode small, twin cysteine proteins, typically located in mitochondria. At12Cys-2 transcript is induced in a variety of mutants with disrupted mitochondrial proteins, but an increase in At12Cys protein is only detected in mutants with reduced mitochondrial complex I abundance. Induction of At12Cys protein in mutants that lack mitochondrial complex I is accompanied by At12Cys protein located in mitochondria, chloroplasts, and the cytosoh Biochemical analyses revealed that even single gene deletions, i.e., At12cys-1 orAtl2cys-2, have an effect on mitochondrial and chloroplast functions. However, only double mutants, i.e., At12cys-1：At12cys.2, affect the abundance of protein and mRNA transcripts encoding translation elongation factors as well as rRNA abundance. Blue native PAGE showed that At12Cys co-migrated with mitochondrial supercomplex I ＋ lU. Likewise, deletion of both At12cys-1 and At12cys-2 genes, but not single gene deletions, results in enhanced tolerance to drought and light stress and increased anti-oxidant capacity. The induction and multiple localization of At12Cys upon a reduction in complex I abundance provides a mechanism to specifically signal mitochondrial dysfunction to the cytosol and then beyond to other organelles in the cell.

关键词： mitochondria complex I retrograde signaling chloroplast cytosol

Glomus Tumors of the Lung: diagnostic Considerations and Treatment

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Open Journal of Thoracic Surgery 2014年第1期4卷 5-8页

作者： Joshil V. Lodhia Thomas d. Christensen simon E. Trotter Ehab S. Bishay department of Histopathology Heart of England Foundation Trust Birmingham UK department of Thoracic Surgery Heart of England Foundation Trust Birmingham UK

Glomus tumors derive from the glomus cell around arteriovenous anastomosis. These are rare tumors and when found are most common in the deep dermis of the extremities. In rarer cases still they have been reported to be found in the lung. These are most commonly incidental findings of solitary lesions of the lung with a pre-operative differential diagnosis of non-small cell carcinomas and carcinoids. due to the rare nature of these tumors, they are rarely considered in the differential diagnosis and are also often misdiagnosed at the time of frozen section. We present three cases of glomus tumors of the lung with emphasis on the consideration of the method of diagnosis, histological findings and management.

关键词： Lung Cancer Glomus Tumor Surgical Therapy

生长抑素及其合成类似物奥曲肽在胃肠病中的应用

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国外医学（消化系疾病分册） 1991年第3期11卷 152-154页

作者： Grosman I simon d 徐萍

奥曲肽(octreotide;:即SMZ 201-995)是一种长效生长抑素类似物。本文综述近年生长抑素及奥曲肽在胃肠道非肿瘤疾病中的应用。腹泻奥曲肽是当前治疗类癌综合征和分泌血管活性肠肽(VIP)肿瘤所致腹泻最有效的药物。在实验动物与人的研究表... 详细信息

奥曲肽(octreotide;:即SMZ 201-995)是一种长效生长抑素类似物。本文综述近年生长抑素及奥曲肽在胃肠道非肿瘤疾病中的应用。腹泻奥曲肽是当前治疗类癌综合征和分泌血管活性肠肽(VIP)肿瘤所致腹泻最有效的药物。在实验动物与人的研究表明,生长抑素及奥曲肽对腹泻疾病可能有效。回肠造口术后腹泻回肠造口术后持续严重的腹泻,通常见于结肠切除术时切除了末段回肠的患者。Cooper等报告5例直、结肠和回肠切除术后出现明显脂肪泻的病人,止泻药和禁食治疗均无效,用奥曲肽后,水、电解质和总排出均减少(除Cl^-外均无统计学差异),但脂肪排出显著增高;2例症状明显改善。

关键词：生长抑素奥曲肽胃肠病

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Second-line therapy for gemcitabine-pretreated advanced or metastatic pancreatic cancer

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World Journal of Gastroenterology 2012年第12期18卷 1357-1364页

作者： Romain Altwegg Marc Ychou Vanessa Guillaumon simon Thezenas Pierre Senesse Nicolas Flori Thibault Mazard Ludovic Caillo Stéphanie Faure Emmanuelle Samalin Eric Assenat the Oncology and digestive Endoscopy department of the CRLC Val d'Aurelle 34000 MontpellierFrance

AIM： To investigate second-line chemotherapy in gemcitabine-pretreated patients with advanced or metastat- ic pancreatic cancer [（frequency, response, outcome, course of carbohydrate antigen 19-9 （CA 19-9）].METHOdS： This retrospective study included all patients with advanced or metastatic pancreatic cancer （adenocarcinoma or carcinoma） treated with secondline chemotherapy in our center between 2000 and 2008. All patients received first-line chemotherapy with gemcitabine, and prior surgery or radiotherapy was permitted. We analyzed each chemotherapy protocol for second-line treatment, the number of cycles and the type of combination used. The primary endpoint was overall survival. Secondary endpoints included progression-free survival, response rate, grade 3-4 toxicity, dosage modifications and CA 19-9 course.a second-line therapy among 206 patients who had initially received first-line treatment with a gemcitabi- ne-based regimen. Median number of cycles was 4 （range： 1-12） and the median duration of treatment was 2.6 mo （range： 0.3-7.4）. The overall disease control rate was 40.0%. The median overall survival and progression-free survival from the start of second-line therapy were 5.8 （95% CI： 4.1-6.6） and 3.4 mo （95% CI： 2.4-4.2）, respectively. Toxicity was generally acceptable. Median overall survival of patients with a CA 19-9 level declining by more than 20% was 10.3 mo （95% CI： 4.5-11.6） vs 5.2 mo （95% CI： 4.0-6.4） for others （P = 0.008）.CONCLUSION： A large proportion of patients could benefit from second-line therapy, and CA 19-9 allows efficient treatment monitoring both in first and secondline chemotherapy.

关键词： Second-line Chemotherapy Pancreatic can-cer Gemcitabine Carbohydrate antigen 19-9

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2005年中国企业信息安全调查

机械设计与制造工程 2006年第4期 72-74页

作者： Helen d'Antoni simon Cheung

中国企业的网络和系统正在遭受越来越多的攻击,但许多公司至今还没有建立起完善的防护网来保护自身的安全.随着中国经济的发展,越来越多美国公司开始积极进入这个新兴的市场.但在进入这块新大陆前,他们需要对本土企业,也就是那些未来可... 详细信息

中国企业的网络和系统正在遭受越来越多的攻击,但许多公司至今还没有建立起完善的防护网来保护自身的安全.随着中国经济的发展,越来越多美国公司开始积极进入这个新兴的市场.但在进入这块新大陆前,他们需要对本土企业,也就是那些未来可能成为他们的客户或商业伙伴的企业的IT安全水平进行适当的调查和了解.然而,与美国同行相比,中国企业的IT系统安全水平令人担心,他们不仅正受到越来越多的攻击;而且对出现的许多威胁显得准备不足.

关键词：安全调查中华人民共和国分公司企业信息安全受访者间谍软件美元本位币卡明斯入侵防护系统入侵检测系统美国美利坚合众国北美洲伯灵顿 IT 咨询公司电气公司

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2000年矿业生产的展望

国外地质勘探技术 1994年第1期 47-49页

作者： simon d.Strauss 郑敏

到2000年,随着人口的增长和世界工业的发展,矿产的消费将继续增长。世界的矿产资源是否足以满足世界范围的日益增长的社会需求已经重新成为令人关注的话题。对矿产资源枯竭性危险的预告是众所周知的,人们已经开始提及在本世纪中叶出版... 详细信息

到2000年,随着人口的增长和世界工业的发展,矿产的消费将继续增长。世界的矿产资源是否足以满足世界范围的日益增长的社会需求已经重新成为令人关注的话题。对矿产资源枯竭性危险的预告是众所周知的,人们已经开始提及在本世纪中叶出版的佩利报告(Paley Report)中所

关键词：铜矿山赞比亚加拿大美国北美洲美利坚合众国矿产资源矿藏资源生产量产量铝土矿铝矿物

decoupling between Oxygen and Radiogenic Isotopes: Evidence for Generation of Juvenile Continental Crust by Partial Melting of Subducted Oceanic Crust

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Journal of Earth Science 2021年第5期32卷 1212-1225页

作者： Xuan-Ce Wang Qiuli Li simon A.Wilde Zheng-Xiang Li Chaofeng Li Kai Lei Shao-Jie Li Linlin Li Manoj K.Pandit School of Earth Sciences Yunnan UniversityKunming 650500China School of Earth Science and Resources Chang1 an UniversityXi'an 710054China State Key Laboratory of Lithospheric Evolution Institute of Geology and GeophysicsChinese Academy of SciencesBeijing 100029China ARC Centre of Excellence for Core to Crust Fluid Systems and The Institute for Geoscience Research Department of Applied GeologyCurtin UniversityPerth 6845Australia department of Geology University of RajasthanJaipur 302004India

There is increasing evidence indicating that melts derived from subducted oceanic crust and sediments may have played a key role in building continental crust. This mechanism predicts that juvenile arc crust should have oxygen isotope characteristics ranging from mantle-like to supracrustal, but consistent mantle-like radiogenic(Nd-Hf) isotopic signatures. Here we present in-situ zircon U-Pb dating, Hf-O isotope analyses, and whole rock major-trace element and Nd isotope analyses of a granitoid from NW India. In-situ secondary ion mass spectrometry(SIMS) zircon U-Pb dating yields a weighted mean ^(207)Pb/^(206)Pb age of 873±6 Ma for the granitoid. It displays mantle-like zircon εHf(εHf(873 Ma)= +9.3 to +10.9) and whole-rock Nd(εNd(873 Ma)= +3.5) values but supracrustal δ^(18)O values, the latter mostly varying between 9‰ and 10‰. The calculated whole-rock δ^(18)O value of 11.3‰±0.6‰ matches well with those of hydrothermally-altered pillow lavas and sheeted dykes from ophiolites. The major and trace element composition of the granitoid is similar to petrological experimental melts derived from a mixture of MORB+sediments. Thus, the granitoid most likely represents the product of partial melting of the uppermost oceanic crust(MORB+sediments). We propose that the decoupling between Hf-Nd and O isotopes as observed in this granitoid can be used as a powerful tool for the identification of slab melting contributing to juvenile continental crustal growth. Such isotopic decoupling can also account for high δ^(18)O values observed in ancient juvenile continental crust, such as Archean tonalitetrondhjemite-granodiorite suites.

关键词： zircon Hf-Nd and O isotopes decoupling slab melting Neoproterozoic continental crustal growth

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Activation of the pattern recognition receptor NOd1 augments colon cancer metastasis

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Protein & Cell 2020年第3期11卷 187-201页

作者： Henry Y.Jiang Sara Najmeh Guy Martel Elyse MacFadden-Murphy Raquel Farias Paul Savage Arielle Leone Lucie Roussel Jonathan Cools-Lartigue Stephen Gowing Julie Berube Betty Giannias France Bourdeau Carlos HFChan Jonathan d.Spicer Rebecca McClure Morag Park simon Rousseau Lorenzo E.Ferri Thoracic and Upper GI Cancer Research Laboratories Research Institute of McGill University Health Centre1001 Decarie BoulevardBlock ELab#E02-4134MontrealQC H4A 3J1Canada department of Experimental Surgery and department of Surgery McGill University1650 Cedar AvenueMontrealQC H3G 1A4Canada Meakins-Christie Laboratories Research Institute of McGill University Health Centre1001 Decarie BoulevardMontrealQC H4A 3J1Canada The Rosalind and Morris Goodman Cancer Research Centre McGill University1160 Pine AvenueMontrealQC H3A 1A3Canada department of Surgery Roy J.and Lucille A.Carver College of MedicineUniversity of IowaUniversity of Iowa Hospitals and Clinics200 Hawkins DriveIowa CityIA 52242USA department of Pathology Health Sciences North41 Ramsey Lake RoadSudburyONCanada

While emerging data suggest nucleotide oligomerization domain receptor 1(NOd1),a cytoplasmic pattern recognition receptor,may play an important and complementary role in the immune response to bacterial infection,its role in cancer metastasis is entirely ***,we sought to determine the effects of NOd1 on ***1 expression in paired human primary colon cancer,human and murine colon cancer cells were determined using immunohistochemistry and immunoblotting(WB).Clinical significance of NOd1 was assessed using TCGA survival data.A series of in vitro and in vivo functional assays,including adhesion,migration,and metastasis,was conducted to assess the effect of NOd1.C12-iE-dAP,a highly selective NOd1 ligand derived from gram-negative bacteria,was used to activate ***130,a specific NOd1 inhibitor,was used to block C12-iE-dAP *** knockdown(Kd)of NOd1 in human colon cancer cells(HT29)was constructed with shRNA lentiviral transduction and the functional assays were thus ***,the predominant signaling pathway of NOd1-activation was identified using WB and functional assays in the presence of specific kinase *** data demonstrate that NOd1 is highly expressed in human colorectal cancer(CRC)and human and murine CRC cell ***,we demonstrate that this increased NOd1 expression negatively impacts survival in patients with ***,we identify NOd1 activation by C12-iE-dAP augments CRC cell adhesion,migration and *** effects are predominantly mediated via the p38 mitogen activated protein kinase(MAPK)*** is the first study implicating NOd1 in cancer metastasis,and thus identifying this receptor as a putative therapeutic target.

关键词： NOd1 iE-dAP ML130 colon cancer metastasis cancer-extracellular matrix adhesion cancer migration p38 MAPK activation intravital microscopy survival analysis

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Risk Management of Cyanotoxins in Singapore

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Journal of Water Resource and Protection 2020年第6期12卷 512-525页

作者： Mong Hoo Lim Hui Shi Melissa Tay denise A. devotta Maxine A. d. Mowe simon M. Mitrovic Water Quality department Public Utilities Board (PUB) Singapore Freshwater and Invasion Biology Laboratory Department of Biological Science National University of Singapore (NUS) Singapore Freshwater and Estuarine Research Group School of Life Sciences University of Technology Sydney Sydney Australia

Cyanotoxins produced by cyanobacteria pose significant challenges to water resource management due to the potential impacts they have on human health. Cylindrospermopsin (CYN) and microcystins (MC) are the more commonly detected cyanotoxins in Singapore’s reservoirs. Among the MC congeners monitored locally, the most frequently detected variants are MC-RR (37.6%), followed by MC-LR (25.6%). MC-LA and MC-YR are the least frequently detected variants (7.1%). No cyanotoxins have been detected in Singapore’s treated drinking water. Singapore’s National Water Agency (PUB) and the National Environment Agency (NEA) developed recreational water quality guidelines using Chl a concentrations of 50 μg/L. In local surface waters, long-term data showed that at 50 μg/L of Chl a, MC-LR concentrations ranged from ddition to using Chl a concentrations, Microcystis cell counts in reservoir water have also been used to manage cyanotoxin risk in drinking water. Specifically, routinely monitored data from all 17 Singapore reservoirs indicated that to keep MC-LR concentrations below the WHO provisional guideline of 1 μg/L in drinking water, Microcystis cell counts needed to be Microcystis isolates showed M. aeruginosa produced the most MC compared to M. ichthyoblabe, M. flos-aquae, and M. viridis. Based on the maximum toxin cell quota equivalent to the WHO provisional guideline for MC-LR of 1 μg/L in drinking water, a 5000 cells/ml cell count guideline was derived for M. aeruginosa. This cell count has also been incorporated into Singapore’s cyanotoxin risk management framework for reservoirs.

关键词： Chlorophyll-a Cyanobacteria Cyanotoxins Nutrients Tropical