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Involvement of haptoglobin in disease development

World Journal of Hematology 2024年第2期11卷 1-7页

作者： Romaric Tuono De Manfouo Josuésimo Louokdom Bernard claude Chetcha Larissa Michelle BakamMagoua Prosper Cabral Biapa Nya Constant Anatole Pieme claude Tayou Tagny Department of Microbiology ParasitologyHematologyand Infectious DiseasesHematology UnitFaculty of Medicine and Biomedical SciencesUniversity of Yaoundé1Yaoundé296Cameroon Higher Institute of Health Sciences Universitédes MontagnesBangangté296Cameroon Public Health and Biotechnology Research Laboratory(LAPHER-Biotech) Faculty of SciencesUniversity of Yaoundé1Yaoundé296Cameroon Faculty of Sciences Universitéde DschangDschang 296Cameroon Department of Biochemistry Faculty of Medicine and Biomedical SciencesUniversity of Yaoundé1Yaoundé296Cameroon

Haptoglobin(HP)is a liver glycoprotein that is actively synthesized during in-flammatory and hemolytic *** also has pro-oxidant and proinflam-matory properties,which are a function of its *** genetic polymorp-hism of the chains leads to synthesis of three phenotypes/proteins,which are related to the number and type of chains and their molecular weight,namely HP1-1,HP1-2 and *** with HP2-2 have more vascular complications,while those with HP1-1 have *** is involved in the worsening of diseases,such as HP2-2 in aggravation of vaso-occlusive crises in sickle cell disease,and worsening of the pathophysiology of other *** contrast,HP1-1 confers better protection against *** of this suggests that further studies should be conducted,including experimental and analytical studies focused on de-monstrating the influence of different HP genotypes on individual clinical and hematological *** would help in understanding the role played by this genetic polymorphism in the pathophysiology of diseases.

关键词： Haptoglobin Protein Properties Polymorphism Diseases

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Influence of Exogenous Auxins on Phenolic Compounds Contents and Polyphenol oxidasic and Peroxidasic Activities in Root Differentiation in <i>Gnetum</i>spp.

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Agricultural Sciences 2019年第8期10卷 1073-1089页

作者： Minyaka Emile simo claude Medueghue Fofou Apollin Oumar Doungous Jetro Nkengafac Njukeng Niemenak Nicolas Omokolo Ndoumou Denis Department of Biochemistry Faculty of Sciences University of Douala Douala Cameroon Laboratory of Plant Physiology Department of Biological Sciences Higher Teacher’s Training College Yaoundé Cameroon Department of Plant Biology Faculty of Science Douala Cameroon Institute of Agricultural Research for Development (IRAD) Buea Cameroon

Root failure is a key limiting factor in Gnetum spp. domestication and production of plants materials for farming. To overcome, root failure in Gnetum spp. may depend on adequate strategies set up and understanding of biochemical markers controlling the rooting process. The present work is principally based on phenolic compounds contents, peroxidasic and polyphenol oxidasic activities during rooting of cuttings (pretreated with IBA, ANA and IAA) at induction, initiation and expression phases of roots formation in Gnetum africanum Welw. and G. buchholzianum Engl. The study revealed that cuttings pretreated with IBA (150 mg/l) were more effective than IAA and NAA. Phenolic compounds analysis revealed that cuttings pretreated with IBA exhibited high phenolic compound contents at initiation and expression phases for both Gnetum species. Indicating that IBA pretreatment promotes phenolic compounds synthesis and accumulation necessary for roots differentiation. Enzyme contents appear to be high during the initiation stage for both species when they are pretreated with IBA (150 mg/l). Peroxidasic and Polyphenol oxidasic activities evolved on the synchroneous maner. This allows us to know that the implication of these enzymes in the rooting process is fundamental makers.

关键词： Gnetum (spp.) Biodiversity Rhizogenesis Biochemical Markers Hormones

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Optimization of Maturation of Radio-Cephalic Arteriovenous Fistula Using a Model Relating Energy Loss Rate and Vascular Geometric Parameters

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Journal of Biomedical Science and Engineering 2021年第6期14卷 271-287页

作者： Yang Yang Nellie Della Schiava Pascale Kulisa Mahmoud El Hajem Benyebka Bou-Saïd Serge simoëns Patrick Lermusiaux Univ Lyon CNRS INSA de Lyon LaMCoS UMR5259 Villeurbanne France Department of Vascular Surgery Hospices Civils de Lyon Lyon France Univ Lyon CNRS Ecole Centrale de Lyon INSA Lyon Univ Claude Bernard Lyon 1 LMFA UMR5509 69130 Ecully France Univ Lyon INSA Lyon CNRS Ecole Centrale de Lyon Univ Claude Bernard Lyon 1 LMFA UMR5509 69621 Villeurbanne France

The main reason for the early failure of radio-cephalic arteriovenous fistula (RCAVF) is non-maturity, which means that the blood flow rate in the fistula cannot increase to the expected value for dialysis. From a mechanical perspective, the vascular resistance at the artificially designed anastomosis causes an energy loss that affects blood flow rate growth and leads to early failure. This research studied how to maximize the RCAVF maturity and primary patency by controlling the energy loss rate. We theoretically analyzed and derived a model that evaluates the energy loss rate Eavf in RCAVF as a function of its blood vessel geometric parameters (GPs) for given flow rates. There was an aggregate of five controllable GPs in RCAVF: radial artery diameter (Dra), cephalic vein diameter (Dcv), blood vessel distance between artery and vein (h), anastomotic diameter (Da), and anastomotic angle (θ). Through this analysis, it was found that Eavf was inversely proportional to Dra, Dcv, Da, and θ, whereas proportional to h. Therefore, we recommended surgeons choose the vessels with large diameters, close distance, and increase the diameter and angle of the anastomosis to decrease the early failure of RCAVF. Simultaneously, we could explain the results of many clinical empiricisms with our formula. We found that increasing Dcv and θ was more significant in reducing Eavf than increasing Dra and Da. Based on our model, we could define two critical energy loss rates (CELa, CELb) to help surgeons evaluate

关键词： Hemodialysis Radio-Cephalic Arteriovenous Fistula (RCAVF) Critical Energy Loss Rate (CEL) Vessel Geometric Parameters Maturity

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