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A functional tacrolimus-releasing nerve wrap for enhancing nerve regeneration following surgical nerve repair

Neural Regeneration Research 2025年第1期20卷 291-304页

作者： simeon c.daeschler Katelyn J.W.So Konstantin Feinberg Marina Manoraj Jenny cheung Jennifer Zhang Kaveh Mirmoeini JPaul Santerre Tessa Gordon Gregory HBorschel SickKids Research Institute Neuroscience and Mental Health ProgramTorontoONCanada Institute of Biomaterials and Biomedical Engineering University of TorontoTorontoONCanada Indiana University School of Medicine IndianapolisINUSA Division of Plastic and Reconstructive Surgery the Hospital for Sick ChildrenTorontoONCanada Translational Biology and Engineering Program Ted Rogers Centre for Heart ResearchInstitute of Biomedical EngineeringFaculty of DentistryUniversity of TorontoTorontoONCanada

Axonal regeneration following surgical nerve repair is slow and often incomplete,resulting in poor functional recovery which sometimes contributes to lifelong ***,there are no FDA-approved therapies available to promote nerve *** accelerates axonal regeneration,but systemic side effects presently outweigh its potential benefits for peripheral nerve *** authors describe herein a biodegradable polyurethane-based drug delivery system for the sustained local release of tacrolimus at the nerve repair site,with suitable properties for scalable production and clinical application,aiming to promote nerve regeneration and functional recovery with minimal systemic drug *** is encapsulated into co-axially electrospun polycarbonate-urethane nanofibers to generate an implantable nerve wrap that releases therapeutic doses of bioactive tacrolimus over 31 *** and drug loading are adjustable for applications in small and large caliber nerves,and the wrap degrades within 120 days into biocompatible *** released from the nerve wrap promotes axon elongation in vitro and accelerates nerve regeneration and functional recovery in preclinical nerve repair models while off-target systemic drug exposure is reduced by 80%compared with systemic *** its surgical suitability and preclinical efficacy and safety,this system may provide a readily translatable approach to support axonal regeneration and recovery in patients undergoing nerve surgery.

关键词： biodegradable local drug delivery nerve injury nerve regeneration nerve wrap tacrolimus

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Optical tissue clearing enables rapid,precise and comprehensive assessment of three-dimensional morphology in experimental nerve regeneration research

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Neural Regeneration Research 2022年第6期17卷 1348-1356页

作者： simeon c.daeschler Jennifer Zhang Tessa Gordon Gregory H.Borschel SickKids Research Institute Neuroscience and Mental Health ProgramTorontoONCanada Institute of Biomaterials and Biomedical Engineering University of TorontoTorontoONCanada Division of Plastic and Reconstructive Surgery the Hospital for Sick ChildrenTorontoONCanada Indiana University School of Medicine IndianapolisINUSA

Morphological analyses are key outcome assessments for nerve regeneration studies but are historically limited to tissue *** optical tissue clearing techniques enabling three-dimensional imaging of entire organs at a subcellular resolution have revolutionized morphological studies of the *** extend their applicability to experimental nerve repair studies we adapted these techniques to nerves and their motor and sensory targets in *** solvent-based protocols rendered harvested peripheral nerves and their target organs transparent within 24 hours while preserving tissue architecture and *** optical clearing was compatible with conventional laboratory techniques,including retrograde labeling studies,and computational image segmentation,providing fast and precise cell ***,optically cleared organs enabled three-dimensional morphometry at an unprecedented scale including dermatome-wide innervation studies,tracing of intramuscular nerve branches or mapping of neurovascular *** their wide-ranging applicability,rapid processing times,and low costs,tissue clearing techniques are likely to be a key technology for next-generation nerve repair *** procedures were approved by the Hospital for Sick children’s Laboratory Animal Services committee(49871/9)on November 9,2019.

关键词： histology image segmentation morphometry nerve regeneration outcome assessment peripheral nerve three-dimensional imaging tissue clearing

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Promoting axonal regeneration following nerve surgery： a perspective on ultrasound treatment for nerve injuries

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Neural Regeneration Research 2018年第9期13卷 1530-1533页

作者： Konstantin D. Bergmeister simeon c. daeschler Patrick Rhodius Philipp Schoenle Arne Bocker Ulrich Kneser Leila Harhaus Department of Hand Plastic and Reconstructive Surgery Burn Center Department of Plastic and Hand Surgery University of Heidelberg BG Trauma Hospital Ludwigshafen Ludwigshafen Germany

Nerve injury is often associated with limited axonal regeneration and thus leads to delayed or incomplete axonal *** a consequence of slow nerve regeneration,target muscle function is often insufficient and leads to a lifelong ***,the diagnosis of nerve injuries has been improved and likewise surgical reconstruction has undergone significant ***,the problem of slow nerve regeneration has not been *** a recent meta-analysis,we have shown that the application of low-intensity ultrasound promotes nerve regeneration experimentally and thereby can improve functional *** we want to demonstrate the experimental effect of low intensity ultrasound on nerve regeneration,the current state of investigations and its possible future clinical applications.

关键词： peripheral nerve injuries nerve regeneration reinnervation experimental studies low-intensityultrasound adjunct treatment nerve reconstruction nerve surgery axonal injury

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Evolution and predictive factors of thyroid disorder due to interferon alpha in the treatment of hepatitis c

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World Journal of Gastroenterology 2009年第3期15卷 328-333页

作者： Moana Gelu-simeon Aurore Burlaud Jacques Young Gilles Pelletier catherine Buffet Department of Hepatology and Gastroenterology Bicetre Hospital78 rue du General LeclercLe Kremlin-Bicetre 94275France Department of Endocrinology Bicetre Hospital78 rue du General LeclercLe Kremlin-Bicetre 94275France

AIM:To study predictive factors of thyroid dysfunction associated with interferon-alpha(IFNα) therapy in chronic hepatitis c(cHc) and to describe its long-term evolution in a large population without previous thyroid ***:We performed a follow-up of thyroid function and detection of thyroid antibodies in 301 patients treated for cHc with IFNα from 1999 to ***:Thyroid disorder developed in 30/301(10%) patients with a mean delay of 6 ± 3.75 mo:13 patients had hyperthyroidism,11 had hypothyroidism,and 6 had biphasic *** a mean follow-up of 41.59 ± 15.39 mo,9 patients with hyperthyroidism,3 with hypothyroidism,and 4 with biphasic evolution normalized thyroid function in 7.88 ± 5.46 *** rate of dysthyroidism was not modified by treatment discontinuation,but was better for patients with negative thyroid antibodies before antiviral treatment(P = 0.02).Women had signif icantly more dysthyroidism(P = 0.05).Positive thyroid peroxidase and thyroglobulin antibodies were more frequent before antiviral treatment in patients who developed dysthyroidism(P ctively).In a multivariate model,low fibrosis was found to be a predictive factor of dysthyroidism(P = 0.039).cONcLUSION:In this monocentric population of cHc,dysthyroidism,especially hyperthyroidism,developed in 10% of *** fibrosis was found to be a predictive factor of *** disorder recovered in 16/30 patients(53%) and recovery was better in the non-autoimmune form.

关键词：慢性丙肝干扰素甲状腺紊乱治疗方法

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Acute Toxicity and Behavioural Responses of African catfish,clarias gariepinus to Amine Salt of 2,4-D

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应用与环境生物学报 2010年第3期16卷 347-352页

作者： GABRIEL Ugwemgorubong Ujagwung MAcAULAY Bonny Koffi EDORI Onisogen simeon Department of Fisheries and Aquatic Environment Rivers State University of Science and Technology Bayelsa State Agricultural Development Programme Ministry of Agriculture Department of chemistry Rivers State University of Education

Fingerlings of African catfish,clarias gariepinus [mean total length,(7.0±1.0) cm SD;mean weight,(3.0±0.7) g SD] were exposed to acute concentrations of amine salt of 2,4-D(0,50,200,250,350,and 400 mg/L) to determine the behavioural responses and *** raised in aquaria the fish became *** beat frequencies(opercular and tail beat frequency per minute,OBF and TBF) of the exposed fish declined with increase in the exposure duration and concentration,but the reverse was the case with percent *** variables signifi cantly differed at both the exposure duration and concentration of the toxicant(Pcated a strong positive relationship(Pcept mortality and exposure *** and TBF were inversely correlated with exposure duration(r=-0.99;Pconcentration was 165.36(133.29～190.51,c.L.) mg/L and the median lethal time at the highest concentration was 20.41(11.87～27.46) *** results from this study revealed that 2,4-D was very toxic to *** under laboratory conditions and its application should therefore,be restricted in the field.

关键词： acute toxicity 2,4-D clarias gariepinus opercular behavioural change

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capacity drop through reaction times in heterogeneous traffic

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Journal of Traffic and Transportation Engineering(English Edition) 2018年第2期5卷 96-104页

作者： simeon c.calvert Femke L.M.van Wageningen-Kessels Serge P.Hoogendoorn Department of Transport & Planning Delft University of Technology

The capacity drop forms a major reason why the prevention of congestion is targeted by traffic management, as lower capacities are detrimental to traffic throughput. Various reasons describing the dynamics behind the capacity have been described, however one of these, reaction times, has had less explicit attention when modelling on a macroscopic flow level. In this contribution, a method to include the effect of reaction times for the capacity drop in heterogeneous traffic is proposed. The applied method further overcomes difficulties in including reaction times in a discrete time model through relaxation of the updating process in the discretization. This approach is novel for application in the considered first order approach, which is practise ready, contrary to many other models that propose similar approaches. The combination of the introduced method and the model form a solid development and method to apply the capacity drop based on this causation of the capacity drop. The results of the experiment case showed that the influence of traffic heterogeneity had a limited effect on the severity of the capacity drop, while it did influence the time of congestion onset. The influence of the reaction time on traffic showed greater capacity drop values for greater reaction time settings. The findings showed the method effective and valid, while the model application is also practise ready.

关键词： capacity drop Traffic modelling Heterogeneous traffic Traffic flowi

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Demographic and clinical Profiles of Blood Transfusion Recipients at a Teaching and Referral Hospital in Kenya

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Open Journal of Blood Diseases 2019年第1期9卷 30-40页

作者： Japheth c. Kipkulei Nathan Buziba simeon Mining Hellen Jepngetich Department of Haematology and Blood Transfusion School of Medicine College of Health Sciences Moi University Eldoret Kenya Department of Immunology School of Medicine College of Health Sciences Moi University Eldoret Kenya Department of Environmental Health School of Public Health College of Health Sciences Moi University Eldoret Kenya

Background: Blood transfusion is an essential component of modern health care. It is required universally to manage various medical, surgical and obstetric conditions. Establishing the profiles of blood recipients would help in predicting the long term needs of blood transfusion as changing patterns of populations, diseases and health care will result in changing demands for blood and blood components. The objective of the study was to determine the pattern of blood use in terms of demographic and clinical profiles of the recipients. Methods: A hospital based medical chart review of 384 patients who were transfused from June 2013 to November 2013 was carried out. Systematic random sampling method was used;data were collected using a structured data collection form and was analyzed using frequency tables. Results: The median age of the recipients was 31.5 years (IQR 13, 45.8) and the range was 0 to 89 years. Females comprised 55.2% of the recipients, of which 57.7% were in the reproductive age group (15 - 49 years). The majority of the recipients (60%) were from surgical and medical wards. The main indication of the transfusion was anaemia (62.8%) and most of the transfused patients were being treated for neoplasms (23.2%), pregnancy and childbirth related conditions (11.7%), injuries (11.5%) and infections (11.4%). conclusion: Majority of the transfused patients were relatively young and were females. Anemia was the main indication of the transfusion and most of the transfused recipients presented with neoplasms, pregnancy and childbirth related conditions, infections and injuries.

关键词： Blood Transfusion Blood Use Presenting condition International classification of Disease (IcD)

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PLANT AND ANIMAL DIVERSITY AT THE RED HILL FOSSIL SITE,NORTH-cENTRAL PENNSYLVANIA, USA, AND IMPLIcATIONS FOR ENVIRONMENTAL INTERAcTIONS IN THE LATE DEVONIAN

PLANT AND ANIMAL DIVERSITY AT THE RED HILL FOSSIL SITE,NORTH...

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第二届国际古生物学大会

作者： Walter L.cRESSLER Ⅲ Edward B.daeschler Francis Harvey Green Library 29 West Rosedale Avenue West Chester University of PennsylvaniaWest Chester PA 19383 USA Vertebrate Zoology Academy of Natural Sciences 1900 Benjamin Franklin ParkwayPhiladelphia PA 19103 USA

Palaeoecological analyses conducted at the Late Devonian (Famennian 2c) Red Hill fossil locality in north-central Pennsylvania, USA, reinforces evidence that by this time interval plants were an increasing influence on the dynamics of floodplain ecosystems, contributed to landscapes with new ecological opportunities for invertebrate and vertebrate faunas, and had the potential to influence global processes.

关键词： Late Devonian palaeoecology plants tetrapods

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Mathematical Model, Optimal control and Transmission Dynamics of Avian Spirochaetosis

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Journal of Applied Mathematics and Physics 2020年第2期8卷 270-293页

作者： Joy I. Uwakwe Blessing O. Emerenini simeon c. Inyama Deapartment of Mathematics Federal University of Technology Owerri Nigeria Department of Mathematics Oregon State University Corvallis USA

Avian Spirochaetosis is an acute endemic tick-borne disease of birds, caused by Borrelia anserins, a species of Borrelia bacteria. In this paper, we present a compartmental mathematical model of the disease for the bird population and Tick population. The disease steady-state and the conditions for reaching a stable disease-free steady state are determined. The analysis by Lyapunov method shows both local and global stability. Further investigation involves the introduction of controls to the model;the existence and uniqueness of optimal control are established. Finally, the effect of the controls is investigated using numerical solutions.

关键词： Avian Spirochaetosis Tick Fever Mathematical Model control Measure Transmission Dynamics

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PFAS: Ecological Implications, Remedial Actions and Ethical considerations

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Health 2023年第3期15卷 306-334页

作者： Oluwafemi Awolesi Peter Oni Abiodun Oshinowo Boluwatife S. Olubusoye Faustina Owusu simeon Pama Sunday Temitope Osobamiro Acaye Ongwech Omotoyosi Awolesi Beatrice Arwenyo Department of Environmental Science Louisiana State University Baton Rouge USA Research & Development Unit Ecoxygiene Services Limited Lagos Nigeria Department of chemistry Mississippi State University Starkville USA Department of chemistry and Biochemistry Worcester Polytechnic Institute Massachusetts USA Department of chemistry and Biochemistry University of Toledo Toledo USA Department of chemistry and Biochemistry University of Mississippi Oxford USA Department of chemical Sciences Olabisi Onabanjo University Ago-Iwoye Nigeria Department of chemistry Gulu University Gulu Uganda Faculty of Law University of Lagos Lagos Nigeria

The c-F bond is one of the strongest in organic chemistry. It is responsible for the great stability of perfluoroalkyl and polyfluoroalkyl substances, commonly referred to as “PFAS”, a group of man-made chemicals that include perfluorooctane sulfonate (PFOS) and perfluorooctanoic acid (PFOA). Thermal stability, surface activity, dielectric characteristics, chemical resistance, and inertness are just a few of the technical advantages that this group has over hydrocarbons, and since the 1950s, these chemicals have been largely utilized in a variety of domestic and industrial endeavors. The hydrophilic and lipophilic nature of this class of chemicals accounts for its uniqueness. Up until today, the chemistry and ecotoxicology of these chemicals continue to emerge. Issues concerning the destructive power of ignorance expedited by an ineffective regulatory institution continue to show that manufacturing chemicals are insufficient without giving serious thought to issues of openness and humanity’s awareness of its own safety. When discussing the nature of humanity and how it can be defined or redefined, it is important to allude to the significance of integrating business with ethics in its various forms. This paper highlights the importance of holding polluters accountable for PFAS contamination cleanup costs while emphasizing the need for chemical manufacturers to test and disclose the health and environmental effects of PFAS compounds. In addition, the sources, types, properties, applications, distribution, toxicological implications, regulations, and analytical methods associated with PFAS (per- and polyfluoroalkyl substances) are explored. The effectiveness of the remedial methods described in this paper needs to be progressively tested while exploring other sustainable approaches.

关键词： Emerging contaminants Per- and Polyfluoroalkyl Substances Non-Polymeric chemicals Remediation Ethics Public Health

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