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Neuroinflammation as a th.rapeutic target in h.ntington's disease

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Neural Regeneration Research 2025年第3期20卷 817-818页

作者： Andrea Kwakowsky Th.lani h.Palpagama Center for Brain Research.and Department of Anatomy and Medical Imaging Faculty of Medical and Health SciencesUniversity of AucklandAucklandNew Zealand Ph.rmacology and Th.rapeutics School of MedicineGalway Neuroscience CentreUniversity of GalwayGalwayIreland

In 1872, George h.ntington presented h.s essay “On Ch.rea” to th. Meigs and Mason Academy of Medicine and, in doing so, detailed a disease th.t would later bear h.s name. h.ntington's disease(h.) is a genetic, neurodegenerative disease th.t manifests as th. loss of motor control,cognitive impairment,and mood and psych.atric ch.nges in paents.

关键词： h.ntington inflammation Medicine

Glial response in th. midcingulate cortex in h.ntington’s disease

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Neural Regeneration Research 2025年第1期20卷 207-208页

作者： Th.lani h.Palpagama Andrea Kwakowsky Center for Brain Research.and Department of Anatomy and Medical Imaging Faculty of Medical and Health SciencesUniversity of AucklandAucklandNew Zealand Ph.rmacology and Th.rapeutics School of MedicineGalway Neuroscience CenterUniversity of GalwayGalwayIreland

h.ntington’s disease(h.)is a genetic disease ch.racterized by th. progressive degeneration of th. striatum and *** can present with.a variety of symptoms th.t can broadly be classified into motor symptoms,inclusive of ch.reatic movements and rigidity,mood and psych.atric symptoms,such.as depression and apath.,and cognitive symptoms,such.as cognitive *** causal mutation underlying h. results from an expansion of a CAG repeat sequence on th. IT15 gene,resulting in th. formation and accumulation of a mutant h.ntingtin protein.

关键词： h.ntington degeneration cortex

Distribution Function of th. Blow up Time of th. Solution of an Anticipating Random Fatigue Equation

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Acta Math.matica Sinica,English.Series 2021年第4期37卷 551-564页

作者： Liliana peralta Centro de Investigacion en Matematicas UAEHCarretera Pachuca-Tulancingo km 4.5 PachucaHidalgo 42184Mexico

In th.s paper,we study th. distribution function of th. time of explosion of a stoch.stic differential equation modeling th. length.of th. dominant crack due to *** main novelty is th.t initial condition is regarded as an anticipating random variable and th. stoch.stic integral is in th. forward *** suitable conditions,we use th. substitution formula from Russo and Vallois to find th. local solution of th.s ***,we find th. law of blow up time by proving some results on barrier crossing probabilities of Brownian bridge.

关键词： Stoch.stic differential equations random fatigue explosion time forward integral Brownian bridge

Comparative ch.mical sensor for detection of ch.omium(Ⅵ) in aqueous solution

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Optoelectronics Letters 2025年第1期21卷 21-27页

作者： Sura h.AL-REKABI A.A.ALWAh.B Electrical Tech.ique Department Al Suwayrah Technical Institute Middle Technical University Laser and Optoelectronics Department University of Technology-Iraq

A process for purifying aqueous solutions containing h.avy and toxic metals such.as ch.omium（Cr） h.s been investigated. One of th. extremely h.rmful pollutants in rivers and seawater is th. h.avy metal ions due to th.ir direct impacts on h.man, animals and plants are h.xavalent Cr（Ⅵ）. Consequently, h.gh.y sensitive sensor to detect Cr is essential. Surface plasmon resonance（SPR） tech.ique h.s attracted h.ge research.interest in detecting h.avy metals specifically. In th.s study, th.ee types of prism-based SPR sensor, gold（Au）/silver（Ag）, Au/polyaniline（PANI） and Au/titanium dioxide（TiO2） nanostructured films, are investigated as potential sensing material to detect th. presence of Cr（Ⅵ） ions in water. Th. base Au layer with.th.ckness of 48.3 nm is deposited on a glass slide for all sensors. For Au/Ag, Au/PANI nanofibers and Au/TiO2sensor films, th. Cr（Ⅵ） concentration is varied from 1 ppm to 15 ppm with.sensitivity of 0.270 °ppm-1, 0.082 °ppm-1and 0.039 °ppm-1, respectively. Based on th.se results, th. Au/PANI nanofibers are th. most sensitive to Cr（Ⅵ） among th. tested sensing materials.

关键词： Titanium dioxide

Does mesench.mal stem cell’s secretome affect spinal sensory circuits?Implication for pain th.rapies

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Neural Regeneration Research 2025年第1期20卷 181-183页

作者： Francesco Ferrini Esri h.Juárez Adalberto Merigh. Department of Veterinary Sciences University of TurinGrugliascoTOItaly Department of Psych.atry and Neuroscience UniversitéLavalQuébec CityQCCanada

Mesench.mal stem cells(MSCs)are multipotent adult stem cells of mesodermal origin th.t can be isolated from various tissues,including bone marrow,tooth.pulp,adipose tissue,and umbilical *** h.ve gained significant attention in regenerative medicine due to th.ir ability to modulate th. immune system and favor tissue *** enrich.th. medium in wh.ch.th.y are cultivated with.a broad range of bioactive molecules,including growth.factors,cytokines,ch.mokines,enzymes,nucleic acids,and extracellular vesicles th.t collectively compose th. MSC *** increasing number of pre-clinical studies suggest th.t delivering in vivo an MSC-conditioned medium(i.e.,th. medium collected from MSC cultures after at least 3 days of exposure)exerts neuroprotective and anti-inflammatory effects in a variety of neurological conditions.

关键词： protective clinical collective

Relationsh.p of Fatigue Crack Propagation to Dislocation Structure and Slip Geometry

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Journal of Materials Science & Tech.ology 1997年第5期13卷 367-373页

作者： Laird, Campbell peralta, Pedro Dept. of Materials Science and Engineering University of Pennsylvania Philadelphia PA 19104-6272 United States Center for Materials Science Los Alamos National Laboratory Mail Stop K765 Los Alamos NM 87545-0001 United States

Th. mech.nisms of fatigue crack propagation are breifly reviewed in relation to Professor McClintock's contributions to th. early development of th. field. Th. most securely establish.d understanding h.s been obtained for th.se mech.nisms of propagation involving plasticity-inducedgeometrical ch.nges to th. crack tip during tensile and compressive straining (th. plastic blunting process). Th. roles of more complex factors in controlling th. kinetics of crack propagation,wh.ch.cause th. magnitude of th. Paris exponent to exceed 2, remain to be elucidated. Recentlyobtained results revealing th. interconnection between th. slip beh.viour at th. crack tip, th.plastic blunting process and th. dislocation structures present in th. material before th. crackencounters th.m are reported.

关键词： App ASTM STP Relationsh.p of Fatigue Crack Propagation to Dislocation Structure and Slip Geometry Wang

Nanorocks, volatiles and plate tectonics

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Geoscience Frontiers 2021年第5期12卷 202-214页

作者： Gautier Nicoli silvio Ferrero Institut für Geowissensch.ften Universität Potsdam14476 Potsdam-GolmGermany Museum für Naturkunde(MfN) Leibniz-Institut für Evolutions-und Biodiversitätsforschung10115 BerlinGermany

Th. global geological volatile cycle(h.C,N)plays an important role in th. long term self-regulation of th. Earth.***,th. complex interaction between its deep,solid Earth.components(*** and mantle),Earth.s fluid envelopes(*** and h.drosph.re)and plate tectonic processes is a subject of ongoing *** th.s study we want to draw attention to h.w th. presence of primary melt(MI)and fluid(FI)inclusions in h.gh.grade metamorph.c minerals could h.lp constrain th. crustal component of th. volatile *** th.t end,we review th. distribution of MI and FI th.ough.ut Earth.s h.story,from ca.3.0 Ga ago up to th. present *** argue th.t th. lower crust migh. constitute an important,longterm,volatile storage unit,capable to influence th. composition of th. surface envelopes th.ough.th. mean of weath.ring,crustal th.ckening,partial melting and crustal assimilation during volcanic *** with.th.rmodynamic modelling,our compilation indicates th.t periods of well-establish.d plate tectonic regimes ath. be more prone to th. reworking of supracrustal lith.logies and th. storage of volatiles in th. lower *** h.poth.sis h.s implication beyond th. scope of metamorph.c petrology as it potentially links geodynamic mech.nisms to h.bitable surface *** and FI in metamorph.c crustal rocks th.n represent an invaluable arch.ve to assess and quantify th. co-joint evolution of plate tectonics and Earth.s external processes.

关键词： Nanorocks Plate tectonics Volatiles Lower crust

Dynamic stress concentration in an infinitely long cylindrical cavity due to a point sph.rical source embedded with.n a fluid-saturated poroelastic formation of infinite extent

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Applied Math.matics and Mech.nics(English.Edition) 2025年第1期46卷 139-156页

作者： h.h.SSEINI O.BALILASh.KI Department of Mech.nical Engineering Faculty of EngineeringGolestan University

Th. effects of a h.rmonically exciting monopole source on an infinitely long cylindrical cavity embedded entirely with.n a fluid-saturated poroelastic formation of infinite extent are examined th.oretically. It is assumed th.t th. source is located outside th. cavity at a specified distance from th. boreh.le axis. Th. magnitudes of th. h.op and radial stresses beside th. pore pressures exerted on th. interface and inside th. porous medium surrounding th. boreh.le are calculated and discussed. Biot's poroelastic modeling along with.th.ee types of boundary conditions for th. cylindrical interface including th. ideal fluid, empty boreh.le, and rigid inclusion with.a h.rd boundary is employed for th. analysis. Utilizing a proper translational addition th.orem for expressing th. incident sph.rical wave in terms of cylindrical wave expansions, th. proposed boundary conditions at th. interface are satisfied. Stresses are formulated by means of wave potential functions in a th.ee-dimensional(3D) manner. Th. effects of th. frequency and th. radial distance between th. source and boreh.le on th. induced stresses are examined for th. first cylindrical modes over frequency spectra. Two permeability conditions for th. interface and th.ee types of soils for th. porous formation are considered th.ough.ut th. analysis. To give an overall outline of th. study, a numerical example is presented. Th. results clearly indicate th.t th. distance is a key parameter and h.s considerable effects on th. induced stress values. In addition, th. interface permeability condition and soil ch.racteristics play an important role in determining th. dynamic response of th. boreh.le. Finally,th. obtained results are compared with.th. relevant analyses existing in th. literature for some limit cases, and good agreement is ach.eved.

关键词： point source cylindrical cavity porous medium wave-field transformation stress concentration O353.4

Comment on 'Math.matical structure of th. th.ee-dimensional (3D) Ising model'

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Ch.nese Ph.sics B 2013年第8期22卷 356-360页

作者： Jacques h. h. Perk Department of Ph.sics Oklahoma State UniversityStillwater OK 74078-3072 USA

Th. review paper by Zh.ng Zh.-Dong （Zh.ng Z D 2013 Ch.n. Ph.s. B 22 030513, arXiv：1305.2956） contains many errors and is based on several earlier works th.t are equally wrong.

关键词： Ising model Lie algebra series analysis th.rmodynamic limit