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Comparison of Clonidine and Metoprolol Effectiveness on the Control of Post-Operative Blood Pressure in Otorhinolaryngology-Head and Neck Surgeries: A Clinical Trial

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Open Journal of Anesthesiology 2021年第2期11卷 49-58页

作者： Sérgio Menezes silvio Caldas Neto Ruy Lins Filho Jayme Santos Neto Rossana Lins Universidade Federal de Pernambuco Recife Brazil

Objectives: Adequate control of hemodynamic parameters in patients undergoing otolaryngology-head and neck (OLHN) surgeries is one of the objectives of peri-operative anesthesia management. In this context, we seek to evaluate the effectiveness of metoprolol compared to clonidine in the post-operative control of systolic (SBP) and diastolic (DBP) blood pressures, and heart rate (HR), when these medications are used in the immediate pre-operative period. Method: this is a randomized double-blind clinical trial. Patients over 18 years old, according to the American Society of Anesthesiologists Physical Status Classification (ASA) I or II, who would undergo OLHN surgery, presenting with greater than 140 mmHg (SBP) or 90 mmHg (DBP), upon arrival at the surgical ward, were included in the study. 46 patients were randomized into two groups (C or M) who received clonidine (75 or 150 mcg) or metoprolol (5 or 10 mg), respectively. The averages of SBP, DBP and HR were compared between groups upon arrival at the post anesthesia care unit (PACU) and four hours post-surgery. Results: In group C, SBP (127.7 ± 18.8 vs 137.3 ± 14.1 mmHg, p = 0.03) and DBP (73.1 ± 15.46 vs 82.6 ± 7.9 mmHg, p 0.01) were lower, when compared with group M. No difference was observed in HR immediately upon PACU arrival. In addition, for four hours post-surgery, no change was noted in the SBP, DBP or HR. Conclusion: metoprolol was less effective than clonidine in reducing systolic and diastolic blood pressures in the immediate post-operative period of OLHN surgeries.

关键词： Clonidine Metoprolol Hypertension Post-Operative

Taking care of volunteers in a stroke trial: a new assisted-management strategy

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Stroke & Vascular Neurology 2016年第3期1卷 108-114页

作者： Amber C Stuart Jason J Sico Catherine M Viscoli Ashis H Tayal silvio E Inzucchi Gary A Ford Karen L Furie Robert Cote J David Spence David Tanne Walter N Kernan on behalf of the IRIS Trial Investigators Department of Internal Medicine Yale University School of MedicineNew HavenConnecticutUSA Department of Neurology Yale University School of MedicineNew HavenConnecticutUSA Department of Neurology Service Veterans Affairs Connecticut Healthcare SystemWest HavenConnecticutUSA Neuroscience Institute Allegheny Health NetworkPittsburghPennsylvaniaUSA Lewis Katz School of Medicine at Temple University PhiladelphiaPennsylvaniaUSA Division of Medical Sciences Oxford UniversityOxfordUK The Warren Alpert Medical School of Brown University ProvidenceRhode IslandUSA Department of Neurology Neurosurgery and MedicineMcGill UniversityMontrealQuebecCanada University of Western Ontario LondonOntarioCanada 10Sheba Medical CenterTel Aviv UniversityTel AvivIsrael 不详

Background and purpose:Providing participants with evidence-based care for secondary prevention is an ethical and scientific priority for trials in stroke *** optimal strategy,however,is *** report the performance of a new approach for delivering preventive care to trial ***:Participants were enrolled in the Insulin Resistance Intervention after Stroke trial,which examined the insulin sensitiser,pioglitazone versus placebo for prevention of stroke and myocardial infarction after ischaemic stroke or transient ischaemic *** care was the responsibility of the participants’personal healthcare providers,but investigators monitored care and provided feedback *** studied achievement of 8 prevention goals at baseline and 3 annual visits,with a focus on 3 priority goals:blood pressure<140/90 mm Hg,lowdensity lipoprotein(LDL)cholesterol<2.59 mmol/L and antithrombotic ***:The proportion of participants achieving the priority goals was highest for antithrombotic use(96–99%in each year)and similar for blood pressure(66–72%in each year)and LDL(68–70%in each year).All 3 priority goals were achieved by 47–52%of participants in any given ***,only 22%of participants achieved all 3 goals in each ***:A strategy of monitoring care and providing feedback was associated with high average yearly achievement of 3 priority secondary prevention goals,but the majority of trial participants did not persist in being at goal over *** registration number:NCT00091949.

关键词： prevention annually goals

Narrow-band imaging endoscopy to assess mucosal angiogenesis in inflammatory bowel disease: A pilot study

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World Journal of Gastroenterology 2010年第19期16卷 2396-2400页

作者： silvio Danese Gionata Fiorino Erika Angelucci Stefania Vetrano Nico Pagano Giacomo Rando Antonino Spinelli Alberto Malesci Alessandro Repici Division of Gastroenterology IRCCS Istituto Clinico Humanitas Rozzano Milan 20089 Italy Department of Surgery IRCCS Istituto Clinico Humanitas Rozzano Milan 20089 Italy Department of Translational Medicine Univer-sity of Milan Milan 20100 Italy

AIM: To investigate whether narrow band imaging (NBI) is a useful tool for the in vivo detection of angiogenesis in inflammatory bowel disease (IBD) patients. METHODS: Conventional and NBI colonoscopy was performed in 14 patients with colonic inflammation (8 ulcerative colitis and 6 Crohn’s disease). Biopsy samples were taken and CD31 expression was assayed immuno- histochemically; microvascular density was assessed by vessel count. RESULTS: In areas that were endoscopically normal but positive on NBI, there was a significant (P < 0.05) increase in angiogenesis (12 ± 1 vessels/field vs 18 ± 2 vessels/field) compared with areas negative on NBI. In addition, in areas that were inflamed on white light endoscopy and positive on NBI, there was a significant (P < 0.01) increase in vessel density (24 ± 7 vessels/f ield) compared with NBI-negative ***: NBI may allow in vivo imaging of intestinal angiogenesis in IBD patients.

关键词： Narrow-band imaging Angiogenesis Inflammatory bowel disease Crohn’s disease Ulcerative colitis

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亲爱的,我让房子动起来了!

缤纷 2002年第9期 67-71页

作者：刘维 silvio Wolf (Mondadori press)

一个只有70平方米大小的家,它的主人在房子的每个角落都装上了轮子,并将一些墙消失在视野中,因此,在这个家里,总是能时时发现惊奇。

关键词：空间平方米房子意大利人主人客厅厨房卫生间书柜红色

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GEMS/WATER—全球水质监测

科学与社会 1983年第1期 90-98页

作者： silvio Barabas 张绍宗世界卫生组织地表地下水质协作中心

GEMS/WATER是联合国组织实施的一项监测世界范围河流、湖泊和含水层中水质的国际合作研究计划。目前,在50个国家中有300个以上的监测站向设在加拿大的全球中心提供水质报告。数据包括水质的13个基本参数。

关键词：决定要素 GEMS/WATER 可比较性数据点含水层储集层水质监测水质污染监测

Which Endpoints Can Be Reliably Assessed in Semi-field Pollinator Species Testing without Estimating False Positive or False Negative？ MDD’s and Replicates Issue

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Journal of Agricultural Science and Technology(A) 2018年第3期8卷 142-161页

作者： Marco Pompeo Candolfi Holger Bargen Sigrun Bocksch Olaf Klein Marco Kleinhenz silvio Knaebe Bronislawa Szczesniak Eurofins Agroscience Services Ecotox GmbH Eutinger Str. 24 Niefern-Oschelbronn 75223 Germany

Statistical power, number of replicates and experiment complexity of semi-field and field studies on Apis and non-Apis bee species has become a major issue after publication of the draft European Food Safety Authority （EFSA） Guidance on risk assessment of plant protection products （PPP） on bees （Apis mellifera, Bombus spp. and solitary bees）. According to this guidance document, field studies have to be designed to be able to detect significance differences as low as 7% for certain endpoints such as reduction in colony size. This will require an immense number of replicates which is obviously not feasible. In the present study, key endpoints such as mortality, termination rate and number of brood cells in honeybee studies, cocoon production and flight activity in solitary bee studies and number of gynes in bumble bee studies （just to mention some of the endpoints considered） in semi-field studies were analyzed, with Apis mellifera, Bombus terrestris and Osmia bicornis during the past five years （2013-2017）. The results indicate huge differences in the percentage minimal detectable differences （%MDDs）（MDD expressed as median of control value of the endpoint in percent） depending on endpoint and species tested. For honeybee semi-field studies, the lowest %MDDs recorded were between 10% and 15% for the endpoints foraging, number of brood cells and colony strength. The highest %MDDs were observed for the endpoint termination rate, with a %MDD of almost 50%. For the endpoints in bumble bee semi-field studies the %MDDs varied between 17% for bumble bee colony weight and 53% for average mortality during the exposure period in the tunnel. The %MDD for the number of gynes （young queens） was slightly below 25%. For the semi-field solitary bee test system, the %MDDs for the measured endpoints seem to be lower than those for the other two species tested. The %MDDs for the endpoints hatching of offspring, nest occupation and number of cocoons were 8%, 13% and 14%, respective

关键词： Apis mellifera Bombus terrestris Osmia bicornis OECD75 minimal detectable difference (MDD) statistical power

Molecular classifications of gastric cancers: Novel insights and possible future applications

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World Journal of Gastrointestinal Oncology 2017年第5期9卷 194-208页

作者： silvio Ken Garattini Debora Basile Monica Cattaneo Valentina Fanotto Elena Ongaro Marta Bonotto Francesca V Negri Rosa Berenato Paola Ermacora Giovanni Gerardo Cardellino Mariella Giovannoni Nicoletta Pella Mario Scartozzi Lorenzo Antonuzzo Nicola Silvestris Gianpiero Fasola Giuseppe Aprile Department of Oncology University and General Hospital Medical Oncology University Hospital Medical Oncology National Cancer InstituteIRCCS Department of Oncology University Hospital

Despite some notable advances in the systemic management of gastric cancer(GC), the prognosis of patients with advanced disease remains overall poor and their chance of cure is anecdotic. In a molecularly selected population, a median overall survival of 13.8 mo has been reached with the use of human epidermal growth factor 2(HER2) inhibitors in combination with chemotherapy, which has soon after become the standard of care for patients with HER2-overexpressing GC. Moreover, oncologists have recognized the clinical utility of conceiving cancers as a collection of different molecularlydriven entities rather than a single disease. Several molecular drivers have been identified as having crucial roles in other tumors and new molecular classifications have been recently proposed for gastric cancer as well. Not only these classifications allow the identification of different tumor subtypes with unique features, but also they serve as springboard for the development of different therapeutic strategies. Hopefully, the application of standard systemic chemotherapy, specifictargeted agents, immunotherapy or even surgery in specific cancer subgroups will help maximizing treatment outcomes and will avoid treating patients with minimal chance to respond, therefore diluting the average benefit. In this review, we aim at elucidating the aspects of GC molecular subtypes, and the possible future applications of such molecular analyses.

关键词： Molecular biology Immunotherapy Gastric cancer Classification Targeted therapy

Nutritional evaluation of integral cassava root silages for growing pigs

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Animal Nutrition 2016年第3期2卷 149-153页

作者： Diego D.Araújo Alessandro B.Amorim Mayra A.D.Saleh Felipe Curcelli Pedro L.Perdigón silvio J.Bicudo Dirlei A.Berto Department of Animal Production Faculty of Animal Science and Veterinary Medicine UNESP-So Paulo State University Institute of Agricultural Sciences and Technologies Federal University of Mato Grosso Department of Crop Science Faculty of Agricultural Sciences UNESP-So Paulo State University Instituto de Ciencia Animal (ICA)

The experiment aimed at determining the nutritional value of integral cassava root silages with yogurt as inoculant or wastewater(manipueira) by liquid addition ensiling process. Eighteen crossbred piglets(Large White x Landrace), castrated males with an initial average weight of 50 kg were allocated in metabolism cages throughout 11-day trial duration(6 days for animal's adaptation to the cages and to the experimental diets, and 5 days of urine and faeces collection). The experimental design was a randomized block arrangement with 3 treatments and 6 replicates: basal diet(100%); mixture composed of75% basal diet and 25% integral cassava root silage with yogurt as inoculant; a mixture composed of 75%of basal diet and 25% integral cassava root silage with wastewater. The silages with wastewater and yogurt presented the following values of apparent digestibility of dry matter 89.96% and 90.01%,apparent digestibility of crude protein of 60.67% and 66.43%, apparent digestibility of gross energy of90.43% and 91.48%, gross energy metabolizability coefficients of 87.88% and 88.93%, digestible energy values of 3,705 and 3,783 kcal/kg on a dry matter(DM) basis, and metabolizable energy values of 3,600 and 3,676 kcal/kg DM, respectively. The results have demonstrated that integral cassava root silages with wastewater or yogurt have a high nutritional value and can be used as an alternative energy source in growing pig's diets.

关键词： Alternative feed Digestibility Energy sources Ensiling Swine

Opening the doors of the intensive care unit to cancer patients: A current perspective

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World Journal of Critical Care Medicine 2015年第3期4卷 159-162页

作者： silvio A ?amendys-Silva Erika P Plata-Menchaca Eduardo Rivero-Sigarroa Angel Herrera-Gómez Department of Critical Care Medicine Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán Department of Critical Care Medicine Instituto Nacional de Cancerología

The introduction of new treatments for cancer and advances in the intensive care of critically ill cancer patients has improved the prognosis and survival. In recent years, the classical intensive care unit(ICU) admission comorbidity criteria used for this group of patients have been discouraged since the risk factors for death that have been studied, mainly the number and severity of organic failures, allow us to understand the determinants of the prognosis inside the ICU. However, the availability of intensive care resources is dissimilar by country, and these differences are known to alter the indications for admission to critical care setting. Three to five days of ICU management is warranted before making a final decision(ICU trial) to consider keep down intensive management of critically ill cancer patients. Nowadays, taking into account only the diagnosis of cancer to consider ICU admission of patients who need full-supporting management is no longer justified.

关键词： Intensive care unit Critical care setting Cancer patients Critically ill cancer patients Organ failures