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State of the art biological therapies in pancreatic cancer

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World Journal of Gastrointestinal Oncology 2016年第1期8卷 55-66页

作者： mariacristina di marco elisa grassi sandra durante silvia vecchiarelli andrea palloni marina macchini riccardo casadei claudio ricci riccardo panzacchi donatella santini guido biasco department of experimental diagnostic and specialty medicineuniversity of bolognasant’orsola-malpighi hospital40138 BolognaItaly department of medical and surgical sciences university of bolognasant’orsola-malpighi hospital40138 BolognaItaly pathology unit sant’orsola-malpighi hospital40138 BolognaItaly

Pancreatic ductal adenocarcinoma(PDAC) is one of the most lethal malignancies with a five-year survival rate of approximately 5%. Several target agents have been tested in PDAC, but almost all have failed to demonstrate efficacy in late phase clinical trials, despite the better understanding of PDAC molecular biology generated by large cancer sequencing initiatives in the past decade. Eroltinib(a small-molecule tyrosine-kinase inhibitor of epidermal growth factor receptor) plus gemcitabine is the only schedule with a biological agent approved for advanced pancreatic cancer, but it has resulted in a very modest survival benefit in unselected patients. In our work, we report a summary of the main clinical trials(closed and ongoing) that refer to biological therapy evaluation in pancreatic cancer treatment.

关键词： Pancreatic cancer Molecular characterization Targeted therapy Epidermal growth factor receptorinhibitors Embryonic pathway inhibitors Antiangiogenictherapies

Medical therapy for advanced gastro-entero-pancreatic and bronchopulmonary neuroendocrine tumors

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Journal of Cancer Metastasis and Treatment 2016年第1期2卷 329-340页

作者： Mariangela Torniai silvia Rinaldi Francesca Morgese Giulia ricci Azzurra Onofri Christian Grohé Rossana Berardi Department of Medical Oncology UniversitàPolitecnica delle Marche60100 AnconaItaly Department of Respiratory Diseases Ev.Lungenklinik BerlinUniversitätsmedizin ChariteLindenberger Weg 2713125 BerlinGermany

Neuroendocrine tumors(NETs)represent a spectrum of rare neoplasms arising in different organism *** on the site of onset,they also can be distinguished using lab exams(secreting ***),clinical symptoms(functioning ***),behavioral,morphological characteristics(tumor cells’architectural growth patterns,mitotic and Ki-67 index,presence of necrosis),and grade of cellular *** aim of this review is to focus on the main signaling pathways targeted by medical treatments of advanced sporadic gastro-entero-pancreatic(GEP)and bronchopulmonary(BP)neuroendocrine *** scientific literature regarding treatment of advanced GEP and BP-NETs has been extensively reviewed using MEDLINE and PubMed databases,selecting principal and more recent research articles,clinical trials,and updated *** analogues represent a valid approach to control symptoms in functioning tumors and to inhibit tumor progression in certain categories on the basis of the typical somatostatin receptor expression observed in *** pathogenesis of NETs has been the subject of increased interest in recent *** driver mutations pathway genes have been identified as important factors in the carcinogenesis process and,therefore,as potential targets for new anticancer *** mutations have been shown in epidermal growth factor receptor,stem cell factor receptor,platelet-derived growth factor receptor,vascular endothelial growth factor,basic-fibroblastic growth factor,transforming growth factor,insulin-like growth factor-1,and their *** M-Tor inhibition pathway modulation has led to the approval of drugs in this field such as *** drugs and several combination regimens with targeted and newer biological agents are being developed and tested in recently conducted and ongoing trials.

关键词： Gastrointestinal and bronchopulmonary neuroendocrine tumors advanced disease medical treatment targeted agents

Soy-Enriched Bread, a Pilot Study to Determine Its Beneficial Effects in Menopause

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Open Journal of Endocrine and Metabolic Diseases 2022年第2期12卷 47-74页

作者： Daniela Giustarini Comasia ricci Ilaria Ceccarelli Stefano Pieretti Paolo Andre silvia Migliorini Lauretta Massai Paola Minosi Ilenia Casini Anna Maria Aloisi Department of Biotechnology Pharmacy and Biochemistry University of Siena Siena Italy Department of Life Sciences University of Siena Siena Italy Department of Medicine Surgery and Neuroscience University of Siena Siena Italy National Center for Drug Research and Evaluation Italian National Institute of Health Rome Italy

Menopause is the last step in the reproductive history of a woman. The ovaries stop producing hormones and the body reacts by lowering its functions, including the cognitive one. Phytoestrogens are plant products with the estrogen-like activity which are able to mimic many of estrogen’s functions. The aim of the present experiment was to study the effects of 30 days of regular consumption of soy-enriched bread containing a known amount of phytoestrogens (genistein and daidzein) in climacteric or menopausal women. Thirty women at different stages of menopause (climacteric, within 5 years of menopause, more than 5 years of menopause) were asked to include 200 g/die of bread containing 40 mg of phytoestrogens in their diet. The effect of the regular consumption of this bread on common menopausal symptoms and cognitive parameters was determined before and after 30 days through questionnaires and experimental tests. Phytoestrogens were measured in the urine. Twenty-five women completed the study. Independence of the menopause stage, there was a significant increase of phytoestrogens in the urine and a decrease of the classical symptoms (i.e., hot flushes). Moreover, the women showed a significant improvement in attentional performance tests, the quality of life index and pain intensity. Phytoestrogens would be an important supplement in aging women due to their ability to induce estrogen-like effects without the potential side effects of estrogens. Their presence in soy-enriched bread, a food commonly present in meals, avoids consideration of their consumption as a drug.

关键词： Menopause Women Phytoestrogens Bread Soy

Role of molecular imaging in the management of patients affected by inflammatory bowel disease:State-of-the-art

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World Journal of Radiology 2016年第10期8卷 829-845页

作者： Federico Caobelli Laura Evangelista Natale Quartuccio Demetrio Familiari Corinna Altini Angelo Castello Mariapaola Cucinotta Rossella Di Dato Cristina Ferrari Aurora Kokomani Iashar Laghai Riccardo Laudicella silvia Migliari Federica Orsini Salvatore Antonio Pignata Cristina Popescu Erinda Puta Martina ricci silvia Seghezzi Alessandro Sindoni Martina Sollini Letterio Sturiale Anna Svyridenka Vittoria Vergura Pierpaolo Alongi Department of Nuclear Medicine Universitatsspital Basel Department of Nuclear Medicine Istituto Oncologico Veneto Wolfson Molecular Imaging Centre Univer-sity of Manchester Department of Nuclear Medicine A.R.N.A.S. Nuclear Medicine Unit Univer-sity"Aldo Moro"of Bari Department of Nuclear Medicine University of Florence Department of medical-surgical science and translational medicine "La Sapienza"University Nuclear Medicine Unit Department of Biomedical Sciences and Morphological and Functional ImagesUniversity of Messina Department of Nuclear Medicine University of Parma Department of Nuclear Medicine University Hospital"Maggiore della Carita di Novara" Department of Nuclear Medicine Niguarda Ca'Grande Hospital Department of Nuclear Medicine Hospital of Treviglio Humanitas University Department of Nuclear Medicine University of Bologna Nuclear Medicine Unit Department of Radio-logical SciencesG.Giglio Institute

AIM To present the current state-of-the art of molecular imaging in the management of patients affected by inflammatory bowel disease(IBD).METHODS A systematic review of the literature was performed in order to find important original articles on the role of molecular imaging in the management of patients affected by IBD. The search was updated until February 2016 and limited to articles in *** Fifty-five original articles were included in this review, highlighting the role of single photon emission tomography and positron emission tomography. CONCLUSION To date, molecular imaging represents a useful tool to detect active disease in IBD. However, the available data need to be validated in prospective multicenter studies on larger patient samples.

关键词： White blood cell scintigraphy Inflammatory bowel disease Inflammation ^(18)F-Fluorodehoxiglucose positron emission tomography/computed tomography Molecular imaging