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Altered Expression of Aromatase, Estrogen Receptors and Progesterone Receptors in Human Leydig Cell Hyperplasia

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Advances in Bioscience and Biotechnology 2015年第1期6卷 1-10页

作者： Candela Rocío González Pablo Ignacio Felipe Inserra Claudio Terradas Roberto Ponzio Elisa Puigdomenech Oscar Levalle Alfredo Daniel Vitullo Ricardo Saúl Calandra silvia Ines gonzalez-Calvar Research Center of Biomedical Biotechnology Environmental and Diagnostic Studies Maimónides University Buenos Aires Argentina División Endocrinología Hospital Durand Buenos Aires Argentina Facultad de Medicina Universidad de Buenos Aires Buenos Aires Argentina Instituto Medico PREFER Calle 995 No 2348 San Martin Argentina Laboratorio de Endocrinología Molecular de la Reproducción Instituto de Biología y Medicina Experimental (CONICET) Buenos Aires Argentina Laboratorio de Endocrinología Molecular de la Reproducción Instituto de Biología y Medicina Experimental (CONICET) Facultad de Medicina Universidad de Buenos Aires Buenos Aires Argentina

Testicular function is regulated by pituitary hormones and also by paracrine and autocrine factors. A number of reports have pointed out the importance of estrogens and progesterone in male reproductive tract. Recently, we have reported in testicular biopsies from men with Sertoli Cell Only Syndrome (SCO) or Hypospermatogenesis (H) with Leydig cell hyperplasia (LCH) an increase in the expression of the TGFB1 and its receptors ALK1 and endoglin, which are involved in the proliferation of Leydig cells. The aim of the present work was to analyze the expression of aromatase, estrogen and progesterone receptors (ERs, PR) in pathological testicular biopsies with SCO or H with and without LCH. The ERs and CYP19 proteins were detected in the Leydig cells from all pathological biopsies analyzed. Biopsies with SCO or H with LCH showed an increment in the immunostaining of CYP19 and ERs in the Leydig cells respect to biopsies without LCH. The gene expression of CYP19 was increased in SCO or H biopsies with LCH respect to SCO and H biopsies without LCH. PR was localized in Leydig cells and showed a significant increment in biopsies with LCH respect from biopsies without LCH. The gene expression of both PRA and PRB was increased in biopsies with LCH respect to biopsies without LCH. In concussion, alterations in the gene expression of aromatase, ERs, and PR and the likely interactions of these systems with locally produced factors such as growth factors and cytokines, might lead to Leydig cell proliferation in testicular pathology.

关键词： Aromatase Progesterone Estrogen Leydig

Fatty Acid Deposition on Broiler Meat in Chickens Supplemented with Tuna Oil

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Food and Nutrition Sciences 2013年第9期4卷 16-20页

作者： Jesus Eduardo Morales-Barrera Mariano Jesus gonzalez-Alcorta Rosa Maria Castillo-Dominguez Omar Francisco Prado-Rebolledo Xochitl Hernandez-Velasco Anita Menconi Guillermo Tellez Billy Marshal Hargis silvia Carrillo-Dominguez Departamento de Producción Agrícola y Animal Universidad Autónoma Metropolitana México City México Department of Poultry Science University of Arkansas Fayetteville USA. Depto. Nutrición Animal Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán México City México Facultad de Medicina Veterinaria y Zootecnia Universidad de Colima Colima México Facultad de Medicina Veterinaria y Zootecnia Universidad Nacional Autónoma de México México City México Universidad Autónoma Chapingo Estado de México México

The aim of the present study was to evaluate the effect of feeding four levels of tuna oil on performance and fatty acid (FA) profiles of broiler chicken meat. 240 Ross broiler chickens were randomly assigned to 20 pens and divided into four treatments: 0%, 0.75%, 1%, and 1.25% of tuna oil. At 49 days, breast and legs-thighs muscles were processed for FA analysis. Concentrations of FA in legs and thighs meat were significantly higher when compared with breast meat. In both types of meats (breast and legs-thighs), the inclusion of 1.0% or 1.25% of tuna oil in the diet significantly increased (P < 0.05) the concentration of n-3 FA (especially docosahexaenoic and eicosapentaenoic acids). Fat in broiler breast contained a proportion of 29% saturated FA (SFA): 36% monosaturated FA (MFA): 35% polyunsaturated FA (PUFA);while legs and thighs meat had a proportion of 28% SFA: 38% MFA: 33% PUFA. The addition of tuna oil in the broiler diet significantly reduced the deposition of SFA, MFA, and PUFA in breast meat, while in legs and thighs these reductions were less noticeable. The significant reduction in the concentration of n-6 PUFA and the increment of n-3 PUFA were more evident in breast than in legs and thighs, and with the addition of 1% and 1.25% of tuna oil. The results of the present study suggest a difference in FA deposition attributable to supplementation with tuna oil. The addition of tuna oil could be recommendable to increase n-3 PUFA in both broiler chicken breast and legs-thighs meats, providing a healthier and functional chicken meat to consumer.

关键词： n-3 Fatty Acids Broilers Tuna Oil Breast Meat Legs and Thighs Meat

Effect of Time and Fatty Acid Composition in Eggs of White Leghorn Hens Supplemented with Tuna Oil

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Food and Nutrition Sciences 2013年第9期4卷 39-44页

作者： Jesus Eduardo Morales-Barrera Mariano Jesus gonzalez-Alcorta Rosa Maria Castillo-Dominguez Omar Francisco Prado-Rebolledo Jose Luis Vazquez Xochitl Hernandez-Velasco Guillermo Tellez Anita Menconi Billy Marshal Hargis silvia Carrillo-Dominguez Departamento de Producción Agrícola y Animal Universidad Autónoma Metropolitana México City México Department of Poultry Science University of Arkansas Fayetteville USA. Depto. Nutrición Animal Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán México City México Facultad de Medicina Veterinaria y Zootecnia Universidad de Colima Colima México Facultad de Medicina Veterinaria y Zootecnia Universidad Nacional Autónoma de México México City México Universidad Autónoma Chapingo Estado de México México

The study evaluated the effect of time and fatty acid (FA) composition in eggs of laying hens supplemented with tuna oil (TO). Two hundred White Leghorn hens 30-week were divided into 5 treatments with 4 replicates of 10 birds each. Treatments were assigned randomly and consisted of 0%, 0.75%, 1.50%, 2.25% and 3% TO in commercial sorghum-soybean meal diets, in which the soybean oil was partially replaced. The experiment was conducted for 90 days. At days 28, 56 and 84 of the experiment, 10 eggs per replicate were collected for chemical analysis. Feed intake, egg production rate, egg weight, and feed conversion were not influenced by dietary treatment. FA content was significantly altered (P < 0.05) by TO, showing a progressive increase in egg n-3 FA (especially docosahexaenoic [DHA] and eicosapentaenoic [EPA] acids) when TO was added. Levels of EPA and DHA were higher (P < 0.05) in the egg lipids of TO fed hens than those in the control group. This was correlated (P < 0.05) with the concentration of TO in the diet. However, no significant differences were observed either in egg weight or percent of egg lay between groups. There was a high correlation (P < 0.05) between TO inclusion level in the diet and the incorporation of EPA (r = 0.96) or DHA (r = 0.92) into the egg yolk and an overall decrease in n-6 FA. There was a high correlation (P < 0.05) between TO inclusion level and the incorporation of linoleic acid (LA, r = -0.95) or arachidonic acid (AA, r = -0.96) into the egg yolk. The highest incorporation (P < 0.05) of total n-3 FA content in eggs was obtained with 3% TO/kg. This increase was proportional to TO inclusion levels in the diets (r = 0.95). The results indicate that the n-3 FA content in eggs can be increased by dietary supplementation with TO, and that TO can serve as a reasonable alternative feed ingredient in layer diets to produce a healthier choice of egg.

关键词： Egg Enrichment Laying Hens n-3 Fatty Acids Tuna Oil

Sunitinib effectiveness and safety as first line treatment in metastatic renal cell carcinoma,in the Costa Rican population

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Journal of Cancer Metastasis and Treatment 2016年第1期2卷 396-401页

作者： Esteban gonzalez silvia Alfaro Allan Ramos-Esquivel Denis Ulises Landaverde Department of Hemato-Oncology Hospital MexicoLa UrucaSan Jose 10107Costa Rica Department of Hemato-Oncology Hospital Calderon GuardiaGuadalupeSan Jose 10801Costa Rica Department of Hemato-Oncology Hospital San Juan de DiosDistrito HospitalSan Jose 10103Costa Rica Department of Medicine Universidad de Costa RicaSan Pedro de Montes de OcaSan José2060Costa Rica

Aim:Tyrosine kinase inhibitors are part of the armamentarium to treat metastatic renal cell carcinomas(mRCC).Costa Rica has approved sunitinib in the first line *** authors conducted a retrospective study to address the effectiveness and safety profile of sunitinib in our population in terms of overall survival(OS)and progression free survival(PFS).Methods:The authors analyzed all patients who were treated with sunitinib diagnosed with mRCC in the three National Hospitals(Hospital Mexico,Hospital San Juan de Dios,and Hospital Calderon Guardia)from February 2007 to June ***,safety profile,and efficacy(OS and PFS)were obtained from medical *** and PFS were calculated using the Kaplan Meier method and a Cox Proportional Model Analysis was used when OS and PFS were compared in subset of ***:Seventy-seven patients were included;mean age was 58.9 ***-four patients were male(70.1%).The most common histologic type was clear cell carcinoma(87%),followed by papillary(9.1%)and chromophobe(2.0%)*** OS was 21.0 months[95%confidence interval(CI):13.42-28.58].Median PFS was 13.7 months(95%CI:11.24-16.16).Patients aged 65 years or older experienced worse PFS and OS than younger patients(median PFS:8.2 vs.17.6 months;P=0.011)(median OS:19.0 vs.29.0 months;P=0.022).Sunitinib was well tolerated and no serious side effects were ***:This is the first study in Central America showing that sunitinib,first line,in mRCC is as effective as reported in pivotal clinical trials and expanded use studies in terms of PFS and OS.

关键词： Sunitinib renal cell carcinoma effectiveness Latin America Costa Rica

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M89酒店意大利米兰

世界建筑导报 2018年第5期33卷 80-83页

作者： luca lazzerotti mauro mandelli silvia calzetti alessandro leanti andrea sforzin carlos noriega daniel gonzalez santiago trujillo erica mensi federico simonetti gianluca iannotta niccolò genesio andrea martiradonna(摄) piuarch

M89酒店对面，是Caproni工厂规则排布的厂房，有着别样的棚屋顶，散发着工业考古学般的魅力。新建的M89四星级酒店，位于via Mecenate大街89号。酒店正对着百年前一大型飞机制造厂厂房，经过Piuarch精心改造和扩建，厂房现在已成为古驰... 详细信息

M89酒店对面，是Caproni工厂规则排布的厂房，有着别样的棚屋顶，散发着工业考古学般的魅力。新建的M89四星级酒店，位于via Mecenate大街89号。酒店正对着百年前一大型飞机制造厂厂房，经过Piuarch精心改造和扩建，厂房现在已成为古驰新总部大楼。

关键词：四星级酒店意大利米兰飞机制造厂厂房考古学 via 屋顶

Recirculating chemohyperthermia as a treatment for non-muscle invasive bladder cancer:Current and future perspectives

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World Journal of Clinical Urology 2017年第2期6卷 34-39页

作者： Javier Flores-Carbajal Alejandro Sousa-Escandón Daniel Sousa-gonzalez silvia Rodriguez Gomez Manuel Lopez Saavedra M Elia Fernandez Martinez Comarcal Hospital of Monforte

About 75% of all bladder cancer diagnosed are non-muscle invasive bladder cancer(NMIBC), recurring over 50% of them after transurethral resection of the bladder tumor. In order to prevent recurrences, adjuvant intravesical chemotherapy with mitomycin C and immunotherapy with bacillus Calmette-Gu-érin(BCG) is traditionally used. Unfortunately, many patients relapse after receiving these treatments and a significant proportion of them require surgery. After a one-to-three years BCG maintenance, the risk for progression at 5 years was 19.3% for T1G3 tumors. Many new treatment approaches are being investigated to increase the effectiveness of adjuvant intravesical therapy. One of the developing treatments for intermediate and high-risk NMIBC is the combination of intravesical chemotherapy and hyperthermia, called chemohyperthermia. This article provides a review of the mechanism of action, current status and indications, results and future perspectives.

关键词： Bladder cancer Thermotherapy Non-muscle invasive Chemohyperthermia Recirculating Intravesical chemotherapy Treatment Mechanism of action