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Endoscopic fluorescent lymphography for gastric cancer

World Journal of Gastrointestinal Endoscopy 2023年第2期15卷 32-43页

作者： Calcedonio Calcara Sila Cocciolillo Ylenia Marten Canavesio Vincenzo Adamo silvia carenzi Daria Ilenia Lucci Alberto Premoli Digestive Endoscopy Unit S.Andrea HospitalVercelli 13100Italy Digestive Endoscopy Unit Padre Pio HospitalVasto 66054Italy Postgraduate School of Gastroenterology Genova UniversityGenova 16132Italy General Surgery Unit S.Andrea HospitalVercelli 13100Italy

Lymphography by radioisotope or dye is a well-known technique for visualizing the lymphatic drainage pattern in a neoplastic lesion and it is in use in gastric *** green(ICG)more recently has been validated in fluorescent lymphography studies and is under evaluation as a novel tracer agent in gastric *** amount and dilution of ICG injected as well as the site and the time of the injection are not *** our unit,endoscopic submucosal injections of ICG are made as 0.5 mg in 0.5 mL at four peritumoral sites the day before surgery(for a total of 2.0 mg in 2.0 mL).Detection instruments for ICG fluorescence are ***-infrared systems integrated into laparoscopic or robotic instruments(near-infrared fluorescence imaging)have shown the most promising *** fluorescence recognizes the node that receives lymphatic flow directly from a primary *** is defined as the sentinel lymph node,and it has a high predictive negative value at the cT1 stage,able to reduce the extent of gastrectomy and lymph node *** also enhances the number of lymph nodes detected during extended lymphadenectomy for advanced gastric ***,the practical effects of ICG use in a single patient are not yet *** of the technique and further studies are needed before fluorescent lymphography can be used extensively *** then,current guidelines recommend an extensive lymphadenectomy as the standard approach for gastric cancer with suspected metastasis.

关键词： Indocyanine green Fluorescence Lymphography Sentinel lymph node Gastric cancer Lymphadenectomy

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