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Tityus serrulatus venom and its toxins Ts1 and Ts5 increase cytosolic Ca^(2+)concentration in isolated vascular smooth muscle cells

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Journal of Biophysical Chemistry 2012年第4期3卷 287-294页

作者： Mario dos A.Neto Flavio vasconcelos Lusiane M.Bendhack Eliane C.Arantes Faculty of Inga-UNINGA MaringaBrazil Laboratory of Pharmacology Department of Physics and ChemistryFaculty of Pharmaceutical Sciences of Ribeirao PretoUniversity of Sao PauloRibeirao PretoBrazil Laboratory of Animal Toxins Department of Physics and ChemistryFaculty of Pharmaceutical Sciences of Ribeirao PretoUniversity of Sao PauloRibeirao PretoBrazil Laboratory of Toxicology Faculty of PharmacyInstitute of Health SciencesFederal University of ParaBelemBrazil

Voltage-gated Na+ channel (Nav channel) scorpion toxins are classified as α- and β-neurotoxins. Ts5 (α-neurotoxin) and Ts1 (β-neurotoxin) from Tityus serrulatus venom (TsV) interact with Nav channels, increasing Na+ influx and activating voltage-dependent Ca2+ channels. This study aimed to investigate the effect of TsV, Ts1 and Ts5 on the cytosolic Ca2+ concentration ([Ca2+]C) in rat aortic smooth muscle cells. Toxins were isolated by ion exchange chromatography (Ts1) followed by RP-HPLC (Ts5). The rat aortic smooth muscle cells were isolated in Hanks buffer pH 7.4 and loaded with 5 μmol/L of Fura-2AM (45 minutes at 37℃), in order to measure [Ca2+]C by fluorescence of Fura-2/AM (ratio 340/380 nm). The fluorescence was measured in one single cell (excitation: 340 and 380 nm;emission: 510 nm). TsV (100 and 500 mg/mL) and its toxins Ts1 and Ts5 (50 and 100 mg/mL each) led to a concentration-dependent increase in [Ca2+]C. Tetrodotoxin (1 mmol/L), a Nav channel blocker, and verapamil (1 mmol/L), a voltage-operated Ca2+ channel blocker, inhibited the increase in [Ca2+]C induced by TsV (500 mg/mL). In conclusion, TsV and its toxins induce a concentration-dependent increase in [Ca2+]C that probably occurs through interaction with Nav channels, thus inducing depolarization and consequent Ca2+ influx. This assumption is based on the fact that this effect is inhibited by tetrodotoxin and verapamil, showing a direct action of TsV toxins on aorta smooth muscle cells.

关键词： Ts1 Ts5 Na^(+) Channel Ca^(2+) Channel Tityus serrulatus

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Genetic Diversity of Accessions and First Generation Progeny of the Mangaba Genebank

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American Journal of Plant Sciences 2018年第8期9卷 1618-1629页

作者： Adrielle Naiana Ribeiro Soares debora Clivati Marília Freitas de vasconcelos Melo Matthew Gitzendanner Pamela Soltis Douglas Soltis Josué Francisco da Silva Júnior Ana da Silva Ledo Ana Veruska Cruz da Silva Federal University of Sergipe S&atilde o Cristov&atilde o Brazil National Institute of Amazonian Research Manaus Brazil Federal University of Alagoas Maceió Brazil University of Florida Gainesville USA Embrapa Coastal Tablelands Aracaju Brazil

Mangaba (Hancornia speciose Gomes—Apocynaceae) is an important fruit tree in Brazil and has an unexplored stock germplasm collection. Commercial varieties are unavailable and little is known about its potential as a source of genetic diversity for molecular breeding programs. Progeny tests may improve studies on commercial variability and facilitate genetic improvement of the species. Our aim was to evaluate the genetic diversity and structure of accessions and progeny from the Mangaba Genebank of Embrapa Coastal Tablelands. We estimated the genetic diversity of 96 individuals using 4 SSR markers. The mean observed heterozygosity was lower than expected, showing an excess of homozygotes, corroborated by the positive coefficient of endogamy. The genetic diversity indexes (Fst) and Nei’s unbiased genetic identity (GI) revealed, in general, moderate genetic diversity between accessions. The relationship between matrices and progenies showed that there may be a greater degree of genetic information sharing between the ABP1 and ABP2 accessions. The Bayesian analysis suggested the presence of two distinct groups of genotypes (K = 2). These results will assist future breeding programs and facilitate the conservation of mangaba.

关键词： Hancornia speciose Gomes Brazilian Fruits Microsatellite Markers Genetic Resources

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A Comparative Analysis between BPMN and SPEM Modeling Standards in the Software Processes Context

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Journal of Software Engineering and Applications 2012年第5期5卷 330-339页

作者： Carlos Portela Alexandre vasconcelos Antonio Silva Ariane Sinimbú Elder Silva Maurício Ronny Wallace Lira Sandro Oliveira Centro de Informática Universidade Federal de PernambucoRecifeBrazil Instituto de Ciências Exatas e Naturais Universidade Federal do ParáBelémBrazil

The main objective of this paper is to analyze the representativeness of the SPEM (Software Process Engineering Metamodel Specification) and the BPMN (Business Process Modeling Notation) standards in the software processes modeling context. To perform this analysis, it was adopted a standard structure to define a software process based upon a process ontology. Then, the SPEM and BPMN standards notations and their semantically corresponding elements in the default process were identified. This mapping also includes components of the CMMI-deV (Capability Maturity Model Integration for development) and MR-MPS (Reference Model for Software Process Improvement) quality models. This was necessary to assist in the mapping evaluation through a case study which models the best practices of these quality models. Finally, we carried out an analysis of these standards through specific characteristics considered necessary to model and to represent software processes.

关键词： Software Processes Modeling SPEM BPMN Quality Models

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xSPIdeR_ML:Proposal of a Software Processes Enactment Language Compliant with SPEM 2.0

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Journal of Software Engineering and Applications 2012年第6期5卷 375-384页

作者： Carlos Portela Alexandre vasconcelos Antonio Silva Elder Silva mariano Gomes Maurício Ronny Wallace Lira Sandro Oliveira Informatics Center Federal University of PernambucoRecifeBrazil Institute of Exact and Natural Sciences Federal University of ParáBelémBrazil

SPEM (Software Process Engineering Metamodel Specification) is the software processes modeling standard defined by OMG (Object Management Group). However, the process enactment support provided by this standard has many deficiencies. Therefore, the main objective of this paper is to propose a language for software process enactment based upon SPEM 2.0 concepts. First, we will present a critical analysis of the SPEM standard approach for enactment. Then, we will present xSPIdeR_ML, an enactment language, and describe its structure, components and associated rules. In order to evaluate the proposed language, a case study is performed through a RUP (Rational Unified Process) process instantiation. The language presented in this paper is part of a support set of tools for flexible software process enactment. Additionally, this set of tools is in compliance with software process quality models.

关键词： Software Process Enactment Language SPEM RUP

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Energy Planning: Brazilian Potential of Generation of Electric Power from Urban Solid Wastes—Under “<i>Waste Production Liturgy</i>” Point of View

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Energy and Power Engineering 2015年第5期7卷 193-202页

作者： Neilton Fidelis da Silva Angela Oliveira da Costa Rachel Martins Henriques Marcio Giannini Pereira Marcos Aurelio Freitas vasconcelos Energy Planning Program (PPE) Coordination of Postgraduate Programs in Engineering at the Federal University of Rio de Janeiro (COPPE/UFRJ) Cidade Universit&aacute ria Rio de Janeiro Brazil International Virtual Institute of Global Change—IVIG Centro de Tecnologia Cidade Universit&aacute ria Rio de Janeiro Brazil Federal Institute of Education Science and Technology of Rio Grande do Norte (IFRN) Natal Brazil

The use of Urban Solid Waste (USW) as sources of energy has acquired rising importance in current discussions of alternative energy supplies, in particular in Brazil. This paper brings to these discussions an examination of the concept of solid wastes, including their historic origins and formation, taking their social, economic and cultural characteristics into account, including point view of waste production liturgy. Consequently, a spendthrift society slanted towards the decreasing marginal utility of assets must make efficient use of its USW in order to reduce excessive output. Besides that, this document presents the Brazilian potential of urban solid waste to produce electric power.

关键词： Urban Solid Wastes Renewable Energy Energy Planning Brazil

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Unraveling one billion years of geological evolution of the southeastern Amazonia Craton from detrital zircon analyses

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Geoscience Frontiers 2022年第5期13卷 129-152页

作者： Camille Rossignol Paul Yves Jean Antonio Francesco Narduzzi Eric Siciliano Rego Lívia Teixeira Romário Almeida de Souza Janaína N.Ávila Marco A.L.Silva Cristiano Lana Ricardo I.F.Trindade Pascal Philippot departamento de Geofísica Instituto de AstronomiaGeofísica e Ciências Atmosféricas da Universidade de São PauloRua do Matão1226-Cidade UniversitáriaSão Paulo 05508-090Brazil Institut de Physique du Globe de Paris Universitéde ParisCNRSParisFrance Géosciences Montpellier Universitéde MontpellierCNRSUniversitédes AntillesMontpellierFrance Instituto de Geociências Universidade de São PauloRua do Lago562-Cidade UniversitáriaSão Paulo 05508-080Brazil Instituto de Geociências e Engenharias Universidade Federal do Sul e Sudeste do Pará–UNIFESSPAFolha 17Quadra 04Lote especialNova MarabáMarabáPará68505-080Brazil Research School of Earth Sciences The Australian National University142 Mills RoadCanberraACT 2601Australia Applied Isotope Research Group Departamento de GeologiaEscola de MinasUniversidade Federal de Ouro PretoRua Diogo de Vasconcelos12235400-000 Ouro PretoMGBrazil

despite representing one of the largest cratons on Earth,the early geological evolution of the Amazonia Craton remains poorly known due to relatively poor exposure and because younger metamorphic and tectonic events have obscured initial *** this study,we investigated the sedimentary archives of the Carajás Basin to unravel the early geological evolution of the southeastern Amazonia *** Carajás Basin contains sedimentary rocks that were deposited throughout a long period spanning more than one billion years from the Mesoarchean to the *** oldest archives preserved in this basin consist of a few ca.3.6 Ga detrital zircon grains showing that the geological roots of the Amazonia Craton were already formed by the *** the Paleoarchean or the early Mesoarchean(deposition of some of the world largest iron *** emplacement of this LIP immediately preceded a period of continental extension that formed a rift infilled first by iron formations followed by terrigenous *** major change of sedimentary regime might have been controlled by the regional tectonic evolution of the Amazonia Craton and its emergence above *** the Paleoproterozoic,at ca.2.1 Ga,the Rio Fresco Group,consisting of terrigenous sediments from the interior of the Amazonia Craton,was deposited in the Carajás *** that time,the Amazonian lithosphere could have either underwent thermal subsidence forming a large intracratonic basin or could have been deformed by long wavelength flexures that induced the formation of basins and swells throughout the craton under the influence of

关键词： Carajás Basin Chemical Abrasion–LA-ICP-MS analyses Age distribution comparison Parauapebas Large Igneous Province Transamazonian orogeny

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Gastric Volvulus Complicates the Hepatectomy for Living Donor Liver Transplantation

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Open Journal of Organ Transplant Surgery 2012年第4期2卷 19-20页

作者： Reinaldo Fernandes Marcelo Enne Klaus Steinbruck José Manoel Martinho Rafael vasconcelos Gustavo Stoduto Lúcio Filgueiras Pacheco-Moreira department of Hepatobiliary Surgery and Liver Transplantation Bonsucesso Federal Hospital Ministry of Health Rio de Janeiro Brazil

Donor safety is the major concern in living donor liver transplantation (LDLT), and a constant aware of postoperative morbidity should be emphasized. Between March 2002 and May 2011 we performed 435 liver transplantations at an our center, one hundred forty eight with living donors. Among them left lobectomy or left lateral resections were conducted in 68 cases. Symptoms of gastric obstruction were recognized in 3 out of 68 patients that underwent left lateral resection (4.4%). The patients were readmitted because of severe symptoms of vomiting and abdominal pain. An upper endoscopy was performed and revealed pyloroantral obstruction due to gastric volvulus (GV). Endoscopic therapy correction was successfully performed in all patients. Reviewing the literature, one article has reported GV in 13 out of 115 donors (11.3%), all patients were submitted to a left resection. The mechanisms underlying this complication, in LDLT scenario, have not been fully elucidated. Nevertheless, clinicians should be aware of this possible association, which could make the diagnosis of GV more likely if a living donor comes back with typical symptoms.

关键词： Living Donors Hepatectomy Postoperative Complications Liver Transplantation Gastric Volvulus

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Modelling Natural Radioactivity in Sand Beaches of Guarapari,Espírito Santo State,Brazil

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World Journal of Nuclear Science and Technology 2013年第2期3卷 65-71页

作者： Danilo C.vasconcelos Patricia A.L.Reis Claubia Pereira Arno H.Oliveira Talita O.Santos Zildete Rocha departamento de Engenharia Nuclear Escola de Engenharia Universidade Federal de Minas GeraisBelo HorizonteBrasil Centro de desenvolvimento da Tecnologia Nuclear/Comissao Nacional de Energia Nuclear(CDTN/CNEN) Laboratório de TrítioBelo HorizonteBrasil

Using gamma-ray spectrometry, the activity concentration of naturally occurring radionuclides 226Ra, 212Pb, 214Pb, 232Th, and 40K was determined in sand beaches samples from different areas in Guarapari, Espírito Santo state, from Brazil. The absorbed dose rates and annual effective dose were calculated and the results were compared with the internationally accepted values as well as others high background radiation areas (HBRAs). The activity concentration of the 232Th in Areia Preta as well as the absorbed dose rates and annual effective dose were higher than the others regions compared. The results show that Areia Preta in Guarapari has higher background found in beaches in world. This work is part of a research project for the natural background determination of the Brazilian coast.

关键词： Gamma-Ray Spectrometry Beach Sand Guarapari

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Governance of Marine Protected Areas： An Approach Using Public Participation Geographic Information Systems--The MARGov Project

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Journal of Environmental Science and Engineering(B) 2013年第1期2卷 25-35页

作者： Marco Painho Tiago H. Moreira de Oliveira Lia vasconcelos New Technologies Laboratory NOVA School of Statistics and Information Management Campolide Campus Lisbon 1070-312 Portugal Science and Environmental Engineering department Faculty of Science and Technology Caparica 2829-516 Portugal

The MARGov Project consisted in strengthening the interaction among the Professor Luiz Saldanha Marine Park stakeholders, and to collaboratively construct, with social and institutional actors, a governance model for the Marine Park, located in the municipality of Sesimbra (Portugal). To pursue this goal, a PPGIS (public participation geographic information system) was developed, allowing the interaction, discussion and public participation of the stakeholders and actors involved. This PPGIS emerged as a crowdsourcing tool, with the purpose of assisting the georeferenced contributes from the local users of the Marine Park, regarding several relevant subjects, such as pollution, economic activities, opportunities and threats to the Marine Park, providing visual, analytical, and demonstrative qualities.

关键词：地理信息系统公众参与海洋保护区治理利益相关者海洋公园经济活动葡萄牙

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Treatment of systemic lupus erythematosus with intravenous immunoglobulin （ivIg） and its impact on cellular subsets and immunoregulation

Treatment of systemic lupus erythematosus with intravenous i...

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The 8th International Congress on SLE

作者： Luiz Fernando Goulart Clara Pereira Ana Monica Gabriel Barbara Leal maria Francisca Fontes Carlos vasconcelos Carlos M.Ferreira Jorge Martins Joo Matos-Costa Berta Martins António Marinho Margarida Lima Jocelyne demengeot Constantin Fesel Instituto Gulbenkian de Ciência OeirasPortugal Instituto de Ciências Biomédicas Abel SalazarPortoPortugal Hospital Geral Santo AntónioPortoPortugal Hospital Santa MariaLisboaPortugal Instituto Gulbenkian de Ciência OeirasPortugal Instituto de Ciências Biomédicas Abel SalazarPortoPortugal Hospital Geral Santo AntónioPortoPortugal Hospital Santa MariaLisboaPortugal Instituto Gulbenkian de Ciência OeirasPortugal Instituto de Ciências Biomédicas Abel SalazarPortoPortugal Hospital Geral Santo AntónioPortoPortugal Hospital Santa MariaLisboaPortugal Instituto Gulbenkian de Ciência OeirasPortugal Instituto de Ciências Biomédicas Abel SalazarPortoPortugal Hospital Geral Santo AntónioPortoPortugal Hospital Santa MariaLisboaPortugal Instituto Gulbenkian de Ciência OeirasPortugal Instituto de Ciências Biomédicas Abel SalazarPortoPortugal Hospital Geral Santo AntónioPortoPortugal Hospital Santa MariaLisboaPortugal Instituto Gulbenkian de Ciência OeirasPortugal Instituto de Ciências Biomédicas Abel SalazarPortoPortugal Hospital Geral Santo AntónioPortoPortugal Hospital Santa MariaLisboaPortugal Instituto Gulbenkian de Ciência OeirasPortugal Instituto de Ciências Biomédicas Abel SalazarPortoPortugal Hospital Geral Santo AntónioPortoPortugal Hospital Santa MariaLisboaPortugal Instituto Gulbenkian de Ciência OeirasPortugal Instituto de Ciências Biomédicas Abel SalazarPortoPortugal Hospital Geral Santo AntónioPortoPortugal Hospital Santa MariaLisboaPortugal Instituto Gulbenkian de Ciência OeirasPortugal Instituto de Ciências Biomédicas Abel SalazarPortoPortugal Hospital Geral Santo AntónioPortoPortugal Hospital Santa MariaLisboaPortugal Instituto Gulbenkian de Ciência OeirasPortugal Instituto de Ciências Biomédicas Abel SalazarPortoPortugal Hospital Geral Santo AntónioPortoPortugal Hospital Santa MariaLisboaPortugal Instituto Gulbenkian de Ciência OeirasPortugal Instituto de Ciências Biomédicas Abel SalazarPortoPortugal Hospital Geral Santo AntónioPortoPort

＜正＞Purpose:Intavenous immunoglobulin（ivIg）,which has well-demonstrated beneficial effects in various autoimmune diseases,is used as a therapeutic option for Systemic Lupus Erythematosus（SLE）patients,particularly for those with poor responses to standard *** studied immune homeostasis and regulation in patients undergoing this

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