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Clinical significance of hepatic derangement in severe acute respiratory syndrome

World Journal of Gastroenterology 2005年第14期11卷 2148-2153页

作者： Henry Lik-Yuen Chan Ambrose Chi-Pong Kwan Ka-Fai To sik-to lai Paul Kay-Sheung Chan Wai-Keung Leung Nelson Lee Alan Wu Joseph Jao-Yiu Sung Department of Medicine and Therapeutics Chinese University of Hong Kong Hong Kong SARChina Department of Medicine Princess Margaret Hospital Hong Kong SARChina Department of Anatomical and Cellular Pathology Chinese University of Hong Kong Hong Kong SARChina Department of Microbiology Chinese University of Hong Kong Hong Kong SARChina

AIM:Elevation of alanine aminotransferase (ALT) level is commonly seen among patients suffering from severe acute respiratory syndrome (SARS). We report the progression and clinical significance of liver derangement in a large cohort of SARS patient. METHODS: Serial assay of serum ALT was followed in patients who fulfilled the WHO criteria of SARS. Those with elevated ALT were compared with those with normal liver functions for clinical outcome. Serology for hepatitis B virus (HBV) infection was checked. Adverse outcomes were defined as oxygen desaturation, need of intensive care unit (ICU) and mechanical ventilation and death. RESULTS: Two hundred and ninety-four patients were included in this study. Seventy (24%) patients had elevated serum ALT on admission and 204 (69%) patients had elevated ALT during the subsequent course of illness. Using peak ALT >5xULN as a cut-off and after adjusting for potential confounding factors, the odds ratio of peak ALT >5x ULN for oxygen desaturation was 3.24 (95%CI 1.23-8.59, P= 0.018), ICU care was 3.70 (95%CI 1.38-9.89, P= 0.009), mechanical ventilation was 6.64 (95%CI 2.22-19.81, P = 0.001) and death was 7.34 (95%CI 2.28-24.89, P= 0.001). Ninety-three percent of the survived patients had ALT levels normalized or were on the improving trend during follow-up. Chronic hepatitis B was not associated with worse clinical outcomes. CONCLUSION: Reactive hepatitis is a common complication of SARS-coronavirus infection. Those patients with severe hepatitis had worse clinical outcome.

关键词： SARS Hepatitis Hepatitis B virus Coronavirus

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Structural Chemical Shifts of Adenine in Deoxyribonucleic Acids

Structural Chemical Shifts of Adenine in Deoxyribonucleic Ac...

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第十四届全国波谱学学术会议

作者： sik Lok Lam Kin Fung lai Department of Chemistry The Chinese University of Hong KongShatinNew TerritoriesHong Kong. Department of Chemistry The Chinese University of Hong KongShatinNew TerritoriesHong Kong.

＜正＞Simple structure-chemical shift relationships are present in *** these relationships have not been observed in nucleic ***,reliable sets of random coil proton,carbon and phosphorus DNA chemical shifts have been ...

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“Random Coil” Proton Chemical Shift of Deoxyribonucleic Acids.

“Random Coil” Proton Chemical Shift of Deoxyribonucleic Ac...

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第十二届全国波谱学学术会议

作者： sik Lok lain lai Nang Ip Department of Chemistry The Chinese University of Hong KongShatinNew TerritoriesHong Kong Department of Chemistry The Chinese University of Hong KongShatinNew TerritoriesHong Kong

＜正＞With the combination of the aromatic proton chemical shills of the central nucleotides in triplets and the correction factors determined for the next nearest neighbor effect, the aromatic proton chemical shills of“random coil”DNA sequences can be predicted *** aromatic proton chemical shifts of 16 unstructured single-strand DNA sequences containing all 64 different types of triplets have been measured.

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未来高密度居住区规划与设计框架研究

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规划师 2020年第21期36卷 35-44页

作者：王才强冯俊才 Cho Im sik Malone-Lee lai Choo 新加坡国立大学设计与环境学院建筑系新加坡国立大学亚洲可持续城市研究中心新加坡国立大学养老与环境研究中心新加坡国立大学设计与环境学院

高密度居住区是许多亚洲城市常见的居住模式,用于解决城市土地稀缺、人口增长快速等问题。然而,社会的发展趋势与颠覆性科技的变革促使人们改变生活习惯,进而影响未来邻里空间的使用与布局。文章探讨影响未来邻里空间变化的3个主要趋势... 详细信息

高密度居住区是许多亚洲城市常见的居住模式,用于解决城市土地稀缺、人口增长快速等问题。然而,社会的发展趋势与颠覆性科技的变革促使人们改变生活习惯,进而影响未来邻里空间的使用与布局。文章探讨影响未来邻里空间变化的3个主要趋势—促进共享与协同合作文化、推广减少用车的居住环境及促进老年友好环境规划与建设,基于新加坡公共住宅的发展与演变经验,建立一个未来居住区综合设计框架,指导邻里空间的规划与建设,使邻里空间具备弹性空间以满足未来使用与分配布局,并提出可广泛应用于高密度居住区规划的新范式。

关键词：高密度居住区公共住宅共享经济人口老龄化综合设计框架都市规划

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Dynamic phenotypic heterogeneity and the evolution of multiple RNA subtypes in hepatocellular carcinoma:the PLANET study

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National Science Review 2022年第3期9卷 96-109页

作者： Weiwei Zhai Hannah lai Neslihan Arife Kaya Jianbin Chen Hechuan Yang Bingxin Lu Jia Qi Lim Siming Ma Sin Chi Chew Khi Pin Chua Jacob Josiah Santiago Alvarez Pauline Jieqi Chen Mei Mei Chang Lingyan Wu Brian K.P.Goh Alexander Yaw-Fui Chung Chung Yip Chan Peng Chung Cheow Ser Yee Lee Juinn Huar Kam Alfred Wei-Chieh Kow Iyer Shridhar Ganpathi Rawisak Chanwat Jidapa Thammasiri Boon Koon Yoong Diana Bee-Lan Ong Vanessa H.de Villa Rouchelle D.Dela Cruz Tracy Jiezhen Loh Wei Keat Wan Zeng Zeng Anders Jacobsen Skanderup Yin Huei Pang Krishnakumar Madhavan Tony Kiat-Hon Lim Glenn Bonney Wei Qiang Leow Valerie Chew Yock Young Dan Wai Leong Tam Han Chong Toh Roger sik-Yin Foo Pierce Kah-Hoe Chow Genome Institute of Singapore Agency for Science Technology and Research Key Laboratory of Zoological Systematics and Evolution Institute of Zoology Chinese Academy of Sciences Center for Excellence in Animal Evolution and Genetics Chinese Academy of Sciences School of Biological Sciences Nanyang Technological University Division of Biosciences Faculty of Life Sciences Division of Surgery and Surgical Oncology National Cancer Centre Department of Hepato-Pancreato-Biliary and Transplant Surgery Singapore General Hospital Division of Hepatobiliary and Pancreatic Surgery Department of Surgery University Surgical Cluster National University Health System Hepato-Pancreato-Biliary Surgery Unit Department of Surgery National Cancer Institute Division of Pathology National Cancer Institute Department of Surgery Faculty of Medicine University of Malaya Department of Surgery and Center for Liver Disease Management and Transplantation The Medical City 13. Department of Laboratories The Medical City Department of Pathology Singapore General Hospital Institute for Infocomm Research ASTAR Department of Pathology National University Health System Translational Immunology Institute (TII) Sing Health Duke-NUS Academic Medical Centre Division of Gastroenterology and Hepatology University Medicine Cluster National University Hospital Department of Biochemistry Yong Loo Lin School of Medicine National University of Singapore Cancer Science Institute of Singapore National University of Singapore Division of Medical Oncology National Cancer Center Singapore Cardiovascular Research Institute National University of Singapore National University Healthcare System Singhealth-Duke-NUS Academic Surgery Program Duke-NUS Graduate Medical School Institute of Molecular and Cell Biology Agency for Science Technology and Research

Intra-tumor heterogeneity(ITH) is a key challenge in cancer treatment, but previous studies have focused mainly on the genomic alterations without exploring phenotypic(transcriptomic and immune)heterogeneity. Using one of the largest prospective surgical cohorts for hepatocellular carcinoma(HCC)with multi-region sampling, we sequenced whole genomes and paired transcriptomes from 67 HCC patients(331 samples). We found that while genomic ITH was rather constant across stages, phenotypic ITH had a very different trajectory and quickly diversified in stage Ⅱ patients. Most strikingly, 30% of patients were found to contain more than one transcriptomic subtype within a single tumor. Such phenotypic ITH was found to be much more informative in predicting patient survival than genomic ITH and explains the poor efficacy of single-target systemic therapies in HCC. Taken together, we not only revealed an unprecedentedly dynamic landscape of phenotypic heterogeneity in HCC, but also highlighted the importance of studying phenotypic evolution across cancer types.

关键词： NADH oxidase H2O2 production oxidative phosphorylation

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喉癌中STK15基因扩增及表达的研究

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中华医学遗传学杂志 2006年第3期23卷 326-329页

作者：叶燕李福才王淑云李婵媛袁海明赵旭富伟能徐振明孙开来中国医科大学基础医学院医学遗传学教研室沈阳110001 空军463医院耳鼻喉科

目的研究喉癌中STK15基因扩增、mRNA和蛋白表达增高在喉癌发生、发展中的作用。方法应用差异PCR方法检测40例喉鳞状细胞癌及癌旁正常对照组织STK15基因扩增的情况;应用逆转录PCR方法检测同批标本STK15mRNA表达情况;用免疫组织化学方法分... 详细信息

目的研究喉癌中STK15基因扩增、mRNA和蛋白表达增高在喉癌发生、发展中的作用。方法应用差异PCR方法检测40例喉鳞状细胞癌及癌旁正常对照组织STK15基因扩增的情况;应用逆转录PCR方法检测同批标本STK15mRNA表达情况;用免疫组织化学方法分析STK15蛋白表达。结果肿瘤组织中STK15基因扩增率为35%(14/40);STK15mRNA表达增高占67.5%(27/40);STK15蛋白表达的阳性率为72.5%(29/40);将扩增与表达的结果与喉癌患者的临床各项指标进行统计学分析,STK15基因扩增、STK15mRNA表达增高与肿瘤的分化程度显著相关(P<0.05);STK15蛋白表达与肿瘤的分化程度和病理分级显著相关(P<0.05)。结论喉癌中STK15基因扩增、mRNA和蛋白表达水平增高,导致中心体复制异常、染色体不稳定,可能在喉癌的发生及恶性进展中起一定作用。

关键词：喉鳞状细胞癌 STK15基因差异-聚合酶链反应基因扩增

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