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Label-free biosensing with singular-phaseenhanced lateral position shift based on atomically thin plasmonic nanomaterials

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Light(Science & Applications) 2024年第5期13卷 810-822页

作者： Shaodi Zhu Rodolphe Jaffiol Aurelian Crunteanu Cyrille Vézy sik-to chan Wu Yuan Ho-Pui Ho Shuwen Zeng Light Nanomaterials&Nanotechnologies(L2n)CNRS-EMR 7004University of Technology of Troyes10000 TroyesFrance. Department of Biomedical Engineering The Chinese University of Hong KongShatinNew TerritoriesHong KongChina XLIM Research Institute UMR 7252 CNRS/University of Limoges123Avenue Albert ThomasLimogesFrance

Rapid plasmonic biosensing has attracted wide attention in early disease diagnosis and molecular biology ***,it was still challenging for conventional angle-interrogating plasmonic sensors to obtain higher sensitivity without secondary amplifying labels such as plasmonic *** address this issue,we developed a plasmonic biosensor based on the enhanced lateral position shift by phase *** singularity presents as a sudden phase retardation at the dark point of reflection from resonating plasmonic substrate,leading to a giant position shift on reflected ***,for the first time,the atomically thin layer of Ge2Sb2Te5(GST)on silver nanofilm was demonstrated as a novel phase-response-enhancing plasmonic *** GST layer was not only precisely engineered to singularize phase change but also served as a protective layer for active silver *** new configuration has achieved a record-breaking largest position shift of 439.3μm measured in calibration experiments with an ultra-high sensitivity of 1.72×10^(8)nm RIU−1(refractive index unit).The detection limit was determined to be 6.97×10^(−7)RIU with a 0.12μm position ***,a large figure of merit(FOM)of 4.54×10^(11)μm(RIU∙°)^(−1)was evaluated for such position shift interrogation,enabling the labelfree detection of trace amounts of *** targeted biosensing experiments,the optimized sensor has successfully detected small cytokine biomarkers(TNF-αand IL-6)with the lowest concentration of 1×10^(−16)*** two molecules are the key proinflammatory cancer markers in clinical diagnosis,which cannot be directly screened by current clinical *** further validate the selectivity of our sensing systems,we also measured the affinity of integrin binding to arginylglycylaspartic acid(RGD)peptide(a key protein interaction in cell adhesion)with different Mn2+ion concentrations,ranging from 1 nM to 1 mM.

关键词： diagnosis protective silver

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Intelligent reflecting surface for sum rate enhancement in MIMO systems

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Digital Communications and Networks 2024年第1期10卷 94-100页

作者： chan-Yeob Park Ji-Sung Jung Yeong-Rong Lee Beom-sik Shin Hyoung-Kyu Song Department of Information and Communication Engineering Sejong UniversitySeoulGwangjin-guGunja-dong 98Republic of Korea Department of Convergence Engineering for Intelligent Drone Sejong University SeoulGwangjin-guGunja-dong 98Republic of Korea

The research for the Intelligent Reflecting Surface(IRS)which has the advantages of cost and energy efficiency has been *** capacity can be effectively increased by appropriately setting the phase value of IRS elements according to the channel ***,the problem of obtaining an appropriate phase value of IRs is difficult to solve due to the non-convex *** paper proposes an iterative algorithm for the alternating optimal solution in the Single User Multiple-Input-Multiple-Output(SU-MIMO)*** proposed iterative algorithm finds an alternating optimal solution that is the phase value of IRS one by *** results show that the proposed method has better performance than that of the randomized IRS *** number of iterations for maximizing the performance of the proposed algorithm depends on the channel state between the IRS and the receiver.

关键词： Intelligent reflecting surface MIMO Sum rate

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Synergic effect of sex pheromone(7R,8S)-cis-7,8-epoxy-2-methyloctadec-17-ene on(+)-disparlure of the Asian gypsy moth,Lymantria dispar, in Korea

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Journal of Forestry Research 2019年第3期30卷 1119-1122页

作者： Il-Kwon Park Hyo-Rim Lee chan-sik Jung Sang-Hyun Koh Department of Forest Sciences Seoul National University Seoul 08826Republic of Korea Research Institute of Agriculture and Life Science College of Agriculture and Life SciencesSeoul National University Seoul 08826Republic of Korea Division of Forest Insect Pests and Diseases National Institute of Forest ScienceSeoul 02455Republic of Korea

field attraction test of (7R,8S)-cis-7,8-epoxy-2- methyloctadec-17-ene (= 7R,8S-epo-2me-17ene-18Hy), a trace component of the sex pheromone gland of the Asian gypsy moth,(Lymantria dispar), traps that were baited with the trace component attracted more L. dispar than traps baited with (7S,8R)-cis-7,8-epoxy-2-methyloctadec-17-ene (= 7S,8R-epo-2me-17ene-18Hy) and unbaited traps. However, traps baited with 7R,8S-epo-2me-17ene-18Hy were less attractive than traps baited with (+)-disparlure [=(7R,8S)-cis-7,8-epoxy-2-methyloctadecane], the sex pheromone of L. dispar. Combination tests with (?)-disparlure, 7R,8S-epo-2me-17ene-18Hy, and 7S,8R-epo-2me- 17ene-18Hy revealed that 7R,8S-epo-2me-17ene-18Hy acted synergistically with (?)-disparlure.

关键词： Asian gypsy moth Lymantria dispar Sex pheromone (+)-disparlure (7R,8S)-cis-7,8-epoxy-2methyloctadec-17ene

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Absence of enhancement in a lesion does not preclude primary central nervous system T-cell lymphoma:A case report

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World Journal of Clinical Cases 2024年第2期12卷 374-382页

作者： chan-Seop Kim Chi-Hoon Choi Kyung sik Yi Yook Kim Jisun Lee chang Gok Woo Young Hun Jeon Department of Radiology Chungbuk National University HospitalChungbuk National University College of MedicineCheongju-si 28644Chungcheongbuk-doSouth Korea Department of Pathology Chungbuk National University HospitalChungbuk National University College of MedicineCheongju-si 28644Chungcheongbuk-doSouth Korea Department of Radiology Seoul National University HosptialSeoul 03080South Korea

BACKGROUND Primary central nervous system lymphoma(PCNSL)is a non-Hodgkin lymphoma that originates in the central nervous system(CNS)and is exclusively limited to the *** most PCNSLs are diffuse large B-cell lymphomas,primary CNS T-cell lymphomas(PCNSTLs)are *** typically demonstrate some degree of enhancement on contrast-enhanced magnetic resonance imaging(MRI).To the best of our knowledge,non-enhancing PCNSTL has not been reported *** SUMMARY A 69-year-old male presented to the neurology department with complaints of mild cognitive impairment and gradual onset of left lower leg weakness over a span of two *** MRI showed asymmetric T2-hyperintense lesions within the *** enhancement was observed on the contrast-enhanced T1 *** initial diagnosis was neuro-Behçet’s *** high-dose steroid therapy,no alterations in the lesions were identified on initial *** patient’s symptoms deteriorated *** MRI performed one month after the initial scan revealed an increased lesion ***,brain biopsy confirmed the diagnosis of *** patient underwent definitive combined ***,the patient developed bacteremia and died of septic shock approximately three months after *** The absence of enhancement in the lesion did not rule out PCNSTL.A biopsy approach is advisable for pathological confirmation.

关键词： Central nervous system neoplasms Non-Hodgkin Lymphoma T-cell Lymphoma Primary central nervous system lymphoma Primary central nervous system T-cell lymphoma Case report

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Comparing 11 early warning scores and three shock indices in early sepsis prediction in the emergency department

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World Journal of Emergency Medicine 2024年第4期15卷 273-282页

作者： Rex Pui Kin Lam Zonglin Dai Eric Ho Yin Lau Carrie Yuen Ting Ip Ho Ching chan Lingyun Zhao Tat ChiTsang Matthew sik Hon Tsui Timothy Hudson Rainer Department of Emergency Medicine School of Clinical MedicineLi Ka Shing Faculty of Medicinethe University of Hong KongHong KongChina School of Public Health Li Ka Shing Faculty of Medicinethe University of Hong KongHong KongChina Accident and Emergency Department Queen Mary HospitalHong KongChina

BACKGROUND:This study aimed to evaluate the discriminatory performance of 11 vital sign-based early warning scores(EWSs)and three shock indices in early sepsis prediction in the emergency department(ED).METHODS:We performed a retrospective study on consecutive adult patients with an infection over 3 months in a public ED in Hong *** primary outcome was sepsis(Sepsis-3 definition)within 48 h of ED *** c-statistics and the DeLong test,we compared 11 EWSs,including the National Early Warning Score 2(NEWS2),Modified Early Warning Score,and Worthing Physiological Scoring System(WPS),etc.,and three shock indices(the shock index[SI],modified shock index[MSI],and diastolic shock index[DSI]),with Systemic Inflammatory Response Syndrome(SIRS)and quick Sequential Organ Failure Assessment(qSOFA)in predicting the primary outcome,intensive care unit admission,and mortality at different time ***:We analyzed 601 patients,of whom 166(27.6%)developed ***2 had the highest point estimate(area under the receiver operating characteristic curve[AUROC]0.75,95%CI 0.70-0.79)and was significantly better than SIRS,qSOFA,other EWSs and shock indices,except WPS,at predicting the primary ***,the pooled sensitivity and specificity of NEWS2≥5 for the prediction of sepsis were 0.45(95%CI 0.37-0.52)and 0.88(95%CI 0.85-0.91),*** discriminatory performance of all EWSs and shock indices declined when used to predict mortality at a more remote time ***:NEWS2 compared favorably with other EWSs and shock indices in early sepsis prediction but its low sensitivity at the usual cut-off point requires further modification for sepsis screening.

关键词： Sepsis Emergency department Clinical prediction rule Early warning score Shock index

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SARS-CoV-2 infection causes immunodeficiency in recovered patients by downregulating CD19 expression in B cells via enhancing B-cell metabolism

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Signal Transduction and Targeted Therapy 2021年第10期6卷 3119-3131页

作者： Yukai Jing Li Luo Ying Chen Lisa S.Westerberg Peng Zhou Zhiping Xu Andres A.Herrada chan-sik Park Masato Kubo Heng Mei Yu Hu Pamela Pui-Wah Lee Bing Zheng Zhiwei Sui Wei Xiao Quan Gong Zhongxin Lu Chaohong Liu Department of Medical Laboratory The Central Hospital of WuhanTongji Medical CollegeHuazhong University of Science and TechnologyWuhanPeople's Republic of China Department of Emergency Shanxi Bethune HospitalShanxi Academy of Medical SciencesTongji Shanxi HospitalThird Hospital of Shanxi Medical UniversityTaiyuanPeople's Republic of China Tongji Hospital Tongji Medical CollegeHuazhong University of Science and TechnologyWuhanPeople's Republic of China Department of Pathogen Biology School of Basic MedicineTongji Medical CollegeHuazhong University of Science and TechnologyWuhanPeople's Republic of China Center for Biosafety Mega Science Wuhan Institute of VirologyChinese Academy of SciencesWuhanPeople's Republic of China Department of Microbiology Tumor and Cell Biology Karolinska InstituteStockholmSweden Wuhan Metware Biotechnology Co. LtdWuhanPeople's Republic of China Lymphatic and Inflammation Research Laboratory Facultad de Ciencias de la SaludInstituto de Ciencias BiomOdicasUniversidad Autdnoma de ChileTalcaChile Department of Pathology Asan Medical CenterUniversity of Ulsan College of MedicineSeoulKorea Laboratory for Cytokine Regulation Center for Integrative Medical Science(IMS)RIKEN Yokohama InstituteKanagawaJapan Institute of Hematology Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhanPeople's Republic of China Department of Paediatrics and Adolescent Medicine LKS Faculty of MedicineThe University of Hong KongHong KongPeople's Republic of China Department of Immunology School of MedicineYangtze UniversityJingzhouHubei ProvincePeople's Republic of China Clinical Molecular Immunology Center School of MedicineYangtze UniversityJingzhouHubei ProvincePeople's Republic of China Center for Advanced Measurement Science National Institute of MetrologyBeijingPeople's Republic of China Department of Respiratory The First Affiliated Hospital of Yangtze UniversityJingzhouHubei ProvincePeople's Republic of China

The SARS-CoV-2 infection causes severe immune ***,it is unclear if disrupted immune regulation still exists and pertains in recovered COVID-19 *** our study,we have characterized the immunephe no type of B cells from 15 recovered COVID-19 patients,and found that healthy controls and recovered patients had similar B-cell populations before and after BCR stimulation,but the frequencies of PBC in patients were significantly increased when compared to healthy controls before ***,the percentage of unswitched memory B cells was decreased in recovered patients but not changed in healthy controls upon BCR ***,we found that CD19 expression was significantly reduced in almost all the B-cell subsets in recovered ***,the BCR signaling and early B-cell response were disrupted upon BCR ***,we found that the reduced CD19 expression was caused by the dysregulation of cell *** conclusion,we found that SARS-CoV-2 infection causes immunodeficiency in recovered patients by downregulating CD19 expression in B cells via enhandng B-cell metabolism,which may provide a new intervention target to cure COVID-19.

关键词： patients metabolism CD19

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Growing Threat of Rapidly-Intensifying Tropical Cyclones in East Asia

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Advances in Atmospheric Sciences 2022年第2期39卷 222-234页

作者： Kin sik LIU Johnny C.L.chan Guy Carpenter Asia-Pacific Climate Impact Centre School of Energy and EnvironmentCity University of Hong KongTat Chee Ave.KowloonHong KongChina

This study examines the long-term change in the threat of landfalling tropical cyclones(TCs) in East Asia over the period 1975–2020 with a focus on rapidly intensifying(RI) TCs. The increase in the annual number of RI-TCs over the western North Pacific and the northwestward shift of their genesis location lead to an increasing trend in the annual number of landfalling RI-TCs along the coast of East Asia. The annual power dissipation index(PDI), a measure of the destructive potential of RI-TCs at landfall, also shows a significant increasing trend due to increases in the annual frequency and mean landfall intensity of landfalling RI-TCs. The increase in mean landfall intensity is related to a higher lifetime maximum intensity(LMI) and the LMI location of the landfalling RI-TCs being closer to the coast. The increase in the annual PDI of East Asia is mainly associated with landfalling TCs in the southern(the Philippines, South China, and Vietnam) and northern parts(Japan and the Korean Peninsula) of East Asia due to long-term changes in vertical wind shear and TC heat potential. The former leads to a northwestward shift of favorable environments for TC genesis and intensification, resulting in the northwestward shift in the genesis, RI, and LMI locations of RI-TCs. The latter provides more heat energy from the ocean for TC intensification, increasing its chances to undergo RI.

关键词： tropical cyclone landfall tropical cyclone intensity climate change rapid intensification

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Recent Decrease in the Difference in Tropical Cyclone Occurrence between the Atlantic and the Western North Pacific

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Advances in Atmospheric Sciences 2022年第9期39卷 1387-1397页

作者： Johnny C.L.chan Kin sik LIU Guy Carpenter Asia-Pacific Climate Impact Centre School of Energy and EnvironmentCity University of Hong KongTat Chee Ave.KowloonHong KongChina

Climatologically,among all ocean basins,the western North Pacific(WNP)has the largest annual number of tropical cyclones(TCs)of around 26 while the Atlantic has around 13,yielding a difference of ***,the difference is-7 in 2020,with 30 TCs in the Atlantic and 23 in the WNP,which is the most negative difference within the last 46 *** fact,during the last 26 years,the difference in TC number is below 10 in ten years,with four years being *** a decreasing difference in TC number can be attributed to the natural multidecadal variation of the Atlantic Multidecadal Oscillation and Interdecadal Pacific Oscillation,as well as other external forcings such as anthropogenic aerosol forcing and increased greenhouse gases,with the additional impact from the La Niña *** result has significant implications on climate model projections of future TC activity in the two ocean basins.

关键词： tropical cyclone frequency Atlantic Multidecadal Oscillation Interdecadal Pacific Oscillation climate change

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Effect of Al addition on corrosion behavior of high-purity Mg in terms of processing history

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Journal of Magnesium and Alloys 2023年第3期11卷 851-868页

作者： Sang Kyu Woo Byeong-chan Suh Ha sik Kim chang Dong Yim Helmholtz Zentrum Hereon Max-Planck-Straße 1Geesthacht D-21502Germany Korea Institute of Materials Science 797 Changwondae-roSeongsan-guChangwonGyeongnam 51508Republic of Korea University of Science and Technology 217 Gajeong-roYuseong-guDaejeon 34113Republic of Korea

In this study,the effects of Al addition on the corrosion behavior of pure Mg with controlled impurity contents were systematically analyzed according to the processing *** results revealed that the corrosion behavior of high-purity Mg-Al alloys is strongly related to changes in the microstructure,including theβphase and Al-Mn or Al-Fe phases,and the protectiveness of the surface film according to the Al content and processing *** the as-cast alloys,the corrosion rate increased due to the increase ofβphase as the Al content increased,but in the as-extruded alloys,the corrosion rate,which was high due to intermetallic compounds caused by impurities in the low Al alloy,decreased as the Al content increased,and then increased *** is due to the combined effect of the increase of theβphase and decrease of the impurity effect,and the increase of the dissolved Al *** results suggest that it is necessary to analyze the effect of alloying elements on the corrosion behavior of pure Mg with information concerning the impurity content and processing history.

关键词： Mg High purity Mg-Al alloys Processing history Micro-galvanic Surface film

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Quantitative analysis of mechanical properties associated with aging treatment and microstructure in Mg-Al-Zn alloys through machine learning

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Journal of Materials Science & Technology 2022年第12期107卷 52-63页

作者： Joung sik Suh Byeong-chan Suh Sang Eun Lee Jun Ho Bae Byoung Gi Moon Advanced Metals Division Korea Institute of Materials ScienceChangwon 51508Republic of Korea

The present study proposes a methodology for predicting the mechanical properties of AZ61 and AZ91alloys associated with microstructure,texture and aging parameters and estimating predictor *** this,we investigate quantitative correlations between microstructure,texture and mechanical properties of aged AZ61 and AZ91 rods through machine *** regression analysis focuses on the precipitation behavior of Mg17Al12as the main second phase of Mg-Al-Zn alloys with respect to aging *** simplify data generation,only SEM images were used to quantify the features of discontinuous and continuous *** overcome the lack of data and make the most of the measured data,we devised a method to extend the existing dataset by a factor of 9 using the mean and standard deviation of the measured *** neural networks predicted tensile and compressive yield strengths and resultant yield asymmetry with a high accuracy of over 98%using 11 predictors for a total of *** tree learning quantitatively assessed the importance of predictors in determining the mechanical properties of aged AZ61 and AZ91 rods.

关键词： Magnesium alloy Aging treatment Microstructure Mechanical properties Machine learning

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