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Magnetic Resonance Letters 2022年第4期2卷 224-232页

作者： sihui luo Jiangfeng Guo Lizhi Xiao College of Artificial Intelligence and College of Petroleum Engineering China University of PetroleumBeijing102249China State Key Laboratory of Petroleum Resources and Prospecting China University of PetroleumBeijing102249China

Borehole nuclear magnetic resonance(NMR)is a powerful technology to characterize the petrophysical properties of underground reservoirs in the petroleum *** rising complexity of oil and gas exploration and development objectives,as well as the novel application contexts of underground reservoirs,have led to increasingly demanding requirements on borehole NMR technology including instrument design and related processing *** mini review summarizes the advances and applications of borehole NMR instruments along with some future *** may be helpful for researchers and engineers in the petroleum industry to understand the development status and future trends of borehole NMR technology.

关键词： Borehole Nuclear magnetic resonance(NMR) Instrument Oil and gas exploration and development Prospects

Numerical simulation study on the effect of temperature on the restricted diffusion in porous media

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Magnetic Resonance Letters 2023年第2期3卷 118-126,I0003页

作者： Zhen Xie Lizhi Xiao sihui luo Guangzhi Liao College of Artificial Intelligence China University of PetroleumBejing102249China State Key Laboratory of Petroleum Resources and Prospecting China University of PetroleumBeijing02249China College of Carbon Neutral Energy China University of PetroleumBeijing102249China

It is of great significance to study how temperature affects the restricted diffusion in pores for an accurate evaluation of reservoir physical properties by using nuclear magnetic resonance(NMR)diffusion-transverse relaxation(D-T2)spectrum under reservoir temperature *** this paper,we simulate the restricted diffusion and twodimensional(2D)NMR D-T2 spectra of water molecules at different temperatures using random-walk *** one-dimensional(1D)restricted diffusion simulation results show that the diffusion coefficient in the pore at room temperature decays with the diffusion time and eventually reaches a *** the condition of long-time diffusion,the ratio of restricted diffusion coefficient to bulk diffusion coefficient at different temperatures tends to be the same *** the increase in temperature,the simulated D-T2 spectra also gradually move *** simulated D-T2 spectra at all temperatures are consistent with the Pade interpolation *** addition,the results calculated by Pade interpolation equation demonstrate that the degree of temperature influence on the D-T2 spectrum of rock is quantitatively related to the pore radius,porosity and cementation index.

关键词： D-T_(2)spectra Temperature Restricted diffusion Numerical simulation

Real-time intelligent big data processing:technology, platform, and applications

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Science China(Information Sciences) 2019年第8期62卷 102-113页

作者： Tongya ZHENG Gang CHEN Xinyu WANG Chun CHEN Xingen WANG sihui luo College of Computer Science and Technology Zhejiang University

Human beings keep exploring the physical space using information means. Only recently, with the rapid development of information technologies and the increasing accumulation of data, human beings can learn more about the unknown world with data-driven methods. Given data timeliness, there is a growing awareness of the importance of real-time data. There are two categories of technologies accounting for data processing: batching big data and streaming processing, which have not been integrated well. Thus,we propose an innovative incremental processing technology named after Stream Cube to process both big data and stream data. Also, we implement a real-time intelligent data processing system, which is based on real-time acquisition, real-time processing, real-time analysis, and real-time decision-making. The real-time intelligent data processing technology system is equipped with a batching big data platform, data analysis tools, and machine learning models. Based on our applications and analysis, the real-time intelligent data processing system is a crucial solution to the problems of the national society and economy.

关键词： batching big data streaming processing technology real-time data processing incremental computation intelligent data processing system

A study on the temperature sensitivity of NMR porosity in porous media based on the intensity of magnetization Dedicated to the special issue “Magnetic Resonance in Porous Media”

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Magnetic Resonance Letters 2024年第1期4卷 28-39页

作者： Lu Zhang Lizhi Xiao Wensheng Wu Guangzhi Liao Yan Zhang sihui luo Xinglong Lei National Key Laboratory of Petroleum Resources and Engineering China University of PetroleumBeijing102249China College of Geophysics China University of PetroleumBeijing102249China PetroChina Huabei Oilfield Company China National Petroleum CorporationRenqiu062552China

The measurement of nuclear magnetic resonance(NMR)porosity is affected by *** considering the impact of NMR logging tools,this phenomenon is mainly caused by variations in magnetization intensity of the measured system due to temperature fluctuations and difference between the temperature of the porous medium and calibration *** this study,the effect of temperature was explained based on the thermodynamic theory,and the rules of NMR porosity responses to temperature changes were identified through core physics *** addition,a method for correcting the influence of temperature on NMR porosity measurement was proposed,and the possible factors that may affect its application were also discussed.

关键词： NMR porosity Temperature Porous media Intensity of magnetization

Association between population migration and epidemic control of coronavirus disease 2019

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Science China(Life Sciences) 2020年第6期63卷 936-939页

作者： Yu Ding sihui luo Xueying Zheng Ping Ling Tong Yue Zhirong Liu Jianping Weng The First Affiliated Hospital of USTC Division of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefei 230001China Institute of Public Health University of Science and Technology of ChinaHefei 230026China Joint Laboratory of Public Health USTC and Anhui NHCHefei 230001China Anhui Provincial Center for Disease Control and Prevention Hefei 230601China Division of Life Sciences and Medicine University of Science and Technology of ChinaHefei 230026China

Dear Editor,In January 2020,a widespread outbreak of coronavirus disease 2019(COVID-19)occurred after the beginning of the largest annual migration in China,which is known as the Spring Festival *** in January 20,2020,the Chinese government took a series of unprecedented measures to contain the spread of *** of the role of Wuhan as a central transportation hub.

关键词： Association between population migration and epidemic control of coronavirus disease 2019

Asymptomatic patients and asymptomatic phases of Coronavirus Disease 2019(COVID-19): a population-based surveillance study

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National Science Review 2020年第10期7卷 1527-1539页

作者： Xueying Zheng sihui luo Yong Sun Mingfeng Han Jian Liu Liangye Sun Liangming Zhang Ping Ling Yu Ding Tengchuan Jin Zhirong Liu Jianping Weng The First Affiliated Hospital of USTC Division of Life Science and Medicine University of Science and Technology of China Key Laboratory for Medical and Health of the 13th Five-Year Plan Anhui Provincial Center for Disease Control and Prevention Fuyang No.2 People's Hospital Anqing Hospital Affiliated to Anhui Medical University (Anqing Municipal Hospital) Lu'an People's Hospital Department of Infectious Disease the First Affiliated Hospital of USTCDivision of Life Science and Medicine University of Science and Technology of China Division of Life Science and Medicine University of Science and Technology of China

In this population-based study, we identified 307 confirmed COVID-19 cases from massive surveillance,including 129 551 individuals screened at fever clinics or returning from Hubei and 3710 close contacts of confirmed COVID-19 patients. Among them, 17 patients were asymptomatic at initial clinical *** asymptomatic patients on admission accounted for a small proportion of all patients(5.54%) with relatively weak transmissibility, and the detection rate was 0.35 per 100 close contacts. Moreover, the dynamics of symptoms of the 307 patients showed that the interval from symptom remission to the final negativity of viral nucleic acid was 5.0 days(interquartile range 2.0 to 11.0 days), with 14 patients(4.56%)having re-detectable viral RNA after discharge. Overall, our findings suggested asymptomatic carriers and presymptomatic patients only accounted for a small proportion of COVID-19 patients. Also, the asymptomatic phase during recovery from COVID-19 implied that negativity in viral RNA is necessary as a de-isolation criterion and follow-up is recommended.

关键词： epidemiology public health surveillance asymptomatic COVID-19 SARS-CoV-2

The zinc finger transcription factor,KLF2,protects against COVID-19 associated endothelial dysfunction

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Signal Transduction and Targeted Therapy 2021年第8期6卷 2502-2510页

作者： Suowen Xu Yujie Liu Yu Ding sihui luo Xueying Zheng Xiumei Wu Zhenghong Liu Iqra Ilyas Suyu Chen Shuxin Han Peter J.Little Mukesh K.Jain Jianping Weng Institute of Endocrine and Metabolic Diseases The First Affiliated Hospital of USTCDivision of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefeiChina Department of Obstetrics and Gynecology The First Affiliated Hospital of USTCDivision of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefeiAnhuiP.R.China Department of Endocrinology and Metabolism The Third Affiliated Hospital of Sun Yat-sen UniversityGuangzhouChina Anhui Province Key Laboratory of Hepatopancreatobiliary Surgery The First Affiliated Hospital of USTCDivision of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefeiChina Sunshine Coast Health Institute University of the Sunshine CoastBirtinyaQLDAustralia School of Pharmacy Pharmacy Australia Centre of Excellencethe University of QueenslandWoolloongabbaQLDAustralia Department of Medicine Case Cardiovascular Research InstituteCase Western Reserve UniversityClevelandOHUSA Department of Medicine Harrington Heart and Vascular InstituteUniversity Hospitals Cleveland Medical CenterClevelandOHUSA The First Affiliated Hospital Bengbu Medical CollegeBengbuChina

Coronavirus disease 2019(COVID-19)is regarded as an endothelial disease(endothelialitis)with its patho-mechanism being incompletely *** evidence has demonstrated that endothelial dysfunction precipitates COVID-19 and its accompanying multi-organ ***,pharmacotherapies targeting endothelial dysfunction have potential to ameliorate COVID-19 and its cardiovascular *** objective of the present study is to evaluate whether kruppel-like factor 2(KLF2),a master regulator of vascular homeostasis,represents a therapeutic target for C0VID-19-induced endothelial ***,we demonstrate that the expression of KLF2 was reduced and monocyte adhesion was increased in endothelial cells treated with COVID-19 patient serum due to elevated levels of pro-adhesive molecules,ICAM1 and ***-1β and TNF-α;two cytokines elevated in cytokine release syndrome in COVID-19 patients,decreased KLF2 gene ***(atorvastatin and tannic acid)and genetic(adenoviral overexpression)approaches to augment KLF2 levels attenuated COVID-19-serum-induced increase in endothelial inflammation and monocyte ***-generation RNA-sequencing data showed that atorvastatin treatment leads to a cardiovascular protective transcriptome associated with improved endothelial function(vasodilation,antiinflammation,antioxidant status,anti-thrombosis/-coagulation,anti-fibrosis,and reduced angiogenesis).Finally,knockdown of KLF2 partially reversed the ameliorative effect of atorvastatin on COVID-19-serum-induced endothelial inflammation and monocyte ***,the present study implicates loss of KLF2 as an important molecular event in the development of COVID-19-induced vascular disease and suggests that efforts to augment KLF2 levels may be therapeutically beneficial.

关键词： KLF2 inflammation elevated

Intrapartum and early postpartum glycemic profiles in women with gestational diabetes mellitus:an observational study

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Chinese Medical Journal 2022年第21期135卷 2547-2553页

作者： Yu Ding Xueying Zheng Yujie Liu Tian Wei Tong Yue Siqi Wang Suyu Chen Jianping Weng sihui luo Department of Endocrinology The First Affiliated Hospital of USTCDivision of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefeiAnhui 230001China Department of Obstetrics and Gynecology The First Affiliated Hospital of USTCDivision of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefeiAnhui 230001China Institute of Endocrine and Metabolic Diseases The First Affiliated Hospital of USTCDivision of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefeiAnhui 230001China

Background: Data on the glycemic profile of pregnant women with gestational diabetes mellitus (GDM) during the perinatal period are sparse. This study described the intrapartum and early postpartum glucose profiles among pregnant women with GDM, and analyzed factors potentially affecting glycemic parameters during the ***: This was a prospective observational study conducted from March 2020 to November 2021. Pregnant women with GDM receiving lifestyle interventions alone during pregnancy and matched women with non-diabetic pregnancies (NDPs) were enrolled from among patients admitted to the obstetrics department for childbirth. Glucose monitoring was performed via a flash glucose monitoring (FGM) system on admission, and glucose readings during labor and early postpartum were analyzed. The clinical characteristics and FGM-based parameters of participants in the two groups were ***: A total of 124 participants (mean age: 29.5 ± 3.5 years, 92 [74.2%] primipara) were included in the final analysis. A total of 17,571 glucose readings were retrieved. There were no significant differences in clinical characteristics between the GDM (n = 60) and NDP (n = 64) groups. The average glucose level was 92.2 mg/dL, and the level was higher in the GDM group (95.5 ± 12.1 mg/dLvs. 89.1 ± 13.4 mg/dL,P = 0.008) during the intrapartum and early postpartum periods. The data were split into the intrapartum period (from the start of labor to delivery of the placenta) and the early postpartum period (within 24 h after placental delivery) for analysis. During intrapartum, women with GDM exhibited glycemic profiles and fluctuations similar to those in the NDP group. However, women with GDM had higher postpartum glucose levels (97.7 ± 13.4 mg/dLvs. 90.8 ± 15.3 mg/dL,P = 0.009), a longer time spent >140 mg/dL (8.7 ± 9.3%vs. 5.9 ± 10.3%,P = 0.011), and greater glycemic fluctuations than those with NDP. Postpartum hyperglycemia in GDM might be associated with high parity a

关键词： Blood glucose Flash glucose monitoring Gestational diabetes mellitus Glycemic profiles

Real-world effectiveness of early insulin therapy on the incidence of cardiovascular events in newly diagnosed type 2 diabetes

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Signal Transduction and Targeted Therapy 2024年第7期9卷 2953-2959页

作者： sihui luo Xueying Zheng Wei Bao Sheng Nie Yu Ding Tong Yue Yilun Zhou Ying Hu Hua Li Qiongqiong Yang Qijun Wan Bicheng Liu Hong Xu Guisen Li Gang Xu Chunbo Chen Huafeng Liu Yongjun Shi Yan Zha Yaozhong Kong Guobin Su Ying Tang Mengchun Gong Linong Ji Fan Fan Hou Jianping Weng Department of Endocrinology First Affiliated Hospital of USTCDivision of Life Sciences and MedicineUniversity of Science and Technology of ChinaHeifeiChina Institute of Public Health Sciences Division of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefeiChina Division of Nephrology National Clinical Research Center for Kidney DiseaseState Key Laboratory of Organ Failure ResearchNanfang HospitalSouthern Medical UniversityGuangzhouChina Department of Nephrology Beijing Tiantan HospitalCapital Medical UniversityBeijingChina The Second Affiliated Hospital of Zhejiang University School of Medicine HangzhouChina Sir Run Run Shaw Hospital Zhejiang University School of MedicineHangzhouChina Department of Nephrology Sun Yat-Sen Memorial HospitalSun Yat-Sen UniversityGuangzhouChina The Second People’s Hospital of Shenzhen Shenzhen UniversityShenzhenChina Institute of Nephrology Zhongda HospitalSoutheast University School of MedicineNanjingChina Children’s Hospital of Fudan University ShanghaiChina Renal Department and Institute of Nephrology Sichuan Provincial People’s HospitalSchool of MedicineUniversity of Electronic Science and Technology of ChinaSichuan Clinical Research Center for Kidney DiseasesChengduChina Division of Nephrology Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhanChina Department of Critical Care Medicine Maoming People’s HospitalMaomingChina Key Laboratory of Prevention and Management of Chronic Kidney Disease of Zhanjiang City Institute of NephrologyAffiliated Hospital of Guangdong Medical UniversityZhanjiangChina Huizhou Central People’s Hospital Sun Yat-Sen UniversityHuizhouChina Guizhou Provincial People’s Hospital Guizhou UniversityGuiyangChina Department of Nephrology the First People’s Hospital of FoshanFoshanChina Department of Nephrology Guangdong Provincial Hospital of Chinese Medicinethe Second Affiliated Hospitalthe Second Clinical CollegeGuangzhou University of Chinese Medicin

Early insulin therapy is capable to achieve glycemic control and restoreβ-cell function in newly diagnosed type 2 diabetes(T2D),but its effect on cardiovascular outcomes in these patients remains *** this nationwide real-world study,we analyzed electronic health record data from 19 medical centers across China between 1 January 2000,and 26 May *** included 5424 eligible patients(mean age 56 years,2176 women/3248 men)who were diagnosed T2D within six months and did not have prior cardiovascular *** Cox regression models were used to estimate the associations of early insulin therapy(defined as the first-line therapy for at least two weeks in newly diagnosed T2D patients)with the incidence of major cardiovascular events including coronary heart disease(CHD),stroke,and hospitalization for heart failure(HF).During 17,158 persons years of observation,we documented 834 incident CHD cases,719 stroke cases,and 230 hospitalized cases for *** diagnosed T2D patients who received early insulin therapy,compared with those who did not receive such treatment,had 31%lower risk of incident stroke,and 28%lower risk of hospitalization for *** significant difference in the risk of CHD was *** found similar results when repeating the aforesaid analysis in a propensity-score matched population of 4578 patients and with inverse probability of treatment weighting *** findings suggest that early insulin therapy in newly diagnosed T2D may have cardiovascular benefits by reducing the risk of incident stroke and hospitalization for HF.

关键词： cardiovascular treatment nationwide

随机轮轨力作用下基于2.5维离散支撑模型的轨道垂向振动分析

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铁道学报 2021年第6期43卷 104-111页

作者：朱志辉王凡罗思慧李奇蒋丽忠中南大学土木工程学院湖南长沙410075 中南大学高速铁路建造技术国家工程实验室湖南长沙410075 同济大学土木工程学院上海200092

针对轨道随机不平顺引起的钢轨高频振动响应问题,建立2.5维有限元离散支撑轨道动力学实体模型。首先结合高速车辆模型建立耦合系统垂向振动模型,进而基于虚拟激励法得到由轨道不平顺引起的动态轮轨力功率谱;然后基于2.5维离散支撑轨道... 详细信息

针对轨道随机不平顺引起的钢轨高频振动响应问题,建立2.5维有限元离散支撑轨道动力学实体模型。首先结合高速车辆模型建立耦合系统垂向振动模型,进而基于虚拟激励法得到由轨道不平顺引起的动态轮轨力功率谱;然后基于2.5维离散支撑轨道数值模型,将动态轮轨力功率谱作为激励,得到轨道系统的随机振动响应。通过与格林函数结果对比,验证了本文模型的正确性。结果表明:采用2.5维有限元法及荷载等效法可快速实现无限长离散支撑实体轨道模型全频域计算,可模型钢轨的横截面变形特征;以CRH3型高速动车为例,高于2800 Hz时轨道结构的横截面开始明显变形;低于50 Hz时四个轮对处的振动加速度功率谱密度差别显著;170~3000 Hz内垫板刚度对轨道结构振动加速度影响较大。

关键词：离散支撑轨道 2.5维有限元法随机振动车辆-轨道耦合系统虚拟激励法