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High-fluence relay-based disposable photoacoustic-ultrasonic endoscopy for in vivo anatomical imaging of gastrointestinal tract

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Photonics Research 2023年第1期11卷 55-64页

作者： XUE WEN PENG LEI SHENGXIN HUANG XIAOYU CHEN YANCHI YUAN DI KE RUI LIU JIAXI LIANG ERQI WANG BO WEI KEDI XIONG sihua yang MOE Key Laboratory of Laser Life Science&Institute of Laser Life Science South China Normal UniversityGuangzhou 510631China Guangdong Provincial Key Laboratory of Laser Life Science College of BiophotonicsSouth China Normal UniversityGuangzhou 510631China Institute of Biological and Medical Engineering Guangdong Academy of SciencesGuangzhou 510316China Department of Gastrointestinal Surgery Third Affiliated HospitalSun Yat-sen UniversityGuangzhou 510182China

Photoacoustic endomicroscopy combined with ultrasound(PAEM-US)has been a long-standing expectation for gastrointestinal tumor ***,we introduce a prototype disposable PAEM-US catheter and corresponding power interface unit,featuring catheter switchability,self-internal three-dimensional scanning,and system repeatability for gastrointestinal *** utilizing high-fluence relays,cascade insertion loss of the optical waveguide is minimized to 0.6 dB with a high performance of power resistance,and a focus-customizable acousto-optic coaxial probe is designed for high-sensitivity optical-resolution photoacoustic *** capability was demonstrated with in vivo anatomical imaging at 30 frames per *** results showed co-registered microscopic visualization of the microvascular and stratification of the rat colorectum with lateral resolution of 18μm and axial resolution of 63μm,holding great potential in the clinical detection of gastrointestinal diseases.

关键词： vivo utilizing insertion

Electronic structure and spin state regulation of vanadium nitride via a sulfur doping strategy toward flexible zinc-air batteries

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Journal of Energy Chemistry 2024年第2期89卷 239-249,I0007页

作者： Daijie Deng Honghui Zhang Jianchun Wu Xing Tang Min Ling sihua Dong Li Xu Henan Li Huaming Li Institute for Energy Research Institute of Quantum and Sustainable TechnologySchool of Chemistry and Chemical EngineeringSchool of Materials Science and EngineeringJiangsu Province and Education Ministry Co-Sponsored Synergistic Innovation Center of Modern Agricultural EquipmentJiangsu UniversityZhenjiang 212013JiangsuChina Key Laboratory of Radio Frequency and Micro-Nano Electronics of Jiangsu Province Nanjing 210023JiangsuChina Zhenjiang Kangyuan Electrical Appliance Co. Ltd.Zhenjiang 212013JiangsuChina College of Chemical and Biological Engineering Zhejiang UniversityHangzhou 310027ZhejiangChina YTO Group Corporation Dongfanghong(Henan)Agricultural Service Technology Co. Ltd.Luoyang 471033HenanChina

Owing to the distinctive structural characteristics,vanadium nitride(VN)is highly regarded as a catalyst for oxygen reduction reaction(ORR)in zinc-air batteries(ZABs).However,VN exhibits limited intrinsic ORR activity due to the weak adsorption ability to O-containing ***,the S-doped VN anchored on N,S-doped multi-dimensional carbon(S-VN/Co/NS-MC)was constructed using the solvothermal and in-situ doping *** sulfur atoms into VN species alters the electron spin state of vanadium in the S-VN/Co/NS-MC for regulating the adsorption energy of vanadium sites to oxygen *** introduced sulfur atoms polarize the V 3d_(z)^(2) electrons,shifting spin-down electrons closer to the Fermi level in the S-VN/Co/***,the introduction of sulfur atoms into VN species enhances the adsorption energy of vanadium sites for oxygen ****OOH dissociation transitions from being unspontaneous on the VN surface to a spontaneous state on the S-doped VN ***,the ORR barrier on the S-VN/Co/NS-MC surface is *** S-VN/Co/NS-MC demonstrates a higher half-wave potential and limiting current density compared to the VN/Co/*** S-VN/Co/NS-MC-based liquid ZABs display a power density of 195.7 m W cm^(-2),a specific capacity of 815.7 m A h g^(-1),and a cycling stability exceeding 250 *** S-VN/Co/NS-MC-based flexible ZABs are successfully employed to charge both a smart watch and a mobile *** approach holds promise for advancing the commercial utilization of VN-based catalysts in ZABs.

关键词： S-doped VN Electronic structures Spin state regulation Oxygen reduction reaction Zinc-air batteries

Aberrant Hippocampal Development in Early‑onset Mental Disorders and Promising Interventions:Evidence from a Translational Study

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Neuroscience Bulletin 2024年第6期40卷 683-694页

作者： Jingyu yang Huiling Guo Aoling Cai Junjie Zheng Juan Liu Yao Xiao sihua Ren Dandan Sun Jia Duan Tongtong Zhao Jingwei Tang Xizhe Zhang Rongxin Zhu Jie Wang Fei Wang Early Intervention Unit Department of PsychiatryAffiliated Nanjing Brain HospitalNanjing Medical UniversityNanjing 210029China School of Biomedical Engineering and Informatics NanjingMedical UniversityNanjing 211166China The Affiliated Changzhou Second People’s Hospital of Nanjing Medical University Changzhou Second People’s HospitalChangzhou Medical CenterNanjing Medical UniversityChangzhou 213004China Department of Radiology First Hospital of China Medical UniversityShenyang 110002China Department of Cardiac Function The People’s Hospital of China Medical University and the People’s Hospital of Liaoning ProvinceShenyang 110067China Key Laboratory of Magnetic Resonance in Biological Systems State Key Laboratory of Magnetic Resonance and Atomic and Molecular PhysicsNational Center for Magnetic Resonance in WuhanWuhan Institute of Physics and MathematicsInnovation Academy for Precision Measurement Science and TechnologyChinese Academy of Sciences-Wuhan National Laboratory for OptoelectronicsWuhan 430064China Institute of Neuroscience and Brain Diseases Xiangyang Central HospitalAffiliated Hospital of Hubei University of Arts and ScienceXiangyang 441021China Functional Brain Imaging Institute of Nanjing Medical University Nanjing 210029China

Early-onset mental disorders are associated with disrupted neurodevelopmental processes during *** methylazoxymethanol acetate(MAM)animal model,in which disruption in neurodevelopmental processes is induced,mimics the abnormal neurodevelopment associated with early-onset mental disorders from an etiological *** conducted longitudinal structural magnetic resonance imaging(MRI)scans during childhood,adolescence,and adulthood in MAM rats to identify specific brain regions and critical windows for ***,the effect of repetitive transcranial magnetic stimulation(rTMS)intervention on the target brain region during the critical window was *** addition,the efficacy of this intervention paradigm was tested in a group of adolescent patients with early-onset mental disorders(diagnosed with major depressive disorder or bipolar disorder)to evaluate its clinical translational *** results demonstrated that,compared to the control group,the MAM rats exhibited significantly lower striatal volume from childhood to adulthood(all P0.05)but was significantly lower than the control group from adolescence to adulthood(both P0.05).In the clinical trial,adolescents with early-onset mental disorders showed a significant increase in hippocampal volume after rTMS treatment compared to baseline(P<0.01),and these volumetric changes were associated with improvement in depressive symptoms(r=−0.524,P=0.018).These findings highlight the potential of targeting aberrant hippocampal development during adolescence as a viable intervent

关键词： Early-onset Mental disorder Neurodevelopment Animal model Hippocampus Repetitive transcranial magnetic stimulation

Classical spin liquid state in a rhombic lattice metal-organic framework

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Nano Research 2024年第4期17卷 3407-3412页

作者： sihua Feng Chao Wang Jiyin Zhao Xuguang Liu Chaocheng Liu Zeming Qi Lei Chen Huijuan Wang Minghui Fan Hengli Duan Wensheng Yan National Synchrotron Radiation Laboratory University of Science and Technology of ChinaHefei 230026China Hefei National Research Center for Physical Sciences at the Microscale University of Science and Technology of ChinaHefei 230026China School of Materials Science and Engineering Hefei University of TechnologyHefei 230009China Experimental Center of Engineering and Material Science University of Science and Technology of ChinaHefei 230026China

Discovering more and new geometrically frustrated systems remains an active point of inquiry in fundamental physics for the existence of unusual states of ***,we report spin-liquid-like behavior in a two-dimensional(2D)rhombic lattice Fe-metal-organic framework(Fe-MOF)with frustrated *** Fe-MOF exhibits a high frustration factor f=|θCW|/TN≥315,and its long-range magnetic order is suppressed down to 180 *** theoretical calculations demonstrate strong antiferromagnetic coupling between adjacent Fe3+ions,indicating the potential of a classical spin-liquid-like ***,a T-linear heat capacity parameter,γ,originating from electronic contributions and with magnetic field independence up to 8 T,can be observed in the specific heat capacity measurements at low-temperature,providing further proof for the spin-liquid-like *** work highlights the potential of MOF materials in geometrically frustrated systems,and will promote the research of exotic quantum physics phenomena.

关键词： spin-liquid-like state two-dimensional metal-organic framework(2D MOF) rhombic lattice ultralow temperature(ULT)measurements spin-frustrated

血管内光声-超声-光学相干层析-光声弹性多模态成像方法及系统

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中国激光 2023年第3期50卷 86-95页

作者：万余洋雷鹏熊科迪杨思华华南师范大学生物光子学研究院激光生命科学教育部重点实验室暨激光生命科学研究所广东广州510631 华南师范大学生物光子学研究院广东省激光生命科学重点实验室广东广州510631 广东省科学院生物与医学工程研究所广东广州510316

识别动脉粥样硬化斑块的易损性是防治急性冠状动脉疾病的重要途径。纤维帽厚度、脂质核心大小、管腔狭窄程度和管腔的力学特性是评估斑块易损性的关键参数。然而,单一模态的血管内成像技术难以通过一次成像获取用于评估斑块易损性的全... 详细信息

识别动脉粥样硬化斑块的易损性是防治急性冠状动脉疾病的重要途径。纤维帽厚度、脂质核心大小、管腔狭窄程度和管腔的力学特性是评估斑块易损性的关键参数。然而,单一模态的血管内成像技术难以通过一次成像获取用于评估斑块易损性的全面信息。本团队通过复用光路和声路,将血管内超声成像(IVUS)和血管内光学相干层析成像(IVOCT)与血管内光声成像(IVPA)、光声弹性成像(IVPAE)有机结合到一起,开发了一种血管内光声-超声-光学相干层析-光声弹性四模态一体化成像探头及成像系统。该一体化成像探头的成像直径仅为0.97 mm,光学相干层析、光声、超声模态的横向分辨率分别为20.5、61.3、122.2μm,纵向分辨率分别为15.8、57.4、72.5μm。离体模拟样品和兔腹主动脉的在体成像实验验证了血管内四模态成像能够提供血管壁的宏观和微观结构信息,同时能够特异性识别脂质成分和反映脂质斑块的弹性力学信息。该一体化探头可一次性获取血管内斑块的多物理影像特性,有望为动脉粥样硬化斑块的深入理解和诊治提供新型的介入成像方法和工具。

关键词：医用光学光声成像超声成像光学相干层析成像光声弹性成像血管内多模态成像

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复合树的Felicitous性质

中山大学学报（自然科学版） 2017年第6期56卷 60-63页

作者：张明军杨思华姚兵兰州财经大学信息工程学院甘肃兰州730020 兰州财经大学陇桥学院甘肃兰州730101 西北师范大学数学与统计学院甘肃兰州730070

将多个具有集有序Felicitous性质的树上的点与一棵集有序优美树上的点重合,构造出一棵较大的复合树,经研究计算,该复合树具有集有序Felicitous性质。

关键词：复合树集有序Felicitous标号集有序优美标号

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探索拓扑编码中的图格与传统格的联系

计算机科学与探索 2021年第11期15卷 2171-2183页

作者：张明军杨思华姚兵兰州财经大学中国西北金融研究中心兰州730020 兰州财经大学信息工程学院兰州730020 甘肃省电子商务技术与应用重点实验室兰州730020 西北师范大学数学与统计学院兰州730070

已知不存在解决某些格困难问题的多项式量子算法,无色图格和着色图格是受格理论启发而产生的多学科交叉的产物。拓扑编码中的一个无色图格或着色图格是建立在图的运算和一组顶点不交的连通图或连通着色图构成的图格基上。基于口令认证... 详细信息

已知不存在解决某些格困难问题的多项式量子算法,无色图格和着色图格是受格理论启发而产生的多学科交叉的产物。拓扑编码中的一个无色图格或着色图格是建立在图的运算和一组顶点不交的连通图或连通着色图构成的图格基上。基于口令认证或数字文件加密,介绍数字串拓扑认证问题,用拓扑编码给出一种非对称加密系统。拓扑编码可以形成一个公钥对应多个私钥,多个公钥对应多个私钥的非对称加密系统;拓扑编码中的拓扑认证需要两个不同领域的数学知识,而且可以产生指数级别的算法。基于图的边连接运算、顶点重合运算等运算,研究了具有优美全着色的着色图格基存在性,建立了边连接图格和F-图格等无穷图格,并证明这些图格对优美全着色具有封闭性。定义了特殊着色图的拓扑向量,建立了图格与非负整数传统格之间的一个联系,为抗量子计算提供可行的技术;说明没有多项式算法解决数字串分解问题,又因为图同构问题是NP-困难,从而拓扑编码建立的图格具有抗超大计算机和量子计算机的计算功能。

关键词：格图格全着色优美标号拓扑编码网络安全

金融业集聚是否促进了京津冀科技创新?--基于京津区级及河北地级市面板数据的实证分析

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河北经贸大学学报 2022年第5期43卷 74-87页

作者：戴宏伟杨思华中央财经大学经济学院北京102206

采用2011—2019年北京、天津各16个区和河北省11个地级市的面板数据,构建固定效应模型和动态GMM模型,探究金融业集聚对科技创新的影响,并分析了地区间的异质性。实证结果显示:总体上京津冀金融业集聚对科技创新有明显的促进作用;具体而... 详细信息

采用2011—2019年北京、天津各16个区和河北省11个地级市的面板数据,构建固定效应模型和动态GMM模型,探究金融业集聚对科技创新的影响,并分析了地区间的异质性。实证结果显示:总体上京津冀金融业集聚对科技创新有明显的促进作用;具体而言,天津和北京的金融业集聚对科技创新的正向作用较河北更为显著;尽管北京的金融业集聚程度远高于天津,但其对科技创新的促进效应却明显弱于天津。从京津冀整体来看,人力资本储备、固定资产投资、财政科技支出、研发经费投入、产业结构和城镇化水平对科技创新均存在积极作用,对外开放水平和房价水平对科技创新的影响则不明显。

关键词：京津冀科技创新金融业集聚

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扩散加权成像在卵巢肿瘤中的应用

国际医学放射学杂志 2019年第2期42卷 203-207页

作者：杨思华汤光宇同济大学附属第十人民医院放射科上海200072

扩散加权成像(DWI)是目前唯一能够检测生物组织内水分子扩散运动的无创方法 ,该种扩散运动可以通过表观扩散系数(ADC)来量化分析。扩散峰度成像(DKI)、体素内不相干运动(IVIM)成像、背景抑制扩散加权全身成像(DWIBS)等DWI新技术用于卵... 详细信息

扩散加权成像(DWI)是目前唯一能够检测生物组织内水分子扩散运动的无创方法 ,该种扩散运动可以通过表观扩散系数(ADC)来量化分析。扩散峰度成像(DKI)、体素内不相干运动(IVIM)成像、背景抑制扩散加权全身成像(DWIBS)等DWI新技术用于卵巢肿瘤的评估提高了卵巢肿瘤影像诊断的准确性。综述DWI及其新技术在卵巢肿瘤定性诊断、分期、疗效评估、预后判断中的作用及其潜在缺陷。

关键词：扩散加权成像表观扩散系数扩散峰度成像体素内不相干运动背景抑制扩散加权全身成像卵巢肿瘤