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PUVA versus NB-UVB in Management of Vitiligo, Clinico-Immuno-Pathological Study

Journal of Cosmetics, Dermatological Sciences and Applications 2013年第3期3卷 16-25页

作者： Sameh K. Attia Sherif S. Awad siham yacoub Department of Dermatology and Venereology Minia University Minya Egypt

Background: Phototherapy is the most commonly used modality in the treatment of vitiligo. Oral PUVA is the classical treatment and the NB-UVB is a recently introduced form excluding the shorter erythemogenic wavelengths. Aims: This study was designed to compare the effects of PUVA and NB-UVB clinically and immuno-pathologically in managing non segmental vitiligo. Patients/Methods: Thirty vitiligo patients were divided randomly into two groups and treated either by oral PUVA or by narrow band UVB for 4 months, and evaluation was done clinically and immuno-pathologically. Results: One patient in PUVA group (3.3%) failed to respond to therapy while 29 patients (93.3%) improved including all NB-UVB cases. Excellent repigmentation was achieved in 6.7% in PUVA group and 66.6% in NB-UVB group;good repigmentation was achieved in 60% in PUVA and 20% in NB-UVB while 26.7% in PUVA and 13.3% in NB-UVB showed mild repigmentation. The color matching was excellent in all NB-UVB patients. Recurrence and activation of vitiligo were demonstrated in some NB-UVB cases and were less in PUVA treated cases. Microscopic examination revealed persistence of dermal lympho-histiocytic infiltrate and the interface changes in biopsies from vitiliginous lesions treated with NB-UVB more than with PUVA. Conclusions: NB-UVB provides significant better results than oral PUVA in managing non-segmental vitiligo. Although NB-UVB therapy gives a rapid effect, yet the observation of recurrences and development of new lesions of vitiligo were less significant with PUVA. It was also observed that PUVA has better immuno-modulatory effect on vitiligo than NB-UVB and may give better response on a longer period of time.

关键词： PUVA Vitiligo NB-UVB

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Overall Assessment of Heat Transfer for a Rarefied Flow in a Microchannel with Obstacles Using Lattice Boltzmann Method

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工程与科学中的计算机建模(英文) 2024年第1期138卷 273-299页

作者： siham Hammid Khatir Naima Omolayo M.Ikumapayi Cheikh Kezrane Abdelkrim Liazid Jihad Asad Mokdad Hayawi Rahman Farhan Lafta Rashid Naseer Ali Hussien Younes Menni Laboratory of Development in Mechanics and Materials(LDMM) Zian Achour UniversityDjelfaPB 3117Algeria Department of Technology University Center Salhi Ahmed Naama(Ctr.Univ.Naama)P.O.Box 66Naama45000Algeria Department of Mechanical and Mechatronics Engineering Afe Babalola University Ado Ekiti360101Nigeria Departement of Physics Faculty of ScienceAbou Bekr Belkaid UniversityTlemcen13000Algeria Department of Physics Faculty of Applied SciencesPalestine Technical University-KadoorieTulkarmPalestine Aeronautical Technical Engineering Al-Farahidi UniversityBaghdad10011Iraq Mechanical Engineering Department University of KerbalaKarbala56001Iraq Information and Communication Technology Research Group Scientific Research CenterAl-Ayen UniversityThi-QarIraq National University of Science and Technology Dhi QarIraq

The objective of this investigation is to assess the effect of obstacles on numerical heat transfer and fluid flow momentum in a rectangular microchannel(MC).Two distinct configurations were studied:one without obstacles and the other with alternating obstacles placed on the upper and lower *** research utilized the thermal lattice Boltzmann method(LBM),which solves the energy and momentum equations of fluids with the BGK approximation,implemented in a Python coding *** jump and slip velocity conditions were utilized in the simulation for the MC and extended to all obstacle *** study aims to analyze the rarefaction effect,with Knudsen numbers(Kn)of 0.012,0.02,and *** outcomes indicate that rarefaction has a significant impact on the velocity and temperature *** presence of nine obstacles led to slower fluid movement inside the microchannel MC,resulting in faster cooling at the *** MCs with obstacles,the rarefaction effect plays a crucial role in decreasing the Nusselt number(Nu)and skin friction coefficient(Cf).Furthermore,the study demonstrated that the obstacles played a crucial role in boosting fluid flow and heat transfer in the *** findings suggest that the examined configurations could have potential applications as cooling technologies in micro-electro-mechanical systems and microdevice applications.

关键词： Microfluid rarefied flow LBM microchannel Knudsen number numerical simulation

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MUF Resins Improved by Citric Acid as Adhesives for Wood Veneer Panels

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Journal of Renewable Materials 2023年第2期11卷 539-553页

作者： Claudio Del Menezzi Antonio Pizzi siham Amirou Xuedong Xi Department of Forestry Engineering Faculty of TechnologyUniversity of BrasiliaBrasíliaBrazil LERMAB University of LorraineNancyFrance SeniorPost-Doctoral Internship LERMAB-ENSTIBUniversity of LorraineEpinalFrance Yunnan Key Laboratory of Wood Adhesives and Glue Products College of Material Science and EngineeringSouthwest Forestry UniversityKunmingChina International Joint Research Center for Biomass Materials Southwest Forestry UniversityKunmingChina

This article presents the first applied results of using citric acid in combinations with a melamine-urea-formal-dehyde(MUF)resin for bonding wood *** chemical reactions involved are shown based on a MALDI ToF analysis of the reaction of the MUF resin with citric *** preliminary results of the physical and mechanical properties of the LVL prepared are also *** from Populus sp were used to manufacture 5-layer laminated veneer lumber(LVL)of small *** combinations of the amount of citric acid,MUF spread rate and pressing parameters were *** bonded with 20%of citric acid+100 g/m^(2)of MUF,hot-pressed using a 3-step process with maximum 1.5 MPa of pressure yielded the board with better dimensional stability and mechanical *** could be concluded that citric acid in combination with MUF can be used for bonding wood veneer and the research should be continued to study further the parameters involved and to enhance the results.

关键词： LVL wood adhesives citric acid MUF resins MALDI ToF mechanical performance

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RBSDEs with optional barriers:monotone approximation

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Probability, Uncertainty and Quantitative Risk 2022年第2期7卷 67-84页

作者： siham Bouhadou Astrid Hilbert Youssef Ouknine Department of Mathematics Faculty of Sciences SemlaliaCadi Ayyad UniversityBd.Prince My AbdellahB.P.239040000 MarrakechMorocco Department of Mathematics Linnaeus UniversityVaxjo 35195Sweden Africa Business School Mohammed VI Polytechnic UniversityLot 660Hay Moulay Rachid Ben Guerir43150Morocco

In this short note we consider reflected backward stochastic differential equations(RBSDEs)with a Lipschitz driver and barrier processes that are optional and right lower *** this case,the barrier is represented as a nondecreasing limit of right continuous with left limit(RCLL)*** combine some well-known existence results for RCLL barriers with comparison arguments for the control process to construct ***,we highlight the connection of these RBSDEs with standard RCLL BSDEs.

关键词： Reflected backward stochastic differential equation g-expectation Optional barrier Monotone approximation Comparison principle

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Optimal stopping in predictable setting

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Probability, Uncertainty and Quantitative Risk 2023年第4期8卷 485-498页

作者： siham Bouhadou Astrid Hilbert Youssef Ouknine Department of Mathematics Faculty of Sciences SemlaliaCadi Ayyad UniversityBd.Prince My AbdellahB.P.239040000 MarrakechMorocco Department of Mathematics Linnaeus UniversityB2051Hus BVäxjöSweden Mohammed VI Polytechnic University Hay Moulay Rachid Ben Guerir43150Morocco

In this study,we delve into the optimal stopping problem by examining the p(ϕ(τ),τ∈T_(0)^(p))case in which the reward is given by a family of nonnegative random variables indexed by predictable stopping *** aim to elucidate various properties of the value function family within this *** prove the existence of an optimal predictable stopping time,subject to specific assumptions regarding the reward functionϕ.

关键词： Optimal stopping Supermartingale Predictable stopping time Admissible family Reward

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Characterization of the Omni-Processor Sewage Sludge Ash for Reuse as Construction Material

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Fluid Dynamics & Materials Processing 2022年第6期18卷 1581-1593页

作者： Prince Momar Gueye siham Kamali-Bernard Dame Keinde Fabrice Bernard Vincent Sambou LE3PI of E S P-UCAD DakarSenegal LGCGM of INSA of Rennes RennesFrance

Omni Processors(OP)are machines which use sludge as a fuel to generate electricity and clean water,but create ash at the same *** the present study,fly ash and bottom ash are investigated as materials for potential reuse in the construction ***,the granular size,density and Blaine finesse are ***,the chemical composition and microstructure are obtained by means of X-ray fluorescence and Scanning Electron Microscopy-Energy Dispersive Spectroscopy(SEM-EDS),***,ashes reactivity is determined by two chemical methods(modified Chapelle test,bound water content R3)and a mechanical method(pozzolanic activity index).The characterization results indicate two material types:fly ash similar to cement and bottom ash similar to fine ***’s why the mortars mechanical strength with fly ash 0%-30%is better than that with bottom ash at the same *** ash slightly decreases the mechanical strength of mortars while bottom ash induces a much more significant decrease.

关键词： Characterization Omni-processor fly Ash bottom ash

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Composition analysis and antimicrobial activity of essential oil from leaves of Laurus nobilis grown in Oman

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Journal of Bioresources and Bioproducts 2022年第4期7卷 328-334页

作者： siham Saleh Al-Abri Sadri Abdullah Said Salem Said Al Touby Mohammed Amzad Hossain Jamal Nasser Al-Sabahi School of Pharmacy College of Pharmacy and NursingUniversity of NizwaPB 33PO 616NizwaNizwa 616Oman School of Nursing College of Pharmacy and NursingUniversity of NizwaNizwa 616Oman Central Instrument Laboratory College of Agriculture and Marine SciencesSultan Qaboos UniversityMuscat 123Oman

Traditionally,Laurus nobilis is used for the treatment of earaches and skin rashes as well as *** most common technique to isolate the oil is hydro-distillation and *** investigation presented in this paper was aimed to unravel the antimicrobial activity and chemical composition of essential oil in the leaves of *** grown in *** essential oil was extracted from the leave of the selected plant species by hydro distillation using Clevenger type *** antimicrobial assay was done by disc diffusion methods against three bac-terial strains,Staphylococcus aureus,Pseudomonas aeruginosa and Escherichia coli,and one fungal strain:Candida *** isolated essential oil was analyzed by gas chromatography-mass spectrometry(GC-MS).The percentage yield of the essential oil was 0.064%(w/w).The essen-tial oil was found actively against the applied bacterial and fungal *** highest activity was found against *** and the lowest was against ***,and the order was ***>***>*** essential oil was also active against the fungus *** range of inhibition zones was 6-14 *** results of GC-MS analysis showed(E)-𝛽-caryophyllene to be the major component about 59.62%.Other major components included𝛼-selinene(14.03%),𝛼-humulene(8.65%),𝛽-selinene(4.99%),and𝛼-pinene(4.98%).In addition,several minor com-ponents were found in the essential oil of *** on the experimental results,it showed that the plant species that grown in Oman were a potential source of therapeutic *** con-clusion,the essential oil and the plant could be used as natural and potential therapeutic agents to treat earaches,skin rashes,and rheumatism.

关键词： Laurus nobilis Clevenger apparatus Essential oil Antimicrobial activity Gas chromatography-mass spectrometry(GC-MS)

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Medical research during the COVID-19 pandemic

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World Journal of Clinical Cases 2020年第15期8卷 3156-3163页

作者： Khalid AlNaamani siham AlSinani Alan N Barkun Division of Gastroenterology Department of Internal MedicineArmed Forces HospitalMuscat 999046Oman Graduate Medical Education Department and Department of Child Health Sultan Qaboos University HospitalMuscat 999046Oman Division of Gastroenterology McGill University and the McGill University Health CentreMontreal H3G1A4Canada

The current pandemic of coronavirus disease 2019(COVID-19)which was first detected in Wuhan,China in December 2019 is caused by the novel coronavirus named severe acute respiratory syndrome coronavirus-2(SARS-CoV-2).The virus has quickly spread to a large number of countries leading to a great number of ***,till today there is no specific treatment or vaccination for *** of the suggested treatment medications are based on in vitro laboratory investigations,experimental animal models,or previous clinical experience in treating similar viruses such as SARS-CoV-1 or other retroviral *** running of any clinical trial during a pandemic is affected at multiple *** for this include patient hesitancy or inability to continue investigative treatments due to self-isolation/quarantine,or limited access to public places(including hospitals).Additional barriers relate to health care professionals being committed to other critical tasks or quarantining themselves due to contact with COVID-19 positive *** best research approaches are those that adapt to such external unplanned *** clinical trials before COVID-19 pandemic have the potential for identifying important therapies in the long-term if they can be completed as ***,these clinical trials may require modifications due a pandemic such as this one to ensure the rights,safety,and wellbeing of participants as well as medical staff involved in the conduction of clinical *** trials initiated during the pandemic must be time-efficient and flexible due to high contagiousness of severe acute respiratory syndrome coronavirus 2,the significant number of reported deaths,and time constraints needed to perform high quality clinical trials,enrolling adequate sample *** between different countries as well as implementation of innovative clinical trial designs are essential to successfully complete such initiatives during the cur

关键词： SARS-CoV-2 COVID-19 Pandemic Research Clinical trials

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Investigation of FOXP3 (rs3761548) polymorphism with the risk of preeclampsia and recurrent spontaneous abortion: A systemic review and meta-analysis

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Asian pacific Journal of Reproduction 2022年第3期11卷 117-124页

作者： Govinda Sri Varshini Sivakumar Harshini Muhammed Ali siham Govindaraj Krishnamurthy Tejaswini Yasam Santhosh Kumar Langeswaran Kulanthaivel Gowtham Kumar Subbaraj Faculty of Allied Health Sciences Chettinad Hospital and Research InstituteChettinad Academy of Research and Education(Deemed to be University)KelambakkamTamil Nadu 603103India Department of Bioinformatics Alagappa UniversityKaraikudi-630003Tamil NaduIndia

Objective:To investigate the association between forkhead box P3(FOXP3)(rs3761548)polymorphism and the risk of preeclampsia and recurrent spontaneous ***:Literature on the association of FOXP3 gene polymorphisms and susceptibility to preeclampsia and unexplained recurrent spontaneous abortion was retrieved by searching databases such as PubMed,Science Direct,Google Scholar and Embase from 2000 to *** association measure was analyzed using an odds ratio(OR)and 95%confidence interval(CI).All the statistical analyses were executed using RevMan 5.4 ***:In the present meta-analysis,11 articles were *** pooled results showed no association between FOXP3 gene polymorphism(rs3761548)and preeclampsia risk in allelic,recessive,dominant and over dominant contrast ***3 gene polymorphism(rs3761548)showed an association with recurrent abortion in allelic,recessive and dominant models(OR 1.85,CI 1.59-2.14;OR 2.02,95%CI 1.56-2.62;OR 2.69,95%CI 1.50-4.83,respectively),while no association in the over dominant contrast model(OR 1.35,CI 0.87-2.10).Conclusions:In the present study,FOXP3 gene(rs3761548)polymorphism is associated with risk of recurrent spontaneous abortion but not ***,larger sample size and multiracial studies are needed in the future to confirm the findings.

关键词： Preeclampsia FOXP3 gene Single nucleotide polymorphism rs3761548 Unexplained recurrent spontaneous abortion

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Octreotide in Hennekam syndrome-associated intestinal lymphangiectasia

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World Journal of Gastroenterology 2012年第43期18卷 6333-6337页

作者： siham Al Sinani Yusria Al Rawahi Hamed Abdoon Child Health Department Sultan Qaboos University HospitalMuscat 123Sultanate of Oman

A number of disorders have been described to cause protein losing enteropathy (PLE) in children. Primary intestinal lymphangiectasia (PIL) is one mechanism leading to PLE. Few syndromes are associated with PIL; Hennekam syndrome (HS) is one of them. The principal treatment for PIL is a high protein, low fat diet with medium chain triglycerides supplementation. Supportive therapy includes albumin infusion. Few publications have supported the use of octreotide to diminish protein loss and minimize hypoalbuminemia seen in PIL. There are no publications on the treatment of PIL with octreotide in patients with HS. We report two children with HS and PLE in which we used octreotide to decrease intestinal protein loss. In one patient, octreotide increased serum albumin to an acceptable level without further need for albumin infusions. The other patient responded more dramatically with near normal serum albumin levels and cessation of albumin infusions. In achieving a good response to octreotide in both patients, we add to the publications supporting the use of octreotide in PIL and suggest that octreotide should be tried in patients with PIL secondary to HS. To the best of our knowledge, this is the first case report on the use of octreotide in HS-associated PIL.

关键词：淋巴管综合征小肠血清白蛋白肽中链甘油三酯蛋白水平低蛋白血症

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