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Ursodeoxycholic Acid in Treatment of non-cholestatic Liver Diseases: A Systematic Review

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Journal of Clinical and Translational Hepatology 2016年第3期4卷 192-205页

作者： Jillian Reardon Trana Hussaini Majid Alsahafi Vladimir Marquez Azalgara siegfried R.Erb nilufar Partovi Eric M.Yoshida Faculty of Pharmaceutical Sciences The University of British Columbia Vancouver British Columbia Canada Division of Gastroenterology The University of British Columbia Diamond Health Vancouver British Columbia Canada Pharmaceutical Sciences Clinical Service Unit Vancouver General Hospital Vancouver British Columbia Canada Division of Gastroenterology The University of British Columbia Diamond Health Vancouver British Columbia Canada Faculty of Pharmaceutical Sciences The University of British Columbia Vancouver British Columbia Canada Pharmaceutical Sciences Clinical Service Unit Vancouver General Hospital Vancouver British Columbia Canada

Aims:To systematically evaluate the literature for evidence to support the use of bile acids in non-cholestatic liver ***:Searches were conducted on the databases of Medline (1948-March 31,2015),Embase (1980-March 31,2015) and the Cochrane Central Register of Controlled Trials,and on Google and Google Scholar to identify articles describing ursodeoxycholic acid (UDCA) and its derivatives for non-cholestatic hepatic *** of the following search terms were used:ursodeoxycholic acid,ursodiol,bile acids and/or salts,non alcoholic fatty liver,non alcoholic steatohepatitis,fatty liver,alcoholic hepatitis,alcohol,liver disease,autoimmune,autoimmune hepatitis,liver transplant,liver graft,transplant rejection,graft rejection,ischemic reperfusion injury,reperfusion injury,hepatitis B,hepatitis C,viral hepatitis,chronic hepatitis,acute hepatitis,transaminases,alanine transaminase,liver enzymes,aspartate aminotransferase,gamma-glutamyl transferase,gammaglutamyl transpeptidase,bilirubin,alkaline *** search limits were ***,references of the included studies were reviewed to identify additional ***:The literature search yielded articles meeting inclusion criteria for the following indications:non-alcoholic fatty liver disease (n =5);alcoholic liver disease (n =2);autoimmune hepatitis (n =6),liver transplant (n =2) and viral hepatitis (n =9).Bile acid use was associated with improved normalization of liver biochemistry in non-alcoholic fatty liver disease,autoimmune hepatitis and hepatitis B and C *** contrast,liver biochemistry normalization was inconsistent in alcoholic liver disease and liver *** majority of studies reviewed showed that normalization of liver biochemistry did not correlate to improvement in histologic *** the prospective trials reviewed,adverse effects associated with the bile acids were limited to minor gastrointestinal complaints (most often,diarrhea) a

关键词： non-alcoholic fatty liver disease Alcoholic liver disease Autoimmune hepatitis Liver transplantation Viral hepatitis

Catch Crop Known to Decrease n-leaching also Counteracts Soil CO_2 Emissions

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Journal of Resources and Ecology 2015年第3期6卷 180-185页

作者： Marie MATTSSOn Marie MAGnHEDEn siegfried FLEISCHER 哈姆斯塔德大学里伯格实验室

CO2 emissions to the atmosphere were studied in a fertilized sandy agricultural soil with and without a catch crop sown into the main crop. The catch crop was grown primarily with the purpose to decrease n-leaching but this study also wanted to find out if the catch crop could have an effect in a climate change perspective. Plots with catch crop showed decreased CO2 emissions from the soil. Since previous results have shown that catch crops effectively decrease n-leaching we recommend growing catch crops as an effective measure for helping both the climate and the eutrophication issue. Seasonal variations in CO2 emissions were pronounced with maximum emissions from the fertilized agricultural soil in June and from an adjacent unmanaged grassland in August. From the plot with catch crop emissions decreased in July and August but somewhat increased later in the autumn. Fertilized agricultural soil showed a within-soil CO2 sink after harvest, i.e. within-soil CO2 uptake. Availability of nH4＋ or nO3- in the soil seems to influence the within-soil CO2 sink, with nH4＋ enforcing the sink while the same amount of nO3 instead increased CO2 emissions.

关键词： catch crop n-leaching grassland C02 sink seasonal change

Conservation genomics of sibling grouse in boreal forests reveals introgression and adaptive population differentiation in genes controlling epigenetic variation

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Zoological Research 2022年第2期43卷 184-187页

作者： Kai Song Bin Gao Peter Halvarsson Yun Fang siegfried Klaus Ying-Xin Jiang Jon E.Swenson Zhi-Ming Han Yue-Hua Sun Jacob Hoglund Key Laboratory of Animal Ecology and Conservation Biology Institute of ZoologyChinese Academy of SciencesBeijing 100101China Animal Ecology Department of Ecology and GeneticsUppsala UniversityUppsala 75236Sweden Unit of Parasitology Department of Biomedicine and Veterinary Public HealthSwedish University of Agricultural SciencesUppsala 75007Sweden Lindenhöhe 5 Jena D-07749Germany Faculty of Environmental Sciences and natural Resource Management Norwegian University of Life SciencesAs NO-1432Norway State Key Laboratory of Reproductive Biology Institute of ZoologyChinese Academy of SciencesBeijing 100101China

The Chinese Grouse(Tetrastes sewerzowi) and Hazel Grouse(T. bonasia) are sibling species that are well-adapted to harsh high-altitude and latitude habitats. In the current study, we sampled and sequenced 29 Chinese Grouse(n=16) and Hazel Grouse(n=13) from eight locations in China, Sweden,Germany, and northeast Poland to analyze population genetic diversity and structure, introgression, and local adaptation.

关键词： northeast adapted controlling

自动温度记录技术在斑尾榛鸡产卵孵卵节律研究中的应用

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北京师范大学学报（自然科学版） 2002年第2期38卷 260-265页

作者：孙悦华方昀 siegfried Klaus 贾陈喜郑光美北京师范大学生命科学学院中国科学院动物研究所北京100080 Thuringer Landesanstalt fur Umwelt

以莲花山斑尾榛鸡 (Bonasasewerzowi)的研究结果为例 ,介绍了利用自动温度记录器技术研究鸟类产卵孵卵节律的方法 .研究表明 ,斑尾榛鸡雌鸟每隔 2d产 1枚卵 ,通过分析 1只斑尾榛鸡雌鸟整个孵卵期的孵卵节律 ,发现它平均每天出巢 (5 .5 5... 详细信息

以莲花山斑尾榛鸡 (Bonasasewerzowi)的研究结果为例 ,介绍了利用自动温度记录器技术研究鸟类产卵孵卵节律的方法 .研究表明 ,斑尾榛鸡雌鸟每隔 2d产 1枚卵 ,通过分析 1只斑尾榛鸡雌鸟整个孵卵期的孵卵节律 ,发现它平均每天出巢 (5 .5 5± 0 .80 )次 (4～ 7次 ,n =2 2 ) ,平均每次出巢时间为 (17.6± 6 .77)min .雌鸟早晨出巢的时刻平均为 6 :0 7± 2 3min ,傍晚出巢的回巢时刻平均为 19:4 0± 2 2min ,日活动期平均为 (812 .5± 35 .1)min .雌鸟出巢的时间长度与环境温度呈正相关 (Spearman相关检验 ,r =0 .2 6 4 ,p =0 .0 0 4 ) 。

关键词：自动温度记录技术孵卵节律繁殖生态学斑尾榛鸡

Quantitative T2＊-Mapping of the Knee Using a Spoiled Gradient Echo Sequence at 3 Tesla： Preliminary Results

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Journal of Pharmacy and Pharmacology 2014年第1期2卷 59-69页

作者： Georg Riegler Xeni Deligianni Vladimir Juras Stefan Zbjgfi Sebastian Apprich Pavol Szomolanyi Michael Weber Oliver Bieri siegfried Trattnig Department of Biomedical Imaging and Image-guided Therapy MR Center of Excellence for High Field MR Medical Universityof Vienna Vienna 1090 Austria Department of Radiology Division of Radiological Physics University of Basel Hospital Basel 4031 Switzerland Department of Imaging Methods Institute of Measurement Science Slovak Academy of Sciences Bratislava 84104 Slovakia

Purpose： To evaluate a me-vTE-SPGR （multi echo variable TE Spoiled Gradient Echo Sequence） approach for quantitative T2＊ mapping of the ME （menisci）, the PT （patellar tendon）, the ACL （anterior cruciate ligament）, the PCL （posterior cruciate ligament） and to compare the results between normal and pathological tissue of the ME in the knee joint at 3T （3 Tesla）. Methods： Eighteen consecutive knee patients （35.7± 11.6 years） were examined on 3T. In addition to standard morphological MRI, T2＊-maps were derived from a 0.7 mm isotropic me-vTE-SPGR scan. T2＊-values were assessed by two independent observers using an ROI analysis for the ME （4 different regions： posterior and anterior horn of the medial and lateral meniscus）, PT, ACL and PCL. Intra-class correlation between readers was calculated. Results： On morphological MRI, the PT, ACL and PCL were diagnosed as normal in all cases. Degenerative meniscus and meniscal tears were diagnosed in 13 cases and 9 cases, respectively. T2＊-values of the menisci on me-vTE-SPGR scans, in relation to morphological imaging, were normal （n = 50; 6.0 ±0.9 ms）; degenerative meniscus （n = 13; 8.0± 1.6 ms）; meniscal tears （n = 9; 12.9 ±3.9 ms）, with significant differences between all groups （P 〈 0.05）/ significantly higher T2＊-values in degenerative meniscus and meniscal tears. Mean T2＊ relaxation times for the PT, ACL and PCL were 2.9± 0.8 ms, 8.4 ± 1.6 ms and 8.9 ＋ 1.3 ms respectively. Intra-class correlation values between readers for the ME, PT, ACL and PCL were R2 = 0.962, R2 = 0.927, R2 = 0.594 and R2= 0.648, respectively. Conclusion： Isotropic 3D （three-dimensional） me vTE-SPGR imaging is able to quantify T2＊ values of multiple tissues in the knee joint with short T2 relaxation times.

关键词： Magnetic resonance imaging quantitative imaging T2* imaging connective tissue knee.

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注入耦合存储器:一个高密度静态双极存储器

计算机研究与发展 1975年第2期 45-50页

作者： siegfried K. Wiedmann ,彭忠良

本文讨论一种新的静态双极存储器的设计,它在密度方面可以与动态场效应晶体管存储器相当,而在性能与功耗方面较优越。少数载流子直接注入的概念既适用于单元电流,又适用于耦合到读/写线。这就导致了器件非常高的集成度,在采用5μ线宽的... 详细信息

本文讨论一种新的静态双极存储器的设计,它在密度方面可以与动态场效应晶体管存储器相当,而在性能与功耗方面较优越。少数载流子直接注入的概念既适用于单元电流,又适用于耦合到读/写线。这就导致了器件非常高的集成度,在采用5μ线宽的标准埋层工艺和单层布线时,单元尺寸达3.1mil2。根据一些包含小矩阵的研究性单片的试验完全证实了这种可能性。单元可在低于100nW 的非常低的直流维持功耗下工作。从模拟64×64位矩阵的测量中可以推算出,一块4K 位的硅片面积大约为160×150mil2,取数时间大约50ns。采用介质隔离和自对准n+引线孔的新方法可得到5μ线宽的1.1mil2的单元。

关键词：存储器电流增益晶体管矩阵单片存贮器计算机半导体三极管数学分析单元尺寸存储单元仪表组合单元

肺栓塞的诊断:妇科肿瘤学中螺旋CT肺动脉造影术的应用经验

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世界核心医学期刊文摘（妇产科学分册） 2005年第11期1卷 42-43页

作者： Martino M.A. Williamson E. siegfried S. 刘亦恒 Department of Obstetrics and Gynecology University of South Florida Harbourside Medical Towers 4 Columbia Drive Tampa FL 33606 United States

Objectives. To review our experience with the diagnosis and prognosis of pulmonary embolism (PE) in gynecologic oncology patients. Methods. Spiral CT pulmonary angiography (CTPA) studies on gynecologic oncology patients were collected from our radiology database from 6/2001 to 6/2003. Patient charts were retrospectively reviewed. Data were abstracted relative to presenting symptoms, demographics and laboratory and diagnostic evaluations. Patient data were compared using chi-square contingency tables and logistic regression analysis. Survival was studied using the Kaplan-Meier method and the log rank test. The effect of PE on survival was adjusted using a proportional hazards regression model. Results. One-hundred and eleven CTPA studies were performed over 2 years and 25 patients were diagnosed with *** PE (n = 25) and non-PE (n = 86) groups were similar for age, race, BMI and cancer diagnosis. Tachycardia (P = 0.02, OR = 3.03 95% CI 1.16-7.94 ) and leukocytosis (P = 0.04, OR = 2.93 95% CI 1.05-8.18 ) were more frequent among PE patients and confirmed as independently prognostic of *** other clinical and laboratory findings were similar between patients with and without PE. Overall survival for patients with and without PE was 63% versus 94% , respectively, at 2 years (P = 0.02). Conclusion. In a gynecologic oncology patient with high clinical suspicion for PE, our clinical pre-test probability was 23.0% . Two-year mortality rates were 6-fold higher for patients diagnosed with PE. The significant overlap in clinical presentations, multiple risk factors and higher mortality rates encourage the aggressive diagnosis and treatment of PE among this population. Further work is needed to reduce the incidence and mortality rate of PE.

关键词：妇科肿瘤学动脉造影术肺栓塞妇科肿瘤患者癌症诊断存活者列联表诊断评价模型校正年死亡率

Diagnostic Power of Diffusion-weighted Magnetic Resonance Imaging for the Presence of Lymph node Metastasis:A Meta-analysis

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Journal of Huazhong University of Science and Technology(Medical Sciences) 2017年第4期37卷 469-474页

作者：孔祥闯熊凌云 Emre Gazyakan Holger Engel Ulrich Kneser Andreas K.nüssler Christoph Hirche 孔祥泉 Department of Radiology Union HospitalTongji Medical CollegeHuazhong University of Science and Technology Department of Plastic and Reconstructive Surgery Union HospitalTongji Medical CollegeHuazhong University of Science and Technology Department of Hand-Plastic and Reconstructive Surgery Burn CenterBG Trauma Center LudwigshafenUniversity of Heidelberg Department of Hand-Plastic and Reconstructive Surgery Medical Center Kassel Eberhard-Karls-University Tuebingen BG Trauma CenterSiegfried Weller Institut

Present work was designed to quantitatively evaluate the performance of diffusion-weighted magnetic resonance imaging（DWI） in the diagnosis of the presence of metastasis in lymph nodes（Lns）. Eligible studies were identified from systematical Pub Med and EMBASE searches. Data were extracted. Meta-analyses were performed to generate pooled sensitivity and specificity on the basis of per-node, per-lesion and per-patient, respectively. Fourteen publications（2458 Lns, 404 lesions and 334 patients） were eligible. Per-node basis demonstrated the pooled sensitivity and specificity was 0.82（P〈0.0001） and 0.90（P〈0.0001）, respectively. Per-lesion basis illustrated the pooled sensitivity and specificity was 0.73（P=0.0036） and 0.85（P〈0.0001）, respectively. Per-patient basis indicated the pooled sensitivity and specificity was 0.67（P=0.0909） and 0.86（P〈0.0001）, respectively. In conclusion, DWI has rather a negative predictive value for the diagnosis of Ln metastasis presence. The difference of the mean apparent diffusion coefficients between benign and malignant Lns is not yet stable. Therefore, the DWI technique has to be further improved.

关键词： Meta-analysis magnetic resonance imaging lymph node metastasis diffusion-weighted

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沉浸式媒体、虚拟现实和视听媒体考古

新美术 2020年第2期41卷 43-51页

作者： [英]迈克尔·n·戈达德卢睿洋(译) 威斯敏斯特大学不详

本文将采用媒体考古学的方法,探讨虚拟现实[VR]和沉浸式媒体在当代的重现,将其作为一种周期性现象嵌入到齐格弗里德·齐林斯基[siegfried Zielinski]称为"视听"[Audiovision]的更为漫长的非线性历史中。为了响应本次大会的媒体考古学这... 详细信息

本文将采用媒体考古学的方法,探讨虚拟现实[VR]和沉浸式媒体在当代的重现,将其作为一种周期性现象嵌入到齐格弗里德·齐林斯基[siegfried Zielinski]称为"视听"[Audiovision]的更为漫长的非线性历史中。为了响应本次大会的媒体考古学这个部分,本文将同时留意新事物中的旧元素和旧事物中的新元素,更加把媒体发展视为螺旋式而非线性的目的论式。

关键词：虚拟现实媒体考古学沉浸式视听媒体新元素旧事物林斯基螺旋式