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Endoscopic sinus surgery and aspirin desensitization improve otologic-specific SNOT-22 scores

World Journal of Otorhinolaryngology-Head and Neck Surgery 2020年第4期6卷 248-254页

作者： James G.Naples Andrew Corr siddhant tripathi Morgan Berman Jason A.Brant Michael J.Ruckenstein John Bosso Beth Israel Deaconess Medical Center Harvard Medical SchoolDivision of Otolaryngolosy-Hecid and Neck SurgeryOtology/Neurotology110 Francis StSuite 6EBostonMA 02215USA University of Pennsylvania Health System Departm ent of Otorhinolaryngology-Head and Neck SurgeryOtolosy/Neurotology3400 Spruce St5 SHversteinPhiladelphiaPA 19104USA University of Cincinnati School of Medicine 230 Eden AveCincinnatiOH 45267USA

Objective:There are few studies evaluating the impact of Aspirin-exacerbated respiratory disease(AERD)treatment on otologic *** aim of this study is to evaluate the effects of endoscopic sinus surgery(ESS)and aspirin desensitization(AD)on otologic symptoms in subjects with ***:Retrospective chart review of adult patients diagnosed with AERD at our tertiary Care Academic Medical Center-Otorhinolaryngology *** of adult patients diagnosed with AERD who underwent ESS and ASA desensitization at our institution’s AERD Center from 2016 to 2019 were ***-Nasal Outcomes Test 22-item survey(SNOT-22)scores were evaluated for patients at various time points including:pre-surgery,post-surgery/pre-aspirin desensitization,and various times post-desensitization up to>12 *** the SNOT-22,otologic-specific subdomain scores were evaluated at similar time *** on immunomodulatory medications other than corticosteroids were excluded from ***:SNOT-22 scores were analyzed for 121 *** was a significant improvement in overall SNOT scores from pre-surgery(44.62)to post surgery/pre-desensitization(23.34)(P<0.0005).Similarly,SNOT-22 otologic-specific scores also improved after surgery prior to desensitization(3.19-2.04)(P=0.005).Following AD,the improvement in the overall SNOT-22 continued to improve for up to 12 months(P<0.005).While the otologic-specific SNOT-22 scores remained stable after surgery and ASA ***:ESS and AD reduce otologic-specific SNOT-22 scores and parallel trends in overall SNOT-22 *** effect of treatment is durable over the course of 12 *** work should aim to correlate otologic SNOT-22 scores with objective otologic data.

关键词： Aspirin exacerbated respiratory disease Otologic symptoms SNOT-22

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Postoperative mometasone irrigations improve quality of life in skull base tumor patients

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World Journal of Otorhinolaryngology-Head and Neck Surgery 2023年第4期9卷 314-319页

作者： Mandy K.Salmon Rijul S.Kshirsagar Jacob G.Eide Auddie M.Sweis Kathleen Davin Aman Prasad Heather Ungerer Elizabeth Stevens Kevin Ig‐Izevbekhai siddhant tripathi Tran B.Locke Theodore Lin Brian M.Sweis Michael A.Kohanski Nithin D.Adappa James N.Palmer Department of Otorhinolaryngology—Headand Neck Surgery University of PennsylvaniaPhiladelphiaPennsylvaniaUSA Division of Otolaryngology—Head and Neck Surgery North Shore University Health SystemThe University of ChicagoEvanstonIllinoisUSA University of Cincinnati School of Medicine CincinnatiOhioUSA Department of Otolaryngology Baylor College of MedicineHoustonTexasUSA Lewis Katz School of Medicine Temple UniversityPhiladelphiaPennsylvaniaUSA Department of Neuroscience University ofMinnesotaMinneapolisMinnesotaUSA

Objectives:The use of topical corticosteroids to manage postoperative sinonasal symptoms after endoscopic skull base surgery (ESBS) has not been well *** quantified long‐term impact of postoperative steroid irrigations (SIs) on quality of life of patients after ***:Retrospective review of patients at the University of Pennsylvania undergoing ESBS from 2010 to *** on patient demographics and postoperative treatment with nasal saline irrigation twice daily with and without dissolved steroids (mometasone or budesonide) was ***,and 1‐,3‐,6‐,12‐,18‐,and 24‐month postoperative Sino‐Nasal Outcome Test (SNOT‐22) scores were ***:A total of 727 patients were assessed (53.4% males),with 479 patients in the no SI group and 248 patients in the SI *** SNOT‐22 scores did not differ significantly (P = 0.19).1‐,3‐,6‐,12‐,18‐,and 24‐month post‐op SNOT‐22 scores did not significantly differ between ***,mometasone irrigations resulted in significantly lower postoperative 2‐year SNOT‐22 scores compared to budesonide (P < 0.01) and saline (P = 0.03).Conclusions:Though corticosteroid irrigations are routine in managing inflammatory sinus disease,their role in postoperative management after ESBS for tumors is *** findings suggest that mometasone irrigation may be effective at improving postoperative quality of life in patients after ESBS.

关键词： postoperative steroid irrigations skull base tumors

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