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Radical Hysterectomy in Cervical Cancer: Patients’ Epidemiological and Clinical Profiles and Perioperative Outcome in Two Referral Hospitals in Cameroon

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Open Journal of Obstetrics and Gynecology 2024年第3期14卷 466-479页

作者： Théophile Njamen Nana Robert Tchounzou Fulbert Nkwele Mangala Alphonse Ngalame Henri Essome Sedrick Tiokeng si.oni. Noa ananga Andrew Tassang Humphry Tatah Neng Isaac Mboh Eyong Gaetan Andre Wambo simo Felix Adolphe Elong Fidelia Kobenge Mbi Junior Cédric Nana Njamen Charlotte Tchente Nguefack Thomas Obinchemti Egbe Gregory Ekane Halle Emile Telesphore Mboudou Marcellin Ngowe Ngowe Department of Obstetrics and Gynaecology Douala General Hospital Douala Cameroon Department of Obstetrics and Gynaecology Faculty of Health Sciences University of Buea Buea Cameroon Department of Obstetrics and Gynaecology Douala Gynaeco-Obstetric and Pediatric Hospital Douala Cameroon Department of Surgery and Specialties Faculty of Medicine and Pharmaceutical Sciences University of Douala Douala Cameroon Department of Pathology Douala General Hospital Douala Cameroon Faculté Des Sciences De La Santé Université Joseph Kizerbo Ouagadougou Burkina Faso

Background: Cervical cancer (CC) is one of the most frequent cancers and the leading cause of death from gynecological cancer in Low and middle income countries, Cameroon inclusive. Surgery is the primary treatment modality when the disease is diagnosed at early stage. Radical hysterectomy in cervical cancer has not been evaluated in recent years in Cameroon. The purpose of this study is thus to evaluate the epidemiological and clinical features and short term outcomes of patients who underwent surgery. Patients and methods: This retrospective study was conducted at the Douala Gynaeco-obstetric and Pediatric Hospital and the Douala General Hospital. Cervical cancer patients who underwent Radical hysterectomy between January 2015 and December 2020 were included. A pre-established data collection tool was used to record socio-demographic, clinical and outcomes information from patients’ files;additional outcome information was obtained from phone calls. Descriptive analysis was done using the SPSS version 26. Bivariate analysis was used to determine associations between disease and patients characteristics and occurrence of adverse postoperative outcome. P value of 0.05 was considered. Results: sixty one patients were enrolled. Their ages ranged from 33 to 74 years with a mean age of 51.95 ± 10.29 years. Over 85% of women were married, 65.57% were unemployed and 86.88% were multiparous. Only 28% had never done cervical cancer screening. Most patients had stage IB1 to IB2 stage disease (57.1%). Less than 9% underwent radical hysterectomy and 8 of those (13.11%) suffered intraoperative complications. Twenty-five patients (40.98%) presented immediate and short term complications. There was no significant association between the disease or patients’ characteristics and adverse outcomes. Conclusion: Cervical cancer patients are relatively young in our settings and only 9% of them reach the hospital at early stage. Postoperative adverse outcomes rate is higher than that rep

关键词： Cervical Cancer Radical Hysterectomy Epidemiological and Clinical Profiles Outcomes Cameroon

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季节性水准测量的最小二乘平差

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武测译文 1992年第1期 18-24页

作者： ananga,N 钟于东

在1988年10月－1989年9月一年内对双色列北部（海法港东北）的11个控制点的季节性垂直位移进行了研究。本文的目的在于用以色列北部的若干水准环作为例子，对各种水准测量平差方法，即传统的最小方差估计、自由网平差法和最小二乘配置... 详细信息

在1988年10月－1989年9月一年内对双色列北部（海法港东北）的11个控制点的季节性垂直位移进行了研究。本文的目的在于用以色列北部的若干水准环作为例子，对各种水准测量平差方法，即传统的最小方差估计、自由网平差法和最小二乘配置法之间的数学等价性进行比较。结果表明，自由网平差法与最小二乘配置法（LSC）之间没有显著的区别。秀自由网平差法和条件平差法计算的水准点之间的高差相同，但高程不同。尽管LSC方法较为复杂和费时，但它验证了基岩上点的稳定性和高压极上点的垂直位移。因此，自由网平差法或LSC法都可用于精密水准测量的数据处理。

关键词：水准测量平差最小二乘季节性

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The Psychological Experience of the Nursing Staff of the Medical Oncology Department in Cameroon: Case of the YaoundéGeneral Hospital

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Journal of Cancer Therapy 2023年第1期14卷 50-58页

作者： Berthe Sabine Esson Mapoko Esther Dina Bell Mbassi Véronique Mboua Batoum Marie Josiane Ntsama Essomba Lionel Tabola Fossa Lionel Bala Etienne Atenguena Okobalemba Ruth Rosine Meka’h Mapenya Anne Juliette Flora Sango Anne Marthe Maison Mayeh si.oni. ananga Noa Ambroise Ntama Zacharie Sando Paul Ndom Faculty of Medicine and Biomedical Sciences University of Yaoundé I Yaoundé Cameroon Faculty of Medicine and Pharmaceutical Sciences University of Douala Douala Cameroon Faculty of Health Sciences University of Buea Buea Cameroon

Background: The world of cancer care is an emotional place, given the severity of the disease being treated, the heavy workload, the suffering of patients, and the high number of deaths. The nursing staff who work there may be exposed to constant stress from these factors. This study aimed to explore the psychological experience of the nursing staff of the Medical Oncology Department of the Yaoundé General Hospital. Methods: We carried out a cross-sectional study, in June 2017, involving the nursing staff of the Medical Oncology Department of the Yaoundé General Hospital. Results: sixteen out of 18 nurses were interviewed. All had worked in at least one other department prior to Oncology. The number of years of experience in Oncology ranged from less than one year to 13 years. The choice of the Oncology department was involuntary for 100% of the staff;of these, 62% had intentions of changing departments. Twenty-five percent had applied for a change of department, which was unsuccessful. Stress was expressed by 94% of the staff;93% thought that there was a solution to the stress experienced on a daily basis in the Oncology department. The main solutions proposed to manage this stress were: support for the staff, provision of work materials, and staff training. Conclusion: The nursing staff of the Medical Oncology Department of the Yaoundé General Hospital experiences a high level of stress and are in need of solutions.

关键词： Psychological Experience Nursing Staff Medical Oncology Department Ya-oundé General Hospital

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GPS网方差——协方差估计

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国外地质与勘测 1995年第2期 36-43页

作者： ananga,N 张振宇

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Profile of Radiotherapy side Effects in Patients Treated for Cervical Cancer in Cameroon: Case of the Douala General Hospital

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Journal of Cancer Therapy 2023年第1期14卷 59-71页

作者： Berthe Sabine Esson Mapoko Anne Marthe Maison Mayeh Ruth Rosine Meka’h Mapenya Orel Kelvin Ndouandju Saha Esther Dina Bell Etienne Atenguena Okobalemba Anne Sango Romeo Talla Ambroise Ntama si.oni. ananga Albertine Eloundou Martin Essomba Biwole Odette Samba Ngano Albert Mouelle Sone Emilienne Guegang Goudjo Faculty of Medicine and Biomedical Sciences University of Yaoundé I Yaoundé Cameroon Faculty of Medicine and Pharmaceutical Sciences University of Douala Douala Cameroon Faculty of Health Sciences University of Buea Buea Cameroon Faculty of Science University of Dschang Dschang Cameroon

Background: Radiotherapy is one of the main therapeutic strategies used in cervical cancer. The first radiotherapy services in Cameroon have existed since 1987 and still treat by conventional radiation techniques. With the evolution of radiation techniques, acute, subacute, and late complications are minimized. Our study aimed to describe the profile of side effects in patients with uterine cervix cancer treated by conventional radiotherapy, still used in our services. Methods: This was a retrospective and descriptive study of the records of patients treated in the radiotherapy department of the Douala General Hospital from January 2015 to December 2019. Data concerning radiation-induced toxicities were collected using the CTCAE Version 4.0 classification. Data analysis was performed using SPSS version 20.0. Results: A total of 270 records were selected. The median age was 54 years. The mean total radiation dose was 55.9 ± 11.8 Gy and 71.1% of patients were treated for less than 8 weeks. We found a frequency of 66.7% of radio-induced lesions with 99% being acute. The main acute lesions encountered were radio dermatitis (40%), radiation cystitis (17.7%), and radiation proctitis (17.1%). As late lesions, we found one case of vaginal fibrosis (0.4%). Exclusive radiotherapy, classical fractionation, and total doses lower than 45 Gy seemed to decrease the toxicity linked to conventional radiotherapy. Conclusion: The frequency of side effects of radiotherapy for cervical cancer at the Douala General Hospital remains high. Early lesions are the most encountered but strategies should be put in place to better evaluate late lesions.

关键词： Cervical Cancer Radiotherapy Radiation-Induced Lesions Cameroon

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应用GPS数据优化区域大地水准面

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世界地质 1997年第1期16卷 97-100页

作者： N.ananga 牛雪峰

在日本Port岛应用全球定位系统（GPS）进行了椭球面高的测量工作。通过GPS获取的椭球面高hGPS以及水准测量获得的正高hLcvcling测试了GPS和重力测量在工作区获得正高的能力．以便后来评价海平面的起伏。该重力测量成果是覆盖0．1°×0．... 详细信息

在日本Port岛应用全球定位系统（GPS）进行了椭球面高的测量工作。通过GPS获取的椭球面高hGPS以及水准测量获得的正高hLcvcling测试了GPS和重力测量在工作区获得正高的能力．以便后来评价海平面的起伏。该重力测量成果是覆盖0．1°×0．1°范围内的6241个空间重力异常点，重力异常值面△g从日本重力数据库搜集，选择的区域由天文经纬度表示，即：34．651°≤≤34．661°，135．212°≤λ≤135．227°，那里有足够数据用于评价大地水准面差距△N。尽管在I’ort岛某些工作区内稀少的重力数据覆盖也能获得小于或等于10×10－6m精度的结果，但是这样的精度仍然不足以用于高精度的应用，比如海水面形态的确定等。应用不同的地球重力位模型（OSU89A，OSU89B，GPM2F）对全部重力测量结果进行比较，在电算化时代的研究室是可行的。当使用OSU89A作为参照模型时，重力测量所得△N的变化范围由-2．2～16．7cm．它们与△NGPS/Lcvcling进行了适当的对比。

关键词： GPS 大地水准面水准测量测量数据

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