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Psychological Status and Warfarin Therapy in Patients after Valve Replacement during the COVID-19 Pandemic:A Cross-sectional Study

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Current Medical Science 2024年第4期44卷 686-691页

作者： Xiao-yan CHEN Sheng HE Zhen tan.Feng GAO Hui JIANG Lu CHEN Li YANG yu-shan LIU si-yi HE Department of Cardiovascular Surgery The General Hospital of Western Theater CommandChengdu610083China Department of Digestive Medicine The General Hospital of Western Theater CommandChengdu610083China Department of General Surgery The General Hospital of Western Theater CommandChengdu610083China

Objective The stan.ardization of warfarin anticoagulant therapy is the key to lifelong treatment for patients after heart valve *** present study explored the possible risk factors for anxiety and depression during the coronavirus disease 2019(COVID-19)pandemic and analyzed the influence of psychological state on medication *** Eligible patients received a web-based questionnaire survey via the Wenjuanxing platform during outpatient *** was evaluated by the Self-Rating Depression Scale(SDS).Anxiety was evaluated by the Self-Rating Anxiety Scale(SAS).Medication adherence was evaluated by the Morisky *** A total of 309 patients(aged 52.2±11.4 years)were included in the present *** SDS score of all included patients was 36.9±9.4 points,of which 11(3.6%)patients were diagnosed as having *** SAS score of all included patients was 43.1±9.3 points,of which 71(23%)patients were diagnosed as having *** patients(2.3%)had both anxiety and *** regression analysis revealed that only monthly income was an independent influencing factor for *** anxiety,patients who underwent repeated operations had a 2.264-fold greater risk,and patients who received combination medication had a 2.140-fold greater *** bleeding events and coagulation disorders could be observed in patients with anxiety,depression or *** anxiety occurred,patients showed worse medication ***,depression had no significant effect on medication *** During the COVID-19 pandemic,the detection rate of mental illnesses such as anxiety and depression was high,which seriously affected the medication safety of *** of its influencing factors will provide a reference for further stan.ardized regulation of warfarin anticoagulant therapy after valve replacement.

关键词： Warfarin COVID-19 valve replacement depression anxiety

Salidroside Ameliorates Lung Injury Induced by PM_(2.5) by Regulating siRT1-PGC-1αin Mice

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Biomedical and Environmental Sciences 2024年第4期37卷 367-376页

作者： LI Xiao Hong LIU yu Mei SHAN Hui tan.Jin Feng ZHOU Jian SONG yuan Jin LI si Qi LIU Chen XU Dong Qun yu Li LI Wan Wei School of Public Health Shandong Second Medical UniversityWeifang 261053ShandongChina Key Laboratory of Health Inspection and Quarantine Weifang 261053ShandongChina Weifang Environmental Monitoring Station Weifang 261042ShandongChina Department of Orthopedics The 80th Army Hospital of PLAWeifang 261000ShandongChina Environment and Health Related Product Safety Institute of Chinese Center for Disease Control and Prevention Beijing 100021China School of Basic Medicine Shandong Second Medical UniversityWeifang 261053ShandongChina

Objective This study aimed to clarify the intervention effect of salidroside(SAL)on lung injury caused by PM_(2.5) in mice and illuminate the function of siRT1-PGC-1ɑ*** Specific pathogen-free(SPF)grade male C57BL/6 mice were randomly assigned to the following groups:control group,SAL group,PM_(2.5) group,SAL+PM_(2.5) *** the first day,SAL was given by gavage,and on the second day,PM_(2.5) suspension was given by intratracheal *** whole experiment consist of a total of 10 cycles,lasting 20 *** the end of treatment,blood samples and lung tissues were collected and *** of pathological changes in lung tissue using inverted microscopy and transmission electron *** expression of inflammatory,antioxidants,apoptosis,and siRT1-PGC-1ɑproteins were detected by Western *** Exposure to PM_(2.5) leads to obvious morphological and pathologica changes in the lung of ***_(2.5) caused a decline in levels of antioxidant-related enzymes and protein expressions of HO-1,Nrf2,SOD2,siRT1 and PGC-1ɑ,and an increase in the protein expressions of IL-6,IL-1β,Bax,caspase-9 and cleaved ***,SAL reversed the aforementioned changes caused by PM_(2.5) by activating the siRT1-PGC-1α *** SAL can activate siRT1-PGC-1ɑ to ameliorate PM2.5-induced lung injury.

关键词： PM_(2.5) Salidroside Oxidative stress Inflammation Apoptosis siRT1-PGC-1α

Weakly Compact Sets and Riesz Representation Theorem in Musielak Sequence Spaces

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Acta Mathematica sinica,English Series 2024年第2期40卷 467-484页

作者： Wan Zhong GONG si yu SHI Zhong Rui SHI Department of Mathematics Anhui Normal UniversityWuhu 241000P.R.China Smeal College of Business Pennsylvania State UniversityUniversity ParkPennsylwania 16802USA Department of Mathematics Shanghai UniversityShanghai 200444P.R.China

In this work,we give some criteria of the weakly compact sets and a representation theorem of Riesz's type in Musielak sequence spaces using the ideas and techniques of sequence spaces and Musielak ***,as an immediate consequence of the criteria considered in this paper,the criteria of the weakly compact sets of Orlicz sequence spaces are deduced.

关键词： Compact set weak topology Banach space dual space Musielak sequence spaces

Investigating the elliptic anisotropy of identified particles in p-Pb collisions with a multi-phase transport model

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Nuclear Science and Techniques 2024年第2期35卷 160-169页

作者： si-yu tan. Liang Zheng Xiao-Ming Zhang Ren-Zhuo Wan School of Mathematical and Physical Sciences Wuhan Textile UniversityWuhan 430200China School of Mathematics and Physics China University of Geosciences(Wuhan)Wuhan 430074China Key Laboratory of Quark and Lepton Physics(MOE)and Institute of Particle Physics Central China Normal UniversityWuhan 430079China Hubei Key Laboratory of Digital Textile Equipment Wuhan Textile UniversityWuhan 430200China School of Electronic and Electrical Engineering Wuhan Textile UniversityWuhan 430200China

The elliptic azimuthal anisotropy coefficient(v_(2))of the identified particles at midrapidity(|η|<0.8)was investigated in p-Pb collisions at√s_(NN)=5.02 TeV using a multi-phase transport model(AMPT).The calculatio... 详细信息

The elliptic azimuthal anisotropy coefficient(v_(2))of the identified particles at midrapidity(|η|sions at√s_(NN)=5.02 TeV using a multi-phase transport model(AMPT).The calculations of differential v_(2)based on the advanced flow extraction method of light flavor hadrons(pions,kaons,protons,andΛ)in small collision systems were extended to a wider transverse momentum(p_(T))range of up to 8 GeV/c for the first *** string-melting version of the AMPT model provides a good description of the measured p_(T)-differential v_(2)of the mesons but exhibits a slight deviation from the baryon v_(2).In addition,we observed the features of mass ordering at low p_(T)and the approximate number-of-constituentquark(NCQ)scaling at intermediate p_(T).Moreover,we demonstrate that hadronic rescattering does not have a significant impact on v_(2)in p-Pb collisions for different centrality selections,whereas partonic scattering dominates in generating the elliptic anisotropy of the final *** study provides further insight into the origin of collective-like behavior in small collision systems and has referential value for future measurements of azimuthal anisotropy.

关键词： Azimuthal anisotropy Small collision systems Transport model

Exploiting blockchain for dependable services in zero-trust vehicular networks

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Frontiers of Computer Science 2024年第2期18卷 157-166页

作者： Min HAO Beihai tan.siming WANG Rong yu Ryan Wen LIU Lisu yu School of Automation Guangdong University of TechnologyGuangzhou 510006China School of Integrated Circuits Guangdong University of TechnologyGuangzhou 510006China School of Navigation Wuhan University of TechnologyWuhan 430063China School of Information Engineering Nanchang UniversityNanchang 330031China

The sixth-generation(6G)wireless communication system is envisioned be cable of providing highly dependable services by integrating with native reliable and trustworthy ***-trust vehicular networks is one of the typical scenarios for 6G dependable *** the technical framework of vehicle-and-roadside collaboration,more and more on-board devices and roadside infrastructures will communicate for information *** reliability and security of the vehicle-and-roadside collaboration will directly affect the transportation *** a zero-trust vehicular environment,to prevent malicious vehicles from uploading false or invalid information,we propose a malicious vehicle identity disclosure approach based on the Shamir secret sharing ***,a two-layer consortium blockchain architecture and smart contracts are designed to protect the identity and privacy of benign vehicles as well as the security of their private *** that,in order to improve the efficiency of vehicle identity disclosure,we present an inspection policy based on zero-sum game theory and a roadside unit incentive mechanism jointly using contract theory and subjective logic *** verify the performance of the entire zero-trust solution through extensive simulation *** the premise of protecting the vehicle privacy,our solution is demonstrated to significantly improve the reliability and security of 6G vehicular networks.

关键词： sixth-generation(6G) zero-trust block-chain vehicular networks privacy preservation

Can serum immunoglobulin G4 levels and age serve as reliable predictors of relapse in autoimmune pancreatitis?

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World Journal of Gastroenterology 2024年第5期30卷 512-515页

作者： Jun-Min Song si-yu Sun Department of Gastroenterology Shengjing Hospital of China Medical UniversityShenyang 110004Liaoning ProvinceChina

We are writing in response to the paper published in the World Journal of Gastroenterology by Zhou et *** authors identified higher serum immunoglobulin(Ig)G4 levels and age over 55 years as independent risk factors for disease *** notable strengths,it is crucial to address potential ***,the cohort study included 189 patients with autoimmune pancreatitis(AIP)type 1(with higher IgG4 seropositivity and higher relapse)and 24 with type 2(with lower IgG4 seropositivity and lower relapse).Consequently,most,if not all,AIP type 2 patients were assigned to the normal group,possibly inflating the association of higher serum IgG4 levels with relapse and potentially exaggerating the association of older age with ***,the authors did not provide sufficient details regarding AIP diagnosis,such as the ratio of definitive vs probable cases and the proportion of *** cases where histological evidence is unavailable or indeterminate,AIP type 2 may be misdiagnosed as definitive type 1,and type 1 may also be misdiagnosed as probable type 2,particularly in cases with normal or mildly elevated serum IgG4 ***,in this retrospective study,approximately one-third of the consecutive patients initially collected were excluded for various ***,the impact of nonrandom exclusion on relapse outcomes should be carefully *** conclusion,the paper by Zhou et al offers plausible,though not entirely compelling,evidence suggesting a predictive role of elevated serum IgG4 levels and advanced age in AIP *** foundation for future investigations lies in ensuring a reliable diagnosis and accurate disease subtyping,heavily dependent on obtaining histological *** this regard,endoscopic ultrasound-guided fine-needle biopsy emerges as a pivotal component of the diagnostic process,contributing to mitigating biases in future explorations of the disease.

关键词： Autoimmune pancreatitis Immunoglobulin Endoscopic ultrasound Relapse Age

Prognostic prediction model of colorectal cancer based on preoperative serum tumor markers

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World Journal of Gastrointestinal Surgery 2024年第5期16卷 1344-1353页

作者： yu-Hang Diao si-Qi Rao Xin-Peng Shu Yong Cheng Can tan.Li-Juan Wang Dong Peng Department of Gastrointestinal Surgery The First Affiliated Hospital of Chongqing Medical UniversityChongqing 400016China

BACKGROUND Preoperative serum tumor markers not only play a role in the auxiliary diagnosis and postoperative monitoring in colorectal cancer(CRC),but also have been found to have potential prognostic *** To analyze whether preoperative serum tumor markers,including carcinoembryonic antigen(CEA)and carbohydrate antigen 19-9(CA19-9),affect the prognosis of *** This was a retrospective study conducted in a single *** with nonmetastatic CRC who underwent initial surgery between January 2011 and January 2020 were enrolled and divided into development site and validation site groups at a ratio of 7:*** independent prognostic factors were screened by Cox regression analysis,and finally,a prognostic nomogram model was *** newly developed model was tested by internal *** Eventually,3526 postoperative patients with nonmetastatic CRC were included in the *** were 2473 patients at the development site and 1056 patients at the validation ***(Psis(TNM)classification(Psidered independent prognostic factors for patients with nonmetastatic CRC and were used as variables in the nomogram *** areas under the curve of the development and validation sites were 0.655 and 0.658,*** calibration plot also showed the significant performance of the newly established *** We successfully constructed a nomogram model based on age,TNM stage,preoperative CEA,and CA19-9 levels to evaluate the overall survival of patients with nonmetastatic CRC.

关键词： Colorectal cancer Prognosis Carcinoembryonic antigen Carbohydrate antigen 19-9 Nomogram

Fourth-order phase-field modeling for brittle fracture in piezoelectric materials

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Applied Mathematics and Mechanics(English Edition) 2024年第5期45卷 837-856页

作者： yu tan.Fan PENG Chang LIU Daiming PENG Xiangyu LI State Key Laboratory of Geohazard Prevention and Geoenvironment Protection Chengdu University of TechnologyChengdu 610059China College of Science Chang'an UniversityXi'an 710064China Applied Mechanics and Structure Safety Key Laboratory of sichuan Province School of Mechanics and Aerospace EngineeringSouthwest Jiaotong UniversityChengdu 610031China

Failure analyses of piezoelectric structures and devices are of engineering and scientific *** this paper,a fourth-order phase-field fracture model for piezoelectric solids is developed based on the Hamilton *** typical electric boundary conditions are involved in the present model to characterize the fracture behaviors in various physical situations.A staggered algorithm is used to simulate the crack *** polynomial splines over hierarchical T-meshes(PHT-splines)are adopted as the basis function,which owns the *** numerical simulations are performed to study the influence of the electric boundary conditions and the applied electric field on the fracture behaviors of piezoelectric *** electric boundary conditions may influence crack paths and fracture loads *** present research may be helpful for the reliability evaluation of the piezoelectric structure in the future applications.

关键词： isogeometric analysis(IGA) brittle fracture fourth-order phase-field model piezoelectric solid

Molecular dynamics study of hydrogen-induced cracking behavior of ferrite–pearlite gas transmission pipeline steel

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Journal of Iron and Steel Research International 2024年第2期31卷 488-500页

作者： Tao-long Xu si-han Guo Gong-zhen He Hao-yu Han Petroleum Engineering School Southwest Petroleum UniversityChengdu610500SichuanChina sichuan East Gas Transmission Sales Center of sinopec Natural Gas Branch Wuhan430074HubeiChina

Hydrogen embrittlement of pipelines depends on the hydrogen-induced cracking behavior of the pipeline steel *** on molecular dynamics analysis,the ferrite–cementite(α-Fe/Fe3C)lamellar atomic structure with the Bagaryatskii orientation relationship was established,and stepwise relaxation of the conjugate gradient energy minimization and constan.-temperature and constan.-pressure relaxation were performed under NPT(the isothermal–isobaric)*** mechanical property curves of theα-Fe/Fe3C models were obtained under different cementite terminal plane structures,and the evolution of the atomic structure was analyzed in *** addition,the influence of different hydrogen concentrations,different temperatures,different strain rates,changes in voids,and different micro-degrees of freedom on the deformation and failure mechanism of the model was investigated,aiming to provide a reliable way to explore the micro-mechanism of macro-cracking behavior of pipeline steel.

关键词： Ferrite-cementite lamellar structure Pipeline steel Failure mechanism Crack propagation Molecular dynamics