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Comparison of 24×20 mm^(2) swept-source OCTA and fluorescein angiography for the evaluation of lesions in diabetic retinopathy

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International Journal of Ophthalmology(English edition) 2022年第11期15卷 1798-1805页

作者： Qiao-Zhu Zeng si-ying li Yu-Ou Yao En-Zhong Jin Jin-Feng Qu Ming-Wei Zhao Department of Ophthalmology Eye Diseases and Optometry InstitutePeking University People's HospitalBeijing 100044China Beijing Key Laboratory of Diagnosis and Therapy of Retinal and Choroid Diseases College of OptometryPeking University Health Science CenterBeijing 100044China

AIM: To compare ultra-widefield(24×20 mm^(2)) sweptsource optical coherence tomography angiography(SSOCTA) and fluorescein angiography(FA) in the evaluation of diabetic retinopathy(DR) lesions. METHODS: Forty-six eyes of 23 patients with treatmentna?ve DR were included at Peking University People’s Hospital from September 1, 2021, until December 31, 2021, as well as 23 age and gender matched healthy controls. Quantitative assessments of DR lesions on FA and SS-OCTA(superficial capillary plexus, SCP, 24×20 mm^(2)) were ***: Area of fovea avascular zone(FAZ) was larger in DR cases than controls(0.34±0.069 mm^(2) vs 0.287±0.108 mm^(2), P=0.006). In DR eyes, the mean FAZ area was 0.34±0.069 and 0.334±0.087 mm^(2) on SS-OCTA and FA, respectively(P=0.428), while the median FAZ perimeter was 2.382(IQR, 2.201-2.59) and 2.333(IQR, 2.138-2.6) mm on SS-OCTA and FA images(P=0.733). There was no significant difference in the size of the non-perfusion area(NPA) between the images on SS-OCTA and FA(12.389, IQR 4.96-28.3 and 11.125, IQR 5-28.31 mm^(2), P=0.197). The median total microaneurysm(MA) count was 35(IQR, 19-46) and 73(IQR, 43-93) on SS-OCTA and FA(Psignificant difference in intra-retinal microvascular abnormality(IRMA) and neovascularization (NV) count was found between the two techniques. The intraclass coefficient(ICCs) of all the parameters above indicated stable ***: Ultra-widefield SS-OCTA represents a reliable, noninvasive, and quantitative imaging technique in the assessment of microvasculature in DR, which offers a potential substitute for FA in DR evaluation.

关键词： ultra-widefield swept-source optical coherence tomography angiography fluorescein angiography comparison diabetic retinopathy

Efficacy of indirect intense pulsed light irradiation on meibomian gland dysfunction: a randomized controlled study

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International Journal of Ophthalmology(English edition) 2024年第11期17卷 2014-2022页

作者： Yu Cheng Wen-Jing Song Mei-Ting Huang Yuan Gao Luo-ying Xie ying-si li Song-lin Yang Xiao-Ming Yan Department of Ophthalmology Peking University First HospitalBeijing 100034China

AIM:To investigate the efficacy and mechanisms of indirect intense pulsed light(IPL)irradiation on meibomian gland dysfunction(MGD).METHODS:A total of 60 MGD patients was included in this prospective randomized controlled *** were randomly assigned 1:1 into two groups(3-mm group and 10-mm group)in which IPL was applied at distances from the lower eyelid margin of 3 and 10 mm,*** groups received three times treatment with 3-week *** gland yield secretion score(MGYSS),standard patient evaluation of eye dryness(SPEED)questionnaire,tear break-up time(TBUT),corneal fluorescein staining(CFS),and in vivo confocal microscopy were performed at baseline and after every ***:After three IPL treatments,both groups had significant improvement in MGYSS(both Plids showed significant improvement in *** of SPEED questionnaire in both groups declined significantly(both Psity of central corneal subepithelial nerves and TBUTs showed no statistically significant *** 3-mm group had improvement on corneal fluorescein staining(P=0.048)and meibomian gland morphology(acini wall thickness P=0.003,hyperreflective points P=0.024)while the 10-mm group had ***:The efficacy of IPL indirect irradiation in improving meibomian gland secretion and alleviating dry eye symptoms remains unchanged with increase in treatment *** may primarily act on the functional improvement of the meibomian glands and corneal nerves.

关键词： meibomian gland disfunction dry eye intense pulsed light ocular surface

Targeting the chromatin structural changes of antitumor immunity

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Journal of Pharmaceutical Analysis 2024年第4期14卷 460-482页

作者： Nian-nian li Deng-xing Lun Ningning Gong Gang Meng Xin-ying Du He Wang Xiangxiang Bao Xin-yang li Ji-wu Song Kewei Hu Lala li si-ying li Wenbo liu Wanping Zhu Yunlong Zhang Jikai li Ting Yao Leming Mou Xiaoqing Han Furong Hao Yongcheng Hu lin liu Hongguang Zhu Yuyun Wu Bin liu Weifang People's Hospital WeifangShandong261000China School of life Sciences Nankai UniversityTianjin300071China Weifang Traditional Chinese Medicine Hospital WeifangShandong261000China Shaanxi Key Laboratory of Sericulture Ankang UniversityAnkangShaanxi725000China Guizhou Education University Guiyang550018China Guizhou Normal University Guiyang550025China School of Medical Imaging Weifang Medical UniversityWeifangShandong261053China Department of Bone and Soft Tissue Oncology Tianjin HospitalTianjin300299China Xinqiao Hospital of Army Military Medical University Chongqing400038China Teda Institute of Biological Sciences&Biotechnology Nankai UniversityTianjin300457China

Epigenomic imbalance drives abnormal transcriptional processes,promoting the onset and progression of *** defective gene regulation generally affects carcinogenesis and tumor suppression networks,tumor immunogenicity and immune cells involved in antitumor responses may also be affected by epigenomic changes,which may have significant implications for the development and application of epigenetic therapy,cancer immunotherapy,and their ***,we focus on the impact of epigenetic regulation on tumor immune cell function and the role of key abnormal epigenetic processes,DNA methylation,histone post-translational modification,and chromatin structure in tumor immunogenicity,and introduce these epigenetic research *** emphasize the value of small-molecule inhibitors of epigenetic modulators in enhancing antitumor immune responses and discuss the challenges of developing treatment plans that combine epigenetic therapy and immuno-therapy through the complex interaction between cancer epigenetics and cancer immunology.

关键词： Antitumor immunity Chromatin structural Cancer epigenetics DNA methylation Histone modification Chemotherapy

Nanostructured ZnO/BiVO_(4)I-scheme heterojunctions for piezocatalytic degradation of organic dyes via harvesting ultrasonic vibration energy

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International Journal of Minerals,Metallurgy and Materials 2025年第2期32卷 488-497页

作者： Yiling li Xiaoyao Yu yingjie Zhou Yao lin ying Wu Key Laboratory of the Ministry of Education for Advanced Catalysis Materials College of Chemistry and Materials ScienceZhejiang Normal UniversityJinhua 321004China

BiVO_(4)porous spheres modified by ZnO were designed and synthesized using a facile two-step *** resulting ZnO/BiVO_(4)composite catalysts have shown remarkable efficiency as piezoelectric catalysts for degrading Rhodamine B(RhB)unde mechanical vibrations,they exhibit superior activity compared to pure *** 40wt%ZnO/BiVO_(4)heterojunction composite displayed the highest activity,along with good stability and *** enhanced piezoelectric catalytic activity can be attributed to the form ation of an I-scheme heterojunction structure,which can effectively inhibit the electron-hole ***,hole(h+)and superoxide radical(·O_(2)^(-))are proved to be the primary active ***,ZnO/BiVO_(4)stands as an efficient and stable piezoelectric catalyst with broad potential application in the field of environmental water pollution treatment.

关键词： piezoelectric catalytic heterojunction dye degradation ultrasonic vibration

蓝莓花芽休眠相关MADS-box基因VcDAM1的克隆与表达分析

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植物生理学报 2017年第9期53卷 1728-1734页

作者：刘思夏秀英李波大连理工大学生命科学与技术学院辽宁大连116024

休眠相关MADS-box(DAM)基因在植物芽休眠及解除过程中发挥重要作用。本研究以‘蓝丰’蓝莓(Vaccinium corymbosum)休眠花芽为材料,利用RT-PCR及RACE技术,克隆获得Vc DAM1基因(Gen Bank登录号为KF871069)。该基因全长1376 bp,包含一个750... 详细信息

休眠相关MADS-box(DAM)基因在植物芽休眠及解除过程中发挥重要作用。本研究以‘蓝丰’蓝莓(Vaccinium corymbosum)休眠花芽为材料,利用RT-PCR及RACE技术,克隆获得Vc DAM1基因(Gen Bank登录号为KF871069)。该基因全长1376 bp,包含一个750 bp的开放阅读框,编码249个氨基酸。序列比对发现,该基因编码的蛋白质具有典型的MIKC^C型MADS-box结构域和K-box结构域,其氨基酸序列与砂梨DAM同源性较高。实时定量PCR结果表明,该基因在蓝莓花芽中表达量最高,且随花芽休眠进程呈现规律变化,在内休眠期间表达量持续上升,内休眠解除后表达量迅速下降;外源脱落酸能使该基因表达上调,外源赤霉素和单氰胺使该基因表达下调。推测该基因调控蓝莓花芽的休眠。

关键词：蓝莓休眠相关MADS-box基因休眠克隆表达分析

Urine proteomics for profiling of mouse toxoplasmosis using liquid chromatography tandem mass spectrometry analysis

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Urine proteomics for profiling of mouse toxoplasmosis using ...

UPLC-MS/MS同时测定静脉注射荭草花提取物大鼠血浆中3种成分及其药代动力学研究

2021中国畜牧兽医学会兽医寄生虫学分会第二届青年科学家学术论坛

作者： Yi Zhang lin-lin Cui Chun-Xue Zhou Bing Han si-ying li Dong-Hui Zhou Key Laboratory of Fujian-Taiwan Animal Pathogen Biology College of Animal Sciences(College of Bee Science)Fujian Agriculture and Forestry University Department of Pathogen Biology School of Basic Medical SciencesCheeloo College of MedicineShandong University

Toxoplasma gondii is an obligate intracellular parasite that causes *** is an easily obtained clinical sample that has been widely applied for diagnostic ***,changes in the urinary proteome during *** infection have never been *** four-hour urine samples were obtained from BALB/c mice with acute infection [11 days post infection(DPI)],mice with chronic infection(35 DPI) and healthy controls,and were analyzed using a label-free liquid chromatography tandem mass spectrometry *** identified a total of 13,414 peptides on 1802 proteins,of which169 and 47 proteins were significantly differentially expressed at acute and chronic infection phases,*** analysis revealed obvious differences in proteome profiles among all *** ontology analysis showed that a large number of differentially expressed proteins(DEPs) detected in acute infection were associated with biological binding activity and single-organism *** pathway enrichment analysis showed that the majority of these DEPs were involved in disease-related and metabolic *** findings revealed global reprogramming of the urine proteome following *** infection,and data obtained in this study will enhance our understanding of the host responses to *** infection and lead to the identification of new diagnostic biomarkers.

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中药材 2016年第7期39卷 1574-1577页

作者：郑林杨武向文英孙佳陈思颖李勇军贵州医科大学贵州省药物制剂重点实验室贵州贵阳550004 贵州医科大学药学院贵州贵阳550004 贵州医科大学民族药与中药开发应用教育部工程研究中心贵州贵阳550004

目的:建立UPLC-MS/MS测定大鼠尾静脉注射荭草花提取物后的大鼠血浆中3种成分(原儿茶酸、山柰素-葡萄糖苷、檞皮苷)含量的分析方法,并研究这3种成分在大鼠体内药代动力学特征。方法:采用Waters BEH C18(50 mm×2.1 mm,1.7μm)色谱柱;流... 详细信息

目的:建立UPLC-MS/MS测定大鼠尾静脉注射荭草花提取物后的大鼠血浆中3种成分(原儿茶酸、山柰素-葡萄糖苷、檞皮苷)含量的分析方法,并研究这3种成分在大鼠体内药代动力学特征。方法:采用Waters BEH C18(50 mm×2.1 mm,1.7μm)色谱柱;流动相为0.1%甲酸乙腈-0.1%甲酸溶液,梯度洗脱;质谱采用电喷雾电离源(Esi);扫描方式为多反应离子监测(MRM)。结果:静脉注射荭草花提取物后原儿茶酸、山柰素-葡萄糖苷、槲皮苷在大鼠体内的半衰期分别为(41.9±12.3)min、(71.3±56.8)min和(90.3±74.8)min,达峰浓度(1.7±0.7)μg/m L、(2.1±0.9)μg/m L和(8.7±3.7)μg/m L。结论:实验结果表明建立的方法快速、准确、灵敏,精密度回收率均符合生物样品的测定要求,适用于原儿茶酸、山柰素-葡萄糖苷、檞皮苷3个成分在大鼠血浆中浓度的测定,3个成分在大鼠体内的药动学特征均符合二室模型。

关键词： UPLC-MS/MS 药动学荭草花提取物

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大学生网络道德问题及教育对策

武汉商学院学报 2016年第6期30卷 92-94页

作者：肖迎司丽娜武汉商学院湖北武汉430056

随着互联网在大学生群体中全面覆盖,网络道德问题也随之而来。对此,近年来已有不少高校思想政治教育工作者从不同视角对大学生网络道德问题进行研究。本文通过对当代大学生群体中突出存在的网络道德问题进行归纳和分析,有针对性地提出... 详细信息

随着互联网在大学生群体中全面覆盖,网络道德问题也随之而来。对此,近年来已有不少高校思想政治教育工作者从不同视角对大学生网络道德问题进行研究。本文通过对当代大学生群体中突出存在的网络道德问题进行归纳和分析,有针对性地提出了教育对策。

关键词：大学生网络道德问题教育对策

Pro-resolving lipid mediator reduces amyloid-β42–induced gene expression in human monocyte–derived microglia

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Neural Regeneration Research 2025年第3期20卷 873-886页

作者： ying Wang Xiang Zhang Henrik Biverstål Nicolas GBazan Shuai Tan Nailin li Makiko Ohshima Marianne Schultzberg Xiaofei li Department of Neurobiology Care Sciences&SocietyDivision of NeurogeriatricsKarolinska InstitutetStockholmSweden Department of Neurology Neuroscience CenterThe First Hospital of Jilin UniversityChangchunJilin ProvinceChina Department of Physiology and Pharmacology Karolinska InstitutetStockholmSweden Department of Biosciences and Nutrition Karolinska InstitutetHuddingeSweden Neuroscience Center of Excellence Louisiana State UniversityNew OrleansLAUSA Department of Medicine SolnaClinical Pharmacology GroupKarolinska University HospitalStockholmSweden

Specialized pro-resolving lipid mediators including maresin 1 mediate resolution but the levels of these are reduced in Alzheimer's disease brain, suggesting that they constitute a novel target for the treatment of Alzheimer's disease to prevent/stop inflammation and combat disease pathology. Therefore, it is important to clarify whether they counteract the expression of genes and proteins induced by amyloid-β. With this objective, we analyzed the relevance of human monocyte–derived microglia for in vitro modeling of neuroinflammation and its resolution in the context of Alzheimer's disease and investigated the pro-resolving bioactivity of maresin 1 on amyloid-β42–induced Alzheimer's disease–like inflammation. Analysis of RNA-sequencing data and secreted proteins in supernatants from the monocyte-derived microglia showed that the monocyte-derived microglia resembled Alzheimer's disease–like neuroinflammation in human brain microglia after incubation with amyloid-β42. Maresin 1 restored homeostasis by down-regulating inflammatory pathway related gene expression induced by amyloid-β42 in monocyte-derived microglia, protection of maresin 1 against the effects of amyloid-β42 is mediated by a re-balancing of inflammatory transcriptional networks in which modulation of gene transcription in the nuclear factor-kappa B pathway plays a major part. We pinpointed molecular targets that are associated with both neuroinflammation in Alzheimer's disease and therapeutic targets by maresin 1. In conclusion, monocyte-derived microglia represent a relevant in vitro microglial model for studies on Alzheimer's disease-like inflammation and drug response for individual patients. Maresin 1 ameliorates amyloid-β42–induced changes in several genes of importance in Alzheimer's disease, highlighting its potential as a therapeutic target for Alzheimer's disease.

关键词： Alzheimer's disease amyloid-β maresin microglia monocyte neuroinflammation resolution RNA-sequencing specialized pro-resolving lipid mediator