检索结果-南通市图书馆

Association between tobacco exposure and bladder cancer recurrence:A systematic review and meta-analysis

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Methodology 2024年第2期14卷 145-157页

作者： Lei Xiang Qi-Qi Xie si-si xu Wen-Jie Ruan Dong-Hui xu Yao-Yao Gan Jia Zuo Wen-Jun xu Zhi-Peng Li Department of Rehabilitation Medicine First Affiliated Hospital of Zhengzhou UniversityZhengzhou 450052Henan ProvinceChina School of Medicine Taizhou UniversityTaizhou 318000Zhejiang ProvinceChina

BACKGROUND However,the connection between smoking and the prognosis of patients with bladder cancer remains *** To determine whether smoking is linked to the recurrence and progression of bladder *** As of July 20,2022,relevant English-language research was identified by searching PubMed,the Web of Science,and the Cochrane *** pooled the available data from the included studies using a random effects *** analysis and sensitivity analysis were also *** A total of 12 studies were included in this *** combined analysis revealed that tobacco exposure was associated with a significantly greater recurrence rate than nonsmoking status[odd ratios(OR)=1.76,95%CI:1.84-2.93],and the progression of bladder cancer was significantly greater in smokers than in nonsmokers(OR=1.21,95%CI:1.02-1.44).Stratified analysis further revealed that current smokers were more likely to experience relapse than never-smokers were(OR=1.85,95%CI:1.11-3.07).Former smokers also had a greater risk of relapse than did never-smokers(OR=1.73,95%CI:1.09-2.73).Subgroup analysis indicated that non-Caucasians may be more susceptible to bladder cancer recurrence than Caucasians are(OR=2.13,95%CI:1.74-2.61).CONCLUsiON This meta-analysis revealed that tobacco exposure may be a significant risk factor for both the recurrence and progression of bladder cancer.

关键词： Smoking Bladder Cancer Recurrence Progress

Dose optimization of intrathecal administration of human umbilical cord mesenchymal stem cells for the treatment of subacute incomplete spinal cord injury

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Neural Regeneration Research 2022年第8期17卷 1785-1794页

作者： Ting-Ting Cao Huan Chen Mao Pang si-si xu Hui-Quan Wen Bin Liu Li-Min Rong Mang-Mang Li Department of Cell Biology School of Basic Medical SciencesSouthern Medical UniversityGuangzhouGuangdong ProvinceChina Department of Spine Surgery The Third Affiliated Hospital of Sun Yat-sen UniversityGuangzhouGuangdong ProvinceChina Guangdong Provincial Center for Engineering and Technology Research of Minimally Invasive Spine Surgery GuangzhouGuangdong ProvinceChina Guangdong Provincial Center for Quality Control of Minimally Invasive Spine Surgery GuangzhouGuangdong ProvinceChina Department of Radiology The Third Affiliated Hospital of Sun Yat-sen UniversityGuangzhouGuangdong ProvinceChina

Human umbilical cord mesenchymal stem cells(hUC-MSCs)are a promising candidate for spinal cord injury(SCI)repair owing to their advantages of low immunogenicity and easy accessibility over other MSC ***,modest clinical efficacy hampered the progression of these cells to clinical *** discrepancy may be due to many variables,such as cell source,timing of implantation,route of administration,and relevant efficacious cell dose,which are critical factors that affect the efficacy of treatment of patients with ***,we have evaluated the safety and efficacy of 4×10^(6) hUC-MSCs/kg in the treatment of subacute SCI by intrathecal implantation in rat *** search for a more accurate dose range for clinical translation,we compared the effects of three different doses of hUC-MSCs-low(0.25×10^(6) cells/kg),medium(1×10^(6) cells/kg)and high(4×10^(6) cells/kg)-on subacute SCI repair through an elaborate combination of behavioral analyses,anatomical analyses,magnetic resonance imaging-diffusion tensor imaging(MRI-DTI),biotinylated dextran amine(BDA)tracing,electrophysiology,and quantification of mRNA levels of ion channels and neurotransmitter *** study demonstrated that the medium dose,but not the low dose,is as efficient as the high dose in producing the desired therapeutic ***,partial restoration of theγ-aminobutyric acid type A(GABAA)receptor expression by the effective doses indicates that GABAA receptors are possible candidates for therapeutic targeting of dormant relay pathways in injured spinal ***,this study revealed that intrathecal implantation of 1×10^(6) hUC-MSCs/kg is an alternative approach for treating subacute SCI.

关键词： effective dose human umbilical cord mesenchymal stem cells intrathecal implantation ion channels neurotransmitter receptors spinal cord injury subacute spinal cord injury γ-aminobutyric acid type A(GABA_(A))receptors

Application of a microscopic optical potential of chiral effective field theory in (p, d) transfer reactions

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Nuclear Science and Techniques 2024年第1期35卷 134-144页

作者： Yi-Ping xu si-Lu Chen Dan-Yang Pang School of Nuclear Science and Engineering North China Electric Power UniversityBeijing 102206China School of Physics Beihang UniversityBeijing 100191China

The microscopic global nucleon–nucleus optical model potential(OMP)proposed by Whitehead,Lim,and Holt,the WLH potential(Whitehead et al.,Phys Rev Lett 127:182502,2021),which was constructed in the framework of many-body per-turbation theory with state-of-the-art nuclear interactions from chiral effective field theory(EFT),was tested with(p,d)transfer reactions calculated using adiabatic wave *** target nuclei included both stable and unstable nuclei,and the incident energies reached 200 *** results were compared with experimental data and predictions using the phenomenological global optical potential of Koning and Delaroche,the KD02 ***,we found that the micro-scopic WLH potential described the(p,d)reaction angular distributions similarly to the phenomenological KD02 potential;however,the former was slightly better than the latter for radioactive *** average,the obtained spectroscopic factors(SFs)using both microscopic and phenomenological potentials were similar when the incident energies were below approxi-mately 120 ***,their difference tended to increase at higher incident energies,which was particularly apparent for the doubly magic target nucleus 40Ca.

关键词： Microscopic optical model potential (p,d)transfer Spectroscopic factors

Molecular dynamics study of hydrogen-induced cracking behavior of ferrite–pearlite gas transmission pipeline steel

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Journal of Iron and Steel Research(International) 2024年第2期31卷 488-500页

作者： Tao-long xu si-han Guo Gong-zhen He Hao-yu Han Petroleum Engineering School Southwest Petroleum UniversityChengdu610500SichuanChina sichuan East Gas Transmission Sales Center of sinopec Natural Gas Branch Wuhan430074HubeiChina

Hydrogen embrittlement of pipelines depends on the hydrogen-induced cracking behavior of the pipeline steel *** on molecular dynamics analysis,the ferrite–cementite(α-Fe/Fe3C)lamellar atomic structure with the Bagaryatskii orientation relationship was established,and stepwise relaxation of the conjugate gradient energy minimization and constant-temperature and constant-pressure relaxation were performed under NPT(the isothermal–isobaric)*** mechanical property curves of theα-Fe/Fe3C models were obtained under different cementite terminal plane structures,and the evolution of the atomic structure was analyzed in *** addition,the influence of different hydrogen concentrations,different temperatures,different strain rates,changes in voids,and different micro-degrees of freedom on the deformation and failure mechanism of the model was investigated,aiming to provide a reliable way to explore the micro-mechanism of macro-cracking behavior of pipeline steel.

关键词： Ferrite-cementite lamellar structure Pipeline steel Failure mechanism Crack propagation Molecular dynamics

Mechanisms of myeloid-derived suppressor cell-mediated immunosuppression in colorectal cancer and related therapies

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastrointestinal Oncology 2024年第5期16卷 1690-1704页

作者： Shu-Chang Nie Yan-Hua Jing Lu Lu si-si Ren Guang Ji Han-Chen xu Institute of Digestive Diseases Longhua HospitalChina-Canada Center of Research for Digestive DiseasesShanghai University of Traditional Chinese MedicineShanghai 200032China Shanghai Frontiers Science Center of Disease and Syndrome Biology of Inflammatory Cancer Transformation Shanghai 200032China State Key Laboratory of Integration and Innovation of Classic Formula and Modern Chinese Medicine(Shanghai University of Traditional Chinese Medicine) Shanghai 200032China

Severe immunosuppression is a hallmark of colorectal cancer(CRC).Myeloid-derived suppressor cells(MDSCs),one of the most abundant components of the tumor stroma,play an important role in the invasion,metastasis,and immune escape of *** create an immunosuppressive microenvironment by inhibiting the proliferation and activation of immunoreactive cells,including T and natural killer cells,as well as by inducing the proliferation of immunosuppressive cells,such as regulatory T cells and tumor-associated macrophages,which,in turn,promote the growth of cancer ***,MDSCs are key contributors to the emergence of an immunosup-pressive microenvironment in CRC and play an important role in the breakdown of antitumor *** this narrative review,we explore the mechanisms through which MDSCs contribute to the immunosuppressive microenvironment,the current therapeutic approaches and technologies targeting MDSCs,and the therapeutic potential of modulating MDSCs in CRC *** study provides ideas and methods to enhance survival rates in patients with CRC.

关键词： Myeloid-derived suppressor cells Tumor microenvironment Colorectal cancer Therapy Immunosuppression

Hydrogen-rich surface of MoC catalysts for efficient CO_(2)hydrogenation induced by a coupled hydrogen donator

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Nano Research 2024年第8期17卷 7762-7767页

作者： Dong xu si-Yuan Xia Qi-Yuan Li Jie-Sheng Chen Xin-Hao Li School of Chemistry and Chemical Engineering Frontiers Science Center for Transformative MoleculesShanghai Jiao Tong UniversityShanghai 200240China

Direct CO_(2)hydrogenation offers an important strategy for promoting the global carbon balance,but high thermodynamic and kinetic stability of CO_(2)has restricted its applicability to only a handful of industrial ***,we introduce a proof-of-concept application of the electron-rich Pt surface to promote hydrogen donation for electron-rich MoC particles acting as hydrogen acceptors,thereby constructing hydrogen-rich surface of MoC active ***,the formed hydrogen-rich and electronrich surface could greatly decrease reaction activation energy to boost the efficient CO_(2)hydrogenation into formic acid over the MoC *** optimized MoC@NC/Pt-0.1(NC:nitrogen-doped carbon)catalyst exhibits a high turnover frequency(TOF)value of 1.2 h^(−1) at a lower temperature of 60℃and a TOF of 24.2 h^(−1) under standard reaction conditions widely used in the literature,exceeding 7 times of MoC@NC catalyst and surpassing the benchmark classical non-noble metal active center-based heterogeneous catalyst.

关键词： electron-rich Pt nanoparticles hydrogen donation hydrogen-rich MoC nanoparticles CO_(2)hydrogenation formic acid

Enhancement of Ising superconductivity in monolayer NbSe_(2) via surface fluorination

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Science China(Technological Sciences) 2024年第7期67卷 2099-2106页

作者： WU JiZheng SHI WuJun WANG Chong DUAN WenHui xu Yong si Chen School of Materials Science and Engineering Beihang UniversityBeijing 100191China Center for Transformative Science ShanghaiTech UniversityShanghai 201210China Shanghai High Repetition Rate XFEL and Extreme Light Facility(SHINE) ShanghaiTech UniversityShanghai 201210China State Key Laboratory of Low Dimensional Quantum Physics and Department of Physics Tsinghua UniversityBeijing 100084China Frontier Science Center for Quantum Information Beijing 100084China

Recently discovered Ising superconductors have garnered considerable interest due to their anomalously large in-plane upper critical fields(B_(c2)). However, the requisite strong spin-orbital coupling in the Ising pairing mechanism generally renders these superconductors heavy-element dominant with notably low superconducting transition temperatures(Tc). Here, based on the Migdal-Eliashberg theory and the mean-field Bogoliubov-de Gennes Hamiltonian, we demonstrate a significant enhancement of Ising superconductivity in monolayer NbSe_(2) through surface fluorination, as evidenced by concomitant improvements in Tcand Bc_(2). This enhancement arises from three predominant factors. Firstly, fluorine atoms symmetrically and stably adhere to both sides of the monolayer NbSe_(2), thereby maintaining the out-of-plane mirror symmetry and locking carrier spins ***, fluorination suppresses the charge density wave in monolayer NbSe_(2) and induces a van Hove singularity in the vicinity of the Fermi level, leading to a marked increase in the number of carriers and, consequently, strengthening the electron-phonon coupling(EPC). Lastly, the appearance of fluorine-related, low-frequency phonon modes further augments the EPC. Our findings suggest a promising avenue to elevate Tcin two-dimensional Ising superconductors without compromising their Ising pairing.

关键词： Ising superconductivity surface functionalization upper critical field NbSe_(2) first-principles calculations

Parallel System Based Quantitative Assessment and Self-evolution for Artificial Intelligence of Active Power Corrective Control

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

CSEE Journal of Power and Energy Systems 2024年第1期10卷 13-28页

作者： Tianyun Zhang Jun Zhang Feiyue Wang Peidong xu Tianlu Gao Haoran Zhang Ruiqi si School of Electrical Engineering and Automation Wuhan UniversityWuhan 430072HubeiChina State Key Laboratory for Management and Control of Complex System Institute of AutomationChinese Academy of SciencesBeijing 100190China

In artificial intelligence(AI)based-complex power system management and control technology,one of the urgent tasks is to evaluate AI intelligence and invent a way of autonomous intelligence ***,there is,currently,nearly no standard technical framework for objective and quantitative intelligence *** this article,based on a parallel system framework,a method is established to objectively and quantitatively assess the intelligence level of an AI agent for active power corrective control of modern power systems,by resorting to human intelligence evaluation *** this basis,this article puts forward an AI self-evolution method based on intelligence assessment through embedding a quantitative intelligence assessment method into automated reinforcement learning(AutoRL)systems.A parallel system based quantitative assessment and self-evolution(PLASE)system for power grid corrective control AI is thereby constructed,taking Bayesian Optimization as the measure of AI evolution to fulfill autonomous evolution of AI under guidance of their intelligence assessment *** results exemplified in the power grid corrective control AI agent show the PLASE system can reliably and quantitatively assess the intelligence level of the power grid corrective control agent,and it could promote evolution of the power grid corrective control agent under guidance of intelligence assessment results,effectively,as well as intuitively improving its intelligence level through selfevolution.

关键词： AI quantitative intelligence assessment and self-evolution automated reinforcement learning Bayesian optimization corrective control parallel system

Experimental Study on the Performance of ORC System Based on Ultra-Low Temperature Heat Sources

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Energy Engineering 2024年第1期121卷 145-168页

作者： Tianyu Zhou Liang Hao Xin xu Meng si Lian Zhang College of Mechanical Engineering Tianjin University of Science&TechnologyTianjin300222China School of Energy Engineering Tianjin Sino-German University of Applied SciencesTianjin300350China Tianjin“The Belt and Road”Joint Laboratory Tianjin Sino-German University of Applied SciencesTianjin300350China

This paper discussed the experimental results of the performance of an organic Rankine cycle(ORC)system with an ultra-low temperature heat *** low boiling point working medium R134a was adopted in the *** simulated heat source temperature(SHST)in this work was set from 39.51°C to 48.60°C by the simulated heat source *** influence of load percentage of simulated heat source(LPSHS)between 50%and 70%,the rotary valve opening(RVO)between 20%and 100%,the resistive load between 36Ωand 180Ωor the no-load of the generator,as well as the autumn and winter ambient temperature on the system performance were *** results showed that the stability of the system was promoted when the generator had a resistive *** power generation(PG)and generator speed(GS)of the system in autumn were better than in winter,but the expander pressure ratio(EPR)was lower than in *** RVO unchanged,the SHST,the mass flow rate(MFR)of the working medium,GS,and the PG of the system increased with the increasing of LPSHS for different generator resistance load *** the RVO was 60%,LPSHS was 70%,the SHST was 44.15°C and the resistive load was 72Ω,the highest PG reached 15.11 ***,a simulation formula was obtained for LPSHS,resistance load,and PG,and its correlation coefficient was between 0.9818 and *** formula can accurately predict the *** experimental results showed that the standard deviation between the experimental and simulated values was below 0.0792,and the relative error was within±5%.

关键词： ORC load percentage of simulated heat source resistive load rotary valve opening power generation