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BL03HB: a Laue microdiffraction beamline for both protein crystallography and materials science at SSRF

Nuclear Science and Techniques 2024年第7期35卷 68-78页

作者： Zhi-Jun wang si-sheng wang Zheng-Huang Su Li Yu Yu-Zhu wang Bo Sun Wen Wen Xing-Yu Gao Shanghai Advanced Research Institute Chinese Academy of SciencesShanghai201210China University of Chinese Academy of Science Beijing100049China

A Laue microdiffraction beamline(BL03HB) was constructed at the Shanghai Synchrotron Radiation Facility(SSRF).This beamline features two consecutive focusing points in two different sectors within its end station, the first dedicated to protein crystallography and the other tailored to materials science applications. Based on a superbend dipole magnet with a magnetic field of 2.29 T, a two-stage focusing design was implemented with two sets of Kirkpatrick-Baez mirrors to achieve a micro white beam as small as 4.2 μ m ×4.3 μ m at the first sector and 0.9 μ m ×1.3 μ m at the second sector in the standard beamline operation mode at SSRF. The X-ray microbeam in the two sectors can be easily switched between monochromatic and white beams by moving a four-bounce monochromator in or out of the light path, respectively. In the protein crystallography sector, white-beam Laue microdiffraction was demonstrated to successfully determine the structure of protein crystals from only a few images of diffraction data collected by a Pilatus 2 M area detector. In the materials science sector,the white-beam Laue diffraction was collected in a reflection geometry using another Pilatus 2 M area detector, which could map the microstructural distribution on the sample surface by scanning the samples. In general, the BL03HB beamline promotes the application of Laue microdiffraction in both protein crystallography and materials science. This paper presents a comprehensive overview of the BL03HB beamline, end station, and the first commission results.

关键词： Crystallography White-beam Laue microdiffraction Beamline Synchrotron

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Universal and efficient hybrid modeling and direct slicing method for additive manufacturing processes

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Advances in Manufacturing 2024年第2期12卷 300-316页

作者： Sen-Lin wang Li-Chao Zhang Chao Cai Ming-Kai Tang si Chen Jiang Huang Yu-sheng Shi State Key Laboratory of Materials Processing and Die and Mould Technology Huazhong University of Science and TechnologyWuhan430074People’s Republic of China School of Machinery and Automation Wuhan University of Science and TechnologyWuhan430081People’s Republic of China

Model design and slicing contour generation in additive manufacturing(AM)data processing face challenges in terms of efficiency and scalability when stereolithography files generated by complex functionally graded structures have millions of *** paper proposes a hybrid modeling and direct slicing method for AM to efficiently construct and handle complex three-dimensional(3D)*** 3D solids,including conformal multigradient structures,were uniformly described using a small amount of data via signed distance *** hybrid representations were quickly discretized into numerous disordered directed lines using an improved marching squares *** establishing a directional HashMap to construct the topological relationship between lines,a connecting algorithm with linear time complexity is proposed to generate slicing contours for *** method replaces the mesh reconstruction and Boolean operation stages and can efficiently construct complex conformal gradient models of arbitrary topologies through hybrid ***,the time and memory consumption of direct slicing are much lower than those of previous methods when handling hybrid models with hundreds of millions of faces after mesh reconstruction.

关键词： Additive manufacturing(AM) Hybrid modeling Direct slicing signed distance field

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Inhibition of EGFR attenuates EGF-induced activation of retinal pigment epithelium cell via EGFR/AKT signaling pathway

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International Journal of Ophthalmology(English edition) 2024年第6期17卷 1018-1027页

作者： Yu-sheng Zhu si-Rui Zhou Hui-Hui Zhang Tong wang Xiao-Dong Chen Faculty of Life Sciences and Medicine Northwest UniversityXi’an 710069Shaanxi ProvinceChina First Affiliated Hospital of Northwest University Northwest UniversityXi’an 710069Shaanxi ProvinceChina Department of Ophthalmology Xi’an No.1 HospitalXi’an 710002Shaanxi ProvinceChina Shaanxi Institute of Ophthalmology Shaanxi Provincial Key Lab of OphthalmologyClinical Research Center for Ophthalmology Diseases of Shaanxi ProvinceXi’an 710002Shaanxi ProvinceChina

AIM:To explore the effect of epidermal growth factor receptor(EGFR)inhibition by erlotinib and EGFR siRNA on epidermal growth factor(EGF)-induced activation of retinal pigment epithelium(RPE)***:Human RPE cell line(ARPE-19 cells)was activated by 100 ng/mL *** and EGFR siRNA were used to intervene EGF *** viability,proliferation,and migration were detected by methyl thiazolyl tetrazolium(MTT)assay,bromodeoxyuridine(BrdU)staining assay and wound healing assay,***/protein kinase B(AKT)pathway proteins and N-cadherin,α-smooth muscle actin(α-SMA),and vimentin were tested by Western blot *** was also determined by immunofluorescence ***:EGF treatment for 24h induced a significant increase of ARPE-19 cells’viability,proliferation and migration,phosphorylation of EGFR/AKT proteins,and decreased total EGFR *** suppressed ARPE-19 cells’viability,proliferation and migration through down regulating total EGFR and AKT protein *** also inhibited EGF-induced an increase of proliferative and migrative ability in ARPE-19 cells and clearly suppressed EGF-induced EGFR/AKT proteins phosphorylation and decreased expression of N-cadherin,α-SMA,and vimentin ***,EGFR inhibition by EGFR siRNA significantly affected EGF-induced an increase of cell proliferation,viability,and migration,phosphorylation of EGFR/AKT proteins,and up-regulation of N-cadherin,α-SMA,and vimentin ***:Erlotinib and EGFR-knockdown suppress EGF-induced cell viability,proliferation,and migration via EGFR/AKT pathway in RPE *** inhibition may be a possible therapeutic approach for proliferative vitreoretinopathy(PVR).

关键词： erlotinib epidermal growth factor receptor protein kinase B epithelial-mesenchymal transition retinal pigment epithelium cell

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Hydrodynamic characteristics and particle tracking of 90° lateral intakes at an inclined river slope

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Water Science and Engineering 2024年第2期17卷 197-208页

作者： Wei He si-yuan Feng Jian Zhang Hong-wu Tang Yang Xiao sheng Chen Chun-sheng Liu College of Water Conservancy and Hydropower Engineering Hohai UniversityNanjing 210098China State Key Laboratory of Hydrology Water Resources and Hydraulic Engineering Hohai UniversityNanjing 210098China Collaborative Innovation Center on Water Safety and Water Science Hohai UniversityNanjing 210098China

Lateral intakes are common in *** pump effciency and sediment deposition are determined by the local hydrodynamic characteristics and mainstream division *** hydraulic characteristics of lateral withdrawal from inclined river slopes at different intake elevations should be ***,the division width exhibits significant vertical non-uniformity at an inclined river slope,which should be ***,a three-dimensional(3-D)hydrodynamic and particle-tracking model was developed with the Open Source Field Operation and Manipulation(Open FOAM),and the model was validated with physical model tests for 90°lateral withdrawal from an inclined side *** flow fields,withdrawal sources,and division widths were investigated with different intake bottom elevations,withdrawal discharges,and main channel *** study showed that under inclined side bank conditions,water entered the intake at an oblique angle,causing significant 3-D spiral flows in the intake rather than two-dimensional closed recirculation.A lower withdrawal discharge,a lower bottom elevation of the intake,or a higher main channel velocity could further strengthen this *** average division width and turbulent kinetic energy were smaller under inclined side bank conditions than under vertical bank *** a low intake bottom elevation,a low withdrawal discharge,or a high main channel velocity,the sources of lateral withdrawal were in similar ranges near the local inclined bank in the vertical *** inclined slope conditions,sediment deposition near the intake entrance could be reduced,compared to that under vertical slope *** results provide hydrodynamic and sediment references for engineering designs for natural rivers with inclined terrains.

关键词： Lateral withdrawal Hydrodynamic characteristics Particle tracking Inclined river slope Bottom elevation of intake OpenFOAM

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Arbitrary topological charge vortex beams from carbon dots random lasers

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Rare Metals 2024年第8期43卷 3844-3853页

作者： Xiang-Dong wang Xiao-Bo Mi Jiu-Ru He Feng-Ying Ma Jun-Qiao wang Li Song Yong-Qiang Zhang si-Yu Lu Yong-sheng Hu School of Physics and Microelectronics Zhengzhou UniversityZhengzhou 450001China State Key Laboratory of Reliability and Intelligence of Electrical Equipment and Tianjin Key Laboratory of Electronic Materials and Devices School of Electronics and Information EngineeringHebei University of TechnologyTianjin 300401China Green Catalysis Center College of ChemistryZhengzhou UniversityZhengzhou450001China

Vortex beams have attracted great attention due to their promising applications in the fields of high-capacity optical communication,optical micromanipulation,and quantum information ***,we demonstrate vortex beams with flexible control of the topological charge and modes in a carbon dots random laser for the first *** beams with different types,including the Laguerre-Gaussian(LG),Bessel-Gaussian(BG),LG-superposition,and polarized vortex beams with topological charges up to 50,have been successfully ***,vortex beams can be well realized in carbon dots random lasers with different emission wavelengths covering from 465 to 612 *** work would not only enrich the types of vortex laser,especially for solution-processable lasers,but also provide a new route to realizing multicolor and wavelength-tunable vortex lasers.

关键词： Carbon dots Random lasers Vortex beam Topological charge Spatial light modulator

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Brain-inspired artificial intelligence research: A review

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Science China Technological Sciences 2024年第8期67卷 2282-2296页

作者： wang GuoYin BAO HuaNan LIU Qun ZHOU TianGang WU si HUANG TieJun YU ZhaoFei LU CeWu GONG YiHong ZHANG ZhaoXiang HE sheng Chongqing Key Laboratory of Computational Intelligence Chongqing University of Posts and Telecommunications Key Laboratory of Cyberspace Big Data Intelligent Security Chongqing University of Posts and Telecommunications College of Computer and Information Science Chongqing Normal University State Key Laboratory of Brain and Cognitive Science Institute of Biophysics Chinese Academy of Sciences Institute of Biophysics Chinese Academy of Sciences School of Psychological and Cognitive Sciences Peking University State Key Laboratory of Multimedia Information Processing School of Computer Science Peking University Department of Computer Science School of Electronics Information and Electrical Engineering Shanghai Jiao Tong University Faculty of Electronic and Information Engineering Xi'an Jiaotong University The Center for Research on Intelligent Perception and Computing Institute of Automation Chinese Academy of Sciences

Artificial intelligence(AI) systems surpass certain human intelligence abilities in a statistical sense as a whole, but are not yet the true realization of these human intelligence abilities and behaviors. There are differences, and even contradictions, between the cognition and behavior of AI systems and humans. With the goal of achieving general AI, this study contains a review of the role of cognitive science in inspiring the development of the three mainstream academic branches of AI based on the three-layer framework proposed by David Marr, and the limitations of the current development of AI are explored and analyzed. The differences and inconsistencies between the cognition mechanisms of the human brain and the computation mechanisms of AI systems are analyzed. They are found to be the cause of the differences and contradictions between the cognition and behavior of AI systems and humans. Additionally, eight important research directions and their scientific issues that need to focus on braininspired AI research are proposed: highly imitated bionic information processing, a large-scale deep learning model that balances structure and function, multi-granularity joint problem solving bidirectionally driven by data and knowledge, AI models that simulate specific brain structures, a collaborative processing mechanism with the physical separation of perceptual processing and interpretive analysis, embodied intelligence that integrates the brain cognitive mechanism and AI computation mechanisms,intelligence simulation from individual intelligence to group intelligence(social intelligence), and AI-assisted brain cognitive intelligence.

关键词： artificial intelligence cognitive science brain science intelligence science large language model

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Hepatocyte growth factor promotes retinal pigment epithelium cell activity through MET/AKT signaling pathway

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International Journal of Ophthalmology(English edition) 2024年第5期17卷 806-814页

作者： si-Rui Zhou Yu-sheng Zhu Wen-Ting Yuan Xiao-Yan Pan Tong wang Xiao-Dong Chen Faculty of Life Sciences and Medicine Northwest UniversityXi’an 710069Shaanxi ProvinceChina First Affiliated Hospital of Northwest University Northwest UniversityXi’an 710069Shaanxi ProvinceChina Department of Ophthalmology Xi’an No.1 HospitalXi’an 710002Shaanxi ProvinceChina Shaanxi Institute of Ophthalmology Shaanxi Provincial Key Lab of OphthalmologyClinical Research Center for Ophthalmology Diseases of Shaanxi ProvinceXi’an 710002Shaanxi ProvinceChina

AIM:To explore the effects of hepatocyte growth factor(HGF)on retinal pigment epithelium(RPE)cell ***:The human adult retinal pigment epithelial cell line-19(ARPE-19)were treated by HGF or mesenchymalepithelial transition factor(MET)inhibitor SU11274 in *** viability was detected by a Cell Counting Kit-8 *** proliferation and motility was detected by a bromodeoxyuridine incorporation assay and a wound healing assay,*** expression levels of MET,phosphorylated MET,protein kinase B(AKT),and phosphorylated AKT proteins were determined by Western blot *** MET and phosphorylated MET proteins were also determined by immunofluorescence ***:HGF increased ARPE-19 cells’viability,proliferation and migration,and induced an increase of phosphorylated MET and phosphorylated AKT ***11274 significantly reduced cell viability,proliferation,and migration and decreased the expression of MET and AKT ***11274 suppressed HGF-induced increase of viability,proliferation,and migration in ARPE-19 ***,SU11274 also blocked HGF-induced phosphorylation of MET and AKT ***:HGF enhances cellular viability,proliferation,and migration in RPE cells through the MET/AKT signaling pathway,whereas this enhancement is suppressed by the MET inhibitor ***-induced MET/AKT signaling might be a vital contributor of RPE cells survival.

关键词： hepatocyte growth factor mesenchymal epithelial transition factor SU11274 retinal pigment epithelial cells

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Measurement of the high energyγ-rays from heavy ion reactions usingČerenkov detector

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Nuclear Science and Techniques 2024年第2期35卷 123-130页

作者： Da-Wei si Yan Zhou sheng Xiao Zhi Qin Dong Guo Yu-Hao Qin Yi-Jie wang Bo-Yuan Zhang Bai-Ting Tian Zhi-Gang Xiao Department of Physics Tsinghua UniversityBeijing 100084China

The energetic bremsstrahlung photons up to 100 MeV produced in heavy ion collisions can be used as a sensitive probe for short-range correlation in atomic nuclei. The energy of the γ-rays can be measured by collecting the Čerenkov light in the medium induced by the fast electrons generated in the Compton scattering or electromagnetic shower of the incident γray. Two types of detectors based on pure water and lead glass as sensitive materials were designed for this purpose. The γresponse and optical photon propagation in the detectors were simulated based on electromagnetic and optical processes in Geant4. The inherent energy resolutions of 0.022(4) + 0.51(2)∕E^(1/2)_(γ) for water and 0.0026(3) + 0.446(3)∕E^(1/2)_(γ) for lead glass were obtained. The geometry sizes of the lead glass and water were optimized to 30 cm × 30 cm × 30 cm and 60 cm × 60 cm ×120 cm, respectively, to detect high-energy γ-rays at 160 MeV. The Hough transform method was applied to reconstruct the direction of the incident γ-rays, providing the ability to experimentally distinguish the high-energy γ-rays produced in the reactions on the target from random background cosmic-ray muons.

关键词： Bremsstrahlungγ-rays Čerenkov Geant4 Energy resolution Direction reconstruction Hough transform

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Hydrogen-rich surface of MoC catalysts for efficient CO_(2) hydrogenation induced by a coupled hydrogen donator

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Nano Research 2024年第8期17卷 7762-7767页

作者： Dong Xu si-Yuan Xia Qi-Yuan Li Jie-sheng Chen Xin-Hao Li School of Chemistry and Chemical Engineering Frontiers Science Center for Transformative MoleculesShanghai Jiao Tong UniversityShanghai 200240China

Direct CO_(2) hydrogenation offers an important strategy for promoting the global carbon balance,but high thermodynamic and kinetic stability of CO_(2) has restricted its applicability to only a handful of industrial ***,we introduce a proof-of-concept application of the electron-rich Pt surface to promote hydrogen donation for electron-rich MoC particles acting as hydrogen acceptors,thereby constructing hydrogen-rich surface of MoC active ***,the formed hydrogen-rich and electronrich surface could greatly decrease reaction activation energy to boost the efficient CO_(2) hydrogenation into formic acid over the MoC *** optimized MoC@NC/Pt-0.1(NC:nitrogen-doped carbon)catalyst exhibits a high turnover frequency(TOF)value of 1.2 h^(−1) at a lower temperature of 60℃and a TOF of 24.2 h^(−1) under standard reaction conditions widely used in the literature,exceeding 7 times of MoC@NC catalyst and surpassing the benchmark classical non-noble metal active center-based heterogeneous catalyst.

关键词： electron-rich Pt nanoparticles hydrogen donation hydrogen-rich MoC nanoparticles CO_(2) hydrogenation formic acid

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Efficacy and safety of Yangxinshi tablet for chronic heart failure:A systematic review and meta-analysis

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World Journal of Clinical Cases 2024年第13期12卷 2218-2230页

作者： sheng-Hua Lu Yun-Feng Yu si-si Dai Ya-Qi Hu Jian-He Liu The First Clinical College of Chinese Medicine Hunan University of Chinese MedicineChangsha 410007Hunan ProvinceChina Branch of National Clinical Research Center for Chinese Medicine Cardiology The First Hospital of Hunan University of Chinese MedicineChangsha 410007Hunan ProvinceChina

BACKGROUND The specific benefits of Yangxinshi tablet(YXST)in the treating chronic heart failure(CHF)remain *** To systematically evaluate the efficacy and safety of YXST in the treatment of *** Randomized controlled trials(RCTs)investigating YXST for CHF treatment were retrieved from eight public databases up to November ***-analyses of the included clinical studies were conducted using Review Manager *** Twenty RCTs and 1845 patients were *** meta-analysis results showed that the YXST combination group,compared to the conventional drug group,significantly increased the clinical efficacy rate by 23%[relative risk(RR)=1.23,95%CI:1.17-1.29],(Psignificant publication bias(P=0.557).CONCLUsiON YXST effectively improves clinical symptoms and cardiac function in patients with CHF while maintaining a favorable safety profile,suggesting its potential as a therapeutic strategy for CHF.

关键词： Yangxinshi tablet Chronic heart failure Cardiac function Systematic evaluation Meta-analysis

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