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Dynamic phase transition theory

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Science China(Physics,Mechanics & Astronomy) 2023年第2期66卷 102-108页

作者： qi-Jun ye Xin-Zheng Li State Key Laboratory for Artificial Microstructure and Mesoscopic Physics Frontier Science Center for Nano-optoelectronics and School of PhysicsPeking UniversityBeijing 100871China Interdisciplinary Institute of Light-Element Quantum Materials Research Center for Light-Element Advanced Materialsand Collaborative Innovation Center of Quantum MatterPeking UniversityBeijing 100871China Peking University Yangtze Delta Institute of Optoelectronics Nantong 226010China

Thermodynamic conventions suffer from describing dynamical distinctions,especially when the structural and energetic changes induced by rare events are *** using the ensemble theory in the trajectory space,we present a statistical approach to address this *** than spatial particle-particle interaction which dominates thermodynamics,the temporal correlation of events dominates the *** zeros of dynamic partition function mark phase transitions in the space-time,i.e.,dynamic phase transition(DPT),as Yang and Lee formulate traditional phase transitions,and hence determine dynamic phases on both sides of the *** to the role of temperature(pressure) as thermal(mechanical) potential,we interpret the controlling variable of DPT,i.e., dynamic field,as the dynamical *** findings offer possibility towards a unified picture of phase and phase transition.

关键词： transition phase transition

Optimal replacement of degrading components: a control-limit policy

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Science China(Information Sciences) 2021年第10期64卷 260-262页

作者： Xiaosheng si Tianmei LI qi ZHANG Department of Automation Rocket Force University of Engineering School of Mechanical Engineering Xi'an Jiaotong University

Dear editor,Components such as gyros, turbines, and bearings are vital in aircraft and spacecraft, and must run safely during their entire life cycle. However, gradual damage inevitably occurs resulting in component failure. Therefore, necessary maintenance such as component replacement should be scheduled. Traditional maintenance models are generally timebased, and in such models, maintenance decisions are made to minimize the expected cost rate,

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Decoupling SERT-nNOS Interaction to Generate Fast-Onset Antidepressants

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Neuroscience Bulletin 2023年第8期39卷 1327-1329页

作者： qing ye si‑si Lin Henning Ulrich Yong Tang International Joint Research Centre on Purinergic signalling/School of Acupuncture and Tuina Chengdu University of Traditional Chinese MedicineChengdu 610075China Department of Biochemistry Institute of ChemistryUniversity of São PauloSão Paulo 05508Brazil Acupuncture and Chronobiology Key Laboratory of sichuan Province/School of Health and Rehabilitation Chengdu University of Traditional Chinese MedicineChengdu 610075China

Major depressive disorder(MDD)is one of the most common psychiatric disorders,and~4.7%of the world's population has an onset of depression in any one-year *** causes constant distress,impairs social function and physiological health,and even leads to suicide[1].Numerous studies support the classic monoamine hypothesis of depressive *** majority of clinical antidepressants have been developed on the basis of this hypothesis to increase 5-hydroxytryptamine(5-HT).

关键词： distress hypothesis clinical

Biopharmaceutics classification evaluation for paris saponin Ⅶ

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Chinese Journal of Natural Medicines 2020年第9期18卷 714-720页

作者： ZHANG Xin SUN Yang CHENG Ying ye Wei-Liang ZHANG Bang-Le MEI qi-Bing ZHOU si-Yuan Depariment of Pharmaceutics School of PharmacyFourh Miliary Medical UniversityXi'an 710032.China Key Laboratory of Gastrointestinal Pharmacology of Chinese Materia Medica of the State Administration of Trulitioral Chinese Medicine Fourl Miliary Medical UnriversinyXi'an 710032China

To study the biopharmaceutics characteristics of paris saponin Ⅶ(PSⅦ). The solubility of PSⅦ was evaluated by measurement of the equilibrium solubility in different solvents and media. The permeability of PSⅦ was evaluated by measuring the oil/water partition coefficient(lgP_(app)) and determining the apparent permeability coefficient(PC_(app)) on a mono-layer Caco-2 cell model. The effects of p-glycoprotein and multidrug resistance related protein 2 on PSⅦ transport in mono-layer Caco-2 cell model were further investigated. Finally, the small intestinal absorption of PSⅦ was investigated in rat. In solvents of different pH, the equilibrium solubility of PSⅦ was quite low, and the dose number of PSⅦ was larger than 1. The lgP_(app) of PSⅦ was less than 0. The apparent permeability coefficient [PC_(app)(AP-BL)] of PSⅦ in mono-layer Caco-2 cell model was less than 14.96 × 10^(-6) cm·s^(-1), and the efflux ratio of PSⅦ in mono-layer Caco-2 cell model was less than 1. The transport rate of PSⅦ in mono-layer Caco-2 cell model was not affected by the inhibitors of p-glycoprotein and multidrug resistance related protein 2. After oral administration, PSⅦ could be detected in rat intestinal contents, but could not be detected in the small intestinal mucosa. PSⅦ showed low solubility and permeability,which would result in low oral bioavailability in clinic. PSⅦ belonged to Class IV compound in biopharmaceutics classification system.

关键词： Paris saponinⅦ Biopharmaceutical classification system Solubility Permeability Oil-water partition coefficient Caco-2 cells

Up-conversion of Nd^(3+)/Yb^(3+)/Tm^(3+) tri-doped CaTeO3 compound under excitation of 808 nm

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Rare Metals 2021年第4期40卷 1008-1013页

作者： Zhong-qiang ye si-Guo Xiao Xiao-Liang Yang School of Physics and Optoelectronics Xiangtan UniversityXiangtan 411105China

Nd^(3+)/Yb^(3+)/Tm^(3+) tri-doped CaTeO3 compounds were prepared by a solid-state reaction *** blue up-conversion(UC) luminescence at around 476 nm,which corresponds to the Tm^(3+):^(1)G_(4)→^(3)H_(6) transition,was observed under 808-nm *** Nd^(3+)→Yb^(3+)→Tm^(3+) energy transfer process was responsible for the strong blue up-conversion emission in the tri-doped *** Tm^(3+) blue up-conversion emission intensity was strongly dependent on the concentrations of Yb^(3+) and Nd^(3+).The possible up-conversion mechanisms for the Nd^(3+)/Yb^(3+)/Tm^(3+) tri-doped CaTeO_(3) phosphor are discussed,based on the Nd^(3+) and Yb^(3+) concentration-dependent UC spectra,near-infrared luminescence spectra and luminescence decay curves.

关键词： Up-conversion Tellurite 808 nm Energy transfer

Studies on the Electronic Structures and Spectra of C_(78)(CH_2)_3

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Chinese Journal of Structural Chemistry 2007年第3期26卷 314-320页

作者： TENG qi-Wen WU Shi CHEN si-Cong Department of Chemistry Zhejiang University Hangzhou 310027. China Department of Biomedicine-engineering Zhejiang University Hangzhou 310027 China

The structures and spectra of 20 possible isomers of C78（CH2）3 have been studied by using AMI, INDO/CIS and DFT methods. The results show that the most stable isomer is 1,2,3,4,5,6-C78（CH2）3 （A） with annulene structures, where three -CH2 groups are added to the 6/6 bonds located at the same hexagon passed by the shortest axis of C78 （C2v）. Compared with that of C78 （C2v）, the first absorption in the electronic spectrum of C78（CH2）3 （A） iS blue-shifted because of its wider LUMO-HOMO energy gap. While the IR frequencies of the C-C bonds on the carbon cage are red-shifted owing to the formation of annulene structures and the extension of the conjugated system. The chemical shifts of the carbon atoms in 13C NMR spectra are moved upfield upon the addition.

关键词： C78(CH2)3 DFT electronic spectra IR spectra NMR spectra

Regulation of intestinal stem cell fate specification

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Science China(Life Sciences) 2015年第6期58卷 570-578页

作者： qi Zhen CHEN ye-Guang State Key Laboratory of Biomembrane and Membrane Biotechnology Tsinghua-Peking Center for Life Sciences School of Life SciencesTsinghua University

The remarkable ability of rapid self-renewal makes the intestinal epithelium an ideal model for the study of adult stem cells. The intestinal epithelium is organized into villus and crypt, and a group of intestinal stem cells located at the base of crypt are responsible for this constant self-renewal throughout the life. Identification of the intestinal stem cell marker Lgr5, isolation and in vitro culture of Lgr5+ intestinal stem cells and the use of transgenic mouse models have significantly facilitated the studies of intestinal stem cell homeostasis and differentiation, therefore greatly expanding our knowledge of the regulatory mechanisms underlying the intestinal stem cell fate determination. In this review, we summarize the current understanding of how signals of Wnt, BMP, Notch and EGF in the stem cell niche modulate the intestinal stem cell fate.

关键词： intestinal stem cells Wnt BMP Notch EGF fate specification

The consensus on liver autotransplantation from an international panel of experts

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Hepatobiliary & Pancreatic Diseases International 2017年第1期16卷 10-16页

作者： qi-Fa ye Norbert Senninger Zhongnan Hospital of Wuhan University Institute of Hepatobiliary Diseases of Wuhan University Transplant Center of Wuhan University Hubei Key Laboratory of Medical Technology on Transplantation Research Center of National Health Ministry on Transplantation Medicine Engineering and Technology The 3rd Xiangya Hospital of Central South University Department of General Surgery University Clinics of Münster

IntroductionMore than 1.0 million patients worldwide are diagnosed with space-occupying lesions in the liver every year, with the number approaching 0.5 million per year in China, and only 20% of the lesions are resectable Due to a lack of available donors, only a limited number of patients underwent allogeneic liver transplantation, the remaining patients simply receive palliative care. Therefore, discovering new options for treating these patients is a high priority. Liver autotransplantation （LAT） is a surgical technique that adopts liver transplantation skills to radically treat spaceoccupying hepatic lesions, benign or malignant,

关键词： The consensus on liver autotransplantation from an international panel of experts

Ferroptosis contributes to JEV-induced neuronal damage and neuroinflammation

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Virologica sinica 2024年第1期39卷 144-155页

作者： Wenjing Zhu qi Li Yong Yin Huanchun Chen Youhui si Bibo Zhu Shengbo Cao Zikai Zhao Jing ye National Key Laboratory of Agricultural Microbiology Huazhong Agricultural UniversityWuhan430070China Frontiers Science Center for Animal Breeding and Sustainable Production Huazhong Agricultural UniversityWuhan430070China The Cooperative Innovation Center for Sustainable Pig Production Huazhong Agricultural UniversityWuhan430070China Hubei Hongshan Laboratory Wuhan430070China

Ferroptosis is a newly discovered prototype of programmed cell death (PCD) driven by iron-dependent phospholipid peroxidation accumulation, and it has been linked to numerous organ injuries and degenerative pathologies. Although studies have shown that a variety of cell death processes contribute to JEV-induced neuroinflammation and neuronal injury, there is currently limited research on the specific involvement of ferroptosis. In this study, we explored the neuronal ferroptosis induced by JEV infection in vitro and in vivo. Our results indicated that JEV infection induces neuronal ferroptosis through inhibiting the function of the antioxidant system mediated by glutathione (GSH)/glutathione peroxidase 4 (GPX4), as well as by promoting lipid peroxidation mediated by yes-associated protein 1 (YAP1)/long-chain acyl-CoA synthetase 4 (ACSL4). Further analyses revealed that JEV E and prM proteins function as agonists, inducing ferroptosis. Moreover, we found that treatment with a ferroptosis inhibitor in JEV-infected mice reduces the viral titers and inflammation in the mouse brains, ultimately improving the survival rate of infected mice. In conclusion, our study unveils a critical role of ferroptosis in the pathogenesis of JEV, providing new ideas for the prevention and treatment of viral encephalitis.

关键词： Japanese encephalitisvirus(JEV) Ferroptosis Neuron Lipid peroxidation Inflammatory response