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METTL14 downregulation drives S100A4^(+)monocyte-derived macrophages via MyD88/NF-κB pathway to promote MAFLD progression

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signal Transduction and Targeted Therapy 2024年第5期9卷 2176-2192页

作者： Yue-fan Wang Wen-li Zhang Zhi-xuan Li Yue Liu Jian Tan Hao-zan Yin Zhi-chao Zhang Xian-jie Piao min-hao Ruan Zhi-hui Dai si-jie Wang Chen-yang Mu Ji-hang Yuan Shu-han Sun Hui Liu Fu Yang The Third Department of hepatic Surgery Eastern Hepatobiliary Surgery Hospital Affiliated to Naval Medical University200438 ShanghaiChina The Department of Medical Genetics Naval Medical University200433 ShanghaiChina Translational Medicine Research Center Medical Innovation Research Division and Fourth Medical Center of the Chinese PLA General Hospital100048 BeijingChina The Department of Pharmaceutical Analysis School of PharmacyNaval Medical University200433 ShanghaiChina Key Laboratory of Biosafety Defense Ministry of Education200433 ShanghaiChina Shanghai Key Laboratory of Medical Biodefense 200433 ShanghaiChina

Without intervention,a considerable proportion of patients with metabolism‐associated fatty liver disease(MAFLD)will progress from simple steatosis to metabolism‐associated steatohepatitis(MASH),liver fibrosis,and even hepatocellular ***,the molecular mechanisms that control progressive MAFLD have yet to be fully ***,we unraveled that the expression of the N6-methyladenosine(m6A)methyltransferase METTL14 is remarkably downregulated in the livers of both patients and several murine models of MAFLD,whereas hepatocyte-specific depletion of this methyltransferase aggravated lipid accumulation,liver injury,and ***,hepatic Mettl14 overexpression alleviated the above pathophysiological changes in mice fed on a high-fat diet(HFD).Notably,in vivo and in vitro mechanistic studies indicated that METTL14 downregulation decreased the level of GLS2 by affecting the translation efficiency mediated by YTHDF1 in an m6A-depedent manner,which might help to form an oxidative stress microenvironment and accordingly recruit Cx3cr1^(+)Ccr2^(+)monocyte-derived macrophages(Mo-macs).In detail,Cx3cr1^(+)Ccr2^(+)Mo-macs can be categorized into M1-like macrophages and S100A4-positive macrophages and then further activate hepatic stellate cells(HSCs)to promote liver *** experiments revealed that CX3CR1 can activate the transcription of S100A4 via CX3CR1/MyD88/NF-κB signaling pathway in Cx3cr1^(+)Ccr2^(+)*** of METTL14 or GLS2,or interfering with this signal transduction pathway such as inhibiting MyD88 could ameliorate liver injuries and *** together,these findings indicate potential therapies for the treatment of MAFLD progression.

关键词： S100A4 MyD88 metabolism

Long noncoding RNA steroid receptor RNA activator 1 inhibits proliferation and glycolysis of esophageal squamous cell carcinoma

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World Journal of Gastrointestinal Oncology 2024年第10期16卷 4194-4208页

作者： ming he Ye Qi Ze-Mao Zheng min Sha Xiang Zhao Yu-Rao Chen Zheng-Hai Chen Rong-Yu Qian Juan Yao Zheng-Dong Yang Department of Radiation Oncology Huai’an Hospital of Huai’anHuai’an 223299Jiangsu ProvinceChina Department of Nursing Huai’an Hospital of Huai’anHuai’an 223299Jiangsu ProvinceChina Institute of Clinical Medicine Taizhou People's Hospital Affiliated of Nantong University of MedicineTaizhou 225300Zhejiang ProvinceChina Department of Thoracic Surgery Huai’an Hospital of Huai’anHuai’an 223299Jiangsu ProvinceChina

BACKGROUND The clinical effects and detailed roles of long non-coding RNA(LncRNA)steroid receptor RNA activator 1(SRA1)in esophageal squamous cell carcinoma(ESCC)remain *** the present study,the complementary sites between lncRNA SRA1,miRNA-363-5p,and phospholysine phosphohistidine inorganic pyrophosphate phosphatase(LHPP)predicted via bioinformatics analysis stimulated us to hypothesize that miRNA-363-5p/LHPP axis might be required for SRA1-mediated ESCC *** To investigate the molecular events of SRA1 in the malignant behavior in *** Thirty-eight ESCC tissues and paired adjacent normal tissues were ***1 expression was detected in ESCC tissues and cell lines using quantitative reverse transcription-polymerase chain *** counting Kit-8 assay,transwell invasion assay,glycolysis assay,and xenograft tumor model were performed to address the malignant biological behaviors of ESCC cells after the introduction of *** t-test and theχ2 test were used for comparison between *** curve analysis was performed using the Kaplan-Meier *** SRA1 downregulation was identified in *** patients exhibiting a low SRA1 expression faced shorter overall survival than those with a high SRA1 *** introduction of SRA1 inhibited cell proliferation,glucose uptake,and lactate production in *** vivo,the growth of ESCC was hindered by SRA1 ***,SRA1 overexpresses the LHPP by inhibiting ***,the introduction of small interfering RNA si-LHPP or miRNA-363-5p mimic could abrogate the inhibition roles triggered by *** SRA1 inhibits the oncogenicity of ESCC via miRNA-363-5p/LHPP *** SRA1/miRNA-363-5p/LHPP pathway may be a therapeutic target for ESCC.

关键词： Steroid receptor RNA activator 1 Esophageal squamous cell carcinoma Phospholysine phosphohistidine inorganic pyrophosphate phosphatase Cancer therapy MicroRNA Long non-coding RNA

Soleus arthrogenic muscle inhibition following acute lateral ankle sprain correlates with symptoms and ankle disability but not with postural control

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Journal of Sport and health Science 2024年第4期13卷 559-568,F0003页

作者： Kyung-min Kim Joo-Sung Kim Alan R.Needle Department of Sport Science Sungkyunkwan UniversitySuwon-si 16419Republic of Korea Department of health and Human Performance Texas State UniversitySan MarcosTX 78666USA Department of Public health&Exercise Science Appalachian State UniversityBooneNC 28608USA Department of Rehabilitation Science Appalachian State UniversityBooneNC 28608USA

Background:Acute lateral ankle sprains(ALAS)are associated with long-term impairments and instability tied to altered neural *** muscle inhibition(AMI)has been observed in this population;however,relationships with injury-related impairments are unclear,potentially due to the resting,prone position in which AMI is typically *** AMI during bipedal stance may provide a better understanding of this ***:AMI was assessed in 38 young adults(19 ALAS within 72 h of injury:10 males,21.4±2.7 years;19 healthy controls:10 males,21.9±2.2 years;mean±SD)using the Hoffmann reflex(H-reflex)during bipedal *** stimulation was administered to identify the _(max)imal H-reflex(H_(max))and _(max)imal motor response(M_(max))from the soleus,fibularis longus,and tibialis anterior *** primary outcome measure was the H_(max)/M_(max) *** outcomes included acute symptoms(pain and swelling),postural control during bipedal stance,and self-reported ***:No significant group-by-limb interactions were observed for any ***,a significant group main effect was observed in the soleus muscle(F(1,35)=6.82,p=0.013),indicating significantly lower H_(max)/M_(max) ratios following ALAS(0.38±0.20)compared to healthy controls(0.53±0.16).Furthermore,lower H_(max)/M_(max) ratios in the soleus significantly correlated with acute symptoms and self-reported function but not with postural ***:This study supports previous evidence of AMI in patients with ALAS,providing insight into neurophysiologic impacts of musculoskeletal *** results suggest that assessing AMI in a standing position following acute injury may provide valuable insight into how AMI develops and guide potential therapeutic options to curb and offset the formation of joint instability.

关键词： Acute injuries Balance Hoffmann reflex Neural excitability Patient-reported outcomes

Highly Elastic,Bioresorbable Polymeric Materials for Stretchable,Transient Electronic Systems

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Nano-Micro Letters 2024年第6期16卷 1-13页

作者： Jeong‑Woong Shin Dong‑Je Kim Tae‑min Jang Won Bae Han Joong Hoon Lee Gwan‑Jin Ko Seung min Yang Kaveti Rajaram Sungkeun Han heeseok Kang Jun Hyeon Lim Chan‑Hwi Eom Amay J.Bandodkar Hanul min Suk‑Won Hwang KU‑KIST Graduate School of Converging Science and Technology Korea University145 Anam‑roSeongbuk‑guSeoul 02841Republic of Korea SK Hynix 2091Gyeongchung‑daeroBubal‑eupIcheon‑siGyeonggi‑do 17336Republic of Korea Hanwha Systems Co. Ltd.188Pangyoyeok‑roBundang‑guSeongnam‑siGyeonggi‑do 13524Republic of Korea Department of Electrical and Computer Engineering North Carolina State UniversityRaleighNC 27606USA Center for Advanced Self‑Powered Systems of Integrated Sensors and Technologies(ASsiST) North Carolina State UniversityRaleighNC 27606USA Department of Integrative Energy Engineering Korea University145 Anam‑roSeongbuk‑guSeoul 02841Republic of Korea Biomaterials Research Center Korea Institute of Science and Technology(KIST)5 Hwarang‑ro 14‑gilSeongbuk‑guSeoul 02792Republic of Korea Semiconductor R&D Center Samsung Electronics Co.Ltd.Hwaseong‑siGyeonggi‑do 18448Republic of Korea Center for Advanced Biomolecular Recognition Biomedical Research DivisionKorea Institute of Science and Technology(KIST)Seoul 02792Republic of Korea

Substrates or encapsulants in soft and stretchable formats are key components for transient,bioresorbable electronic systems;however,elastomeric polymers with desired mechanical and biochemical properties are very limited compared to nontransient ***,we introduce a bioresorbable elastomer,poly(glycolide-co-ε-caprolactone)(PGCL),that contains excellent material properties including high elongation-at-break(silience and toughness,and tunable dissolution *** of PGCLs as polymer matrices,in combination with conducing polymers,yields stretchable,conductive composites for degradable interconnects,sensors,and actuators,which can reliably function under external *** of device components with wireless modules demonstrates elastic,transient electronic suture system with on-demand drug delivery for rapid recovery of postsurgical wounds in soft,time-dynamic tissues.

关键词： Biodegradable elastomer Conductive polymer composites Biomedical device Transient electronics

Monothetic and conductive network and mechanical stress releasing layer on micron-silicon anode enabling high-energy solid-state battery

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Rare Metals 2024年第3期43卷 1017-1029页

作者： Xiang Han min Xu Lan-Hui Gu Chao-Fei Lan min-Feng Chen Jun-Jie Lu Bi-Fu Sheng Peng Wang Song-Yan Chen Ji-Zhang Chen College of Materials Science and Engineering Co-Innovation Center of Efficient Processing and Utilization of Forestry ResourcesNanjing Forestry UniversityNanjing210037China Department of Physics Xiamen UniversityXiamen361005China Western Digital Corporation MilpitasCA95035USA

silicon has ultrahigh capacity,dendrite-free alloy lithiation mechanism and low cost and has been regarded as a promising anode candidate for solid-state *** to the low infiltration of solid-state electrolyte(SSE),not the unstable solid-electrolyte interphase(SEI),but the huge stress during lithiation-and delithiation-induced particle fracture and conductivity lost tend to be the main *** this study,starting with micron-si,a novel monothetic carbon conductive framework and a MgO coating layer are designed,which serve as electron pathway across the whole electrode and stress releasing layer,*** addition,the in situ reaction between si and SSE helps to form a LiF-rich and mechanically stable SEI *** a result,the mechanical stability and charge transfer kinetics of the uniquely designed si anode are significantly ***,high initial Coulombic efficiency,high capacity and durable cycling stability can be achieved by applying the si@MgO@C anode in *** example,high specific capacity of 3224.6 mAh·g^(-1)and long cycling durability of 200 cycles are *** work provides a new concept for designing alloy-type anode that combines surface coating on particle and electrode structure design.

关键词： Lithium-ion battery(LIB) Solid-state electrolyte(SSE) silicon anode Stress relief Coating

Development of RPA-Cas12a-fluorescence assay for rapid and reliable detection of human bocavirus 1

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Animal Models and Experimental Medicine 2024年第2期7卷 179-188页

作者： Weidong Qian Xuefei Wang Ting Wang Jie Huang Qian Zhang Yongdong Li si Chen School of Food and Biological Engineering Shaanxi University of Science and TechnologyXi'anP.R.China Department of Dermatology Huazhong University of Science and Technology Union Shenzhen HospitalShenzhenP.R.China Ningbo Municipal Center for Disease Control and Prevention NingboP.R.China Medical College of Shenzhen University ShenzhenP.R.China

Human bocavirus(HBoV)1 is considered an important pathogen that mainly affects infants aged 6–24 months,but preventing viral transmission in resource-limited regions through rapid and affordable on-site diagnosis of individuals with early infection of HBoV1 remains somewhat ***,we present a novel faster,lower cost,reliable method for the detection of HBoV1,which integrates a recombinase polymerase amplification(RPA)assay with the CRISPR/Cas12a system,designated the RPA-Cas12a-fluorescence *** RPA-Cas12a-fluorescence system can specifically detect target gene levels as low as 0.5 copies of HBoV1 plasmid DNA per microliter within 40 min at 37℃without the need for sophisticated *** method also demonstrates excellent specificity without cross-reactivity to non-target ***,the method was appraised using 28 clinical samples,and displayed high accuracy with positive and negative predictive agreement of 90.9%and 100%,***,our proposed rapid and sensitive HBoV1 detection method,the RPA-Cas12a-fluorescence assay,shows promising potential for early on-site diagnosis of HBoV1 infection in the fields of public health and health *** established RPA-Cas12a-fluorescence assay is rapid and reliable method for human bocavirus 1 *** RPA-Cas12a-fluorescence assay can be completed within 40 min with robust specificity and sensitivity of 0.5 copies/μl.

关键词： CRISPR-Cas12a detection human bocavirus 1 on-site diagnosis recombinase polymerase amplification

AlCrCuFeNb_(x)NiTi高熵合金的摩擦磨损及高温氧化性能

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材料热处理学报 2024年第7期45卷 106-116页

作者：徐思民阴艳丽邝海何文赵海博南昌航空大学材料科学与工程学院江西南昌330063 南昌工学院信息与人工智能学院江西南昌330108 江西科技师范大学江西省光电子与通信重点实验室江西南昌330038

采用真空电弧熔炼方法制备了AlCrCuFeNb_(x)NiTi高熵合金,并研究了铸态合金的组织、摩擦磨损性能和高温氧化性能。结果表明:Nb元素的添加促进了Laves相的形成,使AlCrCuFeNiTi合金的相结构由L2_(1)相、BCC相和FCC相转变为AlCrCuFeNb_(0.5... 详细信息

采用真空电弧熔炼方法制备了AlCrCuFeNb_(x)NiTi高熵合金,并研究了铸态合金的组织、摩擦磨损性能和高温氧化性能。结果表明:Nb元素的添加促进了Laves相的形成,使AlCrCuFeNiTi合金的相结构由L2_(1)相、BCC相和FCC相转变为AlCrCuFeNb_(0.5)NiTi合金的L2_(1)相、Laves相和FCC相。Nb元素的添加会降低AlCrCuFeNiTi合金的耐磨性能,磨损速率从AlCrCuFeNiTi合金的1.572×10^(-5) mm^(3)/(N·m)提高到AlCrCuFeNb_(0.5)NiTi合金的4.483×10^(-5) mm^(3)/(N·m),合金的室温磨损机制均为粘着磨损。合金的氧化动力学遵循抛物线速率定律,Nb元素对AlCrCuFeNb_(x)NiTi合金高温氧化性能的影响随着温度的改变而改变,800和900℃时能提高其高温氧化性能,但1000℃时Laves相的内氧化现象严重导致其高温氧化性能恶化。

关键词： AlCrCuFeNiTi高熵合金 Nb元素显微组织摩擦磨损高温氧化

Synergy of inside doped metals–Outside coated graphene to enhance hydrogen storage in magnesium-based alloys

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Journal of Magnesium and Alloys 2024年第6期12卷 2462-2471页

作者： Kun Zhang Yu Chang Jingjing Lei Jing Chen Tingzhi si Xiaoli Ding Ping Cui Hai-Wen Li Qingan Zhang Yongtao Li School of Materials Science and Engineering&Low-Carbon New Materials Research Center Anhui University of TechnologyMaanshanAnhui 243002China Institute of Nuclear and New Energy Technology Tsinghua UniversityBeijing100084 hefei General Machinery Research Institute HefeiAnhui 230031China Key Laboratory of Green Fabrication and Surface Technology of Advanced Metal Materials of ministry of Education Anhui University of TechnologyMaanshan 243002China

Grain growth of magnesium(Mg)and its hydride is one of the main reasons for kinetic and capacity degradation during the hydrogen absorption and desorption *** solve this problem,herein we propose a novel method involving synergistic effect of inside embedded metals and outside coated graphene to limit the growth of Mg and its hydride *** graphene coated Mg-Y-Al alloys were selected as a model system for demonstrating this positive effect where the Mg_(91)Y_(3)Al_(6)alloy was first prepared by rapidly solidified method and then high-pressure milled with 5 wt%graphene upon 5 MPa hydrogen gas for obtaining in-situ formed YAl_(2)and YH_(3)embedded in the MgH_(2)matrix with graphene shell(denoted as MgH_(2)-Y-Al@GR).In comparison to pure MgH_(2),the obtained MgH_(2)-Y-Al@GR composites deliver much better kinetics and more stable cyclic *** instance,the MgH_(2)-Y-Al@GR can release about 6.1 wt%H_(2)within 30 min at 300℃ but pure MgH_(2)only desorbs∼1.5 wt%H_(2).The activation energy for desorption of MgH_(2)-Y-Al@GR samples is calculated to be 75.3±9.1 kJ/mol that is much lower than approximately 160 kJ/mol for pure MgH_(2).Moreover,its capacity retention is promoted from∼57%of pure MgH_(2)to∼84%after 50th cycles without obvious particle agglomeration and grain *** synergistic effect of outside graphene coating with inside embedded metals which could provide a huge number of active sites for catalysis as well as inhibit the grain growth of Mg and its hydride is believed to be responsible for these.

关键词： Energy Hydrogen storage Mg alloys Synergy effect

元素取代对Ge-As(Sb)-Se玻璃转变阈值行为的影响

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物理学报 2024年第5期73卷 297-303页

作者：许思维王训四沈祥湖南文理学院数理学院常德415000 宁波大学高等技术研究院浙江省光电探测材料及器件重点实验室宁波315211

本文针对Sb取代As元素对Ge_(x)As(Sb)_(20)Se_(80-x)玻璃阈值行为的影响进行研究.对理想共价网络玻璃GexAs20Se80-x的玻璃转变温度、密度和折射率等物理参数进行了系统测量,在其平均配位数为2.4和2.67处验证了转变阈值的存在,这两个转... 详细信息

本文针对Sb取代As元素对Ge_(x)As(Sb)_(20)Se_(80-x)玻璃阈值行为的影响进行研究.对理想共价网络玻璃GexAs20Se80-x的玻璃转变温度、密度和折射率等物理参数进行了系统测量,在其平均配位数为2.4和2.67处验证了转变阈值的存在,这两个转变分别代表玻璃内部的共价网络结构从欠限制的松散状态到过限制的紧致状态的转变和从二维到三维紧致状态的转变.但是,当金属性更强的Sb取代As时,得到的非理想共价网络玻璃Ge_(x)Sb_(20)Se_(80-x)则会引起转变阈值的变化,转变阈值改变为化学计量组成.进一步利用拉曼散射技术对其结构进行表征,并将拉曼光谱通过分峰拟合分解成不同的结构单元的特征峰,它们各自的强度变化表现出相同的行为,这归因于As和Sb的原子半径差异较大所引起的化学效应以及Sb元素具有较强的离子特性.

关键词：硫系玻璃玻璃转变拉曼散射

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