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NOX4 exacerbates Parkinson's disease pathology by promoting neuronal ferroptosis and neuroinflammation

Neural Regeneration Research 2025年第7期20卷 2038-2052页

作者： Zhihao Lin Changzhou Ying Xiaoli si Naijia Xue Yi Liu Ran Zheng Ying Chen Jiali Pu Baorong Zhang Department of Neurology The Second Affiliated HospitalZhejiang University School of MedicineHangzhouZhejiang ProvinceChina

Parkinson's disease is primarily caused by the loss of dopaminergic neurons in the substantia nigra ***,a novel form of regulated cell death characterized by iron accumulation and lipid peroxidation,plays a vital role in the death of dopaminergic ***,the molecular mechanisms underlying ferroptosis in dopaminergic neurons have not yet been completely *** oxidase 4 is related to oxidative stress,however,whether it regulates dopaminergic neuronal ferroptosis remains *** aim of this study was to determine whether NADPH oxidase 4 is involved in dopaminergic neuronal ferroptosis,and if so,by what *** found that the transcriptional regulator activating transcription factor 3 increased NADPH oxidase 4 expression in dopaminergic neurons and astrocytes in an 1-methyl-4-phenyl-1,2,3,6 tetrahydropyridine-induced Parkinson's disease *** oxidase 4 inhibition improved the behavioral impairments observed in the Parkinson's disease model animals and reduced the death of dopaminergic ***,NADPH oxidase 4 inhibition reduced lipid peroxidation and iron accumulation in the substantia nigra of the Parkinson's disease model ***,we found that NADPH oxidase 4 interacted with activated protein kinase Cαto prevent ferroptosis of dopaminergic ***,by lowering the astrocytic lipocalin-2 expression,NADPH oxidase 4 inhibition reduced 1-methyl-4-phenyl-1,2,3,6 tetrahydropyridine-induced *** findings demonstrate that NADPH oxidase 4 promotes ferroptosis of dopaminergic neurons and neuroinflammation,which contribute to dopaminergic neuron death,suggesting that NADPH oxidase 4 is a possible therapeutic target for Parkinson's disease.

关键词： dopaminergic neuron ferroptosis NADPH oxidase 4(NOX4) neuroinflammation Parkinson's disease

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锆基金属有机框架捕获黄连中的生物碱类药物活性成分

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分析测试学报 2025年第1期44卷 188-194页

作者：司甜甜赵薇王慧张红玉刘小烨容蓉冯娟娟山东中医药大学药学院济南大学化学化工学院

采用溶剂热法制备了锆基MOF-808，利用其结构优势实现了中药黄连中生物碱类药物活性成分的富集与捕获，并结合其结构特点探讨了其协同低共熔溶剂捕获生物碱类活性成分过程中的相互作用。通过优化孵育捕获等条件，对黄连粗提液中药根碱... 详细信息

采用溶剂热法制备了锆基MOF-808，利用其结构优势实现了中药黄连中生物碱类药物活性成分的富集与捕获，并结合其结构特点探讨了其协同低共熔溶剂捕获生物碱类活性成分过程中的相互作用。通过优化孵育捕获等条件，对黄连粗提液中药根碱的回收率达到85.78%，结合高效液相色谱技术建立了检测黄连粗提液中5种生物碱类活性成分的方法。方法的线性范围为0.1～300μg·L-1，检出限为0.02～0.05μg·L-1，相对标准偏差为0.40%～4.7%，加标回收率达到69.7%～128%。该研究实现了中药黄连中生物碱类活性成分的高效、快速富集与捕获，为MOFs材料在选择性捕获与富集中药有效成分等领域的研究提供了新思路。

关键词：金属有机框架选择性富集色谱分离生物碱活性成分黄连

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基于电磁感应理论的接地网故障诊断方法

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电力与能源 2015年第5期36卷 670-672页

作者：苏磊陆冰冰陆启宇赵丹丹司文荣国网上海市电力公司电力科学研究院上海200437

电力系统中的接地网对保障电网安全运行和变电站的设备安全有非常重要的作用。由于我国主要以扁钢作为接地网材质,并且接地网深埋在地下,因此很容易受到腐蚀而发生故障,从而给电网运行带来安全隐患。基于电磁感应原理,通过给地网注入高... 详细信息

电力系统中的接地网对保障电网安全运行和变电站的设备安全有非常重要的作用。由于我国主要以扁钢作为接地网材质,并且接地网深埋在地下,因此很容易受到腐蚀而发生故障,从而给电网运行带来安全隐患。基于电磁感应原理,通过给地网注入高频大电流,测量由地网激发的磁感应强度,分析比较正常情况下磁感应强度与实际测量磁感应强度分布,从而测得地网故障。最后通过仿真试验验证了该方法的可行性。

关键词：接地网电磁感应故障诊断

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Response Solutions for Degenerate Reversible Harmonic Oscillators with Zero-average Perturbation

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Acta Mathematica sinica,English Series 2023年第10期39卷 2006-2030页

作者： Xin Yu GUAN Jian Guo si wen si School of Statistics and Mathematics Shandong University of Finance and EconomicsJi’nan 250002P.R.China School of Mathematics Shandong UniversityJi’nan 250100P.R.China

In this paper,we consider a class of normally degenerate quasi-periodically forced reversible systems,obtained as perturbations of a set of harmonic oscillators,{x˙=y+∈f1(ωt,x,y),y˙=λx^(l)+∈f2(ωt,x,y),where 0≠λ∈R,l>1 is an integer and the corresponding involution G is(−θ,x,−y)→(θ,x,y).The existence of response solutions of the above reversible systems has already been proved in[22]if[f2(ωt,0,0)]satisfies some non-zero average conditions(See the condition(H)in[22]),here[·]denotes the average of a continuous function on T^(d).However,discussing the existence of response solutions for the above systems encounters difficulties when[f_(2)(ωt,0,0)]=0,due to a degenerate implicit function must be *** article will be doing work in this *** purpose of this paper is to consider the case where[f2(ωt,0,0)]=*** precisely,with 2p˜0(seeλ˜in(2.2))and sufficiently small,response solutions exist for eachωsatisfying a weak non-resonant condition;(2)Forλ0 and l−p is even,we prove the system admits no response solutions in most regions.

关键词： Degenerate harmonic oscillators zero-average perturbation KAM theory reversible system response solutions

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A holographic description of theta-dependent Yang-Mills theory at finite temperature

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Chinese Physics C 2020年第1期44卷 39-46页

作者： si-wen Li Department of Physics School of ScienceDalian Maritime UniversityDalian 116026China

Theta-dependent gauge theories can be studied using holographic duality through string theory in certain *** this correspondence we consider a stack of N_0 dynamical DO-branes as D-instantons in the background sourced by N_c coincident non-extreme black *** to the gauge-gravity duality,this D0-D4 brane system corresponds to Yang-Mills theory with a theta angle at finite *** solve the IIA supergravity action by taking account into a sufficiently small backreaction of the Dinstantons and obtain an analytical solution for our D0-D4-brane ***,the dual theory in the large N_c limit can be holographically investigated with the gravity *** the dual field theory,we find that the coupling constant exhibits asymptotic freedom,as is expected in *** contribution of the theta-dependence to the free energy gets suppressed at high temperatures,which is basically consistent with the calculation using the Yang-Mills *** topological susceptibility in the large N_c limit vanishes,and this behavior remarkably agrees with the implications from the simulation results at finite ***,we finally find a geometrical interpretation of the theta-dependence in this holographic system.

关键词： AdS/CFT gauge-gravity duality holographic QCD theta dependence

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Effect of 0.5 mass% Cu Addition on Ductility and Magnetic Properties of Fe-6.5si Alloy

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Journal of Iron and Steel Research International 2016年第7期23卷 717-721页

作者： Zhao-yang CHENG Jing LIU wen-si CHEN Jia-chen ZHU Xi-feng LIN Zhi-dong XIANG The State Key Laboratory of Refractories and Metallurgy Wuhan University of Science and Technology

The effect of adding 0.5mass% Cu on ductility and magnetic properties of Fe-6.5si（mass%）alloy was *** alloys with and without 0.5mass% Cu addition were warm rolled into thin sheets of thickness no more than 0.3mm at temperature below 600 ℃.It was found that the alloy with 0.5mass% Cu addition was more easily warm rolled than Cu-free *** tests were carried out to further investigate this phenomenon,which confirmed that the ductility of the alloy with 0.5mass% Cu addition was significantly higher than that of Cu-free alloy at 550 ℃.Based on the results of transmission electron microscopy analysis,the ductility increase of the alloy with 0.5mass% Cu addition was attributed to the effect of Cu on the promotion of dynamic recovery and suppression of long-range order in the alloy during warm rolling *** was also observed that the iron loss was lower and inductance was higher for the alloy with 0.5 mass% Cu ***,it can be concluded that adding a suitably small amount of Cu would not only increase the ductility of Fe-6.5si alloy at warm rolling temperatures but also improve its magnetic properties.

关键词： Fe-6.5si alloy alloying ductility magnetic property microstructure long-range order

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Graphitic carbon nitride/La,Rh co-doped SrTiO_(3)S-scheme heterojunction for photocatalytic CO_(2)reduction

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Rare Metals 2024年第11期43卷 5880-5890页

作者： si-Jie Wan Yan-Ting Hou Wang Wang Guo-Qiang Luo Chuan-Bin Wang rong Tu Shao-wen Cao Chaozhou Branch of Chemistry and Chemical Engineering Guangdong Laboratory Chaozhou 521000China State Key Laboratory of Advanced Technology for Materials Synthesis and Processing Wuhan University of TechnologyWuhan 430070China Hubei Technology Innovation Center for Advanced Composites Wuhan University of TechnologyWuhan 430070China

Photocatalytic reduction of CO_(2)has attracted considerable interest owing to its potential to resolve the energy and environmental ***,the lack of proficient photocatalysts has restricted the application of solar-driven photocatalytic CO_(2)***,we reported an S-scheme heterojunction by combining g-C_(3)N_(4)with La^(3+)and Rh^(3+)co-doped SrTiO_(3)through the electrostatic self-assembly method for the efficient photocatalytic CO_(2)*** comparison with g-C_(3)N_(4),the asprepared CN/LRSTO-30 wt%S-scheme heterojunction not only possesses a broadened visible-light response due to the defect states in La,Rh co-doped SrTiO_(3)induced by codoped La^(3+)and Rh^(3+)but also has more adsorption sites for the capture and activation of CO_(2)***,separation and transfer efficiency of the photoinduced charge carriers is much enhanced in the CN/LRSTO-30wt%S-scheme heterojunction via its robust internal electric field,which is firmly demonstrated by in situ irradiation X-ray photoelectron spectroscopy ***,the prepared S-scheme heterojunction achieves impressive photocatalytic CO_(2)reduction performance with an average CO and CH4 evolution rate of4.1-1.8μmol·g^(-1)·h^(-1),respectively,which are~1.9 and~22.5-fold higher than those of pure g-C_(3)N_(4).This study provides innovative perspectives on the design of creative S-scheme heterojunctions for applications in photocatalytic CO_(2)reduction.

关键词： g-C_(3)N_(4) La Rh co-doped SrTiO_(3) S-scheme heterojunction Separation of photogenerated charge carriers Photocatalytic CO_(2)reduction

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Morphology and phase composition of MAO ceramic coating containing Cu on Ti6Al4V alloy

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Rare Metals 2017年第8期36卷 671-675页

作者： si-rong Yu Qiang Yao Hong-Chao Chu College of Mechanical and Electrical Engineering ChinaUniversity of Petroleum(Huadong)Qingdao 266580China

A ceramic coating containing Cu element was prepared on Ti6Al4V alloy using micro-arc oxidation（MAO）*** copper ions were added to the electrolyte solution of aluminate salt,the anode voltage in MAO process reduces,and the micropore size on the surface of the ceramic coating is more *** crystalline phases of the ceramic coatings prepared in the electrolyte solutions with and without copper ions are mainly Ti element,rutile TiO_2,and anatase TiO_*** addition of copper ions to the electrolyte solution makes rutile TiO_2 content decrease but promotes the formation of Al_2TiO_5 *** spectrum test results confirm that by adding copper ions to the electrolyte solution,the ceramic coating formed in the process of MAO contains copper element.

关键词： Micro-arc oxidation Ti alloy Copper ion Ceramic coating

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阿列克谢耶夫《聊斋志异》译本的译者行为批评分析

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外语学刊 2025年第1期 92-98页

作者：雷丽斯黑龙江大学高级翻译学院哈尔滨150080

《聊斋志异》是我国古代短篇小说的艺术丰碑,由苏联汉学家阿列克谢耶夫完成的俄语选译本在俄罗斯完成经典化。本文以阿列克谢耶夫译本为例,运用文本细读法,从翻译内外二分化视野,对译者行为进行批评分析。研究发现,在翻译外层面上,译者... 详细信息

《聊斋志异》是我国古代短篇小说的艺术丰碑,由苏联汉学家阿列克谢耶夫完成的俄语选译本在俄罗斯完成经典化。本文以阿列克谢耶夫译本为例,运用文本细读法,从翻译内外二分化视野,对译者行为进行批评分析。研究发现,在翻译外层面上,译者身份、译者与作者之间的“知己关系”等因素促使译者行为偏向作者/原文一端;在翻译内层面上,译者运用多种翻译手段最大限度地实现了对作者/原文的求真,同时在求真的基础上,使译文对读者/社会务实,译者行为合理度较佳。

关键词：译者行为批评《聊斋志异》阿列克谢耶夫译者行为典籍翻译

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Development of a cELISA for effective detection of the antibody against H7 subtype of avian influenza virus

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Journal of Integrative Agriculture 2022年第1期21卷 199-207页

作者： WANG Cong-cong WANG si-wen ZHANG Ying SHI Jian-zhong YIN Xin LI Cheng-jun WANG Xiu-rong State Key Laboratory of Veterinary Biotechnology Harbin Veterinary Research InstituteChinese Academy of Agricultural SciencesHarbin 150069P.R.China Shenyang Institute of Technology Shenyang 110870P.R.China

H7 avian influenza viruses(AIVs) normally circulated among birds before. From 1996 to 2012, human infections with H7 AIVs(H7 N2, H7 N3, and H7 N7) were reported in Canada, Italy, Mexico, the Netherlands, the United Kingdom and the USA. Until March 2013, human infections with H7 N9 AIVs were reported in China. since then, H7 N9 AIVs have continued to circulate in both humans and birds. Therefore, the detection of antibodies against the H7 subtype of AIVs has become an important topic. In this study, a competitive enzyme-linked immunosorbent assay(cELISA)method for the detection of antibody against H7 AIVs was established. The optimal concentration of antigen coating was 5 μg mL^(-1), serum dilution was 1/10, and enzyme-labeled antibody was 1/3 000. To determine the cut-off value of cELISA, percent inhibition(PI) was determined by using receiver operating characteristic(ROC) curve analysis in 178 AIVs negative samples and 368 AIVs positive serum samples(n=546). When PI was set at 40%, the specificity and sensitivity of cELISA were 99.4 and 98.9%, respectively. This method could detect the antibodies against H7 Nx(N1–N4, N7–N9) AIVs, and showed no reaction with AIVs of H1–H6 and H8–H15 subtypes or common avian viruses such as Newcastle disease virus(NDV), Infectious bronchitis virus(IBV) and Infectious bursal disease virus(IBDV), exhibiting good specificity. This method showed a coincidence rate of 98.56% with hemagglutinin inhibition(HI) test. And the repeatability experiment revealed that the coefficients of variation(CV) of intra-and inter-batch repetition were all less than 12%. The data indicated that the cELISA antibody-detection method established in this study provided a simple and accurate technical support for the detection of a large number of antibody samples of H7-AIV.

关键词： H7 subtype influenza monoclonal antibody cELISA

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