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Unraveling brain aging through the lens of oral microbiota

Neural Regeneration Research 2025年第7期20卷 1930-1943页

作者： Qinchao Hu si wang Weiqi Zhang Jing Qu Guang-Hui Liu State Key Laboratory of Membrane Biology Institute of ZoologyChinese Academy of SciencesBeijingChina Hospital of Stomatology Guanghua School of StomatologyGuangdong Provincial Key Laboratory of StomatologySun Yat-sen UniversityGuangzhouGuangdong ProvinceChina Advanced Innovation Center for Human Brain Protection and National Clinical Research Center for Geriatric Disorders Xuanwu HospitalCapital Medical UniversityBeijingChina Aging Translational Medicine Center International Center for Aging and CancerBeijing Municipal Geriatric Medical Research CenterXuanwu HospitalCapital Medical UniversityBeijingChina CAS Key Laboratory of Genomic and Precision Medicine Beijing Institute of GenomicsChinese Academy of Sciences and China National Center for BioinformationBeijingChina University of Chinese Academy of Sciences BeijingChina Institute for Stem Cell and Regeneration Chinese Academy of SciencesBeijingChina Aging Biomarker Consortium BeijingChina State Key Laboratory of Stem Cell and Reproductive Biology Institute of ZoologyChinese Academy of SciencesBeijingChina Beijing Institute for Stem Cell and Regenerative Medicine BeijingChina

The oral cavity is a complex physiological community encompassing a wide range of *** of oral microbiota can lead to various oral infectious diseases,such as periodontitis and tooth decay,and even affect systemic health,including brain aging and neurodegenerative *** studies have highlighted how oral microbes might be involved in brain aging and neurodegeneration,indicating potential avenues for intervention *** this review,we summarize clinical evidence demonstrating a link between oral microbes/oral infectious diseases and brain aging/neurodegenerative diseases,and dissect potential mechanisms by which oral microbes contribute to brain aging and *** also highlight advances in therapeutic development grounded in the realm of oral microbes,with the goal of advancing brain health and promoting healthy aging.

关键词： Alzheimer's disease brain aging multiple sclerosis neurodegeneration neurodegenerative diseases oral microbiota Parkinson's disease periodontitis bacteria Porphyromonas gingivalis

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Multiplicity of Periodic Bouncing Solutions for Sublinear Damped Variation Systems via Nonsmooth Variational Methods

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Acta Mathematica sinica,English Series 2023年第7期39卷 1332-1350页

作者： si Qi wang Fei GUO School of Mathematics Tianjin UniversityTianjin 300354China Tianjin Key Laboratory of Brain-Inspired Intelligence Technology Tianjin 300354China

Two results about the multiplicity of nontrivial periodic bouncing solutions for sublinear damped vibration systems-x=g(t)x+f(t,x) are obtained via the Generalized Nonsmooth Saddle Point Theorem and a technique established by Wu Xian and wang *** of them imply the condition "f≥0" required in some previous papers can be weakened,furthermore,one of them also implies the condition about ■F(t,x)/■t required in some previous papers,such as "|■F(t,x)/■t|=σ_(0)F(t,x)" and "|■F(t,x)/■t|≤C(1+F(t,x))", is unnecessary,where F(t,x):=∫_(0)~xf(t,x)ds,and σ_(0),C are positive constants.

关键词： Damped vibration systems generalized Nonsmooth Saddle Point Theorem sublinear conditions periodic bouncing solutions multiplicity

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From the first human gene-editing to the birth of three-parent baby

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Science China(Life Sciences) 2016年第12期59卷 1341-1342页

作者： Xiaoxue Zhang si wang Higher Education Press Beijing 100029China National Laboratory of Biomacromolecules CAS Center for Excellence in Biomacromolecules Institute of BiophysicsChinese Academy of SciencesBeijing 100101China

Gene Editing refers to the process of making targeted modi- fications to the genome, such as the deletion, insertion or replacement of targeted DNA sequences （Pan et al., 2011）. Gene editing technologies fundamentally improve our ap- proaches to biological basic research, gene therapy, genetic improvement, etc. In the field of stem cells, gene editing can be used to modulate cell fate, such as generation of in- duced pluripotent stem cells （iPSCs）（Ding et al., 2015）, cellular differentiation and transdifferentiation （Zhang et al., 2014）. In gene therapy, gene editing can be used to con＇ect disease mutations in patient-derived cells, which holds great promise to cure related diseases in the future （Liu et al., 2012; Liu et al., 2014）.

关键词： gene DNA

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Biological Eagle-eye Inspired Target Detection for Unmanned Aerial Vehicles Equipped with a Manipulator

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Machine Intelligence Research 2023年第5期20卷 741-752页

作者： Yi-Min Deng si-Yuan wang School of Automation Science and Electrical Engineering Beihang UniversityBeijing 100191China

Inspired by eagle eye mechanisms,the structure and information processing characteristics of the eagle′s visual system are used for the target capture task of an unmanned aerial vehicle(UAV)with a mechanical *** this paper,a novel eagle-eye inspired multi-camera sensor and a saliency detection method are proposed.A combined camera system is built by simulating the double fovea structure on the eagle retina.A saliency target detection method based on the eagle midbrain inhibition mechanism is proposed by measuring the static saliency information and dynamic ***,salient targets can be accurately detected through the collaborative work between different cameras of the proposed multi-camera *** results show that the eagle-eye inspired visual system is able to continuously detect targets in outdoor scenes and that the proposed algorithm has a strong inhibitory effect on moving background interference.

关键词： Unmanned aerial vehicle(UAV) eagle eye multi-camera sensor target detection saliency detection

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The Stability of Banach Frames in Banach Spaces

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Acta Mathematica sinica,English Series 2010年第12期26卷 2369-2376页

作者： Yu Can ZHU si Yuan wang Department of Mathematics Fuzhou University Fuzhou 350108 P. R. China Department of Mathematics Shangrao Normal School Shangrao 334000 P. R. China

In this paper, we give some equivalent conditions on a Banach frame for a Banach space by using the pseudoinverse operator. We also consider the stability of a Banach frame for a Banach space X with respect to Xd or an Xd-frame for a Banach space X under perturbation. These results generalize and improve the related works of Balan, Casazza, Christensen, Stoeva and Jian et al.

关键词： Frame Banach frame Xd-frame pseudoinverse operator

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Trimmed and Winsorized Transformed Means Based on a Scaled Deviation

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Acta Mathematicae Applicatae sinica 2015年第2期31卷 475-492页

作者： si-yang wang Heng-jian CUI School of Statistics and Mathematics Central University of Finance and Economics Department Statistics School of Mathematical Sciences Capital Normal University

This paper introduces the Tukey trimmed and Winsorized means for the transformed data based on a scaled deviation. The trimmed and Winsorized means and scale based on a scaled deviation are as special cases. Meanwhile, the trimmed and Winsorized skewness and kurtosis based on a scaled deviation are ***, some of their robust properties（influence function, breakdown points） and asymptotic properties（asymptotic representation and limiting distribution） are also obtained.

关键词： trimmed and Winsorized transformed means influence function skewness kurtosis

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Weakly- and Semi-Supervised Fast Region-Based CNN for Object Detection

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Journal of Computer Science & Technology 2019年第6期34卷 1269-1278页

作者： Xing-Gang wang Jia-si wang Peng Tang Wen-Yu Liu School of Electronic Information and Communications Huazhong University of Science and Technology Wuhan 430074China

Learning an effective object detector with little supervision is an essential but challenging problem in computer vision applications. In this paper, we consider the problem of learning a deep convolutional neural network (CNN) based object detector using weakly-supervised and semi-supervised information in the framework of fast region-based CNN (Fast R-CNN). The target is to obtain an object detector as accurate as the fully-supervised Fast R-CNN, but it requires less image annotation effort. To solve this problem, we use weakly-supervised training images (i.e., only the image-level annotation is given) and a few proportions of fully-supervised training images (i.e., the bounding box level annotation is given), that is a weakly-and semi-supervised (WASS) object detection setting. The proposed solution is termed as WASS R-CNN, in which there are two main components. At first, a weakly-supervised R-CNN is firstly trained;after that semi-supervised data are used for finetuning the weakly-supervised detector. We perform object detection experiments on the PASCAL VOC 2007 dataset. The proposed WASS R-CNN achieves more than 85% of a fully-supervised Fast R-CNN's performance (measured using mean average precision) with only 10%of fully-supervised annotations together with weak supervision for all training images. The results show that the proposed learning framework can significantly reduce the labeling efforts for obtaining reliable object detectors.

关键词： object detection weakly-supervised learning semi-supervised learning fast region-based convolutional neural network (Fast R-CNN)

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Eliminate mitochondrial diseases by gene editing in germ-line cells and embryos

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Protein & Cell 2015年第7期6卷 472-475页

作者： si wang Fei Yi Jing Qu National Laboratory of Biomacromolecules Institute of Biophysics Chinese Academy of Sciences Beijing 100101 China Department of Molecular and Cellular Physiology Stanford University School of Medicine Stanford CA 94305 USA State Key Laboratory of Reproductive Biology Institute of Zoology Chinese Academy of SciencesBeijing 100101 China

Nuclease-based gene editing technologies have opened up opportunities for correcting human genetic diseases. For the first time, scientists achieved targeted gene editing of mitochondrial DNA in mouse oocytes fused with patient cells. This fascinating progression may encourage the development of novel therapy for human maternally inherent mitochondrial diseases.

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Development and evaluation of a herbal formulation with antipathogenic activities and probiotics stimulatory effects

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Journal of Integrative Agriculture 2016年第5期15卷 1103-1111页

作者： ZHOU Qian wang si-si YANG Guang ZHAO Wen LI Hui-ling College of Food Science and Technology Agricultural University of Hebei Baoding 071001 P.R. China Engineering Technology Research Center for Agricultural Product Processing of Hebei Baoding 071001 P.R. China

Searching alternative feed antibiotics is always a study hotspot in the field of animal production. In this study, the antipathogenic activities and probiotics stimulatory effects of 30 kinds of herbs were screened through Oxford cup method and Hungate roll method. 15 herbs showed significantly antibacterial activities（P〈0.05） against Escherichia coli, Salmonella enteritidis, Salmonella typhimurium and Staphylococcus aureus. Seven herbs showed greatly stimulatory promoting effects on Lactobacillus acidophilus and Bifidobacterium longum. Finally, five herbs were combined for the developed formulation with selective antibacterial properties and they were Mume Fructus（35%）, Isatidis Folium（25%）, Moslae Herba（20%）, Chrysanthemi Indici Flos（13%） and Bupleuri Radix（7%）. The herbal formulation showed significantly antibacterial abilities against four pathogens and stimulatory promoting abilities on two probiotics in vitro and the equivalent activities in broiler chickens in vivo against E. coli and L. acidophilus. The toxicity study showed it had no toxicity, which indicated that it would be a kind of preferred candidate for an alternative antibiotic in future animal production.

关键词： herbal formulation alternative feed antibiotic anti-pathogenic activity probiotic stimulatory effect

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Synthesis of MOF-derived nitrogen-doped carbon microtubules via template self-consumption

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Rare Metals 2022年第8期41卷 2582-2587页

作者： Duo wang Ze-Yu Zhao Ping wang si-Miao wang Ming Feng Key Laboratory of Functional Materials Physics and Chemistry of the Ministry of Education Jilin Normal UniversityChangchun130103China

Herein,by optimizing nano-ZnO template,N-doped hollow carbon microtubules with controllable thickness are synthesized deriving from ZnO@zeolitic lmidazolate framework(ZIF-8)nanorod by template self-consumption method,and a superior structure with graphene-like layers of an average length of 5μm and diameter of 200 nm are proposed to be used as the cathode carries for Li-S *** electrochemical testing,we found that the prepared hollow carbon microtubules have higher discharge capacity and better rate performance than the ZIF-8 derived carbon,showing potential application *** work provides a feasible way for the preparation of monodisperse graphene-like hollow materials.

关键词： materials. template carbon

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