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Can serum immunoglobulin G4 levels and age serve as reliable predictors of relapse in autoimmune pancreatitis?

World Journal of Gastroenterology 2024年第5期30卷 512-515页

作者： Jun-Min Song si-Yu sun Department of Gastroenterology Shengjing Hospital of China Medical UniversityShenyang 110004Liaoning ProvinceChina

We are writing in response to the paper published in the World Journal of Gastroenterology by Zhou et *** authors identified higher serum immunoglobulin(Ig)G4 levels and age over 55 years as independent risk factors for disease *** notable strengths,it is crucial to address potential ***,the cohort study included 189 patients with autoimmune pancreatitis(AIP)type 1(with higher IgG4 seropositivity and higher relapse)and 24 with type 2(with lower IgG4 seropositivity and lower relapse).Consequently,most,if not all,AIP type 2 patients were assigned to the normal group,possibly inflating the association of higher serum IgG4 levels with relapse and potentially exaggerating the association of older age with ***,the authors did not provide sufficient details regarding AIP diagnosis,such as the ratio of definitive vs probable cases and the proportion of *** cases where histological evidence is unavailable or indeterminate,AIP type 2 may be misdiagnosed as definitive type 1,and type 1 may also be misdiagnosed as probable type 2,particularly in cases with normal or mildly elevated serum IgG4 ***,in this retrospective study,approximately one-third of the consecutive patients initially collected were excluded for various ***,the impact of nonrandom exclusion on relapse outcomes should be carefully *** conclusion,the paper by Zhou et al offers plausible,though not entirely compelling,evidence suggesting a predictive role of elevated serum IgG4 levels and advanced age in AIP *** foundation for future investigations lies in ensuring a reliable diagnosis and accurate disease subtyping,heavily dependent on obtaining histological *** this regard,endoscopic ultrasound-guided fine-needle biopsy emerges as a pivotal component of the diagnostic process,contributing to mitigating biases in future explorations of the disease.

关键词： Autoimmune pancreatitis Immunoglobulin Endoscopic ultrasound Relapse Age

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Fermi Blazars in the Zwicky Transient Facility Survey:Properties of Large Optical Variations

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Research in Astronomy and Astrophysics 2024年第10期24卷 104-115页

作者： si-si sun Zhong-Xiang Wang Shun-Hao Ji Department of Astronomy School of Physics and AstronomyYunnan UniversityKunming 650091China Shanghai Astronomical Observatory Chinese Academy of SciencesShanghai 200030China

We analyze the optical light curve data,obtained with the Zwicky Transient Facility(ZTF)survey,for 47 γ-ray blazars monitored by the Large Area Telescope onboard the Fermi Gamma-ray Space Telescope(Fermi).These 47sources are selected because they are among the Fermi blazars with the largest optical variations in the ZTF *** color-magnitude variation patterns are seen in them,with one being redder-to-stable-when-brighter(RSWB;in 31 sources)and the other being stable when brighter(in 16 sources).The patterns fit with the results recently reported in several similar studies with different ***,we find that the colors in the stable state of the sources share similar values,for which(after being corrected for the Galactic extinction)most sources are in a range of 0.4–*** feature could be intrinsic and may be applied in,for example,study of the intragalactic *** also determine the turning points for the sources showing the RSWB pattern,after which the color changes saturate and become *** find a correlation between optical fluxes and γ-ray fluxes at the turning *** physical implications of the correlation remain to be investigated,probably better with a sample of high-qualityγ-ray flux measurements.

关键词： (galaxies:)BL Lacertae objects:general (galaxies:)quasars:general gamma-rays:galaxies

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Gut microbiota and female health

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World Journal of Gastroenterology 2024年第12期30卷 1655-1662页

作者： Meng-Yao Wang Li-Xuan Sang si-Yu sun Department of Gastroenterology Shengjing Hospital of China Medical UniversityShenyang 110022Liaoning ProvinceChina Department of Gastroenterology Endoscopic CenterEngineering Research Center of Ministry of Education for Minimally Invasive Gastrointestinal Endoscopic TechniquesShengjing Hospital of China Medical UniversityShenyang 110004Liaoning ProvinceChina

The gut microbiota is recognized as an endocrine organ with the capacity to influence distant organs and associated biological *** advan-cements underscore the critical role of gut microbial homeostasis in female health;with dysbiosis potentially leading to diseases among women such as polycystic ovarian syndrome,endometriosis,breast cancer,cervical cancer,and ovarian cancer *** this,there has been limited discussion on the underlying *** editorial explores the three potential mechanisms through which gut microbiota dysbiosis may impact the development of diseases among women,namely,the immune system,the gut microbiota-estrogen axis,and the metabolite *** focused on approaches for treating diseases in women by addressing gut microbiota imbalances through probiotics,prebiotics supple-mentation,and fecal microbiota transplantation(FMT).Future studies should focus on determining the molecular mechanisms underlying associations between dysbiosis of gut microbiota and female diseases to realize precision medicine,with FMT emerging as a promising intervention.

关键词： Gut microbiota Female health Estrogen Polycystic ovarian syndrome Endometriosis

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Advances in endoscopic diagnosis and management of colorectal cancer

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World Journal of Gastrointestinal Oncology 2024年第10期16卷 4045-4051页

作者： Shi-Wei Li Xiang Liu si-Yu sun Department of Gastroenterology Shengjing Hospital of China Medical UniversityShenyang 110004Liaoning ProvinceChina Engineering Research Center of Ministry of Education for Minimally Invasive Gastrointestinal Endoscopic Techniques Shengjing Hospital of China Medical UniversityShenyang 110004Liaoning ProvinceChina

Colorectal cancer(CRC)is a leading global health concern,and early identification and precise prognosis play a vital role in enhancing patient *** is a minimally invasive imaging technique that is crucial for the screening,diagnosis,and treatment of *** editorial discusses the importance of advances in endoscopic techniques,the integration of artificial intelligence,and the potential of novel technologies in enhancing the diagnosis and management of CRC.

关键词： Colorectal cancer Endoscopic diagnosis Endoscopic management Artificial intelligence Endoscopic devices

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Muscle strength and non-alcoholic fatty liver disease/metabolicassociated fatty liver disease

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World Journal of Gastroenterology 2024年第7期30卷 636-643页

作者： Xuan-Yu Hao Kai Zhang Xing-Yong Huang Fei Yang si-Yu sun Department of Gastroenterology Endoscopic CenterShengjing Hospital of China Medical UniversityShenyang 110004Liaoning ProvinceChina Department of Gastroenterology Endoscopic CenterEngineering Research Center of Ministry of Education for Minimally Invasive Gastrointestinal Endoscopic TechniquesShengjing Hospital of China Medical UniversityShenyang 110004Liaoning ProvinceChina

This editorial comments on an article published in a recent issue of World Journal of Gastroenterology,entitled“Association of low muscle strength with metabolic dysfunction-associated fatty liver disease:A nationwide study”.We focused on the association between muscle strength and the incidence of non-alcoholic fatty liver disease(NAFLD)and metabolic-associated fatty liver disease(MAFLD),as well as the mechanisms underlying the correlation and related clinical ***,which is now redefined as MAFLD,is one of the most common chronic liver diseases globally with an increasing prevalence and is characterized by malnutrition,which may contribute to decreased muscle *** of muscle strength reportedly has a pathogenesis similar to that of NAFLD/MAFLD,including insulin resistance,inflammation,sedentary behavior,as well as insufficient vitamin *** studies have focused on the relationship between sarcopenia or muscle strength and ***,studies investigating the relationship between muscle strength and MAFLD are *** to the shortage of specific medications for NAFLD/MAFLD treatment,early detection is ***,the relationship between muscle strength and NAFLD/MAFLD suggests that improvements in muscle strength may have an impact on disease prevention and may provide novel insights into treatments including dietary therapy,as well as tailored physical activity.

关键词： Muscle strength Non-alcoholic fatty liver disease Metabolic-associated fatty liver disease Sarcopenia Insulin resistance Inflammation

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Role of albumin-bilirubin score in non-malignant liver disease

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World Journal of Gastroenterology 2024年第9期30卷 999-1004页

作者： Shi-Xue Xu Fan Yang Nan Ge Jin-Tao Guo si-Yu sun Department of Gastroenterology Engineering Research Center of Ministry of Education for Minimally Invasive Gastrointestinal Endoscopic TechniquesShengjing Hospital of China Medical UniversityShenyang 110004Liaoning ProvinceChina

The albumin-bilirubin(ALBI)score,which was proposed to assess the prognosis of patients with hepatocellular carcinoma,has gradually been extended to other liver diseases in recent years,including primary biliary cholangitis,liver cirrhosis,hepatitis,liver transplantation,and liver *** ALBI score is often compared with classical scores such as the Child-Pugh and model for end-stage liver disease scores or other noninvasive prediction *** is widely employed because of its immunity to subjective evaluation indicators and ease of obtaining detection *** increasing number of studies have confirmed that it is highly accurate for assessing the prognosis of patients with chronic liver disease;additionally,it has demonstrated good predictive performance for outcomes beyond survival in patients with liver diseases,such as decompensation *** article presents a review of the application of ALBI scores in various non-malignant liver diseases.

关键词： Albumin-bilirubin score Liver cirrhosis Primary biliary cholangitis Hepatitis Liver transplantation Liver injury

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Characteristics of life-cycle carbon dioxide emissions of arterial highway maintenance and the influencing factors

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Advances in Climate Change Research 2024年第4期15卷 751-765页

作者： Yao WANG Yuan-Qing WANG Shu-Juan JI si-Jia sun Shu-Hong MA Ya-Nan GAO Key Laboratory of Transport Industry of Management Control and Cycle Repair Technology for Traffic Network Facilities in Ecological Security Barrier Area Chang'an UniversityXi'an 710064China Guangzhou Aids to Navigation Office Southem Navigation Service CenterMaritime Safety AdministrationGuangzhou 51000China

With the focus of highway development transitioning from construction to maintenance,a comprehensive understanding of the characteristics and influencing factors of carbon dioxide(CO_(2))emissions from highway maintenance activities is crucial for formulating effective strategies to promote the low-carbon development of road ***,the quantitative relationships between CO_(2) emissions from highway maintenance schemes and factors such as pavement deterioration,traffic volume,and road grade remain unclear owing to a lack of compre-hensive,multi-category,and real *** real maintenance data from 340 arterial highway segments in China,this study conducts the life cycle assessment(LCA)to estimate CO_(2) emissions from maintenance activities and examines the primary emission sources among various structural layers and ***,multiple linear regression(MLR)analysis is conducted to investigate the impact of traffic volume,road grade,and pavement deterioration on CO_(2) emissions from maintenance projects,and factors influencing the early-stage degradation of pavement *** results demonstrate that average CO_(2) emissions from heavy rehabilitation projects are 6.97 times higher than those from medium rehabilitation *** from heavy rehabilitation projects exhibit a significantly negative linear relationship with the riding quality index(RQI)before maintenance(psions from medium rehabilitation projects show a significant negative linear relationship with the pavement condition index(PCI)before maintenance(psions from heavy and medium rehabilitation projects are significantly positively correlated with heavy vehicle traffic volume before maintenance(psignificantly negative linear relationships with their respective in-dicators before maintenance(p<0.05).The early-stage d

关键词： Life cycle assessment(LCA) Arterial highway Maintenance Emission factor Pavement performance Traffic volume

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From macroautophagy to mitophagy:Unveiling the hidden role of mitophagy in gastrointestinal disorders

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World Journal of Gastroenterology 2024年第23期30卷 2934-2946页

作者： Duo-Lun Gao Meng-Ran Lin Nan Ge Jin-Tao Guo Fan Yang si-Yu sun Department of Gastroenterology Engineering Research Center of Ministry of Education for Minimally Invasive Gastrointestinal Endoscopic TechniquesShengjing Hospital of China Medical UniversityShenyang 110004Liaoning ProvinceChina

In this editorial,we comment on an article titled“Morphological and biochemical characteristics associated with autophagy in gastrointestinal diseases”,which was published in a recent issue of the World Journal of *** focused on the statement that“autophagy is closely related to the digestion,secretion,and regeneration of gastrointestinal cells”.With advancing research,autophagy,and particularly the pivotal role of the macroautophagy in maintaining cellular equilibrium and stress response in the gastrointestinal system,has garnered extensive ***,the significance of mitophagy,a unique selective autophagy pathway with ubiquitin-dependent and independent variants,should not be *** recent decades,mitophagy has been shown to be closely related to the occurrence and development of gastrointestinal diseases,especially inflammatory bowel disease,gastric cancer,and colorectal *** interplay between mitophagy and mitochondrial quality control is crucial for elucidating disease mechanisms,as well as for the development of novel treatment *** the pathogenesis behind gastrointestinal diseases and providing individualized and efficient treatment for patients are subjects we have been *** article reviews the potential mechanism of mitophagy in gastrointestinal diseases with the hope of providing new ideas for diagnosis and treatment.

关键词： Mitophagy Gastrointestinal diseases Parkin Autophagic receptor Colorectal cancer Gastric cancer Inflammatory bowel disease

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各向异性界面动力学对深胞晶生长形态稳定性的影响

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物理学报 2024年第11期73卷 325-335页

作者：孙思杰蒋晗桂林电子科技大学数学与计算科学学院桂林541004

本文采用匹配渐近法和多重变量法,基于深胞晶生长的定常解,在考虑了各向异性界面动力学后,导出胞晶界面扰动振幅变化率满足的色散关系式及界面形态满足的量子化条件,研究在各向异性界面动力学的影响下定向凝固过程中深胞晶生长界面形态... 详细信息

本文采用匹配渐近法和多重变量法,基于深胞晶生长的定常解,在考虑了各向异性界面动力学后,导出胞晶界面扰动振幅变化率满足的色散关系式及界面形态满足的量子化条件,研究在各向异性界面动力学的影响下定向凝固过程中深胞晶生长界面形态的稳定性.结果表明,考虑了各向异性界面动力学的深胞晶体生长的定向凝固系统包含两种整体不稳定机制:整体振荡不稳定机制和低频不稳定机制.通过稳定性分析发现,低阶近似下各向异性界面动力学对整体振荡不稳定机制有着显著影响,随着各向异性界面动力学参数的增大,中性模式产生强振荡的枝晶结构的整体振荡不稳定区域减小.同时,界面动力学各向异性参数对系统整体波动不稳定性的影响随着界面动力学参数的增大而增大.

关键词：深胞晶生长界面动力学稳定性

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Manganese oxide and derivative-modified materials in advanced oxidation processes:A review of modification enhancement and activation mechanisms

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Chinese Chemical Letters 2024年第3期35卷 40-51页

作者： si sun Shuang Song Shuai Yang Yong-Li He Yang Shi Peng Zhou Zhao-kun Xiong Yang Liu Heng Zhang Ye Du Chuan-Shu He Bo Lai State Key Laboratory of Hydraulics and Mountain River Engineering College of Architecture and EnvironmentSichuan UniversityChengdu 610065China sino-German Centre for Water and Health Research Sichuan UniversityChengdu 610065China Institute of Fundamental and Frontier Sciences University of Electronic Science and Technology of ChinaSichuanChengdu 610054China

Manganese oxides(MNO_(x)),as low-toxicity and high-abundance catalysts,have been demonstrated to hold great promise for application in advanced oxidation processes(AOPs).However,further application of this material is restricted due to its unsatisfactory oxidant activation ***,recently remarkable research on deep activation mechanisms and modification of MNO_(x)have been undertaken to improve its ***,modification enhancement mechanisms of MNO_(x)to efficiently degrade various organic contaminants were discussed and highlighted,including metal doping,coupling with other metal oxides,composite with carbonaceous material,and compounding with other *** activation mechanisms of different MNO_(x)and derivative-modified material(such as doped MNO_(x),metal oxide-MNO_(x)hybrids,and MNO_(x)-carbonaceous material hybrids)were summarized in great details,which was specifically categorized into both radical and non-radical *** effects of pH,inorganic ions,and natural organic matter on degradation reactions are also ***,future research directions and perspectives are presented to provide a clear interpretation on the MNO_(x)initiated AOPs.

关键词： Manganese oxide Derivative-modified materials Modification enhancement mechanisms Advanced oxidation process Activation mechanism

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