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Electroacupuncture Promotes Angiogenesis in Mice with Cerebral Ischemia by Inhibiting miR-7

Chinese Journal of Integrative Medicine 2024年第6期30卷 543-550页

作者： YU Qian shu Shi JU Xin-yao PENG Wei REN Xue-qi si shu-han SONG Shi-zhen XIE Xue-yun FANG Bang-jiang ZHOU shuang School of Acupuncture-Moxibustion and Tuina Shanghai University of Traditional Chinese MedicineShanghai201203China College of Basic Medicine Shanghai University of Traditional Chinese MedicineShanghai201203China Department of Emergency Longhua HospitalShanghai University of Traditional Chinese MedicineShanghai200032China

Objective To observe the angiogenesis effect of electroacupuncture(EA)at shuigou acupoint(GV 26)in the treatment of cerebral ischemia,and explore the value of miRNA-7(miR-7)in *** First,48 mice were randomly divided into sham operation,middle cerebral artery occlusion(MCAO)model,and EA treatment *** 9 mice were divided into carrier control group,miR-7 knockout group and miR-7 overexpression group(n=3 each group).Finally,20 mice were divided into model and carrier control group,model and miR-7 knockout group,EA treatment and carrier control group and EA treatment and miR-7 overexpression group,with 3–6 mice in each *** MCAO model was established in the MCAO and EA *** deficit score and 2,3,5-triphenyltetrazolium chloride(TTC)staining were used to evaluate the severity of cerebral ***-eosin staining was used to describe basic pathological *** was used to quantify cerebral microvessel ***-time PCR and Western blot were used to detect the expression of miR-7 and its downstream target genes Krüppel-like factor 4/vascular endothelial growth factor(KLF4/VEGF)and angiopoietin-2(ANG-2)in the ischemic cerebral *** After EA,neurological deficit scores and infarction volumes decreased,and the density of cerebral microvessels *** the MCAO group,miR-7 expression was higher than that in the sham group(Psion decreased(Psion of downstream target genes KLF4/VEGF and ANG-2 increased as compared with the MCAO group(Psion of miR-7,the expression of downstream target genes KLF4/VEGF and ANG-2 decreased compared to the control EA group(Psion of KLF4/VEGF and ANG-2 increased(Psions EA could promote angiogenesis in MCAO mice likely by inhibiting the expression of miR-7 and relieving inhibition of downstream target genes KLF4/VEG

关键词： electroacupuncture cerebral ischemia miRNA-7 angiogenesis shuigou(GV 26) acupuncture points

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电针调控miR-142-5p和ADAMTS1/PI3K/AKT通路促进缺血性脑卒中大鼠血管新生的机制研究

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针刺研究 2024年第8期49卷 787-796页

作者：司书晗宋世禛解雪云章婷婷蒉潇飞杨晓晖周爽上海中医药大学针灸推拿学院上海201203

目的:观察电针对缺血性脑卒中大鼠miR-142-5p及ADAMTS1/磷脂酰肌醇-3激酶(PI3K)/丝氨酸-苏氨酸蛋白激酶(AKT)通路的影响,探讨电针对缺血性脑卒中后血管新生的调控机制。方法:本研究分为两部分实验。第一部分实验:将SD大鼠随机分为假手... 详细信息

目的:观察电针对缺血性脑卒中大鼠miR-142-5p及ADAMTS1/磷脂酰肌醇-3激酶(PI3K)/丝氨酸-苏氨酸蛋白激酶(AKT)通路的影响,探讨电针对缺血性脑卒中后血管新生的调控机制。方法:本研究分为两部分实验。第一部分实验:将SD大鼠随机分为假手术组、模型组、电针组,每组20只。采用改良的Longa法制备大脑中动脉栓塞大鼠模型。电针组于“水沟”进行电针干预(4 Hz/20 Hz),30 min/次,造模成功后即时干预1次,以后每日1次,共4次。采用亨氏评分法评价造模后大鼠神经功能缺损程度;TTC染色法检测大鼠脑梗死体积;HE染色法观察大鼠大脑皮层的病理改变;免疫组织化学法测定脑微血管密度(MVD);实时荧光定量PCR法和Western blot法检测大鼠大脑皮层缺血半暗带的miR-142-5p及ADAMTS1/PI3K/AKT通路中ADAMTS1、血管内皮生长因子(VEGF)、PI3K、AKT、内皮型一氧化氮合酶(eNOS)mRNA和蛋白表达水平。第二部分实验:将同批次SD大鼠随机分为电针+对照组、电针+miR-142-5p Antagomir(拮抗剂)组,每组8只。电针+对照组给予右侧侧脑室注射0.9%氯化钠溶液,电针+拮抗剂组大鼠造模前30 min给予右侧侧脑室注射miR-142-5p拮抗剂,大鼠注射后进行造模,电针+对照组、电针+拮抗剂组均给予上述同样的电针治疗。实时荧光定量PCR法和Western blot法检测两组大鼠大脑皮层miR-142-5p、ADAMTS1 mRNA及蛋白表达。结果:与假手术组比较,模型组大鼠神经缺损体征评分升高(P<0.01),脑梗死体积增加(P<0.01),脑组织水肿及神经元坏死程度增加,MVD升高(P<0.01),miR-142-5p表达水平及VEGF、AKT、eNOS mRNA表达水平均降低(P<0.01,P<0.05),VEGF、磷酸化(p)-AKT、eNOS蛋白表达水平均降低(P<0.01),ADAMTS1、PI3K mRNA及ADAMTS1、p-PI3K蛋白表达水平均升高(P<0.01,P<0.05)。与模型组比较,电针组大鼠神经缺损体征评分降低(P<0.01),脑梗死体积缩小(P<0.01),脑组织水肿及神经元坏死程度减轻,MVD升高(P<0.01),miR-142-5p及VEGF、PI3K、AKT、eNOS mRNA的表达水平升高(P<0.01),VEGF、p-PI3K、p-AKT、eNOS蛋白表达水平均升高(P<0.01,P<0.05),ADAMTS1 mRNA及蛋白表达水平降低(P<0.05,P<0.01)。注射miR-142-5p拮抗剂后,与电针+对照组比较,电针+拮抗剂组miR-142-5p表达水平降低(P<0.05),ADAMTS1 mRNA及蛋白表达水平升高(P<0.01,P<0.05)。结论:电针“水沟”可改善缺血性脑卒中大鼠的神经功能损伤,减少脑梗死体积,促进血管新生,其机制可能是通过促进miR-142-5p表达抑制其靶基因ADAMTS1的表达,上调VEGF表达,从而进一步激活PI3K/AKT通路,促进eNOS释放,促进缺血性脑卒中大鼠脑血管新生。

关键词：缺血性脑卒中电针大脑中动脉栓塞 miR-142-5p ADAMTS1/PI3K/AKT通路

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非编码RNA与缺血性脑卒中研究进展

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医学信息 2024年第2期37卷 168-171+181页

作者：司书晗解雪云俞倩宋世禛周爽上海中医药大学针灸推拿学院

脑卒中是由多种因素引起的一种急性脑循环障碍疾病，其中以缺血性脑卒中最常见。非编码RNA(ncRNAs)是一类不具有蛋白编码功能的RNA，在缺血性脑卒中的发生发展中具有重要的调控作用。近年来ncRNAs成为研究的热点，已有不少研究证实与缺... 详细信息

脑卒中是由多种因素引起的一种急性脑循环障碍疾病，其中以缺血性脑卒中最常见。非编码RNA(ncRNAs)是一类不具有蛋白编码功能的RNA，在缺血性脑卒中的发生发展中具有重要的调控作用。近年来ncRNAs成为研究的热点，已有不少研究证实与缺血性脑卒中的病理生理的密切相关。本文主要从微小miRNA(miRNA)、长链非编码RNA(lncRNA)、环状RNA(circRNA)及竞争性内源RNA(ceRNA)调控网络研究进行综述，为缺血性脑卒中的防治提供新的思路。

关键词：缺血性脑卒中非编码RNA 微小RNA 长链非编码RNA 环状RNA 竞争性内源性RNA

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Mechanisms of myeloid-derived suppressor cell-mediated immunosuppression in colorectal cancer and related therapies

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World Journal of Gastrointestinal Oncology 2024年第5期16卷 1690-1704页

作者： shu-Chang Nie Yan-Hua Jing Lu Lu si-si Ren Guang Ji han-Chen Xu Institute of Digestive Diseases Longhua HospitalChina-Canada Center of Research for Digestive DiseasesShanghai University of Traditional Chinese MedicineShanghai 200032China Shanghai Frontiers Science Center of Disease and Syndrome Biology of Inflammatory Cancer Transformation Shanghai 200032China State Key Laboratory of Integration and Innovation of Classic Formula and Modern Chinese Medicine(Shanghai University of Traditional Chinese Medicine) Shanghai 200032China

Severe immunosuppression is a hallmark of colorectal cancer(CRC).Myeloid-derived suppressor cells(MDSCs),one of the most abundant components of the tumor stroma,play an important role in the invasion,metastasis,and immune escape of *** create an immunosuppressive microenvironment by inhibiting the proliferation and activation of immunoreactive cells,including T and natural killer cells,as well as by inducing the proliferation of immunosuppressive cells,such as regulatory T cells and tumor-associated macrophages,which,in turn,promote the growth of cancer ***,MDSCs are key contributors to the emergence of an immunosup-pressive microenvironment in CRC and play an important role in the breakdown of antitumor *** this narrative review,we explore the mechanisms through which MDSCs contribute to the immunosuppressive microenvironment,the current therapeutic approaches and technologies targeting MDSCs,and the therapeutic potential of modulating MDSCs in CRC *** study provides ideas and methods to enhance survival rates in patients with CRC.

关键词： Myeloid-derived suppressor cells Tumor microenvironment Colorectal cancer Therapy Immunosuppression

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Molecular dynamics study of hydrogen-induced cracking behavior of ferrite–pearlite gas transmission pipeline steel

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Journal of Iron and Steel Research International 2024年第2期31卷 488-500页

作者： Tao-long Xu si-han Guo Gong-zhen He Hao-yu han Petroleum Engineering School Southwest Petroleum UniversityChengdu610500SichuanChina sichuan East Gas Transmission Sales Center of sinopec Natural Gas Branch Wuhan430074HubeiChina

Hydrogen embrittlement of pipelines depends on the hydrogen-induced cracking behavior of the pipeline steel *** on molecular dynamics analysis,the ferrite–cementite(α-Fe/Fe3C)lamellar atomic structure with the Bagaryatskii orientation relationship was established,and stepwise relaxation of the conjugate gradient energy minimization and constant-temperature and constant-pressure relaxation were performed under NPT(the isothermal–isobaric)*** mechanical property curves of theα-Fe/Fe3C models were obtained under different cementite terminal plane structures,and the evolution of the atomic structure was analyzed in *** addition,the influence of different hydrogen concentrations,different temperatures,different strain rates,changes in voids,and different micro-degrees of freedom on the deformation and failure mechanism of the model was investigated,aiming to provide a reliable way to explore the micro-mechanism of macro-cracking behavior of pipeline steel.

关键词： Ferrite-cementite lamellar structure Pipeline steel Failure mechanism Crack propagation Molecular dynamics

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Automated identification of steel weld defects,a convolutional neural network improved machine learning approach

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Frontiers of Structural and Civil Engineering 2024年第2期18卷 294-308页

作者： Zhan shu Ao WU Yuning si hanlin DONG Dejiang WANG Yifan LI School of Mechanics and Engineering Science Shanghai UniversityShanghai 200444China School of Civil Engineering Shanghai Normal UniversityShanghai 201418China Shanghai PinlanData Technology Co. Ltd.Shanghai 200072China

This paper proposes a machine-learning-based methodology to automatically classify different types of steel weld defects,including lack of the fusion,porosity,slag inclusion,and the qualified(no defects)*** methodology solves the shortcomings of existing detection methods,such as expensive equipment,complicated operation and inability to detect internal *** study first collected percussed data from welded steel members with or without weld ***,three methods,the Mel frequency cepstral coefficients,short-time Fourier transform(STFT),and continuous wavelet transform were implemented and compared to explore the most appropriate features for classification of weld *** and convolutional neural network-enhanced algorithms were used to classify,the extracted ***,experiments were designed and performed to validate the proposed *** showed that STFT achieved higher accuracies(up to 96.63%on average)in the weld status *** convolutional neural network-enhanced support vector machine(SVM)outperformed six other algorithms with an average accuracy of 95.8%.In addition,random forest and SVM were efficient approaches with a balanced trade-off between the accuracies and the computational efforts.

关键词： steel weld machine learning convolutional neural network weld defect detection classification task percussion

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Atomically Substitutional Engineering of Transition Metal Dichalcogenide Layers for Enhancing Tailored Properties and Superior Applications

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Nano-Micro Letters 2024年第5期16卷 248-284页

作者： Zhaosu Liu si Yin Tee Guijian Guan Ming‑Yong han Institute of Molecular Plus Tianjin UniversityTianjin 300072People’s Republic of China Institute of Materials Research and Engineering A*STARSingapore 138634Singapore

Transition metal dichalcogenides(TMDs)are a promising class of layered materials in the post-graphene era,with extensive research attention due to their diverse alternative elements and fascinating semiconductor *** MX2 layers with different metal and/or chalcogen elements have similar structural parameters but varied optoelectronic properties,providing opportunities for atomically substitutional engineering via partial alteration of metal or/and chalcogenide atoms to produce ternary or quaternary *** resulting multinary TMD layers still maintain structural integrity and homogeneity while achieving tunable(opto)electronic properties across a full range of composition with arbitrary ratios of introduced metal or chalcogen to original counterparts(0–100%).Atomic substitution in TMD layers offers new adjustable degrees of freedom for tailoring crystal phase,band alignment/structure,carrier density,and surface reactive activity,enabling novel and promising *** review comprehensively elaborates on atomically substitutional engineering in TMD layers,including theoretical foundations,synthetic strategies,tailored properties,and superior *** emerging type of ternary TMDs,Janus TMDs,is presented specifically to highlight their typical compounds,fabrication methods,and potential ***,opportunities and challenges for further development of multinary TMDs are envisioned to expedite the evolution of this pivotal field.

关键词： Transition metal dichalcogenides Atomic substitution Tailored structure Tunable bandgap Enhanced applications

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RFFsNet-SEI:a multidimensional balanced-RFFs deep neural network framework for specific emitter identification

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Journal of Systems Engineering and Electronics 2024年第3期35卷 558-574,F0002页

作者： FAN Rong si Chengke han Yi WAN Qun School of Information and Communication Engineering University of Electronic Science and Technology of ChinaChengdu 611731China Institute of Electronic and Electrical Engineering Civil Aviation Flight University of ChinaGuanghan 618307China

Existing specific emitter identification(SEI)methods based on hand-crafted features have drawbacks of losing feature information and involving multiple processing stages,which reduce the identification accuracy of emitters and complicate the procedures of *** this paper,we propose a deep SEI approach via multidimensional feature extraction for radio frequency fingerprints(RFFs),namely,***,we extract multidimensional physical RFFs from the received signal by virtue of variational mode decomposition(VMD)and Hilbert transform(HT).The physical RFFs and I-Q data are formed into the balanced-RFFs,which are then used to train *** introducing model-aided RFFs into neural network,the hybrid-driven scheme including physical features and I-Q data is *** improves physical interpretability of ***,since RFFsNet-SEI identifies individual of emitters from received raw data in end-to-end,it accelerates SEI implementation and simplifies procedures of ***,as the temporal features and spectral features of the received signal are both extracted by RFFsNet-SEI,identification accuracy is ***,we compare RFFsNet-SEI with the counterparts in terms of identification accuracy,computational complexity,and prediction *** results illustrate that the proposed method outperforms the counterparts on the basis of simulation dataset and real dataset collected in the anechoic chamber.

关键词： specific emitter identification(SEI) deep learning(DL) radio frequency fingerprint(RFF) multidimensional feature extraction(MFE) variational mode decomposition(VMD)

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Time-lagged Effects of the Spring Atmospheric Heat Source over the Tibetan Plateau on Summer Precipitation in Northeast China during 1961–2020:Role of Soil Moisture

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Advances in Atmospheric Sciences 2024年第8期41卷 1527-1538页

作者： Yizhe han Dabang JIANG Dong si Yaoming MA Weiqiang MA Institute of Atmospheric Physics Chinese Academy of SciencesBeijing 100029China National Institute of Natural Hazards Ministry of Emergency Management of ChinaBeijing 100085China State Key Laboratory of Tibetan Plateau Earth System Environment and Resources(TPESER)Institute of Tibetan Plateau ResearchChinese Academy of SciencesBeijing 100101China University of Chinese Academy of Sciences Beijing 100049China College of Atmospheric Sciences Lanzhou UniversityLanzhou 730000China National Observation and Research Station for Qomolongma Special Atmospheric Processes and Environmental Changes Dingri 858200China Kathmandu Center of Research and Education Chinese Academy of SciencesBeijing 100101China China-Pakistan Joint Research Center on Earth Sciences Chinese Academy of SciencesIslamabad 45320Pakistan

The spring atmospheric heat source(AHS)over the Tibetan Plateau(TP)has been suggested to affect the Asian summer monsoon and summer precipitation over South ***,its influence on the summer precipitation in Northeast China(NEC)remains *** connection between spring TP AHS and subsequent summer precipitation over NEC from 1961 to 2020 is analyzed in this *** illustrate that stronger spring TP AHS can enhance subsequent summer NEC precipitation,and higher soil moisture in the Yellow River Valley-North China region(YRVNC)acts as a *** spring,the strong TP AHS could strengthen the transportation of water vapor to East China and lead to excessive rainfall in the ***,soil moisture increases,which regulates local thermal conditions by decreasing local surface skin temperature and sensible *** to the memory of soil moisture,the lower spring sensible heat over the YRVNC can last until mid-summer,decrease the land–sea thermal contrast,and weaken the southerly winds over the East Asia–western Pacific region and convective activities over the South China Sea and tropical western *** modulates the East Asia–Pacific teleconnection pattern,which leads to a cyclonic anomaly and excessive summer precipitation over NEC.

关键词： Tibetan Plateau atmospheric heat source Northeast China summer precipitation soil moisture

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Resurgence of pertussis:reasons and coping strategies

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World Journal of Pediatrics 2024年第7期20卷 639-642页

作者： Chun-Zhen Hua han-Qing He Qiang shu Department of Infectious Diseases National Clinical Research Center for Child HealthChildren’s HospitalZhejiang University School of MedicineHangzhou310052China Department of Immunization Program Zhejiang Provincial Center for Disease Control and PreventionHangzhou310051China National Clinical Research Center for Child Health Children’s HospitalZhejiang University School of MedicineHangzhou310052China

Pertussis(whooping cough)is an acute and contagious respiratory disease caused by the pathogen Bordetella pertussis(***).*** can infect individuals of all *** with pertussis may experience severe and persistent coughing and paroxysms;for newborns and infants,pertussis may be *** development and widespread administration of the pertussis vaccine had once successfully brought pertussis under control,maintaining it at a low level for many ***,resurgence of pertussis has been reported in many countries even with high vaccination coverage *** resurgence of pertussis was first reported in the United States(USA)in 1993[1].During 2000–2016,the baseline incidence increased and the age distribution of pertussis changed in the USA[2].Other countries including Canada[3],Australia[4],European Union countries,and South Korea have also reported a rise in pertussis outbreaks[2,5].

关键词： pertussis Canada surge

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