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Human ESC-derived vascular cells promote vascular regeneration in a HIF-1α dependent manner

Protein & Cell 2024年第1期15卷 36-51页

作者： Jinghui Lei Xiaoyu Jiang Daoyuan Huang Ying Jing Shanshan yang Lingling Geng Yupeng yan Fangshuo Zheng Fang Cheng Weiqi Zhang Juan Carlos Izpisua Belmonte Guang-Hui Liu si Wang Jing Qu Advanced Innovation Center for Human Brain Protection National Clinical Research Center for Geriatric DisordersXuanwu Hospital Capital Medical UniversityBeijing 100053China State Key Laboratory of Membrane Biology Institute of ZoologyChinese Academy of SciencesBeijing 100101China State Key Laboratory of Stem Cell and Reproductive Biology Institute of ZoologyChinese Academy of SciencesBeijing 100101China Aging Translational Medicine Center Intermational Center for Aging and CancerBeijing Municipal Geriatric Medical Research CenterXuanwu HospitalCapital Medical UniversityBeijing 100053China University of Chinese Academy of Sciences Beijing 100049China Institute for Stem Cell and Regeneration CASBeijing 100101China The Fifth People's Hospital of Chongqing Chongqing 400062China Beijing Institute for Stem Cell and Regenerative Medicine Beijing 100101China National Laboratory of Biomacromolecules CAs Center for Excellence in BiomacromoleculesInstitute of BiophysicsBeijing 100101China CAS Key Laboratory of Genomic and Precision Medicine Beijing Institute of GenomicsChinese Academy of SciencesBeijing 100101China China National Center for Bioinformation Beijing 100101China sino-Danish College University of Chinese Academy of SciencesBeijing 101408China sino-Danish Center for Education and Research Beijing 101408China Aging Biomarker Consortium China Altos Labs San DiegoCA 92121United State

Hypoxia-inducible factor(HIF-1α),a core transcription factor responding to changes in cellular oxygen levels,is closely associated with a wide range of physiological and pathological ***,its differential impacts on vascular cell types and molecular programs modulating human vascular homeostasis and regeneration remain largely ***,we applied CRISPR/Cas9-mediated gene editing of human embryonic stem cells and directed differentiation to generate HIF-ia-deficient human vascular cells including vascular endothelial cells,vascular smooth muscle cells,and mesenchymal stem cells(MsCs),as a platform for discovering cell type-specific hypox-ia-induced response *** comparative molecular profiling across cell types under normoxic and hypoxic conditions,we provide insight into the indispensable role of HIF-1αin the promotion of ischemic vascular *** found human MSCs to be the vascular cell type most susceptible to HIF-1a deficiency,and that transcriptional inactivation of ANKZF1,an effector of HIF-1a,impaired pro-angiogenic ***,our findings deepen the understanding of HIF-ia in human angiogenesis and support further explorations of novel therapeutic strategies of vascular regeneration against ischemic damage.

关键词： HIF-1 human ESC vascular cell regeneration

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Adaptive admittance tracking control for interactive robot with prescribed performance

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Journal of Systems Engineering and Electronics 2024年第2期35卷 444-450页

作者： MENG Qingrui LIN yan School of Automation Science and Electrical Engineering Beihang UniversityBeijing 100190China College of Electrical Engineering and Automation Shandong University of Science and TechnologyQingdao 266590China

An adaptive control approach is presented in this paper for tracking desired trajectories in interactive manipulators. The controller design incorporates prescribed performance functions (PPFs) to improve dynamic performance. Notably, the performance of the output error is confined in an envelope characterized by exponential convergence, leading to convergence to zero. This feature ensures a prompt response from admittance control and establishes a reliable safety framework for interactions. simulation results provide practical insights,demonstrating the viability of the control scheme proposed in this paper.

关键词： prescribed performance admittance control adaptive control robots

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Rational surface charge engineering of haloalkane dehalogenase for boosting the enzymatic performance in organic solvent solutions

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Chinese Journal of Chemical Engineering 2024年第1期65卷 276-285页

作者： Yin Wu yan Sun Department of Biochemical Engineering School of Chemical Engineering and Technology and Key Laboratory of Systems Bioengineering and Frontiers Science Center for Synthetic Biology(Ministry of Education)Tianjin UniversityTianjin 300350China

Biocatalysis in organic solvents(OSs)has numerous important applications,but native enzymes in OSs often exhibit limited catalytic ***,we proposed a computation-aided surface charge engineering strategy to improve the catalytic performance of haloalkane dehalogenase DhaA in OSs based on the energetic analysis of substrate binding to the DhaA *** variants with enhanced OS resistance were obtained by replacing negative charged residues on the surface with positive charged residue(Arg).Particularly,a four-substitution variant E16R/E93R/E121R/E257R exhibited the best catalytic performance(five-fold improvement in OS resistance and seven-fold half-life increase in 40%(vol)dimethylsulfoxide).As a result,the overall catalytic performance of the variant could be at least 26 times higher than the wild-type *** spectroscopy and molecular dynamics simulation studies revealed that the residue substitution mainly enhanced OS resistance from four aspects:(a)improved the overall structural stability,(b)increased the hydrophobicity of the local microenvironment around the catalytic triad,(c)enriched the hydrophobic substrate around the enzyme molecule,and(d)lowered the contact frequency between OS molecules and the catalytic *** findings validate that computationaided surface charge engineering is an effective and ingenious rational strategy for tailoring enzyme performance in OSs.

关键词： Surface charge engineering Organic solvent resistance Molecular dynamics simulation Haloalkane dehalogenase

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Ultra-flexible all-in-one anti-freeze photothermally enhanced supercapacitors

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Nano Research 2024年第8期17卷 7221-7229页

作者： Yongxin Lu Keke Li yan-yan Song Zhida Gao Condense matter of physics College of ScienceNortheazistern UniversityShenyang 110004China

Wearable electronics powered by flexible energy storage devices have captured global *** low-temperature conditions,unfortunately,solidification of flexible hydrogel electrolyte and decreased pseudo-capacity of these devices largely hamper their practical *** this study,photothermally-active Prussian blue(PB)was introduced onto poly(3,4-ethylenedioxythiophene)/polyacrylamide(PEDOT/PAM)networks to address the challenges of electrolyte solidification and degraded pseudo-capacitance for flexible all-in-one device at low *** as-constructed PB/PEDOT/PAM hydrogel device delivers stable electrochemical performance and remarkable mechanical property with 1652%***,this hydrogel device well retains its flexibility in cold environment with a freezing point below−30℃.The incorporation of PB extends the voltage range to 1.5 V as a single device,thus significantly enhancing the electrochemical performance as an all-inone integrated *** from the outstanding photo-to-thermal conversion ability of embedded PB nanocubes,the temperature of the assembled all-in-one PB/PEDOT/PAM device increased from^(−2)0 to 17.7℃ after solar-light irradiation for only 5 ***,the degraded pseudo-capacitance was subsequently boosted to 287.1%of its original capacitance at−20℃.This study establishes a connection between flexible all-solid-state hydrogel devices and photothermally enhanced pseudocapacitors in freezing environments,thereby expanding the potential applications of multi-functional pseudo-capacitors.

关键词： all-in-one energy storage devices all-solid-state photothermal flexible low temperatures

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Direct conversion of CO and H_(2)O to hydrocarbons at atmospheric pressure using a TiO_(2-x)/Ni photothermal catalyst

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Science China Materials 2024年第3期67卷 1009-1010页

作者： yan Zhu School of Chemistry and Chemical Engineering Nanjing UniversityNanjing 210093China

Generating high-value chemical compounds by catalytically converting carbon resources—typically derived from coal and biomass, etc.—is crucial. It is more meaningful to achieve“carbon neutrality” and lower production costs by utilizing industrial waste carbon sources, such as steel mill waste gases,which are typically intended for direct emission or burning into CO_(2).

关键词： typically utilizing meaningful

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Numerical Investigation on Characteristics of Supercritical CO_(2)Heat Transfer in Vertical Circular Tubes with Circumferentially Half-side Heating

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Journal of Thermal Science 2024年第5期33卷 1744-1756页

作者： ZHANG yan ZHANG Xinyi yan Chenshuai WU Wenhua GAO Erman School of Energy and Power Engineering Northeast Electric Power UniversityJilin 132012China

The design of heat exchangers in the advanced supercritical power conversion system cannot be separated from the study of heat transfer ***-side heating mode is often encountered for solar receiver and supercritical ***,the characteristics of supercritical CO_(2)(sCO_(2))convection heat transfer in vertical tubes with circumferentially half-side heating was numerically investigated through the SST k-ωturbulent model which matches well with the experimental ***,heat transfer between sCO_(2)upflow and downflow was *** to film boiling heat transfer at subcritical pressure,numerical results were processed according to the supercritical pseudo-phase transition hypothesis,with liquid-like phase in the tube core region and vapor-like film in the region near the heated tube *** structure of two layers was demarcated by pseudo-critical temperature T_(pc).Therefore,sCO_(2)heat transfer was assessed according to double thermal resistances caused by vapor-like film near the wall and core liquid-like *** findings suggest that wall temperature for upflow is higher than that for downflow,which is attributed to larger thermal resistance in the fluid domain for upflow than that for *** difference guarantees the excellent heat transfer performance for downflow than *** is also further concluded that the formation of vapor-like film near the wall due to pseudo-phase transition plays a key role in dominating wall temperature and inducing heat transfer deterioration in half-side heating *** present contribution is significant to the design of supercritical heat exchanger under half-side heating mode.

关键词： supercritical CO_(2) pseudo-phase transition half-side heating thermal resistance flow direction

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二氧化碳自由基负离子在有机合成中的应用

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Science Bulletin 2023年第24期68卷 3124-3128页

作者：贵永远颜思顺王伟陈林章炜叶剑衡余达刚 College of Chemistry and Materials Science Sichuan Normal UniversityChengdu 610068China Key Laboratory of Green Chemistry&Technology of Ministry of Education College of ChemistrySichuan UniversityChengdu 610064China Leibniz Institute for Catalysis e.V. University of RostockRostock 18059Germany West China School of Public Health and West China Fourth Hospital Sichuan UniversityChengdu 610041China

The progress of modern chemistry heavily relies on the profound comprehension and sophisticated manipulation of reactive intermediates,such as carbanions,carbocations,radicals,and *** of these species possesses a distinct pattern of reactivity,which contributes significantly to the advancements of modern *** this context,the exploration and application of the carbon dioxide radical anion(CO_(2)^(·-))in organic synthesis have garnered significant interest from both the academia and industry.

关键词： chemistry dioxide reactivity

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On the core entropy of Newton maps

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Science China Mathematics 2024年第1期67卷 77-128页

作者： yan Gao Department of Mathematics Shenzhen UniversityShenzhen 518060China

In this paper,we define the core entropy for postcritically-finite Newton maps and study its continuity within this *** show that the entropy function is not continuous in this family,which is different from the polyn... 详细信息

关键词： core entropy extended Newton graph critical marking polynomial Newton map

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Jianqu,a traditional Chinese medicine,alleviates functional dyspepsia in high-calorie and high-protein diet mice

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Traditional Medicine Research 2024年第6期9卷 42-54页

作者： Jing-yan yang Xiao-Xing Li Juan Chen yan-Jun Liu Yue-Hong Wu Ning-Yu Luo Cai-Xia yang yang Li si-Jing Liu Jin-Lin Guo College of Medical Technology Chengdu University of Traditional Chinese MedicineChengdu 611137China Chongqing Key Laboratory of sichuan-Chongqing Co-construction for Diagnosis and Treatment of Infectious Diseases Integrated Traditional Chinese and Western Medicine Chengdu 611137China Key Laboratory of Characteristic Chinese Medicine Resources in Southwest China College of PharmacyChengdu University of Traditional Chinese MedicineChengdu 611137China

Background:Jianqu has been used to alleviate symptoms in patients with functional dyspepsia,but its specific anti-functional dyspepsia effect is still ***,our study aimed to investigate the impact of Jianqu on functional dyspepsia in ***:The phytochemical profile of Jianqu was analyzed by ***,Kunming mice were fed a high-calorie or high-protein diet(HCHP)for 7 days,and then orally treated with vehicle or Jianqu(1.62 g/kg body weight(b.w.)and 3.25 g/kg b.w.)for 10 days.A carbon powder solution was used to detect the gastric emptying and intestinal transit *** pathological changes in stomach and duodenum were evaluated by hematoxylin-eosin *** occludin,claudin-1,ZO-1 and CD45 expression was measured by immunocytochemical ***,the serum gastrointestinal hormones were detected by *** addition,the gut microbiota composition was determined using 16S rRNA gene *** cecal short chain fatty acids were assessed by gas ***:In general,17 phytochemical compounds were identified from Jianqu,which significantly improved the gastric emptying rate and intestinal transit rate(psignificant pathological lesions in the gastrointestinal tract,increased the expression of CD45 in the duodenum(psion of CD45(psignificantly normalized by Jianqu intervention(psion:The present results showed that Jianqu alleviated dyspeptic symptoms in HCHP mice possibly through reducing the duodenal leukocyte infiltration,and regulating the expression of gastrointestinal *** effects may be partly related to the increasing cecal short ch

关键词： herbal formula dyspepsia gastrointestinal hormones gastric emptying intestinal transit

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Individual virome analysis reveals the general co-infection of mammal-associated viruses with SARS-related coronaviruses in bats

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Virologica sinica 2024年第4期39卷 565-573页

作者： Hao-Rui si Ke Wu Jia Su Tian-Yi Dong yan Zhu Bei Li Ying Chen yang Li Zheng-Li Shi Peng Zhou Wuhan Institute of Virology Chinese Academy of SciencesWuhan 43000China Guangzhou National Laboratory Guangzhou International Bio IslandGuangzhou 510005China University of Chinese Academy of Sciences Beijing 100000China State Key Laboratory of Respiratory Disease The First Affiliated Hospital of Guangzhou Medical SchoolGuangzhou 510005China

Bats are the natural reservoir hosts for SARS-related coronavirus(SARSr-CoV)and other highly pathogenic ***,it is conceivable that an individual bat may harbor multiple ***,there is limited knowledge on the overall co-circulation of microorganisms in ***,we conducted a 16-year monitoring of bat viruses in south and central China and identified 238 SARSr-CoV positive samples across nine bat species from ten provinces or administrative *** these,76 individual samples were selected for further metagenomics *** found a complex microenvironment characterized by the general cocirculation of microbes from two different sources:mammal-associated viruses or environment-associated *** later includes commensal bacteria,enterobacteria-related phages,and insect or fungal viruses of food *** showed that 25%(19/76)of the samples contained at least one another mammal-associated virus,notably alphacoronaviruses(13/76)such as AlphaCoV/YN2012,HKU2-related CoV and AlphaCoV/Rf-HuB2013,along with viruses from other ***,we observed three viruses co-circulating within a single bat,comprising two coronavirus species and one *** analysis also revealed the potential presence of pathogenic bacteria or fungi in ***,we obtained 25 viral genomes from the 76 bat SARSr-CoV positive samples,some of which formed new evolutionary ***,our study reveals the complex microenvironment of bat microbiome,facilitating deeper investigations into their pathogenic potential and the likelihood of cross-species transmission.

关键词： Bat Microbiome SARS-related coronavirus Co-infection Alphacoronavirus

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