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Analytics of an Imperfect Four-Layer Production Inventory Model Under Two-Level Credit Period Using Branch-and-Bound Technique

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Journal of the Operations Research Society of China 2022年第4期10卷 725-748页

作者： Subrata Panja shyamal kumar Mondal Department of Applied Mathematics with Oceanology and Computer Programming Vidyasagar UniversityMidnaporeW.B.721102India

This paper explains an integrated production inventory supply chain model,which consists of a supplier,a manufacturer and a retailer under two-level credit *** is manufacturer’s credit period offered by the supplier,and other is retailer’s credit period offered by the ***,the manufacturer replenishes raw materials from the supplier and produces non-deteriorating products in some cycles of equal *** is noted that here four inventory structures have been considered to show the flow of the materials as either raw materials or finished products from supplier to retailer via *** in this model,manufacturer’s imperfect production has been *** imperfect items are not *** retailer receives good finished products from the manufacturer and sells these to his/her customers during some cycles of equal length in total time *** main objective is to find the optimal number of production and business cycles of the manufacturer such that the integrated system can get the maximum *** above discussed model is elaborated with the help of a numerical example,and a sensitivity analysis is done with respect to some parameters used in this model.

关键词： Supply chain Integrated production inventory Four-layer inventory system Imperfect production Two-level credit period

Multi-item EPQ model with learning effect on imperfect production over fuzzy-random planning horizon

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Journal of Management Analytics 2017年第1期4卷 80-110页

作者： Amalesh kumar Manna Barun das Jayanta kumar Dey shyamal kumar Mondal Department of Applied Mathematics with Oceanology and Computer Programming Vidyasagar UniversityMidnapore-721102WBIndia Department of Mathematics Sidho-Kanho-Birsha UniversityPuruliaWBIndia Department of Mathematics Mahishadal Raj CollegeMahishadal721628WBIndia

Uncertainty is certain in the world of *** study revisits an economic production quantity(EPQ)model with shortages for stock-dependent demand of the items with reworking and disposing of the imperfect ones over a random planning horizon under the joint effect of inflation and time value of money,where the expected time length is imprecise in *** of learning effect has been incorporated to reduce the defective *** total expected profit over the random planning horizon is maximized subject to the imprecise space *** possibility,necessity and credibility measures have been introduced to defuzzify the *** simulation-based genetic algorithm is used to make decision for the above EPQ model in different measures of *** model is illustrated through an *** analysis shows the impacts of different parameters on the objective function in the model.

关键词： imperfect production rework shortage learning effect random planning horizon genetic algorithm

Translocator protein and neurodegeneration: insights from Alzheimer’s disease

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Neural Regeneration Research 2025年第4期20卷 1090-1091页

作者： Arpit kumar Pradhan Rainer Rupprecht Gerhard Rammes Klinik für Anaesthesiologie und Intensivmedizin der Technischen Universität München Klinikum rechts der IsarMunichGermany Graduate School of Systemic Neurosciences Ludwig-Maximilians-Universität MünchenMartinsriedGermany Department of Psychiatry and Psychotherapy University RegensburgRegensburgGermany

The 18 kDa translocator protein(TSPO)located on the outer mitochondrial membrane regulates several key cellular processes including mitochondrial homeostasis,cholesterol transport,apoptosis,cell proliferation,and maintenance of mitochondrial health(Rupprecht et al.,2022,2023).TSPO is expressed in both peripheral organs and the central nervous system,with a more pronounced expression in tissues that produce *** main reason why TSPO has garnered so much attention is because it plays a key role in neurosteroidogenesis by transferring cholesterol from the outer to the inner mitochondrial membrane,which is the rate-limiting step in neurosteroid synthesis.A cholesterol-recognizing amino acid consensus domain has been identified in the cytosolic C terminus of the TSPO protein by both in vitro and site-directed mutagenesis experiments(Li et al.,2001).However,the role of TSPO in the process of neurosteroid synthesis has been challenged by several studies,particularly TSPO knockout models,which suggest that TSPO removal does not affect the phenotype or the system’s viability(Tu et al.,2014).However,ligands targeting TSPO have been shown to enhance levels of neurosteroids which suggests that neurosteroidogenesis is one of the major functional roles mediated by the TSPO protein.

关键词： cholesterol organs

Evaluation of the CROPGRO-Peanut model in simulating appropriate sowing date and phosphorus fertilizer application rate for peanut in a subtropical region of eastern India

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The Crop Journal 2017年第4期5卷 317-325页

作者： Debjani Halder Rabindra kumar Panda Rajiv kumar Srivastava shyamal Kheroar Department of Agriculture Government of West Bengal Mathabhanga Cooch Behar 736 146 West Bengal India School of Infrastructure Indian Institute of Technology Bhubaneswar 751 013 Odisha India Agricultural and Food Engineering Department Indian Institute of Technology Kharagpur 721 302 West Bengal India Department of Agronomy Uttar Banga Krishi Viswavidyalaya Pundibari Cooch Behar 736 165 West Bengal India

Projected changes in weather parameters, mainly temperature and rainfall, have already started to show their effect on agricultural production. To cope with the changing scenarios, adoption of appropriate management strategies is of paramount importance. A study was undertaken to evaluate the most appropriate combination of sowing date and phosphorus fertilization level for peanut crops grown in sandy loam soil in a subhumid region of eastern India. Field experiments were conducted during the summer seasons of 2012 and 2013 on peanut crops at the farm of the Indian Institute of Technology, Kharagpur. The DSSAT v4.5 CROPGRO-Peanut model was used to predict the phenology, growth, and yield of peanut crop under combinations of four sowing dates and four phosphorus fertilization levels. The model was calibrated with a 2012 dataset of growth, phenology, and yield parameters for estimating the genetic coefficients of cultivar TMV-2 and was validated with a 2013 dataset of the same parameters. Simulations of pod yield and other yield parameters using the calibrated model were found to be quite accurate. The model was able to reasonably simulate pod yield and final biomass with low normalized root mean square error (RMSE_n), low absolute root mean square error (RMSE_a) and high coefficient of determination (R^2> 0.7) over a wide range of sowing dates and different phosphorus fertilization levels sensitivity analysis indicated that sowing from the second week of January to the end of February with 30–50 kg P_2O_5 ha^(-1)would give the highest pod yield.

关键词： Sowing date Phosphorus fertilizer CROPGRO-Peanut model Sensitivity analysis RMSE

H_(∞) Load Frequency Control Design Based on Delay Discretization Approach for Interconnected Power Systems with Time Delay

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Journal of Modern Power Systems and Clean Energy 2021年第6期9卷 1468-1477页

作者： Subrat kumar Pradhan Dushmanta kumar das Department of Electrical and Electronics Engineering National Institute of Technology Nagaland

This paper proposes a delay discretization based H∞load frequency control strategy for interconnected power *** effect of time delay is considered in the system for the design of stabilizing *** improve the tolerable delay margin of the system,a two-term state feedback controller structure is *** controller requires delayed state information as control *** the proposed approach,the amount of delay introduced in the state of the system,i.e.,artificial delay,for taking control action is assumed to be *** approach is based on the discretization of this delay *** order to define a simple Lyapunov-Krasovskii(LK)function for each of the discretized interval,a stabilization criterion is developed in such a way that a single one satisfies the requirement of all the *** developed criterion is computationally simple and efficient.

关键词： Interconnected power system load frequency control(LFC) state feedback controller time delay

Analysis of a harvested tritrophic food chain model in the presence of additional food for top predator

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International Journal of Biomathematics 2018年第4期11卷 271-299页

作者： Prabir Panja Swarup Poria shyamal kumar Mondal Department of Applied ScienceHaldia Institute of Technology Haldia-721657 West Bengal India Departmcnt of Applied MathematicsUniversity of Calcutta 92 APC Road Kolkata 700009 India Department of Applied Mathematics with Oceanology and Computer ProgrammingVidyasagar University Midnapore 721 102 West Bengal India

In this paper, we propose and analyze a three-species predator prey system in the presence of additional food for top predator. It is assumed that the middle predator is acting as a prey as well as a predator and the top predator consumes both prey as well as middle predator. It is also considered that a constant amount of additional food for top predator exists in the ecosystem. The effects of harvesting of top predator are investigated. The existence and stability conditions of the equilibria have been discussed analytically. The Hopf bifurcation analysis of the system with respect to predation rate of prey to the top predator and the harvesting effort have been analyzed both analytically and numerically. Pontryagin＇s maximum principle is used to determine the optimal harvesting of top predator population to maximize the discounted net revenue. From our analysis, it is seen that the additional food has a significant impact to prevent the extinction risk of top predator population and also to increase revenue collection. Finally, some numerical results have been given in support of our analytical findings.

关键词： Predator Prey Hopf bifurcation Pontryagin's maximum principle Harvesting.

Powder mixed electrochemical discharge process for micro machining of C103 niobium alloy

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Defence Technology（防务技术） 2023年第8期26卷 84-101页

作者： Niladri Mandal Nitesh kumar Alok kumar das Defence Research&Development Laboratory(DRDL)-DRDO HyderabadIndia Department of Mechanical Engineering Indian Institute of Technology(ISM)DhanbadIndia

This work demonstrates the viability of the powder-mixed micro-electrochemical discharge machining(PMECDM) process to fabricate micro-holes on C103 niobium-based alloy for high temperature *** processes are involved simultaneously *** erosion,chemical etching,and abrasive grinding for removal of material while the classical electrochemical discharge machining process involves double actions *** erosion,and chemical *** powder-mixed electrolyte process resulted in rapid material removal along with a better surface finish as compared to the classical microelectrochemical discharge machining(MECDM).Further,the results are optimized through a multiobjective optimization approach and study of the surface topography of the hole wall surface obtained at optimized *** the selected range of experimental parameters,PMECDM shows a higher material removal rate(MRR) and lower surface roughness(R_(a))(MRR:2.8 mg/min and R_(a) of 0.61 μm) as compared to the MECDM process(MRR:2.01 mg/min and corresponding Raof 1.11 μm).A detailed analysis of the results is presented in this paper.

关键词： Micro-electrochemical discharge machining C103 niobium alloy Surface integrity Material removal rate Hybrid powder mixed ECDM

A Cocktail of Natural Compounds Holds Promise for New Immunotherapeutic Potential in Head and Neck Cancer

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Chinese Journal of Integrative Medicine 2024年第1期30卷 42-51页

作者： Sunil kumar Asmita das Department of Biotechnology Delhi Technological UniversityDelhi(110042)India

Objective: To obtain detailed understanding on the gene regulation of natural compounds in altering prognosis of head and neck squamous cell carcinomas(HNSC). Methods: Gene expression data of HNSC samples and peripheral blood mononuclear cells(PBMCs) of HNSC patients were collected from Gene Expression Omnibus(GEO). Differential gene expression analysis of GEO datasets were achieved by the GEO2R tool. Common differentially expressed gerres(DEGs) were screened by comparing DEGs of HNSC with those of PBMCs. The combination was further analyzed for regulating pathways and biological processes that were affected. Results: Totally 110 DEGs were retrieved and identified to be involved in biological processes related to tumor regulation. Then 102 natural compounds were screened for a combination such that the expressions of all 110 commonly DEGs were altered. A combination of salidroside, ginsenoside Rd, oridonin, britanin, and scutellarein was chosen. A multifaceted, multi-dimensional tumor regression was showed by altering autophagy, apoptosis, inhibiting cell proliferation, angiogenesis, metastasis and inflammatory cytokines production. Conclusions: This study has helped develop a unique combination of natural compounds that will markedly reduce the propensity of development of drug resistance in tumors and immune evasion by tumors. The result is crucial to developing a combinatorial natural therapeutic cocktail with accentuated immunotherapeutic potential.

关键词： natural compounds chemopreventive gene expression head and neck cancer immunomodulator salidroside ginsenoside Rd oridonin britanin scutellarein

Analysis and design of open trench barriers in screening steady-state surface vibrations

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Earthquake Engineering and Engineering Vibration 2014年第3期13卷 545-554页

作者： Ankurjyoti Saikia Utpal kumar das Department of Civil Engineering Tezpur University

The problem of vibration isolation by rectangular open trenches in a plane strain context is numerically studied using a finite element code, PLAXIS. The soil media is assumed to be linear elastic, isotropic, and homogeneous subjected to a vertical harmonic load producing steady-state vibration. The present model is validated by comparing it with previously published works. The key geometrical features of a trench, i.e., its depth, width, and distance from the source of excitation, are normalized with respect to the Rayleigh wavelength. The attenuation of vertical and horizontal components of vibration is studied for various trench dimensions against trench locations varied from an active to a passive case. Results are depicted in non-dimensional forms and conclusions are drawn regarding the effects of geometrical parameters in attenuating vertical and horizontal vibration components. The screening efficiency is primarily governed by the normalized depth of the barrier. The effect of width has little significance except in some specific cases. Simplified regression models are developed to estimate average amplitude reduction factors. The models applicable to vertical vibration cases are found to be in excellent agreement with previously published results.

关键词： finite element open trench vibration isolation wave barrier non-dimensional