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The Effect of Xu’s Influenza Decoction Combined with Oseltamivir on Influenza A:A Propensity Score Matching Study

Clinical Complementary Medicine and Pharmacology 2024年第1期4卷 1-9页

作者： Tianxi Chen shuyan fu Fengyuan Tian Qiushuang Li Hongyu Ling Yijie Lou Jun Tang Hong Zheng Basic Medical School Zhejiang Chinese Medical UniversityHangzhou 310053ZhejiangChina Department of Infectious Diseases First Affiliated Hospital of Zhejiang Chinese Medical UniversityHangzhou 31006ZhejiangChina First School of Clinical Medicine Zhejiang Chinese Medical UniversityHangzhou 310053ZhejiangChina Center of Clinical Evaluation and Analysis First Affiliated Hospital of Zhejiang Chinese Medicine UniversityHangzhou 31006ZhejiangChina Department of General Practice First Affiliated Hospital of Zhejiang Chinese Medical UniversityHangzhou 31006ZhejiangChina

Background:The resurgence of seasonal influenza virus circulation has been seen in 2021-2022 after the tempo-rary suppression in *** inhibitors(NAIs)are widely applied in the clinical treatment of influenza A despite several ***:To access the efficacy of Xu’s influenza decoction(XID)in combination therapy with oseltamivir for the treatment of influenza ***:In this retrospective cohort study,the eligible participants were diagnosed with influenza A between June 1,2018,and May 30,2022,in the First Affiliated Hospital of Zhejiang Chinese Medical *** to whether Xu’s influenza decoction was applied,patients were divided into two groups:treated with or without *** score matching(PSM)was used to further adjust the covariates between *** primary outcome was to compare time to defervescence via K-M curves,Breslow tests,and Cox regression *** Cox proportional hazards model,a univariate analysis was performed to obtain preliminary results,while a further multivariate analysis was conducted to study the independent factors that influence *** analysis was conducted according to body temperature and time from onset to *** secondary outcome consisted of routine blood and C-reactive protein(CRP),length of stay,and medical ***:A total of 336 patients with influenza A were enrolled in this study(i.e.,163 patients in the XID+oseltamivir group;173 patients in the oseltamivir group).After 1:1 matching via PSM,230 patients meeting the criteria were included in the analysis,with 115 in each *** XID+oseltamivir group had shorter time to defervescence(36 h vs 44 h,P=0.011),shorter length of stay(3 days vs 4 days,P=0.018),and higher defervescence possibility(HR=1.384,95%CI:1.054-1.818).Subgroup analysis indicated that for patients during non-window period(≥48 h)with medium-grade fever(38.1℃-39℃),the XID+oseltamivir combination therapy reduced time to defervescence

关键词： Influenza A Xu’s influenza decoction Oseltamivir Time to defervescence,Cox regression Propensity score matching Cohort study

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Co-immunoprecipitation for identifying protein–protein interaction on lipid droplets

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Biophysics Reports 2024年第2期10卷 102-110页

作者： Xiaochuan fu shuyan Zhang Pingsheng Liu Institute of Biophysics Chinese Academy of Sciences University of Chinese Academy of Sciences Institute of Infectious Diseases Beijing Key Laboratory of Emerging Infectious Diseases Beijing Ditan HospitalCapital Medical University Beijing Institute of Infectious Diseases

The lipid droplet(LD) is a conserved organelle that exists in almost all organisms, ranging from bacteria to mammals. Dysfunctions in LDs are linked to a range of human metabolic syndromes. The formation of protein complexes on LDs is crucial for maintaining their function. Investigating how proteins interact on LDs is essential for understanding the role of LDs. We have developed an effective method to uncover protein–protein interactions and protein complexes specifically on LDs. In this method, we conduct co-immunoprecipitation(co-IP) experiments using LD proteins extracted directly from isolated LDs, rather than utilizing proteins from cell lysates. To elaborate, we begin by purifying LDs with high-quality and extracting LD-associated proteins. Subsequently, the co-IP experiment is performed on these LD-associated proteins directly, which would enhance the co-IP experiment specificity of LDassociated proteins. This method enables researchers to directly unveil protein complexes on LDs and gain deeper insights into the functional roles of proteins associated with LDs.

关键词： Lipid droplet Co-immunoprecipitation Protein interaction

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Deleterious variants in RNF111 impair female fertility and induce premature ovarian insufficiency in humans and mice

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Science China(Life Sciences) 2024年第7期67卷 1325-1337页

作者： Chengcheng Song Yingying Qin Yan Li Bingyi Yang Ting Guo Wenqing Ma Dian Xu Keyan Xu Fangfang fu Li Jin Yanhua Wu shuyan Tang Xiaojun Chen Feng Zhang Obstetrics and Gynecology Hospital State Key Laboratory of Genetic EngineeringInstitute of Medical Genetics and GenomicsFudan UniversityShanghai 200011China Human Phenome Institute Zhangjiang Fudan International Innovation CenterFudan UniversityShanghai 201203China Center for Reproductive Medicine Cheeloo College of MedicineShandong UniversityJinan 250021China State Key Laboratory of Reproductive Medicine and Offspring Health Key Laboratory of Reproductive Endocrinology of Ministry of EducationNational Research Center for Assisted Reproductive Technology and Reproductive GeneticsShandong Key Laboratory of Reproductive MedicineShandong Provincial Clinical Research Center for Reproductive HealthShandong UniversityJinan 250021China Department of Obstetrics and Gynecology Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China National Demonstration Center for Experimental Biology Education School of Life SciencesFudan UniversityShanghai 200433China Department of Gynecology the Tenth People’s Hospital of Tongji UniversityShanghai 200072China Soong Ching Ling Institute of Maternity and Child Health International Peace Maternity and Child Health Hospital of China Welfare InstituteShanghai 200030China

Premature ovarian insufficiency(POI)is a heterogeneous female disorder characterized by the loss of ovarian function before the age of *** represents a significant detriment to female ***,the known POI-causative genes currently account for only a fraction of *** elucidate the genetic factors underlying POI,we conducted whole-exome sequencing on a family with three fertile POI patients and identified a deleterious missense variant in *** a subsequent replication study involving 1,030 POI patients,this variant was not only confirmed but also accompanied by the discovery of three additional predicted deleterious RNF111 *** variants collectively account for eight cases,representing 0.78%of the study cohort.A further study involving 500 patients with diminished ovarian reserve also identified two additional RNF111 ***,RNF111 encodes an E3 ubiquitin ligase with a regulatory role in the TGF-β/BMP signaling *** analysis revealed that RNF111/RNF111 is predominantly expressed in the oocytes of mice,monkeys,and *** further investigate the functional implications of RNF111 variants,we generated two mouse models:one with a heterozygous missense mutation(Rnf111+/M)and another with a heterozygous null mutation(Rnf111^(+/-)).Both mouse models exhibited impaired female fertility,characterized by reduced litter sizes and small ovarian ***,RNA-seq and quantitative proteomics analysis unveiled that Rnf111 haploinsufficiency led to dysregulation in female gonad development and negative regulation of the BMP signaling pathway within mouse *** conclusion,our findings strongly suggest that monoallelic deleterious variants in RNF111 can impair female fertility and induce POI in both humans and mice.

关键词： POI RNF111 female fertility ovarian reserve

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Research Progress of Traditional Chinese Medicine in the Treatment of Acute Respiratory Distress Syndrome

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Medicinal Plant 2021年第4期12卷 83-88,92页

作者： Mengqi YAO shuyan fu Ziqiang ZHOU Fangyun SUN Department of Medicine Xizang Minzu University/Engineering Research Center for Tibetan Medicine Testing Technology of the Ministry of EducationXianyang 712082China

Based on the modern pathological research mechanism of ARDS,this paper summarizes the clinical therapeutic effect of traditional Chinese medicine on ARDS from the aspects of reducing inflammatory mediators,cells and factors,regulating signal pathway,regulating aquaporin,anticoagulation and so *** purpose is to provide new theoretical basis and ideas for scholars in the future,and to improve the internationalization process of traditional Chinese medicine in the treatment of acute respiratory distress syndrome.

关键词： Acute respiratory distress syndrome Acute lung injury Traditional Chinese medicine Inflammation Cytokines Aquaporin

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Advances in Research of Pharmacological Action and Mechanism of Tibetan Medicine Ranasampel

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Medicinal Plant 2021年第3期12卷 10-14,20页

作者： shuyan fu Mengqi YAO Ziqiang ZHOU Fangyun SUN Department of Medicine Xizang Minzu UniversityEngineering Research Center for Tibetan Medicine Testing Technology of Ministry of EducationXianyang 712082China

Qishiwei Zhenzhu Wan(Ranasampel)was included in Chinese Pharmacopoeia and consists of 70 kinds of traditional Chinese medicines,including Zogta,Margarita,Croci Stigma,Santali Albi Lignum,and Dalbergiae Odoriferae Lignum,*** present,research on the pharmacological effects of Ranasampel is mainly focused on anti-Alzheimer's disease,anti-cerebral ischemia-reperfusion injury,anti-Parkinson,improving learning and memory ability,and anti-myocardial *** mechanisms involved include nervous,cardiovascular and other *** article systematically expounded the pharmacological effects and mechanism of Ranasampel,in order to provide a certain theoretical reference for its future further research and clinical application.

关键词： Qishiwei Zhenzhu Wan(Ranasampel) Alzheimer's disease Learning and memory Nyocardial ischemia Liver injury

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基于ANSYS的大型渡槽地震动力结构性态分析

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水利规划与设计 2023年第3期 93-97页

作者：李伟娟傅蜀燕太原市水利勘测设计院山西太原030001 云南农业大学水利学院云南昆明650201

大型渡槽广泛应用在长距离输水工程,不少渡槽会穿于地震高烈度地区。为了提高渡槽的抗震性能及优化渡槽结构,需要对渡槽不利部位的特征点进行抗震动力计算。文章首先计算了渡槽结构的自振特性,采用了附加质量法模拟动水压力,结合规范要... 详细信息

大型渡槽广泛应用在长距离输水工程,不少渡槽会穿于地震高烈度地区。为了提高渡槽的抗震性能及优化渡槽结构,需要对渡槽不利部位的特征点进行抗震动力计算。文章首先计算了渡槽结构的自振特性,采用了附加质量法模拟动水压力,结合规范要求的反应谱构造了人工波的地震动输入,分析了槽身侧墙和底板动力响应的最值点的变化特性。由工程案例可知:槽身侧墙的中间高度较为容易出现破坏,槽身底板在跨端部位较跨中处更容易出现破坏。该研究方法可为同类大型渡槽的动力分析提供范例指导。

关键词：渡槽地震响应动力计算性态分析

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以竹代塑加工技术与产品现状及其市场发展潜力

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林业科学 2024年第1期60卷 129-141页

作者：叶翰舟傅金和程海涛陈复明杨淑艳王戈国际竹藤中心北京100102 中国循环经济协会北京100037 中国竹产业协会北京100102

我国竹资源丰富、竹加工技术先进、研发能力过硬、国际竞争力强,竹产业是我国绿色朝阳产业,在发展绿色经济、推进国家生态文明建设和现代林业建设,以及践行“一带一路”、乡村振兴和精准扶贫等国家战略中发挥着重要作用。当前,传统塑料... 详细信息

我国竹资源丰富、竹加工技术先进、研发能力过硬、国际竞争力强,竹产业是我国绿色朝阳产业,在发展绿色经济、推进国家生态文明建设和现代林业建设,以及践行“一带一路”、乡村振兴和精准扶贫等国家战略中发挥着重要作用。当前,传统塑料行业面临非可再生资源依赖度高、能源消耗大、环境污染严重等挑战,随着世界经济的发展以及人们对环保的重视,各国政府和组织已启动多项“限塑禁塑”政策和措施并推广可持续塑料替代品的行动。竹子是一种加工单元多样、材性优良、可再生可降解的环保低碳优质生物质材料,具有很大的加工选择性和产品可设计性,可为相适应的以竹代塑产品开发提供多种可能和选择。作为一种环保型替代方案,以竹代塑逐渐受到政府、市场和消费者的青睐。2022年11月,中国政府同国际竹藤组织携手共同发起“以竹代塑”倡议,推动各国减少塑料污染,应对气候变化,加快落实联合国2030年可持续发展议程。2023年11月,《“以竹代塑”全球行动计划(2023—2030)》在首届以竹代塑国际研讨会开幕式上正式发布,提出以竹代塑六大行动目标、23项具体行动。中国向全世界发出“以竹代塑”的强音和保护生态环境的决心,多项以竹代塑决策陆续部署,为竹产业发展提供了有力支持。本研究基于我国竹资源和竹产业的优势特点以及传统塑料行业的绿色转型需求,分析以竹代塑替代方案的迫切需求和可行性;着重梳理汽车部件、家用电器壳体、冷却塔填料、管道管材、建筑装饰材、一次性餐具等典型重点行业产品现状及其以竹代塑加工技术和产品市场发展潜力,提出以竹代塑行动建议、发展趋势与展望,旨在为我国以竹代塑技术产品的推广和应用提供一定参考。

关键词：以竹代塑限塑禁塑加工技术重点行业市场分析行动建议

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基于IMM-KF算法改进的欺骗式干扰检测算法

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电讯技术 2024年第4期64卷 559-566页

作者：陈世淼倪淑燕程凌峰付琦玮雷拓峰航天工程大学研究生院北京101416 航天工程大学电子与光学工程系北京101416

针对基于接收机基线长度的欺骗干扰检测方法在短基线和低定位精度下检测性能差的问题,提出了一种交互多模型卡尔曼滤波(Interactive Multi-model Kalman Filtering,IMM-KF)算法改进的欺骗式干扰检测算法。该方法通过IMM-KF算法对两个接... 详细信息

针对基于接收机基线长度的欺骗干扰检测方法在短基线和低定位精度下检测性能差的问题,提出了一种交互多模型卡尔曼滤波(Interactive Multi-model Kalman Filtering,IMM-KF)算法改进的欺骗式干扰检测算法。该方法通过IMM-KF算法对两个接收机天线的位置信息进行最优估计,提高基线解算精度,从而提升基于基线长度的欺骗干扰检测方法的检测性能。首先,详细分析了基于基线长度的欺骗干扰检测方法的数学原理;其次,建立欺骗检测算法模型,并对其性能进行仿真分析;然后,根据算法应用场景引入IMM-KF算法优化基线长度估计量;最后,针对不同的基线长度和定位精度进行仿真实验,对算法进行性能评估。仿真结果表明,该算法可以在接收机伪距测量精度为0.1 m、基线长度为0.5 m的情况下达到86%的检测成功率,而传统算法在此情况下检测成功率仅为10%。

关键词：全球卫星导航系统(GNSS) 欺骗式干扰检测基线长度交互式多模型卡尔曼滤波

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徐志瑛治疗肝硬化低蛋白血症的经验

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浙江中医杂志 2005年第11期40卷 461-462页

作者：傅淑艳浙江中医学院附属医院 310006

徐志瑛主任医师系全国名老中医,行医数十年,医术精湛.不仅擅长治疗呼吸系统疾病,而且对临床各科皆有独到的见解及显著的临床疗效.众所周知,我国是肝炎高发地区,肝病严重危害着我国人民的身心健康,迄今尚无根治的方法及药物,尤其发展到... 详细信息

徐志瑛主任医师系全国名老中医,行医数十年,医术精湛.不仅擅长治疗呼吸系统疾病,而且对临床各科皆有独到的见解及显著的临床疗效.众所周知,我国是肝炎高发地区,肝病严重危害着我国人民的身心健康,迄今尚无根治的方法及药物,尤其发展到肝硬化晚期,治疗更为棘手.徐师在多年的临床实践中总结出了一套治疗肝硬化低蛋白血症、腹水的经验和方药,临床疗效令人鼓舞.现总结介绍如下.

关键词：肝硬化低蛋白血症徐志瑛低蛋白血症肝硬化徐志瑛治疗呼吸系统疾病临床疗效名老中医主任医师医术精湛

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卫星导航欺骗干扰检测与抑制技术综述

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电讯技术 2024年第5期64卷 812-820页

作者：倪淑燕陈世淼付琦玮毛文轩雷拓峰宋鑫航天工程大学电子与光学工程系北京101416 航天工程大学研究生院北京101416 军事科学院国防科技创新研究院北京100071

全球导航卫星系统(Global Navigation Satellite System,GNSS)欺骗式干扰具有隐蔽性强、危害性大的特点,对GNSS造成了严重的安全威胁。介绍了生成式和转发式欺骗干扰的原理和关键技术,总结了现有的欺骗式干扰检测方法和抑制方法,并从成... 详细信息

全球导航卫星系统(Global Navigation Satellite System,GNSS)欺骗式干扰具有隐蔽性强、危害性大的特点,对GNSS造成了严重的安全威胁。介绍了生成式和转发式欺骗干扰的原理和关键技术,总结了现有的欺骗式干扰检测方法和抑制方法,并从成本、性能、复杂度、研究重点等方面对现有技术进行了详细分析。以性能和成本为指标,对比分析了现有干扰攻击、检测和抑制方法。最后,对未来欺骗式干扰防御研究值得关注的问题进行了展望,以期为后续研究提供思路。

关键词：全球卫星导航系统(GNSS) 欺骗式干扰欺骗干扰检测欺骗干扰抑制

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